(Q37099790)

18 August 2017

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title

Structural basis for drug resistance mechanisms for non-nucleoside inhibitors of HIV reverse transcriptase (English)

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18 August 2017

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Jingshan Ren

1

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author name string

David K Stammers

series ordinal

2

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18 August 2017

3 March 2008

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18 August 2017

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18 August 2017

134

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18 August 2017

157-170

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18 August 2017

1-2

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The phenylmethylthiazolylthiourea nonnucleoside reverse transcriptase (RT) inhibitor MSK-076 selects for a resistance mutation in the active site of human immunodeficiency virus type 2 RT.

18 August 2017

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Structure-activity and cross-resistance evaluations of a series of human immunodeficiency virus type-1-specific compounds related to oxathiin carboxanilide

7 January 2021

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2-Amino-6-arylsulfonylbenzonitriles as non-nucleoside reverse transcriptase inhibitors of HIV-1

7 January 2021

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Novel benzophenones as non-nucleoside reverse transcriptase inhibitors of HIV-1.

7 January 2021

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Crystal structures of 8-Cl and 9-Cl TIBO complexed with wild-type HIV-1 RT and 8-Cl TIBO complexed with the Tyr181Cys HIV-1 RT drug-resistant mutant

7 January 2021

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Roles of Conformational and Positional Adaptability in Structure-Based Design of TMC125-R165335 (Etravirine) and Related Non-nucleoside Reverse Transcriptase Inhibitors That Are Highly Potent and Effective against Wild-Type and Drug-Resistant HIV-1 V

7 January 2021

1 reference

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Crystal structures of clinically relevant Lys103Asn/Tyr181Cys double mutant HIV-1 reverse transcriptase in complexes with ATP and non-nucleoside inhibitor HBY 097.

7 January 2021

1 reference

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HIV resistance to reverse transcriptase inhibitors

7 January 2021

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New developments in anti-HIV chemotherapy

7 January 2021

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Structure of HIV-1 RT/TIBO R 86183 complex reveals similarity in the binding of diverse nonnucleoside inhibitors

7 January 2021

1 reference

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A mutation in reverse transcriptase of bis(heteroaryl)piperazine-resistant human immunodeficiency virus type 1 that confers increased sensitivity to other nonnucleoside inhibitors

7 January 2021

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Mechanism of inhibition of HIV-1 reverse transcriptase by non-nucleoside inhibitors

7 January 2021

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Unique features in the structure of the complex between HIV-1 reverse transcriptase and the bis(heteroaryl)piperazine (BHAP) U-90152 explain resistance mutations for this nonnucleoside inhibitor

7 January 2021

1 reference

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Continuous and Discontinuous Changes in the Unit Cell of HIV-1 Reverse Transcriptase Crystals on Dehydration

7 January 2021

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Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 2.

7 January 2021

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S-1153 inhibits replication of known drug-resistant strains of human immunodeficiency virus type 1

7 January 2021

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Factors contributing to the inhibition of HIV reverse transcriptase by chain-terminating nucleotides in vitro and in vivo

7 January 2021

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Patterns of resistance mutations selected by treatment of human immunodeficiency virus type 1 infection with zidovudine, didanosine, and nevirapine

7 January 2021

1 reference

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A mutation in the 3' region of the human immunodeficiency virus type 1 reverse transcriptase (Y318F) associated with nonnucleoside reverse transcriptase inhibitor resistance

7 January 2021

1 reference

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Crystal structures for HIV-1 reverse transcriptase in complexes with three pyridinone derivatives: a new class of non-nucleoside inhibitors effective against a broad range of drug-resistant strains

7 January 2021

1 reference

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Complexes of HIV-1 reverse transcriptase with inhibitors of the HEPT series reveal conformational changes relevant to the design of potent non-nucleoside inhibitors

7 January 2021

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Design of MKC-442 (emivirine) analogues with improved activity against drug-resistant HIV mutants

7 January 2021

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Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 1.

7 January 2021

1 reference

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Structure of unliganded HIV-1 reverse transcriptase at 2.7 A resolution: implications of conformational changes for polymerization and inhibition mechanisms

7 January 2021

1 reference

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Structures of Tyr188Leu mutant and wild-type HIV-1 reverse transcriptase complexed with the non-nucleoside inhibitor HBY 097: inhibitor flexibility is a useful design feature for reducing drug resistance

7 January 2021

1 reference

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The Lys103Asn mutation of HIV-1 RT: a novel mechanism of drug resistance

7 January 2021

1 reference

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Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance

7 January 2021

1 reference

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Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor

7 January 2021

1 reference

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3'-Azido-3'-deoxythymidine resistance suppressed by a mutation conferring human immunodeficiency virus type 1 resistance to nonnucleoside reverse transcriptase inhibitors

7 January 2021

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Structural basis for the inhibitory efficacy of efavirenz (DMP-266), MSC194 and PNU142721 towards the HIV-1 RT K103N mutant

7 January 2021

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Resistance to nevirapine of HIV-1 reverse transcriptase mutants: loss of stabilizing interactions and thermodynamic or steric barriers are induced by different single amino acid substitutions.

