(Q37071188)

18 August 2017

1 reference

title

New developments in medulloblastoma treatment: the potential of a cyclopamine-lovastatin combination (English)

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18 August 2017

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Eli E Bar

1

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18 August 2017

Duncan Stearns

series ordinal

2

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18 August 2017

language of work or name

English

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publication date

1 February 2008

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Expert Opinion on Investigational Drugs

18 August 2017

published in

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18 August 2017

volume

17

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18 August 2017

issue

2

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18 August 2017

page(s)

185-195

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Phase III study of craniospinal radiation therapy followed by adjuvant chemotherapy for newly diagnosed average-risk medulloblastoma.

18 August 2017

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Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): long-term results from a prospective, multicentre trial

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Multiagent chemotherapy and deferred radiotherapy in infants with malignant brain tumors: a report from the Children's Cancer Group

21 January 2018

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Current treatment of medulloblastoma: recent advances and future challenges

21 January 2018

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Outcome of medulloblastoma in children: long-term complications and quality of life.

21 January 2018

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Neurocognitive consequences of risk-adapted therapy for childhood medulloblastoma

21 January 2018

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Endocrine outcome in children with medulloblastoma treated with 18 Gy of craniospinal radiation therapy

21 January 2018

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High-dose chemotherapy with autologous stem cell rescue followed by posterior fossa irradiation for local medulloblastoma recurrence or progression after conventional chemotherapy.

21 January 2018

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Treatment of early childhood medulloblastoma by postoperative chemotherapy alone

21 January 2018

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Clinical, histopathologic, and molecular markers of prognosis: toward a new disease risk stratification system for medulloblastoma

21 January 2018

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Clinical and molecular stratification of disease risk in medulloblastoma

21 January 2018

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PDGFRB is overexpressed in metastatic medulloblastoma

21 January 2018

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Expression profiling of medulloblastoma: PDGFRA and the RAS/MAPK pathway as therapeutic targets for metastatic disease

21 January 2018

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American Cancer Society guidelines on nutrition and physical activity for cancer prevention: Reducing the risk of cancer with healthy food choices and physical activity

21 January 2018

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Pharmacology of competitive inhibitors of HMG-CoA reductase.

21 January 2018

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Comparative tolerability of the HMG-CoA reductase inhibitors

21 January 2018

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HMG-CoA reductase inhibitors

21 January 2018

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Novel lipid-regulating drugs

21 January 2018

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Structural mechanism for statin inhibition of HMG-CoA reductase

21 January 2018

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Long-term safety of hepatic hydroxymethyl glutaryl coenzyme A reductase inhibitors: the role of metabolism-monograph for physicians

21 January 2018

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NK-104: a novel synthetic HMG-CoA reductase inhibitor

21 January 2018

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Pharmacodynamics and pharmacokinetics of the HMG-CoA reductase inhibitors. Similarities and differences

21 January 2018

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Preclinical and clinical pharmacology of Rosuvastatin, a new 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor

21 January 2018

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Clinical pharmacokinetics of cerivastatin

21 January 2018

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Safety profiles for the HMG-CoA reductase inhibitors: treatment and trust

21 January 2018

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HMG-CoA reductase inhibitors and myotoxicity

21 January 2018

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Oncogenes and Cancer: The p21rasGenes

21 January 2018

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New insights into the interaction of Ras with the plasma membrane

21 January 2018

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Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity

21 January 2018

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Molecular signals in anti-apoptotic survival pathways.

21 January 2018

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Lovastatin induces apoptosis of anaplastic thyroid cancer cells via inhibition of protein geranylgeranylation and de novo protein synthesis.

21 January 2018

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Inhibition of Ras prenylation: a novel approach to cancer chemotherapy

21 January 2018

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Role of stem cells in cancer therapy and cancer stem cells: a review

21 January 2018

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Therapeutic implications of cancer stem cells.

21 January 2018

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Cancer stem cells: lessons from leukaemia

21 January 2018

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Cancer stem cells and therapeutic perspectives.

21 January 2018

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Cancer stem cells: are we missing the target?

21 January 2018

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Cancer stem cells in the mammalian central nervous system

21 January 2018

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Stem cells, cancer, and cancer stem cells

21 January 2018

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Intracellular cholesterol transport.

21 January 2018

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Lipid rafts and signal transduction

21 January 2018

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The involvement of lipid rafts in epidermal growth factor-induced chemotaxis of breast cancer cells.

21 January 2018

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Statins and the risk of colorectal cancer

21 January 2018

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Statin use and the risk of 10 cancers.

21 January 2018

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Statins and prostate cancer risk: a case-control study

21 January 2018

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A Phase I trial of prolonged administration of lovastatin in patients with recurrent or metastatic squamous cell carcinoma of the head and neck or of the cervix

21 January 2018

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Hedgehog signaling in animal development: paradigms and principles

21 January 2018

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Hedgehog signalling: how to get from Smo to Ci and Gli.

21 January 2018

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A defective response to Hedgehog signaling in disorders of cholesterol biosynthesis

21 January 2018

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The Hedgehog response network: sensors, switches, and routers

21 January 2018

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Medulloblastoma growth inhibition by hedgehog pathway blockade

21 January 2018

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Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours

21 January 2018

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Hedgehog signalling in prostate regeneration, neoplasia and metastasis

21 January 2018

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Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.17.2.185

Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.17.2.185

Autoproteolysis in hedgehog protein biogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.17.2.185

Cholesterol modification of hedgehog signaling proteins in animal development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.17.2.185

Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.17.2.185

Hedgehog patterning activity: role of a lipophilic modification mediated by the carboxy-terminal autoprocessing domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.17.2.185

A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.17.2.185

Regulation of the mevalonate pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.17.2.185

Common critical pathways in embryogenesis and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.17.2.185

Developmental defects in Gorlin syndrome related to a putative tumor suppressor gene on chromosome 9

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.17.2.185

Hedgehog signaling promotes medulloblastoma survival via Bc/II

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.17.2.185

REN(KCTD11) is a suppressor of Hedgehog signaling and is deleted in human medulloblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.17.2.185

Mutations in SUFU predispose to medulloblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.17.2.185

Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.17.2.185

The cholesterol lowering drug lovastatin induces cell death in myeloma plasma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.17.2.185

3-Hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitors, atorvastatin and simvastatin, induce apoptosis of vascular smooth muscle cells by downregulation of Bcl-2 expression and Rho A prenylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.17.2.185

Apoptosis of medulloblastoma cells in vitro follows inhibition of farnesylation using manumycin A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.17.2.185

Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.17.2.185

Regulation of lymphocyte survival by the bcl-2 gene family

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.17.2.185

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.17.2.185

Purkinje-cell-derived Sonic hedgehog regulates granule neuron precursor cell proliferation in the developing mouse cerebellum

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.17.2.185

Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.17.2.185

Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.17.2.185

Identification of human brain tumour initiating cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.17.2.185

Glioma stem cells promote radioresistance by preferential activation of the DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.17.2.185

HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.17.2.185

Targeting medulloblastoma: small-molecule inhibitors of the Sonic Hedgehog pathway as potential cancer therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.17.2.185

Efficacy and safety of statin therapy in children with familial hypercholesterolemia: a randomized controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.17.2.185

Self-reported history of hypercholesterolaemia and gallstones and the risk of prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.17.2.185

10.1517/13543784.17.2.185

21 January 2018

Identifiers

DOI

1 reference

18 August 2017

1 reference