(Q37123797)

18 August 2017

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title

Hedgehog signaling pathway: development of antagonists for cancer therapy (English)

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18 August 2017

Jingwu Xie

1

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18 August 2017

1 March 2008

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18 August 2017

Current Oncology Reports

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18 August 2017

10

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18 August 2017

107-113

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18 August 2017

2

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https://scigraph.springernature.com/pub.10.1007/s11912-008-0018-7

18 August 2017

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cites work

Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways.

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12 December 2020

Gas1 extends the range of Hedgehog action by facilitating its signaling

1 reference

12 December 2020

The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice

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12 December 2020

Hedgehog signaling and human disease

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12 December 2020

Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists

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12 December 2020

Vertebrate Smoothened functions at the primary cilium

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12 December 2020

Evidence for the direct involvement of {beta}TrCP in Gli3 protein processing

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12 December 2020

Divergence of hedgehog signal transduction mechanism between Drosophila and mammals

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12 December 2020

Boc is a receptor for sonic hedgehog in the guidance of commissural axons

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12 December 2020

Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function

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12 December 2020

Cdo functions at multiple points in the Sonic Hedgehog pathway, and Cdo-deficient mice accurately model human holoprosencephaly

1 reference

12 December 2020

Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions.

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12 December 2020

Cilia and Hedgehog responsiveness in the mouse

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12 December 2020

Sonic hedgehog induces the segregation of patched and smoothened in endosomes

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12 December 2020

Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway

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12 December 2020

Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli

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12 December 2020

Hedgehog signaling in prostate cancer

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12 December 2020

Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours

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12 December 2020

Frequent activation of the hedgehog pathway in advanced gastric adenocarcinomas.

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12 December 2020

Mutations affecting segment number and polarity in Drosophila

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12 December 2020

Selective modulation of Hedgehog/GLI target gene expression by epidermal growth factor signaling in human keratinocytes.

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12 December 2020

Suppressor of Fused represses Gli-mediated transcription by recruiting the SAP18-mSin3 corepressor complex

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12 December 2020

Gas1 is a modifier for holoprosencephaly and genetically interacts with sonic hedgehog

1 reference

12 December 2020

Hedgehog signalling in prostate regeneration, neoplasia and metastasis

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12 December 2020

Somatic mutations in the PTCH, SMOH, SUFUH and TP53 genes in sporadic basal cell carcinomas

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12 December 2020

PTCH mutations: distribution and analyses

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12 December 2020

Regulation of Gli1 localization by the cAMP/protein kinase A signaling axis through a site near the nuclear localization signal

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12 December 2020

Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway

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12 December 2020

Hedgehog signalling in the mouse requires intraflagellar transport proteins

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12 December 2020

The Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse development

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12 December 2020

Repression of smoothened by patched-dependent (pro-)vitamin D3 secretion

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12 December 2020

Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer

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12 December 2020

Negative regulation of Gli1 and Gli2 activator function by Suppressor of fused through multiple mechanisms

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12 December 2020

Inhibition of smoothened signaling prevents ultraviolet B-induced basal cell carcinomas through regulation of Fas expression and apoptosis

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12 December 2020

Activation of the hedgehog pathway in advanced prostate cancer

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12 December 2020

Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis

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12 December 2020

Activation of the hedgehog pathway in human hepatocellular carcinomas.

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12 December 2020

The ihog cell-surface proteins bind Hedgehog and mediate pathway activation

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12 December 2020

Hedgehog signaling pathway is a new therapeutic target for patients with breast cancer

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12 December 2020

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists

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12 December 2020

Hedgehog/Ras interactions regulate early stages of pancreatic cancer

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12 December 2020

Mice deficient in the fused homolog do not exhibit phenotypes indicative of perturbed hedgehog signaling during embryonic development

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12 December 2020

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

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12 December 2020

Tectonic, a novel regulator of the Hedgehog pathway required for both activation and inhibition.

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12 December 2020

Loss of the serine/threonine kinase fused results in postnatal growth defects and lethality due to progressive hydrocephalus

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12 December 2020

In vivo inhibition of endogenous brain tumors through systemic interference of Hedgehog signaling in mice.

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12 December 2020

Targeting the Hedgehog pathway in cancer

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12 December 2020

HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity

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12 December 2020

A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro

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12 December 2020

Small molecule modulation of Smoothened activity

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12 December 2020

10.1007/S11912-008-0018-7

Identifiers

DOI

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18 August 2017

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PubMed ID

18377823