(Q37113086)

18 August 2017

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title

Spermidine/spermine-N(1)-acetyltransferase: a key metabolic regulator (English)

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18 August 2017

Anthony E Pegg

1

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18 August 2017

publication date

18 March 2008

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American Journal of Physiology - Endocrinology and Metabolism

18 August 2017

published in

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18 August 2017

volume

294

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18 August 2017

issue

6

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18 August 2017

page(s)

E995-1010

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A novel member of the GCN5-related N-acetyltransferase superfamily from Caenorhabditis elegans preferentially catalyses the N-acetylation of thialysine [S-(2-aminoethyl)-L-cysteine].

18 August 2017

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Activation of polyamine catabolism in transgenic rats induces acute pancreatitis

21 January 2018

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Expression of spermidine/spermine N1-acetyltransferase in HeLa cells is regulated by amino acid sufficiency

21 January 2018

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Polyamines as modifiers of genetic risk factors in human intestinal cancers

21 January 2018

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Induction of spermidine/spermine N1-acetyltransferase (SSAT) by aspirin in Caco-2 colon cancer cells

21 January 2018

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Tumor necrosis factor alpha induces spermidine/spermine N1-acetyltransferase through nuclear factor kappaB in non-small cell lung cancer cells

21 January 2018

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Cyclooxygenase-independent Induction of Apoptosis by Sulindac Sulfone Is Mediated by Polyamines in Colon Cancer

21 January 2018

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Spermidine/spermine-N1-acetyltransferase 2 is an essential component of the ubiquitin ligase complex that regulates hypoxia-inducible factor 1alpha

21 January 2018

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Spermidine/spermine N(1)-acetyltransferase-1 binds to hypoxia-inducible factor-1alpha (HIF-1alpha) and RACK1 and promotes ubiquitination and degradation of HIF-1alpha

21 January 2018

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Emerging concepts in targeting the polyamine metabolic pathway in epithelial cancer chemoprevention and chemotherapy

21 January 2018

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Structures of wild-type and mutant human spermidine/spermine N1-acetyltransferase, a potential therapeutic drug target

21 January 2018

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Polyamine-based analogues as biochemical probes and potential therapeutics

21 January 2018

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Phosphorylation of recombinant human spermidine/spermine N(1)-acetyltransferase by CK1 and modulation of its binding to mitochondria: a comparison with CK2

21 January 2018

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High specific induction of spermidine/spermine N1-acetyltransferase in a human large cell lung carcinoma

21 January 2018

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Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases

21 January 2018

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X-linked spermine synthase gene (SMS) defect: the first polyamine deficiency syndrome

21 January 2018

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Spermidine/spermine N1-acetyltransferase specifically binds to the integrin alpha9 subunit cytoplasmic domain and enhances cell migration

21 January 2018

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Genomic identification and biochemical characterization of a second spermidine/spermine N1-acetyltransferase

21 January 2018

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Combination of 5-fluorouracil and N1,N11-diethylnorspermine markedly activates spermidine/spermine N1-acetyltransferase expression, depletes polyamines, and synergistically induces apoptosis in colon carcinoma cells

21 January 2018

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Inactivation of IkappaB contributes to transcriptional activation of spermidine/spermine N(1)-acetyltransferase.

21 January 2018

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Role of the carboxyl terminal MATEE sequence of spermidine/spermine N1-acetyltransferase in the activity and stabilization by the polyamine analog N1,N12-bis(ethyl)spermine

21 January 2018

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Structure and critical residues at the active site of spermidine/spermine-N1-acetyltransferase

21 January 2018

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Polyamine analogues inhibit the ubiquitination of spermidine/spermine N1-acetyltransferase and prevent its targeting to the proteasome for degradation

21 January 2018

1 reference

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Targeted expression of spermidine/spermine N1-acetyltransferase increases susceptibility to chemically induced skin carcinogenesis

21 January 2018

1 reference

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Spermidine/spermine-N1-acetyltransferase-2 (SSAT2) acetylates thialysine and is not involved in polyamine metabolism

21 January 2018

1 reference

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Cloning and sequence analysis of the gene and cDNA encoding mouse spermidine/spermine N1-acetyltransferase--a gene uniquely regulated by polyamines and their analogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

Effects of polyamines, polyamine analogs, and inhibitors of protein synthesis on spermidine-spermine N1-acetyltransferase gene expression

21 January 2018

1 reference

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Structural and functional evidence for Bacillus subtilis PaiA as a novel N1-spermidine/spermine acetyltransferase

21 January 2018

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Induction of spermidine/spermine N1-acetyltransferase in breast cancer tissues treated with the polyamine analogue N1, N11-diethylnorspermine

