(Q37081505)

18 August 2017

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title

Bone morphogenetic protein-7 and connective tissue growth factor: novel targets for treatment of renal fibrosis? (English)

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18 August 2017

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Tri Q Nguyen

1

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author name string

Roel Goldschmeding

series ordinal

2

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PubMed ID

18266088

18 August 2017

language of work or name

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12 February 2008

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18 August 2017

Pharmaceutical Research

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18 August 2017

25

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18 August 2017

2416-2426

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18 August 2017

10

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Upregulation of connective tissue growth factor in a rat model of chronic allograft nephropathy.

18 August 2017

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12 December 2020

Inhibition of TGF-beta 1 expression by antisense oligonucleotides suppressed extracellular matrix accumulation in experimental glomerulonephritis

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12 December 2020

Connective tissue growth factor is a biomarker and mediator of kidney allograft fibrosis.

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12 December 2020

Natural inhibitor of transforming growth factor-β protects against scarring in experimental kidney disease

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12 December 2020

Osteogenic protein-1 (bone morphogenetic protein-7) reduces severity of injury after ischemic acute renal failure in rat.

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12 December 2020

Regulation of connective tissue growth factor gene expression in human skin fibroblasts and during wound repair

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12 December 2020

BMP-4 affects the differentiation of metanephric mesenchyme and reveals an early anterior-posterior axis of the embryonic kidney

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12 December 2020

Treatment of a murine model of high-turnover renal osteodystrophy by exogenous BMP-7

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12 December 2020

Renal fibrosis: new insights into the pathogenesis and therapeutics

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12 December 2020

Modulation of the expression of connective tissue growth factor by alterations of the cytoskeleton

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12 December 2020

Temporal expression profile and distribution pattern indicate a role of connective tissue growth factor (CTGF/CCN-2) in diabetic nephropathy in mice

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12 December 2020

Role of connective tissue growth factor (CTGF) module 4 in regulating epithelial mesenchymal transition (EMT) in HK-2 cells

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12 December 2020

Aldosterone induces CTGF in mesangial cells by activation of the glucocorticoid receptor

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12 December 2020

Identification of human ccn2 (connective tissue growth factor) promoter polymorphisms

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12 December 2020

Inhibition of gene markers of fibrosis with a novel inhibitor of transforming growth factor-beta type I receptor kinase in puromycin-induced nephritis

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12 December 2020

Reactive oxygen species-selective regulation of aortic inflammatory gene expression in Type 2 diabetes

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12 December 2020

Kinetics of connective tissue growth factor expression during experimental proliferative glomerulonephritis

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12 December 2020

Osteogenic protein-1 prevents renal fibrogenesis associated with ureteral obstruction.

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12 December 2020

CCN proteins: multifunctional signalling regulators

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12 December 2020

The amount of calcium-deficient hexagonal hydroxyapatite in aortic valves is influenced by gender and associated with genetic polymorphisms in patients with severe calcific aortic stenosis

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12 December 2020

Transforming growth factor-beta is a potent immunosuppressive agent that inhibits IL-1-dependent lymphocyte proliferation

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12 December 2020

Bone morphogenic protein-7 (BMP-7), a novel therapy for diabetic nephropathy

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12 December 2020

Renal Fibrosis and Glomerulosclerosis in a New Mouse Model of Diabetic Nephropathy and Its Regression by Bone Morphogenic Protein-7 and Advanced Glycation End Product Inhibitors

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12 December 2020

Neutralization of TGF-beta by anti-TGF-beta antibody attenuates kidney hypertrophy and the enhanced extracellular matrix gene expression in STZ-induced diabetic mice

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12 December 2020

Hypoxic induction of Ctgf is directly mediated by Hif-1.

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12 December 2020

Expression of transforming growth factor beta is elevated in human and experimental diabetic nephropathy

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12 December 2020

Connective tissue growth factor: just another factor in renal fibrosis?

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12 December 2020

Renal fibrosis and the origin of the renal fibroblast

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12 December 2020

Increased excretion of urinary transforming growth factor beta in patients with focal glomerular sclerosis

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12 December 2020

Tubular expression of connective tissue growth factor correlates with interstitial fibrosis in type 2 diabetic nephropathy

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12 December 2020

Tyrosine phosphorylation of the LDL receptor-related protein (LRP) and activation of the ERK pathway are required for connective tissue growth factor to potentiate myofibroblast differentiation

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12 December 2020

Excessive Matrix Accumulation in the Kidneys of MRL/lpr Lupus Mice Is Dependent on Complement Activation

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12 December 2020

Renal Bone Morphogenetic Protein-7 Protects against Diabetic Nephropathy

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12 December 2020

Resequencing of the characterised CTGF gene to identify novel or known variants, and analysis of their association with diabetic nephropathy

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12 December 2020

Clinical applications of BMP-7/OP-1 in fractures, nonunions and spinal fusion

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12 December 2020

Induction of connective tissue growth factor by angiotensin II: integration of signaling pathways

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12 December 2020

Transforming growth factor beta induces anchorage-independent growth of NRK fibroblasts via a connective tissue growth factor-dependent signaling pathway.

