(Q37127375)

18 August 2017

title

Epigenetic contributions to cancer metastasis (English)

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18 August 2017

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David I Rodenhiser

1

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18 August 2017

publication date

2 April 2008

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Clinical & Experimental Metastasis

18 August 2017

published in

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18 August 2017

volume

26

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18 August 2017

issue

1

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18 August 2017

page(s)

5-18

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Epigenetics and human disease: translating basic biology into clinical applications

18 August 2017

cites work

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https://api.crossref.org/works/10.1007%2FS10585-008-9166-2

Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10585-008-9166-2

New insights into the tumor metastatic process revealed by gene expression profiling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10585-008-9166-2

Hypermethylation of Syk gene in promoter region associated with oncogenesis and metastasis of gastric carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10585-008-9166-2

Dynamic regulation of estrogen receptor-beta expression by DNA methylation during prostate cancer development and metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10585-008-9166-2

Essential role for activation of the Polycomb group (PcG) protein chromatin silencing pathway in metastatic prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10585-008-9166-2

Overexpression of S100A4 in pancreatic ductal adenocarcinomas is associated with poor differentiation and DNA hypomethylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10585-008-9166-2

The relationship between hypomethylation and CpG island methylation in colorectal neoplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10585-008-9166-2

Reduced metastasis-suppressor gene mRNA-expression in breast cancer brain metastases

21 January 2018

1 reference

12 December 2020

Microarray analysis of gene expression in metastatic gastric cancer cells after incubation with the methylation inhibitor 5-aza-2'-deoxycytidine.

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12 December 2020

Expression profiling of sodium butyrate (NaB)-treated cells: identification of regulation of genes related to cytokine signaling and cancer metastasis by NaB.

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12 December 2020

Deciphering the underlying genetic and epigenetic events leading to gastric carcinogenesis

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12 December 2020

Epigenetic therapy of cancer: past, present and future

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12 December 2020

Expression profiling reveals that methylation of TIMP3 is involved in uveal melanoma development

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12 December 2020

Lymphatic metastasis in breast cancer: importance and new insights into cellular and molecular mechanisms

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12 December 2020

Alteration of the methylation status of tumor-promoting genes decreases prostate cancer cell invasiveness and tumorigenesis in vitro and in vivo.

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12 December 2020

Promoter hypermethylation of the potential tumor suppressor DAL-1/4.1B gene in renal clear cell carcinoma

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12 December 2020

Colorectal cancer and genetic alterations in the Wnt pathway

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12 December 2020

Promoter hypomethylation of protease-activated receptor 2 associated with carcinogenesis in the stomach.

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12 December 2020

Epigenetic therapy of cancer with 5-aza-2'-deoxycytidine (decitabine).

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12 December 2020

Genome-epigenome interactions in cancer

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12 December 2020

Metastasis Suppressor Genes: Basic Biology and Potential Clinical Use

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12 December 2020

Epigenetic inactivation of SOCS-1 by CpG island hypermethylation in human gastric carcinoma

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12 December 2020

The epigenomics of cancer

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12 December 2020

Molecular Portraits and 70-Gene Prognosis Signature Are Preserved throughout the Metastatic Process of Breast Cancer

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12 December 2020

A molecular signature of metastasis in primary solid tumors

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12 December 2020

High sensitivity mapping of methylated cytosines

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12 December 2020

Molecular signature associated with bone marrow micrometastasis in human breast cancer

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12 December 2020

The Polycomb group protein EZH2 directly controls DNA methylation

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12 December 2020

High prevalence of decreased expression of KAI1 metastasis suppressor in human oral carcinogenesis

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12 December 2020

Down-regulation of PIK3CG, a catalytic subunit of phosphatidylinositol 3-OH kinase, by CpG hypermethylation in human colorectal carcinoma.

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12 December 2020

GnT-V expression and metastatic phenotypes in macrophage-melanoma fusion hybrids is down-regulated by 5-Aza-dC: evidence for methylation sensitive, extragenic regulation of GnT-V transcription

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12 December 2020

RhoGDI2 is an invasion and metastasis suppressor gene in human cancer

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12 December 2020

Inverse correlation between the expression of O6-methylguanine-DNA methyl transferase (MGMT) and p53 in breast cancer

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12 December 2020

Tumor-derived aberrant methylation in plasma of invasive ductal breast cancer patients: clinical implications

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12 December 2020

Dissemination and growth of cancer cells in metastatic sites

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12 December 2020

Epigenetic silencing of CXCL12 increases the metastatic potential of mammary carcinoma cells

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12 December 2020

Validation and clinical utility of a 70-gene prognostic signature for women with node-negative breast cancer

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12 December 2020

Down-regulation of human DAB2IP gene expression mediated by polycomb Ezh2 complex and histone deacetylase in prostate cancer

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12 December 2020

Increasing 14-3-3 sigma expression with declining estrogen receptor alpha and estrogen-responsive finger protein expression defines malignant progression of endometrial carcinoma

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12 December 2020

Mithramycin A inhibits DNA methyltransferase and metastasis potential of lung cancer cells

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12 December 2020

Diagnostic and prognostic information in prostate cancer with the help of a small set of hypermethylated gene loci.

