(Q37122081)

18 August 2017

1 reference

title

Rho GTPases and regulation of hematopoietic stem cell localization (English)

1 reference

18 August 2017

David A Williams

1

1 reference

18 August 2017

Yi Zheng

series ordinal

2

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18 August 2017

Jose A Cancelas

series ordinal

3

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18 August 2017

language of work or name

English

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publication date

1 January 2008

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18 August 2017

published in

Methods in Enzymology

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18 August 2017

volume

439

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18 August 2017

page(s)

365-393

1 reference

Rac2 is critical for neutrophil primary granule exocytosis.

18 August 2017

cites work

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7 January 2021

Structure of Cdc42 in complex with the GTPase-binding domain of the 'Wiskott-Aldrich syndrome' protein

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7 January 2021

Mobilization of hematopoietic stem cells during homeostasis and after cytokine exposure

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7 January 2021

The chemokine SDF-1 is a chemoattractant for human CD34+ hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34+ progenitors to peripheral blood.

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7 January 2021

A role for Cdc42 in macrophage chemotaxis

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7 January 2021

Human neutrophil immunodeficiency syndrome is associated with an inhibitory Rac2 mutation

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7 January 2021

Two novel activating mutations in the Wiskott-Aldrich syndrome protein result in congenital neutropenia

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7 January 2021

Association of Bcr-Abl with the proto-oncogene Vav is implicated in activation of the Rac-1 pathway

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7 January 2021

Rac1 and Rac3 isoform activation is involved in the invasive and metastatic phenotype of human breast cancer cells

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7 January 2021

TGF-beta-induced RhoA and p160ROCK activation is involved in the inhibition of Cdc25A with resultant cell-cycle arrest

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7 January 2021

Intrinsic dendritic cell abnormalities in Wiskott-Aldrich syndrome

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7 January 2021

Stromal cell-derived factor-1/CXCL12 directly enhances survival/antiapoptosis of myeloid progenitor cells through CXCR4 and Gαi proteins and enhances engraftment of competitive, repopulating stem cells

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7 January 2021

Rho and Rac take center stage

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7 January 2021

Lymphocyte homing and homeostasis

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7 January 2021

The role of chemokine activation of Rac GTPases in hematopoietic stem cell marrow homing, retention, and peripheral mobilization

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7 January 2021

Rac GTPases differentially integrate signals regulating hematopoietic stem cell localization

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7 January 2021

Rac2 regulates neutrophil chemotaxis, superoxide production, and myeloid colony formation through multiple distinct effector pathways

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7 January 2021

Roles of the Rac1 and Rac3 GTPases in human tumor cell invasion

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7 January 2021

RhoH is required to maintain the integrin LFA-1 in a nonadhesive state on lymphocytes

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7 January 2021

Generation of rac3 null mutant mice: role of Rac3 in Bcr/Abl-caused lymphoblastic leukemia.

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7 January 2021

Generation and characterization of Rac3 knockout mice.

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7 January 2021

Rac2-deficient mice display perturbed T-cell distribution and chemotaxis, but only minor abnormalities in TH 1 responses

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7 January 2021

The Rac2 guanosine triphosphatase regulates B lymphocyte antigen receptor responses and chemotaxis and is required for establishment of B-1a and marginal zone B lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900427-2

7 January 2021

Genomic structure and assignment of the RhoH/TTF small GTPase gene (ARHH) to 4p13 by in situ hybridization

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900427-2

7 January 2021

Rho GTPases control migration and polarization of adhesion molecules and cytoskeletal ERM components in T lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900427-2

7 January 2021

Impaired dendritic-cell homing in vivo in the absence of Wiskott-Aldrich syndrome protein

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900427-2

7 January 2021

Rapid mobilization of CD34+ cells following administration of the CXCR4 antagonist AMD3100 to patients with multiple myeloma and non-Hodgkin's lymphoma

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900427-2

7 January 2021

RhoH is important for positive thymocyte selection and T-cell receptor signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900427-2

7 January 2021

Membrane-bound stem cell factor is a key regulator in the initial lodgment of stem cells within the endosteal marrow region.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900427-2

7 January 2021

Wiskott-Aldrich syndrome protein regulates lipid raft dynamics during immunological synapse formation.

