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English
The role of hypoxia-inducible factors in tumorigenesis.
scientific article published on 15 February 2008
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scholarly article
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stated in
Europe PubMed Central
PMC publication ID
3050610
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18259193%20AND%20SRC:MED&resulttype=core&format=json
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2 January 2020
review article
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Europe PubMed Central
title
The role of hypoxia-inducible factors in tumorigenesis
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
3050610
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18259193%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 January 2020
main subject
hypoxia
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author
Erinn B. Rankin
series ordinal
1
1 reference
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Europe PubMed Central
PMC publication ID
3050610
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18259193%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 January 2020
author name string
A J Giaccia
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2
1 reference
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Europe PubMed Central
PMC publication ID
3050610
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18259193%20AND%20SRC:MED&resulttype=core&format=json
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2 January 2020
publication date
15 February 2008
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Europe PubMed Central
PMC publication ID
3050610
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18259193%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 January 2020
published in
Cell Death & Differentiation
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Europe PubMed Central
PMC publication ID
3050610
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18259193%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 January 2020
volume
15
1 reference
stated in
Europe PubMed Central
PMC publication ID
3050610
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18259193%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 January 2020
issue
4
1 reference
stated in
Europe PubMed Central
PMC publication ID
3050610
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18259193%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 January 2020
page(s)
678-685
1 reference
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Europe PubMed Central
PMC publication ID
3050610
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18259193%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 January 2020
exact match
https://scigraph.springernature.com/pub.10.1038/cdd.2008.21
0 references
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Hypoxia Attenuates the Expression of E-Cadherin via Up-Regulation of SNAIL in Ovarian Carcinoma Cells
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Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
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Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia
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Loss of PTEN facilitates HIF-1-mediated gene expression
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The Hallmarks of Cancer
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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
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Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
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Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway
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HIF-1 alpha is required for solid tumor formation and embryonic vascularization.
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29 September 2017
HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1 alpha and developmentally expressed in blood vessels
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29 September 2017
A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development
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29 September 2017
Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells
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29 September 2017
Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit
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29 September 2017
Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein
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29 September 2017
Nucleotide sequence, chromosomal assignment and mRNA expression of mouse hypoxia-inducible factor-1 alpha
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29 September 2017
cDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS factor (Arnt2) with close sequence similarity to the aryl hydrocarbon receptor nuclear translocator (Arnt)
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3050610
retrieved
29 September 2017
Identification of the von Hippel-Lindau disease tumor suppressor gene
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3050610
retrieved
29 September 2017
Molecular genetic studies of sporadic and familial renal cell carcinoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3050610
retrieved
29 September 2017
Purification and characterization of hypoxia-inducible factor 1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3050610
retrieved
29 September 2017
Cloning of a Factor Required for Activity of the Ah (Dioxin) Receptor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3050610
retrieved
29 September 2017
Identification of the Ah Receptor Nuclear Translocator Protein (Arnt) as a Component of the DNA Binding Form of the Ah Receptor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3050610
retrieved
29 September 2017
Identification of transactivation and repression functions of the dioxin receptor and its basic helix-loop-helix/PAS partner factor Arnt: inducible versus constitutive modes of regulation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3050610
retrieved
29 September 2017
BNIP3 is an RB/E2F target gene required for hypoxia-induced autophagy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3050610
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27 June 2018
Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1alpha/ARNT
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3050610
retrieved
27 June 2018
The transcriptional activator hypoxia inducible factor 2 (HIF-2/EPAS-1) regulates the oxygen-dependent expression of erythropoietin in cortical astrocytes.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3050610
retrieved
4 September 2018
Regulation of E-cadherin expression by VHL and hypoxia-inducible factor.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3050610
retrieved
4 September 2018
Genetic evidence for a tumor suppressor role of HIF-2alpha.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3050610
retrieved
4 September 2018
Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3050610
retrieved
4 September 2018
Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3050610
retrieved
4 September 2018
Protection of HIF-1-deficient primary renal tubular epithelial cells from hypoxia-induced cell death is glucose dependent
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3050610
retrieved
4 September 2018
Targeted replacement of hypoxia-inducible factor-1alpha by a hypoxia-inducible factor-2alpha knock-in allele promotes tumor growth.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3050610
retrieved
4 September 2018
Protocol of radiotherapy for glioblastoma according to the expression of HIF-1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3050610
retrieved
4 September 2018
Prognostic impact of hypoxia-inducible factors 1alpha and 2alpha in colorectal cancer patients: correlation with tumor angiogenesis and cyclooxygenase-2 expression.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3050610
retrieved
4 September 2018
Hypoxia-inducible factor 1 alpha expression correlates with angiogenesis and unfavorable prognosis in bladder cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3050610
retrieved
4 September 2018
mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3050610
retrieved
4 September 2018
Prognostic significance of HIF-1 alpha overexpression in human pancreatic cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3050610
retrieved
4 September 2018
Hypoxia-inducible factors 1alpha and 2alpha are related to vascular endothelial growth factor expression and a poorer prognosis in nodular malignant melanomas of the skin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3050610
retrieved
4 September 2018
TSC2 regulates VEGF through mTOR-dependent and -independent pathways
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3050610
retrieved
4 September 2018
Hypoxia promotes a dedifferentiated phenotype in ductal breast carcinoma in situ.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3050610
retrieved
4 September 2018
Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3050610
retrieved
4 September 2018
Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3050610
retrieved
4 September 2018
Inhibition of PPAR gamma 2 gene expression by the HIF-1-regulated gene DEC1/Stra13: a mechanism for regulation of adipogenesis by hypoxia
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3050610
retrieved
4 September 2018
Characteristic chromosomal aberrations in sporadic cerebellar hemangioblastomas revealed by comparative genomic hybridization.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3050610
retrieved
4 September 2018
Induction of vascular endothelial growth factor by hypoxia is modulated by a phosphatidylinositol 3-kinase/Akt signaling pathway in Ha-ras-transformed cells through a hypoxia inducible factor-1 transcriptional element
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3050610
retrieved
4 September 2018
The relation between hypoxia-inducible factor (HIF)-1α and HIF-2α expression with anemia and outcome in surgically treated head and neck cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2008.21
retrieved
21 January 2018
Overexpression of hypoxia-inducible factor 1alpha is a marker for an unfavorable prognosis in early-stage invasive cervical cancer
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/18259193
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/18259193
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Expression of HIF-1alpha, CA IX, VEGF, and MMP-9 in surgically resected non-small cell lung cancer
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/18259193
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Expression of hypoxia-inducible factor 1alpha, hypoxia-inducible factor 2alpha, and von Hippel-Lindau protein in epithelial ovarian neoplasms and allelic loss of von Hippel-Lindau gene: nuclear expression of hypoxia-inducible factor 1alpha is an ind
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/18259193
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Coexpression of hypoxia-inducible factors 1alpha and 2alpha, carbonic anhydrase IX, and vascular endothelial growth factor in nasopharyngeal carcinoma and relationship to survival
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/18259193
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Activation of Hypoxia-inducible Factor-1; Definition of Regulatory Domains within the α Subunit
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/18259193
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1038/CDD.2008.21
1 reference
stated in
Europe PubMed Central
PMC publication ID
3050610
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18259193%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 January 2020
PMC publication ID
3050610
1 reference
stated in
Europe PubMed Central
PMC publication ID
3050610
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18259193%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 January 2020
PubMed publication ID
18259193
1 reference
stated in
Europe PubMed Central
PMC publication ID
3050610
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18259193%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 January 2020
ResearchGate publication ID
5593407
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