(Q37122098)

18 August 2017

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title

Structure and function of vitamin K epoxide reductase (English)

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18 August 2017

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1 reference

Jian-Ke Tie

1

1 reference

PubMed ID

18374192

18 August 2017

Darrel W Stafford

series ordinal

2

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18 August 2017

1 January 2008

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18 August 2017

Vitamins and Hormones

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18 August 2017

78

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18 August 2017

103-130

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How do Bax and Bak lead to permeabilization of the outer mitochondrial membrane?

18 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

The crystal structure of NAD(P)H quinone oxidoreductase 1 in complex with its potent inhibitor dicoumarol.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Characterization and purification of the vitamin K1 2,3 epoxide reductases system from rat liver

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Vitamin K Activity of Phylloquinone Oxide

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Warfarin and the Inhibition of Vitamin K Activity by an Oxide Metabolite

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Mechanism of action of warfarin. Warfarin and metabolism of vitamin K 1

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

The vitamin K-dependent carboxylase

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

The aromatic residues Trp and Phe have different effects on the positioning of a transmembrane helix in the microsomal membrane.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Assembly of the warfarin-sensitive vitamin K 2,3-epoxide reductase enzyme complex in the endoplasmic reticulum membrane

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Purified vitamin K epoxide reductase alone is sufficient for conversion of vitamin K epoxide to vitamin K and vitamin K to vitamin KH2

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Sequence motifs, polar interactions and conformational changes in helical membrane proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

A new vitamin K epoxide reductase complex subunit-1 (VKORC1) mutation in a patient with decreased stability of CYP2C9 enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

A polymorphism in the VKORC1 gene is associated with an interindividual variability in the dose-anticoagulant effect of warfarin.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

A quantum chemical study of the mechanism of action of Vitamin K carboxylase (VKC) III. Intermediates and transition states

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Motifs of serine and threonine can drive association of transmembrane helices

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Interfacial anchor properties of tryptophan residues in transmembrane peptides can dominate over hydrophobic matching effects in peptide-lipid interactions

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

How do helix-helix interactions help determine the folds of membrane proteins? Perspectives from the study of homo-oligomeric helical bundles

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Vitamin K and energy transduction: a base strength amplification mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Vitamin k contents of meat, dairy, and fast food in the u.s. Diet

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Vitamin K1 hydroquinone formation catalyzed by a microsomal reductase system

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Vitamin K1 hydroquinone formation catalyzed by DT-diaphorase

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Warfarin inhibition of vitamin K 2,3-epoxide reductase in rat liver microsomes

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Homozygosity mapping of a second gene locus for hereditary combined deficiency of vitamin K-dependent clotting factors to the centromeric region of chromosome 16.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Some characteristics of a vitamin K-dependent carboxylating system from rat liver microsomes

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Vitamin K epoxide and quinone reductase activities. Evidence for reduction by a common enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Synthesis and structure-activity relationships of novel warfarin derivatives.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Topogenesis of membrane proteins: determinants and dynamics.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Ineffectiveness of phylloquinone epoxide as an inhibitor of prothrombin synthesis in the rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Vitamin K epoxide reductase: homology, active site and catalytic mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Co-purification of microsomal epoxide hydrolase with the warfarin-sensitive vitamin K1 oxide reductase of the vitamin K cycle

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

r-VKORC1 expression in factor IX BHK cells increases the extent of factor IX carboxylation but is limited by saturation of another carboxylation component or by a shift in the rate-limiting step.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Pharmacodynamic resistance to warfarin associated with a Val66Met substitution in vitamin K epoxide reductase complex subunit 1.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Solubilization and characterization of vitamin K epoxide reductase from normal and warfarin-resistant rat liver microsomes.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

The conversion of vitamin K epoxide to vitamin K quinone and vitamin K quinone to vitamin K hydroquinone uses the same active site cysteines

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Vitamin K-dependent carboxylase. Possible role for thioredoxin in the reduction of vitamin K metabolites in liver

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Topology models for 37 Saccharomyces cerevisiae membrane proteins based on C-terminal reporter fusions and predictions

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Interaction of membrane proteins and lipids with solubilizing detergents

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

How lipids affect the activities of integral membrane proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Metabolism of vitamin K and vitamin K 2,3-epoxide via interaction with a common disulfide

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Identification of a warfarin-sensitive protein component in a 200S rat liver microsomal fraction catalyzing vitamin K and vitamin K 2,3-epoxide reduction

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Identification of the gene for vitamin K epoxide reductase

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Polymorphisms in the VKORC1 gene are strongly associated with warfarin dosage requirements in patients receiving anticoagulation

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Isolation and characterization of a new metabolite of phylloquinone in the rat

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Reliability measures for membrane protein topology prediction algorithms.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Targeted disruption of the microsomal epoxide hydrolase gene. Microsomal epoxide hydrolase is required for the carcinogenic activity of 7,12-dimethylbenz[a]anthracene

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Evaluation of methods for the prediction of membrane spanning regions

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Purification of a vitamin K epoxide reductase that catalyzes conversion of vitamin K 2,3-epoxide to 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Vitamin K epoxide reductase complex subunit 1 (VKORC1): the key protein of the vitamin K cycle

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Specific lipid requirements of membrane proteins--a putative bottleneck in heterologous expression

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

The genetic basis of resistance to anticoagulants in rodents

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

The vitamin K-dependent carboxylase

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Is thioredoxin the physiological vitamin K epoxide reducing agent?