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12 December 2020

Endothelial-to-mesenchymal transition contributes to cardiac fibrosis

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12 December 2020

CCN2, connective tissue growth factor, stimulates collagen deposition by gingival fibroblasts via module 3 and alpha6- and beta1 integrins

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12 December 2020

Physiological actions and clinical applications of transforming growth factor-beta (TGF-beta).

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12 December 2020

Successful treatment of an adynamic bone disorder with bone morphogenetic protein-7 in a renal ablation model

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12 December 2020

Hepatocyte growth factor counteracts transforming growth factor-beta1, through attenuation of connective tissue growth factor induction, and prevents renal fibrogenesis in 5/6 nephrectomized mice.

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12 December 2020

A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye

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12 December 2020

In vitro evidence for differential involvement of CTGF, TGFbeta, and PDGF-BB in mesangial response to injury

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12 December 2020

Connective tissue growth factor mediates transforming growth factor beta-induced collagen synthesis: down-regulation by cAMP

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12 December 2020

Expression of gremlin, a bone morphogenetic protein antagonist, in human diabetic nephropathy

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12 December 2020

The control of ccn2 (ctgf) gene expression in normal and scleroderma fibroblasts

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12 December 2020

Cyclosporine-A induced nephrotoxicity is associated with decreased renal bone morphogenetic protein-7 expression in rats.

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12 December 2020

Connective tissue growth factor participates in scar formation of crescentic glomerulonephritis.

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12 December 2020

Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10

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12 December 2020

Human connective tissue growth factor is expressed in advanced atherosclerotic lesions

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12 December 2020

Specific down-regulation of connective tissue growth factor attenuates progression of nephropathy in mouse models of type 1 and type 2 diabetes

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12 December 2020

Transforming growth factor-beta production in anti-glomerular basement membrane disease in the rabbit.

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12 December 2020

Oral administration of GW788388, an inhibitor of TGF-beta type I and II receptor kinases, decreases renal fibrosis.

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12 December 2020

Connective tissue growth factor/CCN2 stimulates actin disassembly through Akt/protein kinase B-mediated phosphorylation and cytoplasmic translocation of p27(Kip-1)

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12 December 2020

Reduction of VEGF-A and CTGF expression in diabetic nephropathy is associated with podocyte loss.

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12 December 2020

BMP4 substitutes for loss of BMP7 during kidney development

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12 December 2020

Expression of transforming growth factor-beta isoforms in human glomerular diseases

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12 December 2020

Connective tissue growth factor in tubulointerstitial injury of diabetic nephropathy

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12 December 2020

The cysteine-rich domain protein KCP is a suppressor of transforming growth factor beta/activin signaling in renal epithelia

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12 December 2020

Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-beta

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12 December 2020

Transforming growth factor-beta1 is a new form of tumor suppressor with true haploid insufficiency.

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12 December 2020

Reduction in connective tissue growth factor by antisense treatment ameliorates renal tubulointerstitial fibrosis.

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12 December 2020

IN-1130, a novel transforming growth factor-beta type I receptor kinase (ALK5) inhibitor, suppresses renal fibrosis in obstructive nephropathy

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12 December 2020

Overexpression of connective tissue growth factor in podocytes worsens diabetic nephropathy in mice

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12 December 2020

Expression of connective tissue growth factor in human renal fibrosis

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12 December 2020

Suppression of experimental glomerulonephritis by antiserum against transforming growth factor β1

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12 December 2020

Inhibition of endogenous BMP in the glomerulus leads to mesangial matrix expansion

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12 December 2020

CT domain of CCN2/CTGF directly interacts with fibronectin and enhances cell adhesion of chondrocytes through integrin alpha5beta1

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12 December 2020

Role of connective tissue growth factor in fibronectin expression and tubulointerstitial fibrosis

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12 December 2020

Expression of bone morphogenetic protein-7 mRNA in normal and ischemic adult rat kidney

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12 December 2020

Loss of responsiveness to transforming growth factor beta induces malignant transformation of nontumorigenic rat prostate epithelial cells.

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12 December 2020

Downregulation of the expression of bone morphogenetic protein 7 in experimental pyelonephritis

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12 December 2020

Transforming growth factor-beta protein and mRNA in glomeruli in normal and diseased human kidneys

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12 December 2020

A polymorphism in the CTGF promoter region associated with systemic sclerosis.

