(Q37110590)

English

A network of hydrophobic residues impeding helix alphaC rotation maintains latency of kinase Gcn2, which phosphorylates the alpha subunit of translation initiation factor 2.

scientific article published on 29 December 2008

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19114556%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

A network of hydrophobic residues impeding helix alphaC rotation maintains latency of kinase Gcn2, which phosphorylates the alpha subunit of translation initiation factor 2 (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19114556%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

phosphorylation

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inferred from title

5

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19 January 2020

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Andrés Gárriz

1

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19 January 2020

Hongfang Qiu

2

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19 January 2020

Madhusudan Dey

3

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19 January 2020

Eun-Joo Seo

4

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19 January 2020

Alan G Hinnebusch

6

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19 January 2020

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29 December 2008

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19 January 2020

Molecular and Cellular Biology

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19 January 2020

29

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19 January 2020

6

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19 January 2020

1592-1607

1 reference

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19 January 2020

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Conserved intermolecular salt bridge required for activation of protein kinases PKR, GCN2, and PERK.

1 reference

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Translational control of hippocampal synaptic plasticity and memory by the eIF2alpha kinase GCN2

1 reference

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14 September 2017

Structural basis for autoinhibition and mutational activation of eukaryotic initiation factor 2alpha protein kinase GCN2.

1 reference

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1 reference

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14 September 2017

Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells

1 reference

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A strategy for the design of multiplex inhibitors for kinase-mediated signalling in angiogenesis

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14 September 2017

Mutations that bypass tRNA binding activate the intrinsically defective kinase domain in GCN2.

1 reference

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14 September 2017

The tRNA-binding moiety in GCN2 contains a dimerization domain that interacts with the kinase domain and is required for tRNA binding and kinase activation

1 reference

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14 September 2017

Principles for the buffering of genetic variation

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14 September 2017

Regulated translation initiation controls stress-induced gene expression in mammalian cells

1 reference

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14 September 2017

Uncharged tRNA activates GCN2 by displacing the protein kinase moiety from a bipartite tRNA-binding domain

1 reference

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The penultimate rotamer library

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1 reference

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14 September 2017

Dimerization by translation initiation factor 2 kinase GCN2 is mediated by interactions in the C-terminal ribosome-binding region and the protein kinase domain

1 reference

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14 September 2017

Autophosphorylation in the activation loop is required for full kinase activity in vivo of human and yeast eukaryotic initiation factor 2alpha kinases PKR and GCN2

1 reference

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14 September 2017

Homologous segments in three subunits of the guanine nucleotide exchange factor eIF2B mediate translational regulation by phosphorylation of eIF2.

1 reference

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High-resolution crystal structures of human cyclin-dependent kinase 2 with and without ATP: bound waters and natural ligand as guides for inhibitor design

1 reference

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14 September 2017

Histidyl-tRNA synthetase-related sequences in GCN2 protein kinase regulate in vitro phosphorylation of eIF-2.

1 reference

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14 September 2017

Active and inactive protein kinases: structural basis for regulation

1 reference

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Mammalian eukaryotic initiation factor 2 alpha kinases functionally substitute for GCN2 protein kinase in the GCN4 translational control mechanism of yeast

1 reference

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14 September 2017

The histidyl-tRNA synthetase-related sequence in the eIF-2 alpha protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acids

1 reference

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14 September 2017

Juxtaposition of domains homologous to protein kinases and histidyl-tRNA synthetases in GCN2 protein suggests a mechanism for coupling GCN4 expression to amino acid availability

1 reference

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1 reference

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Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast

1 reference

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Mutations activating the yeast eIF-2 alpha kinase GCN2: isolation of alleles altering the domain related to histidyl-tRNA synthetases

1 reference

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1 reference

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1 reference

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based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/19114556

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/MCB.01446-08

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19114556%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

PMC publication ID

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19114556%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19114556%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

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