1 reference

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7 January 2021

Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900427-2

7 January 2021

Defective actin polymerization in EBV-transformed B-cell lines from patients with the Wiskott-Aldrich syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900427-2

7 January 2021

Localization of Rac2 via the C terminus and aspartic acid 150 specifies superoxide generation, actin polarity and chemotaxis in neutrophils.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900427-2

7 January 2021

CXCL9 inhibits eosinophil responses by a CCR3- and Rac2-dependent mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900427-2

7 January 2021

Aberrant somatic hypermutation in multiple subtypes of AIDS-associated non-Hodgkin lymphoma

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900427-2

7 January 2021

WIP and WASP play complementary roles in T cell homing and chemotaxis to SDF-1alpha.

1 reference

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7 January 2021

Rational design and characterization of a Rac GTPase-specific small molecule inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900427-2

7 January 2021

Inhibition of RhoA GTPase activity enhances hematopoietic stem and progenitor cell proliferation and engraftment.

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7 January 2021

Rac1 deletion in mouse neutrophils has selective effects on neutrophil functions.

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7 January 2021

Endosteal marrow: a rich source of hematopoietic stem cells

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7 January 2021

Rac2, a hematopoiesis-specific Rho GTPase, specifically regulates mast cell protease gene expression in bone marrow-derived mast cells

1 reference

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7 January 2021

RhoH GTPase recruits and activates Zap70 required for T cell receptor signaling and thymocyte development

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7 January 2021

Hematopoietic Cell Regulation by Rac1 and Rac2 Guanosine Triphosphatases

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7 January 2021

RhoH, a hematopoietic-specific Rho GTPase, regulates proliferation, survival, migration, and engraftment of hematopoietic progenitor cells

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7 January 2021

Biochemical and biological characterization of a human Rac2 GTPase mutant associated with phagocytic immunodeficiency

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7 January 2021

The interaction between Cdc42 and WASP is required for SDF-1-induced T-lymphocyte chemotaxis.

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7 January 2021

G proteins and small GTPases: distant relatives keep in touch

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7 January 2021

Differential interaction and activation of Rho family GTPases by p210bcr-abl and p190bcr-abl

1 reference

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7 January 2021

Decrease of L-selectin expression on human CD34+ cells on freeze-thawing and rapid recovery with short-term incubation

1 reference

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7 January 2021

Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900427-2

7 January 2021

Rac2-deficient hematopoietic stem cells show defective interaction with the hematopoietic microenvironment and long-term engraftment failure.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900427-2

7 January 2021

Lack of CD54 expression and mutation of p53 gene relate to the prognosis of childhood Burkitt's lymphoma

1 reference

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7 January 2021

Signals from the sympathetic nervous system regulate hematopoietic stem cell egress from bone marrow

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7 January 2021

Rac3-mediated transformation requires multiple effector pathways

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7 January 2021

SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells

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https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900427-2

7 January 2021

Rac2 is an essential regulator of neutrophil nicotinamide adenine dinucleotide phosphate oxidase activation in response to specific signaling pathways

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7 January 2021

Rapid and efficient homing of human CD34(+)CD38(-/low)CXCR4(+) stem and progenitor cells to the bone marrow and spleen of NOD/SCID and NOD/SCID/B2m(null) mice

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7 January 2021

The role of cytokines and adhesion molecules for mobilization of peripheral blood stem cells

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7 January 2021

A defect in hematopoietic stem cell migration explains the nonrandom X-chromosome inactivation in carriers of Wiskott-Aldrich syndrome

1 reference

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7 January 2021

Divergence of mechanisms regulating respiratory burst in blood and sputum eosinophils and neutrophils from atopic subjects

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7 January 2021

The essential roles of the chemokine SDF-1 and its receptor CXCR4 in human stem cell homing and repopulation of transplanted immune-deficient NOD/SCID and NOD/SCID/B2m(null) mice

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7 January 2021

The pasteurella multocida toxin interacts with signalling pathways to perturb cell growth and differentiation.