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12 December 2020

Urinary connective tissue growth factor excretion in patients with type 1 diabetes and nephropathy

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12 December 2020

Matrix metalloproteinases cleave connective tissue growth factor and reactivate angiogenic activity of vascular endothelial growth factor 165

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12 December 2020

BMP-2 promotes phosphate uptake, phenotypic modulation, and calcification of human vascular smooth muscle cells

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12 December 2020

Expression of connective tissue growth factor is increased in injured myocardium associated with protein kinase C beta2 activation and diabetes

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12 December 2020

Connective tissue growth factor CCN2 interacts with and activates the tyrosine kinase receptor TrkA

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12 December 2020

Transforming growth factor-beta1, vascular endothelial growth factor, and bone morphogenic protein-7 expression in tacrolimus-induced nephrotoxicity in rats

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12 December 2020

Signaling mechanism of TGF-beta1 in prevention of renal inflammation: role of Smad7.

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12 December 2020

BMP-2 and OP-1 exert direct and opposite effects on renal branching morphogenesis

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12 December 2020

Osteogenic protein-1 mRNA expression is selectively modulated after acute ischemic renal injury.

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12 December 2020

Expression of BMP-7 and USAG-1 (a BMP antagonist) in kidney development and injury

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12 December 2020

Connective tissue growth factor and igf-I are produced by human renal fibroblasts and cooperate in the induction of collagen production by high glucose

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12 December 2020

Connective tissue growth factor binds vascular endothelial growth factor (VEGF) and inhibits VEGF-induced angiogenesis

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12 December 2020

Bone morphogenic protein-7 inhibits monocyte-stimulated TGF-beta1 generation in renal proximal tubular epithelial cells

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12 December 2020

Connective Tissue Growth Factor Expressed in Tubular Epithelium Plays a Pivotal Role in Renal Fibrogenesis

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12 December 2020

Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition.

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12 December 2020

Connective tissue growth factor is increased in plasma of type 1 diabetic patients with nephropathy

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12 December 2020

TGF-beta signaling and the fibrotic response

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12 December 2020

Increased expression of TGF-beta 1 mRNA in the obstructed kidney of rats with unilateral ureteral ligation

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12 December 2020

Gene therapy by transforming growth factor-beta receptor-IgG Fc chimera suppressed extracellular matrix accumulation in experimental glomerulonephritis.

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12 December 2020

Divergence and convergence of TGF-beta/BMP signaling

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12 December 2020

Connective tissue growth factor induces apoptosis in human breast cancer cell line MCF-7.

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12 December 2020

Urinary CCN2 (CTGF) as a possible predictor of diabetic nephropathy: preliminary report

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12 December 2020

Influence of connective tissue growth factor antisense oligonucleotide on angiotensin II-induced epithelial mesenchymal transition in HK2 cells

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12 December 2020

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death

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12 December 2020

Bone morphogenetic protein-7 delays podocyte injury due to high glucose

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12 December 2020

Elevated plasma levels of transforming growth factor-beta 1 in NIDDM

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12 December 2020

Proposal for a unified CCN nomenclature

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12 December 2020

Bone Morphogenetic Protein 7 is Elevated in Patients with Chronic Liver Disease and Exerts Fibrogenic Effects on Human Hepatic Stellate Cells

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12 December 2020

Urinary connective tissue growth factor excretion correlates with clinical markers of renal disease in a large population of type 1 diabetic patients with diabetic nephropathy.

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12 December 2020

Are there endogenous molecules that protect kidneys from injury? The case for bone morphogenic protein-7 (BMP-7).

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12 December 2020

BMP-7 regulates chemokine, cytokine, and hemodynamic gene expression in proximal tubule cells

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12 December 2020

Antagonistic effects of bone morphogenetic protein-4 and -7 on renal mesangial cell proliferation induced by aldosterone through MAPK activation

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12 December 2020

Epithelial-mesenchymal transition and its implications for fibrosis

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12 December 2020

Connective tissue growth factor plays an important role in advanced glycation end product-induced tubular epithelial-to-mesenchymal transition: implications for diabetic renal disease.

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12 December 2020

Transforming growth factor-beta 1 expression and phenotypic modulation in the kidney of hypertensive rats

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12 December 2020

Loss of tubular bone morphogenetic protein-7 in diabetic nephropathy

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12 December 2020

Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development

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12 December 2020

Transforming growth factor beta 1 in renal allograft recipients

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12 December 2020

Id1 regulates angiogenesis through transcriptional repression of thrombospondin-1

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12 December 2020

Identification of a family of low-affinity insulin-like growth factor binding proteins (IGFBPs): characterization of connective tissue growth factor as a member of the IGFBP superfamily

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12 December 2020

Role of BMP family members during kidney development

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12 December 2020

BMP7 antagonizes TGF-beta -dependent fibrogenesis in mesangial cells

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12 December 2020

Transforming growth factor-beta in renal disease.

