(Q44019897)

29 November 2017

Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway (English)

1 reference

29 November 2017

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4

1 reference

29 November 2017

6

Leonard M Neckers

1 reference

29 November 2017

3

Edward G Mimnaugh

1 reference

29 November 2017

Jennifer S Isaacs

1

1 reference

29 November 2017

Yun-Jin Jung

series ordinal

2

1 reference

29 November 2017

Frank Cuttitta

series ordinal

5

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29 November 2017

language of work or name

English

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publication date

6 June 2002

1 reference

Journal of Biological Chemistry

29 November 2017

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29 November 2017

277

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29 November 2017

29936-29944

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29 November 2017

33

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Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

29 November 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204733200

Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204733200

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204733200

The von Hippel-Lindau tumor suppressor protein is a component of an E3 ubiquitin-protein ligase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204733200

Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204733200

A conserved family of prolyl-4-hydroxylases that modify HIF

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204733200

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204733200

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204733200

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204733200

Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204733200

The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204733200

Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204733200

Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204733200

Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204733200

HIF-1 alpha is required for solid tumor formation and embryonic vascularization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204733200

Transcription factor HIF-1 is a necessary mediator of the pasteur effect in mammalian cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204733200

Hypoxia-inducible factor-1-mediated expression of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) gene. Its possible role in the Warburg effect

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204733200

Hypoxia, clonal selection, and the role of HIF-1 in tumor progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204733200

Conditional switching of vascular endothelial growth factor (VEGF) expression in tumors: induction of endothelial cell shedding and regression of hemangioblastoma-like vessels by VEGF withdrawal

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204733200

Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204733200

Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204733200

The amino-terminal domain of heat shock protein 90 (hsp90) that binds geldanamycin is an ATP/ADP switch domain that regulates hsp90 conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204733200

Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204733200

Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204733200

Definition of a minimal domain of the dioxin receptor that is associated with Hsp90 and maintains wild type ligand binding affinity and specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204733200

Conformational activation of a basic helix-loop-helix protein (MyoD1) by the C-terminal region of murine HSP90 (HSP84)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204733200

Mutant conformation of p53 translated in vitro or in vivo requires functional HSP90.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204733200

Modulation of Akt kinase activity by binding to Hsp90

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204733200

Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204733200

The specific interaction of the Rous sarcoma virus transforming protein, pp60src, with two cellular proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204733200

Heat-shock protein hsp90 governs the activity of pp60v-src kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204733200

Distinct roles of the molecular chaperone hsp90 in modulating dioxin receptor function via the basic helix-loop-helix and PAS domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204733200

p50(cdc37) acting in concert with Hsp90 is required for Raf-1 function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204733200

The hsp90 chaperone complex regulates intracellular localization of the dioxin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204733200

Polyubiquitination and proteasomal degradation of the p185c-erbB-2 receptor protein-tyrosine kinase induced by geldanamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204733200

Geldanamycin-induced destabilization of Raf-1 involves the proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204733200

Geldanamycin-stimulated destabilization of mutated p53 is mediated by the proteasome in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204733200

Functional interference between hypoxia and dioxin signal transduction pathways: competition for recruitment of the Arnt transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204733200

Hypoxia-induced activation of HIF-1: role of HIF-1alpha-Hsp90 interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204733200

Protective function of von Hippel-Lindau protein against impaired protein processing in renal carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204733200

The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204733200

Herbimycin A induces the 20 S proteasome- and ubiquitin-dependent degradation of receptor tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204733200

Perturbation of Hsp90 interaction with nascent CFTR prevents its maturation and accelerates its degradation by the proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204733200

Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204733200

Carboxyl-terminal transactivation activity of hypoxia-inducible factor 1 alpha is governed by a von Hippel-Lindau protein-independent, hydroxylation-regulated association with p300/CBP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204733200

Hypoxia-inducible nuclear factors bind to an enhancer element located 3' to the human erythropoietin gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204733200

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204733200

Functional requirement of the hypoxia-responsive element in the activation of the inducible nitric oxide synthase promoter by the iron chelator desferrioxamine

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204733200

Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204733200

Intracerebral tumor-associated hemorrhage caused by overexpression of the vascular endothelial growth factor isoforms VEGF121 and VEGF165 but not VEGF189

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204733200

The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204733200

The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204733200

Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204733200

Heat induction of the unphosphorylated form of hypoxia-inducible factor-1alpha is dependent on heat shock protein-90 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204733200

A radicicol derivative, KF58333, inhibits expression of hypoxia-inducible factor-1alpha and vascular endothelial growth factor, angiogenesis and growth of human breast cancer xenografts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204733200

Measuring hypoxia and predicting tumor radioresistance with nuclear medicine assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204733200

21 January 2018

Identifiers

DOI

10.1074/JBC.M204733200

1 reference

29 November 2017

1 reference