(Q34688845)

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Spermidine/spermine N(1)-acetyltransferase-1 binds to hypoxia-inducible factor-1alpha (HIF-1alpha) and RACK1 and promotes ubiquitination and degradation of HIF-1alpha

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scholarly article

1 reference

Europe PubMed Central

4 August 2017

Spermidine/spermine N(1)-acetyltransferase-1 binds to hypoxia-inducible factor-1alpha (HIF-1alpha) and RACK1 and promotes ubiquitination and degradation of HIF-1alpha (English)

1 reference

Europe PubMed Central

4 August 2017

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protein ubiquitination

1 reference

based on heuristic

inferred from title

Gregg L. Semenza

6

object named as

Gregg L Semenza

1 reference

Europe PubMed Central

4 August 2017

author name string

Jin H Baek

1

1 reference

Europe PubMed Central

4 August 2017

Ye V Liu

2

1 reference

Europe PubMed Central

4 August 2017

Karin R McDonald

3

1 reference

Europe PubMed Central

4 August 2017

Jacob B Wesley

4

1 reference

Europe PubMed Central

4 August 2017

Huafeng Zhang

5

1 reference

Europe PubMed Central

4 August 2017

language of work or name

0 references

publication date

17 September 2007

1 reference

Europe PubMed Central

4 August 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

4 August 2017

282

1 reference

Europe PubMed Central

4 August 2017

46

1 reference

Europe PubMed Central

4 August 2017

33358-33366

1 reference

Europe PubMed Central

4 August 2017

Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1.

1 reference

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21 January 2018

Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependent dioxygenase inhibition: the role of HIF-1alpha, HIF-2alpha, and other pathways

1 reference

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21 January 2018

HIF-1 and hypoxic response: the plot thickens.

1 reference

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21 January 2018

Harnessing the hypoxia-inducible factor in cancer and ischemic disease

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HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705627200

21 January 2018

HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

1 reference

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21 January 2018

HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells

1 reference

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21 January 2018

Purification and characterization of hypoxia-inducible factor 1

1 reference

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21 January 2018

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

1 reference

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21 January 2018

Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1

1 reference

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21 January 2018

Transactivation and inhibitory domains of hypoxia-inducible factor 1alpha. Modulation of transcriptional activity by oxygen tension

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705627200

21 January 2018

Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

1 reference

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21 January 2018

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

1 reference

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21 January 2018

Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705627200

21 January 2018

HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705627200

21 January 2018

Coordinate regulation of the oxygen-dependent degradation domains of hypoxia-inducible factor 1 alpha

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705627200

21 January 2018

The use of dioxygen by HIF prolyl hydroxylase (PHD1)

1 reference

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21 January 2018

The length of peptide substrates has a marked effect on hydroxylation by the hypoxia-inducible factor prolyl 4-hydroxylases

1 reference

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21 January 2018

Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay

1 reference

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21 January 2018

Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705627200

21 January 2018

RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705627200

21 January 2018

Immunophilin-ligands FK506 and CsA inhibit HIF1alpha expression by a VHL- and ubiquitin-independent mechanism

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705627200

21 January 2018

Histone deacetylase inhibitors induce VHL and ubiquitin-independent proteasomal degradation of hypoxia-inducible factor 1alpha

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705627200

21 January 2018

Induction of HIF-1alpha in response to hypoxia is instantaneous

1 reference

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21 January 2018

OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705627200

21 January 2018

Spermidine/spermine-N1-acetyltransferase 2 is an essential component of the ubiquitin ligase complex that regulates hypoxia-inducible factor 1alpha

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705627200

21 January 2018

FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705627200

21 January 2018

Expression of hypoxia-inducible factor 1? in brain tumors

1 reference

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21 January 2018

Structure and critical residues at the active site of spermidine/spermine-N1-acetyltransferase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705627200

21 January 2018

RGFGIGS is an amino acid sequence required for acetyl coenzyme A binding and activity of human spermidine/spermine N1acetyltransferase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705627200

21 January 2018

Structures of wild-type and mutant human spermidine/spermine N1-acetyltransferase, a potential therapeutic drug target

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705627200

21 January 2018

Hypoxia, gene expression, and metastasis

1 reference

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21 January 2018

Hypoxia and adaptive landscapes in the evolution of carcinogenesis

1 reference

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21 January 2018

Effects of hypoxia on tumor metabolism

1 reference

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21 January 2018

Hypoxia and radiotherapy: opportunities for improved outcomes in cancer treatment

1 reference

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21 January 2018

Hypoxia-driven selection of the metastatic phenotype

1 reference

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21 January 2018

Targeting hypoxia cell signaling for cancer therapy

1 reference

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21 January 2018

The hypoxia-inducible factor-1 alpha is a negative factor for tumor therapy.

1 reference

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21 January 2018

The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme

1 reference

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21 January 2018

Activation of Hypoxia-inducible Factor-1; Definition of Regulatory Domains within the α Subunit

1 reference

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21 January 2018

Constitutive/hypoxic degradation of HIF-alpha proteins by the proteasome is independent of von Hippel Lindau protein ubiquitylation and the transactivation activity of the protein

1 reference

12 October 2022

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Mechanical loading regulates expression of talin and its mRNA, which are concentrated at myotendinous junctions

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Hypoxia Response Elements in the Aldolase A, Enolase 1, and Lactate Dehydrogenase A Gene Promoters Contain Essential Binding Sites for Hypoxia-inducible Factor 1

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The role of spermidine/spermine N1-acetyltransferase in determining response to chemotherapeutic agents in colorectal cancer cells

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Identifiers

10.1074/JBC.M705627200

1 reference

Europe PubMed Central

4 August 2017

1 reference

Europe PubMed Central

4 August 2017

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