(Q40288458)

English

r-VKORC1 expression in factor IX BHK cells increases the extent of factor IX carboxylation but is limited by saturation of another carboxylation component or by a shift in the rate-limiting step.

scientific article published on May 2006

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16634640%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

r-VKORC1 expression in factor IX BHK cells increases the extent of factor IX carboxylation but is limited by saturation of another carboxylation component or by a shift in the rate-limiting step (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16634640%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

4

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19 January 2020

Kathleen L Berkner

5

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19 January 2020

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Kevin W Hallgren

1

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19 January 2020

Wen Qian

2

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19 January 2020

Anna V Yakubenko

3

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19 January 2020

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1 May 2006

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19 January 2020

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19 January 2020

45

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19 January 2020

17

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19 January 2020

5587-5598

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19 January 2020

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11 June 2022

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Vitamin K epoxide reductase significantly improves carboxylation in a cell line overexpressing factor X.

1 reference

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22 September 2017

Increased production of functional recombinant human clotting factor IX by baby hamster kidney cells engineered to overexpress VKORC1, the vitamin K 2,3-epoxide-reducing enzyme of the vitamin K cycle

1 reference

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The vitamin K-dependent carboxylase

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22 September 2017

Identification of the gene for vitamin K epoxide reductase

1 reference

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22 September 2017

Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2

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22 September 2017

Carboxylase overexpression effects full carboxylation but poor release and secretion of factor IX: implications for the release of vitamin K-dependent proteins

1 reference

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22 September 2017

Tethered processivity of the vitamin K-dependent carboxylase: factor IX is efficiently modified in a mechanism which distinguishes Gla's from Glu's and which accounts for comprehensive carboxylation in vivo

1 reference

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NRH:quinone oxidoreductase2 (NQO2).

1 reference

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22 September 2017

Identification of the vitamin K-dependent carboxylase active site: Cys-99 and Cys-450 are required for both epoxidation and carboxylation

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22 September 2017

Vitamin K-dependent carboxylation of the carboxylase

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22 September 2017

Processive post-translational modification. Vitamin K-dependent carboxylation of a peptide substrate

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22 September 2017

In vitro and in vivo functional characterization of bovine vitamin K-dependent gamma-carboxylase expressed in Chinese hamster ovary cells

1 reference

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22 September 2017

Isolation and characterization of a cDNA coding for human factor IX

1 reference

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22 September 2017

Vitamin K-dependent carboxylase

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22 September 2017

Expression, purification, and characterization of recombinant gamma-carboxylated factor IX synthesized in Chinese hamster ovary cells

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Mechanism of coumarin action: significance of vitamin K epoxide reductase inhibition

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Vitamin K-dependent carboxylase. Requirements of the rat liver microsomal enzyme system

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Isolation of the human gamma-carboxylase and a gamma-carboxylase-associated protein from factor IX-expressing mammalian cells.

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Report of Workshop on expression of vitamin K-dependent proteins in bacterial and mammalian cells, Madison, Wisconsin, USA, April 1986.

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1 reference

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Identifiers

10.1021/BI051986Y

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Europe PubMed Central

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19 January 2020

PMC publication ID

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19 January 2020

PubMed publication ID

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Europe PubMed Central

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19 January 2020

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