(Q37104928)

English

Identification of small molecular weight inhibitors of Src homology 2 domain-containing tyrosine phosphatase 2 (SHP-2) via in silico database screening combined with experimental assay

scientific article published on December 2008

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Identification of small molecular weight inhibitors of Src homology 2 domain-containing tyrosine phosphatase 2 (SHP-2) via in silico database screening combined with experimental assay (English)

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

0 references

1 reference

based on heuristic

inferred from title

author name string

Wen-Mei Yu

1

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Olgun Guvench

2

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Alexander D Mackerell

3

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Cheng-Kui Qu

4

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

language of work or name

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publication date

1 December 2008

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Journal of Medicinal Chemistry

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Europe PubMed Central

PMC publication ID

18 August 2017

51

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

23

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

7396-7404

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

All-atom empirical potential for molecular modeling and dynamics studies of proteins

1 reference

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14 September 2017

Protein tyrosine phosphatases: from genes, to function, to disease

1 reference

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Discovery of a novel shp2 protein tyrosine phosphatase inhibitor

1 reference

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Sequence specificity of SHP-1 and SHP-2 Src homology 2 domains. Critical roles of residues beyond the pY+3 position

1 reference

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Functional analysis of leukemia-associated PTPN11 mutations in primary hematopoietic cells

1 reference

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Human somatic PTPN11 mutations induce hematopoietic-cell hypersensitivity to granulocyte-macrophage colony-stimulating factor

1 reference

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Activating mutations of the noonan syndrome-associated SHP2/PTPN11 gene in human solid tumors and adult acute myelogenous leukemia

1 reference

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Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation

1 reference

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1 reference

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The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling

1 reference

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Crystal structure of human protein-tyrosine phosphatase SHP-1

1 reference

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Role of the SHP-2 tyrosine phosphatase in cytokine-induced signaling and cellular response

1 reference

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14 September 2017

Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome

1 reference

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1 reference

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

1 reference

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14 September 2017

Structural basis for substrate specificity of protein-tyrosine phosphatase SHP-1

1 reference

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Asparagine and glutamine: using hydrogen atom contacts in the choice of side-chain amide orientation

1 reference

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14 September 2017

Crystal structure of the catalytic domain of protein-tyrosine phosphatase SHP-1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2645921

14 September 2017

Crystal structure of the tyrosine phosphatase SHP-2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2645921

14 September 2017

VMD: visual molecular dynamics

1 reference

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14 September 2017

Spatial constraints on the recognition of phosphoproteins by the tandem SH2 domains of the phosphatase SH-PTP2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2645921

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A geometric approach to macromolecule-ligand interactions

1 reference

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Solvent-accessible surfaces of proteins and nucleic acids

1 reference

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A computational procedure for determining energetically favorable binding sites on biologically important macromolecules

1 reference

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Structure-based strategies for drug design and discovery

1 reference

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The Protein Data Bank. A computer-based archival file for macromolecular structures

1 reference

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Catalytic-dependent and -independent roles of SHP-2 tyrosine phosphatase in interleukin-3 signaling

1 reference

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Diverse biochemical properties of Shp2 mutants. Implications for disease phenotypes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2645921

27 June 2018

Revealing mechanisms for SH2 domain mediated regulation of the protein tyrosine phosphatase SHP-2.

1 reference

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Effects of a leukemia-associated gain-of-function mutation of SHP-2 phosphatase on interleukin-3 signaling

1 reference

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3 September 2018

Prognostic, therapeutic, and mechanistic implications of a mouse model of leukemia evoked by Shp2 (PTPN11) mutations.

1 reference

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Identification of non-phosphate-containing small molecular weight inhibitors of the tyrosine kinase p56 Lck SH2 domain via in silico screening against the pY + 3 binding site.

1 reference

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Mutations in PTPN11 implicate the SHP-2 phosphatase in leukemogenesis

1 reference

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Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia

1 reference

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1 reference

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12 December 2020

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Identifiers

10.1021/JM800229D

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

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