(Q34597501)

3 August 2017

title

Conserved intermolecular salt bridge required for activation of protein kinases PKR, GCN2, and PERK. (English)

1 reference

3 August 2017

4

Thomas E Dever

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3 August 2017

Madhusudan Dey

1

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3 August 2017

Chune Cao

series ordinal

2

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3 August 2017

Frank Sicheri

series ordinal

3

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3 August 2017

language of work or name

English

0 references

publication date

3 January 2007

1 reference

Journal of Biological Chemistry

3 August 2017

number of pages

8

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based on heuristic

inferred from page(s)

published in

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3 August 2017

volume

282

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3 August 2017

issue

9

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3 August 2017

page(s)

6653-6660

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Gene-specific regulation by general translation factors

3 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607897200

Translational regulation of GCN4 and the general amino acid control of yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607897200

Mutations activating the yeast eIF-2 alpha kinase GCN2: isolation of alleles altering the domain related to histidyl-tRNA synthetases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607897200

Mammalian eukaryotic initiation factor 2 alpha kinases functionally substitute for GCN2 protein kinase in the GCN4 translational control mechanism of yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607897200

Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607897200

Pancreatic eukaryotic initiation factor-2alpha kinase (PEK) homologues in humans, Drosophila melanogaster and Caenorhabditis elegans that mediate translational control in response to endoplasmic reticulum stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607897200

Dimerization by translation initiation factor 2 kinase GCN2 is mediated by interactions in the C-terminal ribosome-binding region and the protein kinase domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607897200

Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607897200

Heterologous dimerization domains functionally substitute for the double-stranded RNA binding domains of the kinase PKR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607897200

Binding of double-stranded RNA to protein kinase PKR is required for dimerization and promotes critical autophosphorylation events in the activation loop.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607897200

Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607897200

On the mechanism of sensing unfolded protein in the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607897200

X-ray crystal structure and functional analysis of vaccinia virus K3L reveals molecular determinants for PKR subversion and substrate recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607897200

Cytoprotection by pre-emptive conditional phosphorylation of translation initiation factor 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607897200

Structural basis for autoinhibition and mutational activation of eukaryotic initiation factor 2alpha protein kinase GCN2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607897200

Regulation of the protein kinase PKR by the vaccinia virus pseudosubstrate inhibitor K3L is dependent on residues conserved between the K3L protein and the PKR substrate eIF2alpha.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607897200

Uncharged tRNA activates GCN2 by displacing the protein kinase moiety from a bipartite tRNA-binding domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607897200

Autophosphorylation in the activation loop is required for full kinase activity in vivo of human and yeast eukaryotic initiation factor 2alpha kinases PKR and GCN2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607897200

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607897200

EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607897200

Wolcott-Rallison Syndrome: clinical, genetic, and functional study of EIF2AK3 mutations and suggestion of genetic heterogeneity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607897200

Mechanistic Link between PKR Dimerization, Autophosphorylation, and eIF2α Substrate Recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607897200

Higher-Order Substrate Recognition of eIF2α by the RNA-Dependent Protein Kinase PKR

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607897200

21 January 2018

Identifiers

DOI

10.1074/JBC.M607897200

1 reference

3 August 2017

1 reference