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7 January 2021

Granulocyte colony-stimulating factor induces the release in the bone marrow of proteases that cleave c-KIT receptor (CD117) from the surface of hematopoietic progenitor cells

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7 January 2021

Chemoattractant-stimulated Rac activation in wild-type and Rac2-deficient murine neutrophils: preferential activation of Rac2 and Rac2 gene dosage effect on neutrophil functions

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7 January 2021

The hematopoiesis-specific GTP-binding protein RhoH is GTPase deficient and modulates activities of other Rho GTPases by an inhibitory function

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7 January 2021

Mobilization of hematopoietic progenitor cells in healthy volunteers by AMD3100, a CXCR4 antagonist

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7 January 2021

The chemokine receptor CXCR4 is required for the retention of B lineage and granulocytic precursors within the bone marrow microenvironment

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7 January 2021

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900427-2

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7 January 2021

WAVE, a novel WASP-family protein involved in actin reorganization induced by Rac

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7 January 2021

IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling

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7 January 2021

Endogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21-activated kinase-dependent pathway

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7 January 2021

Primary diffuse large B-cell lymphomas of the central nervous system are targeted by aberrant somatic hypermutation

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7 January 2021

A complex of N-WASP and WIP integrates signalling cascades that lead to actin polymerization

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7 January 2021

The small GTPase RAC3 gene is located within chromosome band 17q25.3 outside and telomeric of a region commonly deleted in breast and ovarian tumours

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7 January 2021

Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1

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7 January 2021

A novel CXC chemokine PBSF/SDF-1 and its receptor CXCR4: their functions in development, hematopoiesis and HIV infection

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7 January 2021

Structure-function based design of small molecule inhibitors targeting Rho family GTPases

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7 January 2021

Spatial localization of transplanted hemopoietic stem cells: inferences for the localization of stem cell niches

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7 January 2021

The Wiskott-Aldrich syndrome

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7 January 2021

Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1.

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7 January 2021

Bone marrow homing: the players, the playfield, and their evolving roles

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7 January 2021

Homing and trafficking of hemopoietic progenitor cells

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https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900427-2

7 January 2021

The VLA4/VCAM-1 adhesion pathway defines contrasting mechanisms of lodgement of transplanted murine hemopoietic progenitors between bone marrow and spleen

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7 January 2021

The role of G-protein signaling in hematopoietic stem/progenitor cell mobilization.

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https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900427-2

7 January 2021

Molecular pathways in bone marrow homing: dominant role of alpha(4)beta(1) over beta(2)-integrins and selectins

1 reference

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7 January 2021

Synergistic mobilization of hemopoietic progenitor cells using concurrent beta1 and beta2 integrin blockade or beta2-deficient mice.

1 reference

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7 January 2021

Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas

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https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900427-2

7 January 2021

The chemokine SDF-1 stimulates integrin-mediated arrest of CD34(+) cells on vascular endothelium under shear flow

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900427-2

7 January 2021

Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4

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https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900427-2

7 January 2021

Clinical significance of p53 mutations in newly diagnosed Burkitt's lymphoma and acute lymphoblastic leukemia: a report of 48 cases

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900427-2

7 January 2021

Nonrandom 4p13 rearrangements of the RhoH/TTF gene, encoding a GTP-binding protein, in non-Hodgkin's lymphoma and multiple myeloma

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7 January 2021

Efficient mobilization and recruitment of marrow-derived endothelial and hematopoietic stem cells by adenoviral vectors expressing angiogenic factors

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7 January 2021

Rac is required for v-Abl tyrosine kinase to activate mitogenesis

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https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900427-2

7 January 2021

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900427-2

7 January 2021

Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense

1 reference

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7 January 2021

The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly

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7 January 2021

Nuclear translocation of LIM kinase mediates Rho-Rho kinase regulation of cyclin D1 expression

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7 January 2021

Rho signalling at a glance

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https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900427-2

7 January 2021

Deletion of alpha4 integrins from adult hematopoietic cells reveals roles in homeostasis, regeneration, and homing.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900427-2

7 January 2021

Abl-dependent tyrosine phosphorylation of Sos-1 mediates growth-factor-induced Rac activation

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https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900427-2

7 January 2021

BCR/ABL-mediated leukemogenesis requires the activity of the small GTP-binding protein Rac.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900427-2

7 January 2021

WASP deficiency leads to global defects of directed leukocyte migration in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900427-2