21 January 2018

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Polyamines and cancer: old molecules, new understanding

21 January 2018

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Rationale for, and design of, a clinical trial targeting polyamine metabolism for colon cancer chemoprevention

21 January 2018

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Gene dosage of the spermidine/spermine N(1)-acetyltransferase ( SSAT) gene with putrescine accumulation in a patient with a Xp21.1p22.12 duplication and keratosis follicularis spinulosa decalvans (KFSD)

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

Paracrine inducers of uterine endometrial spermidine/spermine N1-acetyltransferase gene expression during early pregnancy in the pig.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

In vitro and in vivo effects of the conformationally restricted polyamine analogue CGC-11047 on small cell and non-small cell lung cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

Crystal structure of Homo sapiens thialysine Nepsilon-acetyltransferase (HsSSAT2) in complex with acetyl coenzyme A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

Polyamine metabolism in rat myocardial ischemia-reperfusion injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

Mechanistic and Structural Analysis of Human Spermidine/Spermine N 1 -Acetyltransferase † , ‡

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

Subcellular distribution of spermidine/spermine N1-acetyltransferase

21 January 2018

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Synthesis and accumulation of polyamines in rat liver regenerating after treatment with carbon tetrachloride

21 January 2018

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Fatal bilateral chylothorax in mice lacking the integrin alpha9beta1.

21 January 2018

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Molecular mechanisms of polyamine analogs in cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

Induction of spermidine/spermine N1-acetyltransferase by interferon type I in cells of hematopoietic origin

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

Increased thioredoxin-1 inhibits SSAT expression in MCF-7 human breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

Role of hypusinated eukaryotic translation initiation factor 5A in polyamine depletion-induced cytostasis

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

Mechanisms of polyamine catabolism-induced acute pancreatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

Polyamine-regulated unproductive splicing and translation of spermidine/spermine N1-acetyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

Suppression of polyamine catabolism by activated Ki-ras in human colon cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

Regulation of SSAT expression by synaptic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

Genetic approaches to the cellular functions of polyamines in mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

Genetic manipulation of polyamine catabolism in rodents

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

Genetically altered expression of spermidine/spermine N1-acetyltransferase affects fat metabolism in mice via acetyl-CoA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

Activation of polyamine catabolism by N1, N11-diethylnorspermine alters the cellular localization of mTOR and downregulates mTOR protein level in glioblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

Overexpression of spermidine/spermine N1-acetyltransferase elevates the threshold to pentylenetetrazol-induced seizure activity in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

Spermidine/spermine N1-acetyltransferase overexpression in mice induces hypoactivity and spatial learning impairment

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

Activated polyamine catabolism depletes acetyl-CoA pools and suppresses prostate tumor growth in TRAMP mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

Metabolic and antiproliferative consequences of activated polyamine catabolism in LNCaP prostate carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

Induction of a SSAT isoform in response to hypoxia or iron deficiency and its protective effects on cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

Polyamine acetylation modulates polyamine metabolic flux, a prelude to broader metabolic consequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

The polyamine binding site in inward rectifier K+ channels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

A yeast polyamine acetyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

RGFGIGS is an amino acid sequence required for acetyl coenzyme A binding and activity of human spermidine/spermine N1acetyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

Leishmania major thialysine Nepsilon-acetyltransferase: identification of amino acid residues crucial for substrate binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

Polyamines as targets for therapeutic intervention

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

Differential induction of spermidine/spermine N1-acetyltransferase activity in cisplatin-sensitive and -resistant ovarian cancer cells in response to N1,N12-bis(ethyl)spermine involves transcriptional and post-transcriptional regulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

Cisplatin-resistance modulates the effect of protein synthesis inhibitors on spermidine/spermine N(1)-acetyltransferase expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

Spermidine/spermine N1-acetyltransferase transient overexpression restores sensitivity of resistant human ovarian cancer cells to N1,N12-bis(ethyl)spermine and to cisplatin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

Altered spermidine/spermine N1-acetyltransferase activity as a mechanism of cellular resistance to bis(ethyl)polyamine analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

Properties of the spermidine/spermine N1-acetyltransferase mutant L156F that decreases cellular sensitivity to the polyamine analogue N1, N11-bis(ethyl)norspermine

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

Accumulation of spermidine/spermine N1-acetyltransferase and alternatively spliced mRNAs as a delayed response of HeLa S3 cells following X-ray irradiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

Spermidine/spermine N1-acetyl transferase activity in rat brain following transient focal cerebral ischemia and reperfusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

