(Q37101028)

English

Serotonin-induced growth of pulmonary artery smooth muscle requires activation of phosphatidylinositol 3-kinase/serine-threonine protein kinase B/mammalian target of rapamycin/p70 ribosomal S6 kinase 1

scientific article published on 29 September 2005

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Serotonin-induced growth of pulmonary artery smooth muscle requires activation of phosphatidylinositol 3-kinase/serine-threonine protein kinase B/mammalian target of rapamycin/p70 ribosomal S6 kinase 1 (English)

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

0 references

author name string

Yinglin Liu

1

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Barry L Fanburg

2

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

publication date

29 September 2005

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

American Journal of Respiratory Cell and Molecular Biology

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

34

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

2

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

182-191

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

The major target of the endogenously generated reactive oxygen species in response to insulin stimulation is phosphatase and tensin homolog and not phosphoinositide-3 kinase (PI-3 kinase) in the PI-3 kinase/Akt pathway

1 reference

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PKC-eta mediates glioblastoma cell proliferation through the Akt and mTOR signaling pathways

1 reference

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Upstream and downstream of mTOR

1 reference

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Genetic basis of pulmonary arterial hypertension: current understanding and future directions

1 reference

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S-glutathiolation of Ras mediates redox-sensitive signaling by angiotensin II in vascular smooth muscle cells.

1 reference

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Proliferation and signaling in fibroblasts: role of 5-hydroxytryptamine2A receptor and transporter

1 reference

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Redox regulation of PI 3-kinase signalling via inactivation of PTEN

1 reference

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Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

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Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

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1 reference

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Function of the serotonin 5-hydroxytryptamine 2B receptor in pulmonary hypertension

1 reference

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Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin

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Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

1 reference

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The phosphoinositide 3-kinase pathway

1 reference

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Regulation of cell size in growth, development and human disease: PI3K, PKB and S6K.

1 reference

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Ten years of protein kinase B signalling: a hard Akt to follow

1 reference

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PKB/Akt: a key mediator of cell proliferation, survival and insulin responses?

1 reference

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Linking a serotonin transporter polymorphism to vascular smooth muscle proliferation in patients with primary pulmonary hypertension

1 reference

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Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase.

1 reference

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14 September 2017

Effect of a serotonin receptor antagonist on interleukin-6-induced pulmonary hypertension in rats

1 reference

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14 September 2017

Attenuated hypoxic pulmonary hypertension in mice lacking the 5-hydroxytryptamine transporter gene.

1 reference

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14 September 2017

Role of serotonin in the pathogenesis of acute and chronic pulmonary hypertension

1 reference

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Structural and functional analysis of pp70S6k

1 reference

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Cytokine-induced phosphoinositide 3-kinase activity promotes Cdk2 activation in factor-dependent hematopoietic cells.

1 reference

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Akt is a major downstream target of PI3-kinase involved in angiotensin II-induced proliferation

1 reference

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Serotonin stimulates mitogen-activated protein kinase activity through the formation of superoxide anion

1 reference

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1 reference

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A new role for an old molecule: serotonin as a mitogen

1 reference

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Paradoxical constriction to platelets by arteries from rats with pulmonary hypertension

1 reference

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Functional interactions between 5-hydroxytryptamine receptors and the serotonin transporter in pulmonary arteries

1 reference

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5-HT1A and beta-adrenergic receptors regulate proliferation of rat blood lymphocytes

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Rho kinase-induced nuclear translocation of ERK1/ERK2 in smooth muscle cell mitogenesis caused by serotonin

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Overexpression of the 5-hydroxytryptamine transporter gene: effect on pulmonary hemodynamics and hypoxia-induced pulmonary hypertension.

1 reference

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Serotonin-induced smooth muscle hyperplasia in various forms of human pulmonary hypertension

1 reference

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TOR kinase and Ran are downstream from PI3K/Akt in H2O2-induced mitosis

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Redox regulation of PI3K/Akt and p53 in bovine aortic endothelial cells exposed to hydrogen peroxide

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Serotonin transporter inhibitors protect against hypoxic pulmonary hypertension

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Requirement for phosphatidylinositol-3 kinase activity during progression through S-phase and entry into mitosis.

1 reference

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Adverse pulmonary vascular effects of high dose tricyclic antidepressants: acute and chronic animal studies

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Signals of oxidant-induced cardiomyocyte hypertrophy: key activation of p70 S6 kinase-1 and phosphoinositide 3-kinase

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Contribution of the 5-HT(1B) receptor to hypoxia-induced pulmonary hypertension: converging evidence using 5-HT(1B)-receptor knockout mice and the 5-HT(1B/1D)-receptor antagonist GR127935.

1 reference

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H(2)O(2) signals 5-HT-induced ERK MAP kinase activation and mitogenesis of smooth muscle cells

1 reference

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3 September 2018

Activation of Akt1 by human 5-hydroxytryptamine (serotonin)1B receptors is sensitive to inhibitors of MEK.

1 reference

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Mild hypoxia causes severe pulmonary hypertension in fawn-hooded but not in Tester Moriyama rats

1 reference

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Fawn-Hooded Rat; an animal model of development of pulmonary hypertension

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Mechanisms of 5-hydroxytryptamine(2A) receptor activation of the mitogen-activated protein kinase pathway in vascular smooth muscle.

1 reference

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3 September 2018

Reactive oxygen species mediate the activation of Akt/protein kinase B by angiotensin II in vascular smooth muscle cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2644181

3 September 2018

Increased plasma serotonin in primary pulmonary hypertension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2644181

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Relationship of increased lung serotonin levels to endotoxin-induced pulmonary hypertension in sheep. Effect of a serotonin antagonist

1 reference

https://pubmed.ncbi.nlm.nih.gov/16195541

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dual effect of serotonin on growth of bovine pulmonary artery smooth muscle cells in culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/16195541

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of 5-hydroxytryptamine in the progression of monocrotaline induced pulmonary hypertension in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/16195541

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signaling pathways mediating induction of the early response genes prostaglandin G/H synthase-2 and egr-1 by serotonin via 5-HT2A receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16195541

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development of monocrotaline-induced pulmonary hypertension is attenuated by a serotonin receptor antagonist

1 reference

https://pubmed.ncbi.nlm.nih.gov/16195541

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of cyclin D(1) expression and DNA synthesis by phosphatidylinositol 3-kinase in airway smooth muscle cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16195541

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PI3K is required for proliferation and migration of human pulmonary vascular smooth muscle cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16195541

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1165/RCMB.2005-0163OC

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

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