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Vitamin K1 2,3-epoxide and quinone reduction: mechanism and inhibition

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Formation of 3-hydroxy-2,3-dihydrovitamin K1 in vivo: relationship to vitamin K epoxide reductase and warfarin resistance.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Relationship of dithiothreitol-dependent microsomal vitamin K quinone and vitamin K epoxide reductases inhibition of epoxide reduction by vitamin K quinone

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Analysis of the role of interfacial tryptophan residues in controlling the topology of membrane proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Tryptophan supports interaction of transmembrane helices

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

A single negatively charged residue affects the orientation of a membrane protein in the inner membrane of Escherichia coli only when it is located adjacent to a transmembrane domain.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Mechanism of action of coumarins. Significance of vitamin K epoxide

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

From interactions of single transmembrane helices to folding of alpha-helical membrane proteins: analyzing transmembrane helix-helix interactions in bacteria

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Membrane proteins, lipids and detergents: not just a soap opera.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Folding of helical membrane proteins: the role of polar, GxxxG-like and proline motifs

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Vitamin K epoxide reductase: Evidence that Vitamin K dihydroquinone is a product of Vitamin K epoxide reduction

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Solubilization of vitamin K epoxide reductase and vitamin K-dependent carboxylase from rat liver microsomes

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Reduced thioredoxin: a possible physiological cofactor for vitamin K epoxide reductase. Further support for an active site disulfide

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Solubilization and functional reconstitution of biomembrane components

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Stimulation of the dithiol-dependent reductases in the vitamin K cycle by the thioredoxin system. Strong synergistic effects with protein disulphide-isomerase

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

1 reference

7 January 2021

Vitamin K epoxide reductase significantly improves carboxylation in a cell line overexpressing factor X.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

BPROMPT: A consensus server for membrane protein prediction

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Microsomal lipoamide reductase provides vitamin K epoxide reductase with reducing equivalents

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Membrane topology mapping of vitamin K epoxide reductase by in vitro translation/cotranslocation.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Gamma-carboxyglutamate-containing proteins and the vitamin K-dependent carboxylase

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Control of topology and mode of assembly of a polytopic membrane protein by positively charged residues

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Membrane-protein topology

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Pharmacogenetics of warfarin: current status and future challenges

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Increased production of functional recombinant human clotting factor IX by baby hamster kidney cells engineered to overexpress VKORC1, the vitamin K 2,3-epoxide-reducing enzyme of the vitamin K cycle

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Engineering of a recombinant vitamin K-dependent gamma-carboxylation system with enhanced gamma-carboxyglutamic acid forming capacity: evidence for a functional CXXC redox center in the system

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Disulfide-dependent protein folding is linked to operation of the vitamin K cycle in the endoplasmic reticulum. A protein disulfide isomerase-VKORC1 redox enzyme complex appears to be responsible for vitamin K1 2,3-epoxide reduction

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Tryptophans in membrane proteins. X-ray crystallographic analyses

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Purification of warfarin-sensitive vitamin K epoxide reductase

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Vitamin K-dependent carboxylation and vitamin K epoxidation. Evidence that the warfarin-sensitive microsomal NAD(P)H dehydrogenase reduces vitamin K1 in these reactions

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

NAD(P)H dehydrogenase and its role in the vitamin K (2-methyl-3-phytyl-1,4-naphthaquinone)-dependent carboxylation reaction

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Rat and human liver vitamin K epoxide reductase: inhibition by thiol blockers and vitamin K1

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Vitamin K 2,3-epoxide reductase and the vitamin K-dependent gamma-carboxylation system

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

VKORC1 haplotypes are associated with arterial vascular diseases (stroke, coronary heart disease, and aortic dissection)

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Mechanism of coumarin action: significance of vitamin K epoxide reductase inhibition

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

The preference of tryptophan for membrane interfaces.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Warfarin dose and the pharmacogenomics of CYP2C9 and VKORC1 - rationale and perspectives

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

A novel functional VKORC1 promoter polymorphism is associated with inter-individual and inter-ethnic differences in warfarin sensitivity.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Phospholipids as determinants of membrane protein topology. Phosphatidylethanolamine is required for the proper topological organization of the gamma-aminobutyric acid permease (GabP) of Escherichia coli

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

Biochemical basis of hereditary resistance to warfarin in the rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2807%2900006-4

7 January 2021

10.1016/S0083-6729(07)00006-4

Identifiers

DOI

1 reference

18 August 2017

1 reference

PubMed ID

18374192