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12 December 2020

Involvement of cis-acting repressive element(s) in the 3'-untranslated region of human connective tissue growth factor gene

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12 December 2020

TGF-beta stimulation and inhibition of cell proliferation: new mechanistic insights

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12 December 2020

Differential expression of connective tissue growth factor in microglia and pericytes in the human diabetic retina

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12 December 2020

Suppression subtractive hybridization identifies high glucose levels as a stimulus for expression of connective tissue growth factor and other genes in human mesangial cells

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12 December 2020

Overlapping expression domains of bone morphogenetic protein family members potentially account for limited tissue defects in BMP7 deficient embryos

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12 December 2020

BMP7 is a podocyte survival factor and rescues podocytes from diabetic injury

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12 December 2020

TGFbeta stimulated re-epithelialisation is regulated by CTGF and Ras/MEK/ERK signalling

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12 December 2020

BMP-7 functions as a novel hormone to facilitate liver regeneration

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12 December 2020

Myofibroblast progenitor cells are increased in number in patients with type 1 diabetes and express less bone morphogenetic protein 6: a novel clue to adverse tissue remodelling?

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12 December 2020

Connective-tissue growth factor modulates WNT signalling and interacts with the WNT receptor complex

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12 December 2020

BMP-7 is an efficacious treatment of vascular calcification in a murine model of atherosclerosis and chronic renal failure.

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12 December 2020

All in the CCN family: essential matricellular signaling modulators emerge from the bunker

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12 December 2020

Bone morphogenetic protein-7 improves renal fibrosis and accelerates the return of renal function

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12 December 2020

Homologous peptide of connective tissue growth factor ameliorates epithelial to mesenchymal transition of tubular epithelial cells

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12 December 2020

The low density lipoprotein receptor-related protein/alpha2-macroglobulin receptor is a receptor for connective tissue growth factor

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12 December 2020

Uterine sensitization-associated gene-1 (USAG-1), a novel BMP antagonist expressed in the kidney, accelerates tubular injury.

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12 December 2020

Thrombospondin-1 is an endogenous activator of TGF-beta in experimental diabetic nephropathy in vivo

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12 December 2020

Connective tissue growth factor and regulation of the mesangial cell cycle: role in cellular hypertrophy

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12 December 2020

Kielin/chordin-like protein, a novel enhancer of BMP signaling, attenuates renal fibrotic disease

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12 December 2020

Bone morphogenetic proteins BMP-6 and BMP-7 have differential effects on survival and neurite outgrowth of cerebellar granule cell neurons

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12 December 2020

In situ expression of connective tissue growth factor in human crescentic glomerulonephritis

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12 December 2020

Regulatory mechanism of human connective tissue growth factor (CTGF/Hcs24) gene expression in a human chondrocytic cell line, HCS-2/8.

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12 December 2020

Dexamethasone induces connective tissue growth factor expression in renal tubular epithelial cells in a mouse strain-specific manner

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12 December 2020

Connective tissue growth factor with a novel fibronectin binding site promotes cell adhesion and migration during rat oval cell activation

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12 December 2020

Myeloma light chains induce epithelial-mesenchymal transition in human renal proximal tubule epithelial cells.

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12 December 2020

Connective tissue growth factor (CCN2) induces adhesion of rat activated hepatic stellate cells by binding of its C-terminal domain to integrin alpha(v)beta(3) and heparan sulfate proteoglycan

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12 December 2020

A human bone morphogenetic protein antagonist is down-regulated in renal cancer

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12 December 2020

Regulation of connective tissue growth factor activity in cultured rat mesangial cells and its expression in experimental diabetic glomerulosclerosis

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12 December 2020

Bone morphogenic protein-7 inhibits progression of chronic renal fibrosis associated with two genetic mouse models

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12 December 2020

The CCN family of angiogenic regulators: the integrin connection

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12 December 2020

Regulation of in vitro vascular calcification by BMP4, VEGF and Wnt3a

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12 December 2020

The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms

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12 December 2020

Bone morphogenetic protein-7 reduces the severity of colon tissue damage and accelerates the healing of inflammatory bowel disease in rats.

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12 December 2020

TGF-beta signaling in renal disease

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12 December 2020

The time has come to target connective tissue growth factor in diabetic complications.

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12 December 2020

BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury

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12 December 2020

Bone Morphogenic Protein-7 Induces Mesenchymal to Epithelial Transition in Adult Renal Fibroblasts and Facilitates Regeneration of Injured Kidney

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12 December 2020

Role of connective tissue growth factor in vascular and renal damage associated with hypertension in rats. Interactions with angiotensin II

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12 December 2020

10.1007/S11095-008-9548-9

Identifiers

DOI

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18 August 2017

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PubMed ID

18266088