(Q37071340)

English

Chronic oral administration of minocycline to sheep with ovine CLN6 neuronal ceroid lipofuscinosis maintains pharmacological concentrations in the brain but does not suppress neuroinflammation or disease progression

scientific article published on 30 July 2013

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Chronic oral administration of minocycline to sheep with ovine CLN6 neuronal ceroid lipofuscinosis maintains pharmacological concentrations in the brain but does not suppress neuroinflammation or disease progression (English)

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

0 references

1 reference

based on heuristic

inferred from title

neuronal ceroid lipofuscinosis

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

2

object named as

David N Palmer

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

author name string

Graham W Kay

1

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

language of work or name

1 reference

based on heuristic

inferred from title

publication date

30 July 2013

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Journal of Neuroinflammation

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

10

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

97

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

copyright license

Creative Commons Attribution 2.0 Generic

30 July 2013

1 reference

April 2022 Public Data File from Crossref

copyright status

1 reference

April 2022 Public Data File from Crossref

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1 reference

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1 reference

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1 reference

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Mutation of the parkinsonism gene ATP13A2 causes neuronal ceroid-lipofuscinosis

1 reference

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29 September 2017

Update of the mutation spectrum and clinical correlations of over 360 mutations in eight genes that underlie the neuronal ceroid lipofuscinoses

1 reference

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29 September 2017

Mutations in DNAJC5, encoding cysteine-string protein alpha, cause autosomal-dominant adult-onset neuronal ceroid lipofuscinosis

1 reference

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Neuroprotection by minocycline caused by direct and specific scavenging of peroxynitrite

1 reference

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1 reference

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1 reference

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Life and death of microglia

1 reference

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29 September 2017

Minocycline restores striatal tyrosine hydroxylase in GDNF heterozygous mice but not in methamphetamine-treated mice

1 reference

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1 reference

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29 September 2017

Location and connectivity determine GABAergic interneuron survival in the brains of South Hampshire sheep with CLN6 neuronal ceroid lipofuscinosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733893

29 September 2017

Minocycline attenuates lipopolysaccharide (LPS)-induced neuroinflammation, sickness behavior, and anhedonia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733893

29 September 2017

Minocycline modulates neuroinflammation independently of its antimicrobial activity in staphylococcus aureus-induced brain abscess

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733893

29 September 2017

Minocycline down-regulates MHC II expression in microglia and macrophages through inhibition of IRF-1 and protein kinase C (PKC)alpha/betaII

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733893

29 September 2017

The significance of neuroinflammation in understanding Alzheimer's disease.

1 reference

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29 September 2017

Microglia, major player in the brain inflammation: their roles in the pathogenesis of Parkinson's disease

1 reference

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29 September 2017

Pharmacokinetics and pharmacodynamics of the tetracyclines including glycylcyclines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733893

29 September 2017

NSAIDs and Alzheimer disease: epidemiological, animal model and clinical studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733893

29 September 2017

Minocycline attenuates microglial activation but fails to mitigate striatal dopaminergic neurotoxicity: role of tumor necrosis factor- alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733893

29 September 2017

Clinical potential of minocycline for neurodegenerative disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733893

29 September 2017

The role of inflammation in Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733893

29 September 2017

Microglia and neuroinflammation: a pathological perspective

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733893

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Differential expression of chemokines and chemokine receptors during microglial activation and inhibition

1 reference

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Lysine 43 is trimethylated in subunit C from bovine mitochondrial ATP synthase and in storage bodies associated with batten disease

1 reference

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Control of glial immune function by neurons

1 reference

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29 September 2017

Minocycline provides neuroprotection against N-methyl-D-aspartate neurotoxicity by inhibiting microglia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733893

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A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window

1 reference

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1 reference

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1 reference

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1 reference

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29 September 2017

Batten disease: past, present, and future.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733893

29 September 2017

Acute minocycline treatment mitigates the symptoms of mild blast-induced traumatic brain injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733893

27 June 2018

Anti-inflammatory impact of minocycline in a mouse model of tauopathy.

1 reference

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27 June 2018

TNF-alpha knockout and minocycline treatment attenuates blood-brain barrier leakage in MPTP-treated mice

1 reference

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27 June 2018

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1 reference

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1 reference

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4 September 2018

A missense mutation (c.184C>T) in ovine CLN6 causes neuronal ceroid lipofuscinosis in Merino sheep whereas affected South Hampshire sheep have reduced levels of CLN6 mRNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733893

4 September 2018

Activation of non-neuronal cells within the prenatal developing brain of sheep with neuronal ceroid lipofuscinosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733893

4 September 2018

Glial activation spreads from specific cerebral foci and precedes neurodegeneration in presymptomatic ovine neuronal ceroid lipofuscinosis (CLN6).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733893

4 September 2018

Minocycline inhibits LPS-induced retinal microglia activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733893

4 September 2018

Minocycline reduces the lipopolysaccharide-induced inflammatory reaction, peroxynitrite-mediated nitration of proteins, disruption of the blood-brain barrier, and damage in the nigral dopaminergic system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733893

4 September 2018

Optimal delivery of minocycline to the brain: implication for human studies of acute neuroprotection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733893

4 September 2018

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1 reference

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4 September 2018

A futility study of minocycline in Huntington's disease

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-10-97

21 January 2018

Ovine ceroid lipofuscinosis. The major lipopigment protein and the lipid-binding subunit of mitochondrial ATP synthase have the same NH2-terminal sequence

1 reference

https://pubmed.ncbi.nlm.nih.gov/23899308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacotherapeutics of the newer tetracyclines

1 reference

https://pubmed.ncbi.nlm.nih.gov/23899308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasma levels of oxytetracycline, doxycycline, and minocycline in pigs after oral administration in feed1

1 reference

https://pubmed.ncbi.nlm.nih.gov/23899308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spatial and temporal correlation between neuron loss and neuroinflammation in a mouse model of neuronopathic Gaucher disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/23899308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The specific loss of GnRH-positive neurons from the hypothalamus of sheep with CLN6 neuronal ceroid lipofuscinosis occurs without glial activation and has only minor effects on reproduction

1 reference

https://pubmed.ncbi.nlm.nih.gov/23899308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroglial activation repertoire in the injured brain: graded response, molecular mechanisms and cues to physiological function

1 reference

https://pubmed.ncbi.nlm.nih.gov/23899308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial ATP synthase subunit c storage in the ceroid-lipofuscinoses (Batten disease)

1 reference

https://pubmed.ncbi.nlm.nih.gov/23899308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification and determination of the two principal metabolites of minocycline in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/23899308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The neuronal ceroid lipofuscinoses: the same, but different?

1 reference

https://pubmed.ncbi.nlm.nih.gov/23899308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/1742-2094-10-97

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Dimensions Publication ID

0 references

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

ResearchGate publication ID

0 references

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