7 January 2021

Modulation of Rho GTPase Signaling Regulates a Switch between Adipogenesis and Myogenesis

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https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900427-2

7 January 2021

Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm

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https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900427-2

7 January 2021

Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxis

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900427-2

7 January 2021

Differential Roles of WAVE1 and WAVE2 in Dorsal and Peripheral Ruffle Formation for Fibroblast Cell Migration

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https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900427-2

7 January 2021

Sulfated polysaccharides increase plasma levels of SDF-1 in monkeys and mice: involvement in mobilization of stem/progenitor cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900427-2

7 January 2021

Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization

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https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900427-2

7 January 2021

Rho GTPase CDC42 regulates directionality and random movement via distinct MAPK pathways in neutrophils

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900427-2

7 January 2021

Genetic evidence for convergence of c-Kit- and alpha4 integrin-mediated signals on class IA PI-3kinase and the Rac pathway in regulating integrin-directed migration in mast cells

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900427-2

7 January 2021

CXCR4 regulates migration and development of human acute myelogenous leukemia stem cells in transplanted NOD/SCID mice

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900427-2

7 January 2021

Rac guanosine triphosphatases represent integrating molecular therapeutic targets for BCR-ABL-induced myeloproliferative disease

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900427-2

7 January 2021

Mechanisms of mobilization of hematopoietic progenitors with granulocyte colony-stimulating factor

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https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900427-2

7 January 2021

Wiskott-Aldrich syndrome: a disorder of haematopoietic cytoskeletal regulation

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https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900427-2

7 January 2021

Support of human hematopoiesis in long-term bone marrow cultures by murine stromal cells selectively expressing the membrane-bound and secreted forms of the human homolog of the steel gene product, stem cell factor

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https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900427-2

7 January 2021

VLA-5 is expressed by mouse and human long-term repopulating hematopoietic cells and mediates adhesion to extracellular matrix protein fibronectin

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https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900427-2

7 January 2021

Structure of the N-WASP EVH1 Domain-WIP Complex

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https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900427-2

7 January 2021

Critical Roles for Rac1 and Rac2 GTPases in B Cell Development and Signaling

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https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900427-2

7 January 2021

SCID-repopulating cell activity of human cord blood-derived CD34- cells assured by intra-bone marrow injection

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900427-2

7 January 2021

Genetic deletion of Cdc42GAP reveals a role of Cdc42 in erythropoiesis and hematopoietic stem/progenitor cell survival, adhesion, and engraftment

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900427-2

7 January 2021

Chemokine-induced monocyte transmigration requires cdc42-mediated cytoskeletal changes

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https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900427-2

7 January 2021

Timing of cyclin D1 expression within G1 phase is controlled by Rho.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900427-2

7 January 2021

Wiskott-Aldrich syndrome protein deficiency leads to reduced B-cell adhesion, migration, and homing, and a delayed humoral immune response

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900427-2

7 January 2021

Fibronectin and VLA-4 in haematopoietic stem cell-microenvironment interactions

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900427-2

7 January 2021

Bone-marrow haematopoietic-stem-cell niches

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900427-2

7 January 2021

Hematopoietic stem cells are uniquely selective in their migratory response to chemokines

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900427-2

7 January 2021

Physiological migration of hematopoietic stem and progenitor cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900427-2

7 January 2021

Rac and Cdc42 GTPases control hematopoietic stem cell shape, adhesion, migration, and mobilization

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900427-2

7 January 2021

Rac2 stimulates Akt activation affecting BAD/Bcl-XL expression while mediating survival and actin function in primary mast cells

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900427-2

7 January 2021

Transposition of the rice miniature inverted repeat transposable element mPing in Arabidopsis thaliana

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900427-2

7 January 2021

Cdc42 critically regulates the balance between myelopoiesis and erythropoiesis

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900427-2

7 January 2021

Chemotaxis of macrophages is abolished in the Wiskott-Aldrich syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900427-2

7 January 2021

Genetic and pharmacologic evidence that Rac1 GTPase is involved in regulation of platelet secretion and aggregation.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900427-2

7 January 2021

10.1016/S0076-6879(07)00427-2

Identifiers

DOI

1 reference

18 August 2017

1 reference