7 January 2021

1 reference

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Mechanisms of resistance to nucleoside analogue inhibitors of HIV-1 reverse transcriptase.

7 January 2021

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Inhibition of HIV-1 Replication by a Nonnucleoside Reverse Transcriptase Inhibitor

7 January 2021

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Molecular targets for AIDS therapy

7 January 2021

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A novel lead for specific anti-HIV-1 agents: 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine

7 January 2021

1 reference

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Structure of HIV-1 reverse transcriptase bound to an inhibitor active against mutant reverse transcriptases resistant to other nonnucleoside inhibitors.

7 January 2021

1 reference

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Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivatives

7 January 2021

1 reference

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Mutational analysis of Tyr-318 within the non-nucleoside reverse transcriptase inhibitor binding pocket of human immunodeficiency virus type I reverse transcriptase

7 January 2021

1 reference

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Novel antiretroviral agents in HIV therapy

7 January 2021

1 reference

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High resolution structures of HIV-1 RT from four RT-inhibitor complexes

7 January 2021

1 reference

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The structure of HIV-1 reverse transcriptase complexed with 9-chloro-TIBO: lessons for inhibitor design

7 January 2021

1 reference

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Crystal structures of HIV-1 reverse transcriptase in complex with carboxanilide derivatives

7 January 2021

1 reference

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Phenylethylthiazolylthiourea (PETT) non-nucleoside inhibitors of HIV-1 and HIV-2 reverse transcriptases. Structural and biochemical analyses

7 January 2021

1 reference

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Structural basis for the resilience of efavirenz (DMP-266) to drug resistance mutations in HIV-1 reverse transcriptase

7 January 2021

1 reference

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Binding of the second generation non-nucleoside inhibitor S-1153 to HIV-1 reverse transcriptase involves extensive main chain hydrogen bonding

7 January 2021

1 reference

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Structural mechanisms of drug resistance for mutations at codons 181 and 188 in HIV-1 reverse transcriptase and the improved resilience of second generation non-nucleoside inhibitors

7 January 2021

1 reference

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Structure of HIV-2 reverse transcriptase at 2.35-A resolution and the mechanism of resistance to non-nucleoside inhibitors.

7 January 2021

1 reference

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Crystal structures of HIV-1 reverse transcriptases mutated at codons 100, 106 and 108 and mechanisms of resistance to non-nucleoside inhibitors.

7 January 2021

1 reference

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Structural insights into mechanisms of non-nucleoside drug resistance for HIV-1 reverse transcriptases mutated at codons 101 or 138

7 January 2021

1 reference

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Relationship of potency and resilience to drug resistant mutations for GW420867X revealed by crystal structures of inhibitor complexes for wild-type, Leu100Ile, Lys101Glu, and Tyr188Cys mutant HIV-1 reverse transcriptases

7 January 2021

1 reference

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The structure of unliganded reverse transcriptase from the human immunodeficiency virus type 1

7 January 2021

1 reference

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Understanding the basis of resistance in the irksome Lys103Asn HIV-1 reverse transcriptase mutant through targeted molecular dynamics simulations

7 January 2021

1 reference

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Identification of a putative binding site for [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)thymine (TSAO) derivatives at the p51-p66 interface of HIV-1 reverse transcriptase.

7 January 2021

1 reference

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The molecular basis of resilience to the effect of the Lys103Asn mutation in non-nucleoside HIV-1 reverse transcriptase inhibitors studied by targeted molecular dynamics simulations

7 January 2021

1 reference

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Emergence of drug-resistant HIV-1 variants in patients undergoing structured treatment interruptions

7 January 2021

1 reference

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Mechanisms of inhibition of HIV replication by non-nucleoside reverse transcriptase inhibitors

7 January 2021

1 reference

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Human immunodeficiency virus type 1 reverse transcriptase dimer destabilization by 1-[Spiro[4"-amino-2",2" -dioxo-1",2" -oxathiole-5",3'-[2', 5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]]]-3-ethylthy mine

7 January 2021

1 reference

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Structure of the binding site for nonnucleoside inhibitors of the reverse transcriptase of human immunodeficiency virus type 1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2007.12.018

Mechanism of inhibition of HIV-1 reverse transcriptase by nonnucleoside inhibitors.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2007.12.018

HIV-1 reverse transcriptase resistance to nonnucleoside inhibitors

7 January 2021

1 reference

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Probing nonnucleoside inhibitor-induced active-site distortion in HIV-1 reverse transcriptase by transient kinetic analyses

7 January 2021

1 reference

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L-743, 726 (DMP-266): a novel, highly potent nonnucleoside inhibitor of the human immunodeficiency virus type 1 reverse transcriptase

7 January 2021

1 reference

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10.1016/J.VIRUSRES.2007.12.018

7 January 2021

Identifiers

DOI

1 reference

18 August 2017

1 reference

PubMed ID

18313784