Cytotoxicity of novel unsymmetrically substituted inhibitors of polyamine biosynthesis in human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

Mice with targeted disruption of spermidine/spermine N1-acetyltransferase gene maintain nearly normal tissue polyamine homeostasis but show signs of insulin resistance upon aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

Targeted disruption of spermidine/spermine N1-acetyltransferase gene in mouse embryonic stem cells. Effects on polyamine homeostasis and sensitivity to polyamine analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

Induction of alternatively spliced spermidine/spermine N1-acetyltransferase mRNA in the human kidney cells infected by venezuelan equine encephalitis and tick-borne encephalitis viruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

Post-transcriptional regulation of the content of spermidine/spermine N1-acetyltransferase by N1N12-bis(ethyl)spermine

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

Recent advances in the biochemistry of polyamines in eukaryotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

Transgenic mouse models for studies of the role of polyamines in normal, hypertrophic and neoplastic growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

Polyamine metabolism and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

Relation of skin polyamines to the hairless phenotype in transgenic mice overexpressing spermidine/spermine N-acetyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

Enhanced polyamine catabolism alters homeostatic control of white adipose tissue mass, energy expenditure, and glucose metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

Spermine oxidase SMO(PAOh1), Not N1-acetylpolyamine oxidase PAO, is the primary source of cytotoxic H2O2 in polyamine analogue-treated human breast cancer cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

A polyamine analogue prevents acute pancreatitis and restores early liver regeneration in transgenic rats with activated polyamine catabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

Gossypol activates pancreatic polyamine catabolism in normal rats and induces acute pancreatitis in transgenic rats over-expressing spermidine/spermine N1-acetyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

Polyamine- and insulin-like growth factor-I-mediated proliferation of porcine uterine endometrial cells: a potential role for spermidine/spermine N(1)-acetyltransferase during peri-implantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

Myocardial SSAT induction via AMPK signaling and its implication for ischemic injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

Novel CoA-polyamine conjugates for effective inhibition of spermine/spermidine-N1-acetyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

Measurement of spermidine/spermine-N1-acetyltransferase activity by high-performance liquid chromatography with N1-dansylnorspermine as the substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

Potent modulation of intestinal tumorigenesis in Apcmin/+ mice by the polyamine catabolic enzyme spermidine/spermine N1-acetyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

Integrin alpha9beta1 directly binds to vascular endothelial growth factor (VEGF)-A and contributes to VEGF-A-induced angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

Spermidine/Spermine N1-Acetyltransferase 2 (SSAT2) functions as a coactivator for NF-kappaB and cooperates with CBP and P/CAF to enhance NF-kappaB-dependent transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

Identification and characterization of a novel flavin-containing spermine oxidase of mammalian cell origin

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

A perspective of polyamine metabolism

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

Polyamine analogues - an update

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

Mammalian polyamine catabolism: a therapeutic target, a pathological problem, or both?

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

Characterization of the interaction between the transcription factors human polyamine modulated factor (PMF-1) and NF-E2-related factor 2 (Nrf-2) in the transcriptional regulation of the spermidine/spermine N1-acetyltransferase (SSAT) gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

Cloning and characterization of human polyamine-modulated factor-1, a transcriptional cofactor that regulates the transcription of the spermidine/spermine N(1)-acetyltransferase gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

Properties of purified recombinant human polyamine oxidase, PAOh1/SMO

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

The identification of a cis-element and a trans-acting factor involved in the response to polyamines and polyamine analogues in the regulation of the human spermidine/spermine N1-acetyltransferase gene transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

Inhibition of murine N1-acetylated polyamine oxidase by an acetylenic amine and the allenic amine, MDL 72527.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

Differential transcription of the human spermidine/spermine N1-acetyltransferase (SSAT) gene in human lung carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

Structure of the human spermidine/spermine N1-acetyltransferase gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

Characterization of a full-length cDNA which codes for the human spermidine/spermine N1-acetyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

Cryptosporidium parvum spermidine/spermine N1-acetyltransferase exhibits different characteristics from the host enzyme.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

Spermidine/spermine N1-acetyltransferase overexpression in kidney epithelial cells disrupts polyamine homeostasis, leads to DNA damage, and causes G2 arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

Expression of SSAT, a novel biomarker of tubular cell damage, increases in kidney ischemia-reperfusion injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

HIF-1alpha: a master regulator of innate host defenses?

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

Mechanistic studies of the Nrf2-Keap1 signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90217.2008

10.1152/AJPENDO.90217.2008

21 January 2018

Identifiers

DOI

1 reference

18 August 2017

1 reference