(Q37100064)

English

MitoNEET-driven alterations in adipocyte mitochondrial activity reveal a crucial adaptive process that preserves insulin sensitivity in obesity.

scientific article published on 09 September 2012

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12 February 2020

MitoNEET-driven alterations in adipocyte mitochondrial activity reveal a crucial adaptive process that preserves insulin sensitivity in obesity (English)

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12 February 2020

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12 February 2020

Christine M Kusminski

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Christine M Kusminski

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12 February 2020

Philipp E. Scherer

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Philipp E Scherer

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William L Holland

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12 February 2020

Jiyoung Park

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12 February 2020

Stephen B Spurgin

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12 February 2020

Ying Lin

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12 February 2020

G Roger Askew

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12 February 2020

Cai Li

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12 February 2020

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9 September 2012

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12 February 2020

Nature Medicine

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12 February 2020

1539-1549

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12 February 2020

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12 February 2020

https://scigraph.springernature.com/pub.10.1038/nm.2899

0 references

A ceramide-centric view of insulin resistance

1 reference

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1 reference

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High throughput microplate respiratory measurements using minimal quantities of isolated mitochondria

1 reference

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Facile transfer of [2Fe-2S] clusters from the diabetes drug target mitoNEET to an apo-acceptor protein

1 reference

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Adipose tissue remodeling and obesity

1 reference

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Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin.

1 reference

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Iron overload and diabetes risk: a shift from glucose to Fatty Acid oxidation and increased hepatic glucose production in a mouse model of hereditary hemochromatosis.

1 reference

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Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2+) and AMPK/SIRT1.

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Downregulation of adipose glutathione S-transferase A4 leads to increased protein carbonylation, oxidative stress, and mitochondrial dysfunction

1 reference

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Enhanced metabolic flexibility associated with elevated adiponectin levels

1 reference

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1 reference

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Succination of thiol groups in adipose tissue proteins in diabetes: succination inhibits polymerization and secretion of adiponectin

1 reference

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14 September 2017

Mitochondrial dysfunction results from oxidative stress in the skeletal muscle of diet-induced insulin-resistant mice

1 reference

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14 September 2017

Essential role of mitochondrial function in adiponectin synthesis in adipocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745511

14 September 2017

MitoNEET is a uniquely folded 2Fe 2S outer mitochondrial membrane protein stabilized by pioglitazone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745511

14 September 2017

Crystal structure of human mitoNEET reveals distinct groups of iron sulfur proteins

1 reference

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Obesity-associated improvements in metabolic profile through expansion of adipose tissue

1 reference

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14 September 2017

MitoNEET is an iron-containing outer mitochondrial membrane protein that regulates oxidative capacity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745511

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Reversible gene knockdown in mice using a tight, inducible shRNA expression system

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14 September 2017

Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction

1 reference

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Obesity-related derangements in metabolic regulation

1 reference

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Adipose tissue lipolysis as a metabolic pathway to define pharmacological strategies against obesity and the metabolic syndrome

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14 September 2017

Reactive oxygen species have a causal role in multiple forms of insulin resistance

1 reference

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Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphology

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Oxidative stress in diabetes: a mechanistic overview of its effects on atherogenesis and myocardial dysfunction.

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14 September 2017

Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor gamma agonists

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Glyceroneogenesis revisited

1 reference

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Identification of a novel mitochondrial protein (“mitoNEET”) cross-linked specifically by a thiazolidinedione photoprobe

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Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans

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1 reference

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27 June 2018

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1 reference

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3 September 2018

The outer mitochondrial membrane protein mitoNEET contains a novel redox-active 2Fe-2S cluster

1 reference

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1 reference

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12 December 2020

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https://pubmed.ncbi.nlm.nih.gov/22961109

12 December 2020

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10.1038/NM.2899

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Europe PubMed Central

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12 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22961109%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

1 reference

Europe PubMed Central

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12 February 2020

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