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12 December 2020

Dissection of a metastatic gene expression signature into distinct components

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12 December 2020

Translational approaches using metastasis suppressor genes

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12 December 2020

[Correlation of E-cadherin hypermethylation to tumorigenesis and development of gastric cancer]

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12 December 2020

Gene expression profiling predicts clinical outcome of breast cancer

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12 December 2020

The extracellular matrix protein ITIH5 is a novel prognostic marker in invasive node-negative breast cancer and its aberrant expression is caused by promoter hypermethylation

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12 December 2020

Epigenetic activation of alpha4, beta2 and beta6 integrins involved in cell migration in trichostatin A-treated Hep3B cells

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12 December 2020

Epigenetic deregulation of multiple S100 gene family members by differential hypomethylation and hypermethylation events in medulloblastoma

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12 December 2020

CDH1 promoter hypermethylation and E-cadherin protein expression in infiltrating breast cancer

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12 December 2020

Gene arrays for diagnosis, prognosis and treatment of breast cancer metastasis

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12 December 2020

The Hallmarks of Cancer

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12 December 2020

Environmental epigenomics in human health and disease

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12 December 2020

Expression and regulation of MIM (Missing In Metastasis), a novel putative metastasis suppressor gene, and MIM-B, in bladder cancer cell lines

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12 December 2020

Invasion and metastasis of oral cancer cells require methylation of E-cadherin and/or degradation of membranous beta-catenin

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12 December 2020

A multigenic program mediating breast cancer metastasis to bone

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12 December 2020

Differential targets of CpG island hypermethylation in primary and metastatic head and neck squamous cell carcinoma (HNSCC)

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12 December 2020

The gene encoding the prostatic tumor suppressor PSP94 is a target for repression by the Polycomb group protein EZH2.

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12 December 2020

Gene promoter hypermethylation in tumors and lymph nodes of stage I lung cancer patients

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12 December 2020

Epigenetic drugs as pleiotropic agents in cancer treatment: biomolecular aspects and clinical applications.

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12 December 2020

THY1 is a candidate tumour suppressor gene with decreased expression in metastatic nasopharyngeal carcinoma.

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12 December 2020

The epigenetic silencing of LIMS2 in gastric cancer and its inhibitory effect on cell migration

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12 December 2020

Genomewide DNA hypomethylation is associated with alterations on chromosome 8 in prostate carcinoma

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12 December 2020

DNA hypomethylation and human diseases.

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12 December 2020

Colorectal cancer: genetics of development and metastasis

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12 December 2020

Co-downregulation of PTEN, KAI-1, and nm23-H1 tumor/metastasis suppressor proteins in non-small cell lung cancer.

1 reference

12 December 2020

Depletion of DNA methyltransferase 1 and/or DNA methyltransferase 3b mediates growth arrest and apoptosis in lung and esophageal cancer and malignant pleural mesothelioma cells

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12 December 2020

Down-regulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancers

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12 December 2020

Roles of mismatch repair proteins hMSH2 and hMLH1 in the development of sporadic breast cancer

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12 December 2020

Silencing of epithelial CXCL12 expression by DNA hypermethylation promotes colonic carcinoma metastasis

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12 December 2020

Microarrays bring new insights into understanding of breast cancer metastasis to bone

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12 December 2020

p300 expression repression by hypermethylation associated with tumour invasion and metastasis in oesophageal squamous cell carcinoma.

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12 December 2020

Identification of enhancer of zeste homolog 2 expression in peripheral circulating tumor cells in metastatic prostate cancer patients: a preliminary study

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12 December 2020

Frequent LOH on 22q12.3 and TIMP-3 inactivation occur in the progression to secondary glioblastomas.

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12 December 2020

A polycomb repression signature in metastatic prostate cancer predicts cancer outcome

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12 December 2020

Promoter hypermethylation profile of ovarian epithelial neoplasms

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12 December 2020

Promoter hypermethylation of Death-associated protein-kinase gene associated with advance stage gastric cancer.

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12 December 2020

Methylation profiles of multiple CpG island loci in extrahepatic cholangiocarcinoma versus those of intrahepatic cholangiocarcinomas

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12 December 2020

Studies on the methylation status of CpG sequences located in promoters of selected tumour suppressor genes in breast cancer cells

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12 December 2020

DNA methyltransferase expression and DNA methylation in human hepatocellular carcinoma and their clinicopathological correlation.

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12 December 2020

Epigenetic inactivation of the chromosomal stability control genes BRCA1, BRCA2, and XRCC5 in non-small cell lung cancer

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12 December 2020

A gene hypermethylation profile of human cancer

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12 December 2020

Aberrant hypermethylation of ID4 gene promoter region increases risk of lymph node metastasis in T1 breast cancer.

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12 December 2020

Lin-7C/VELI3/MALS-3: an essential component in metastasis of human squamous cell carcinoma

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12 December 2020

Cancer epigenomics: DNA methylomes and histone-modification maps

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12 December 2020

Chromatin modifications and their function

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12 December 2020

Allelic imbalance of APAF-1 locus at 12q23 is related to progression of colorectal carcinoma

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12 December 2020

Loss of beta-catenin expression in metastatic gastric cancer

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12 December 2020

Transcriptional silencing of hedgehog-interacting protein by CpG hypermethylation and chromatic structure in human gastrointestinal cancer.

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12 December 2020

Characterization of a novel tumor-suppressor gene PLC delta 1 at 3p22 in esophageal squamous cell carcinoma

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12 December 2020

Reversal of the hypomethylation status of urokinase (uPA) promoter blocks breast cancer growth and metastasis

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12 December 2020

Prognostic value of p16INK4a and p14ARF gene hypermethylation in human colon cancer.

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12 December 2020

Reduced expression of oestrogen receptor β in invasive breast cancer and its re‐expression using DNA methyl transferase inhibitors in a cell line model

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12 December 2020

PGP9.5 methylation in diffuse-type gastric cancer

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12 December 2020

Causes and consequences of DNA hypomethylation in human cancer

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12 December 2020

Tumor dormancy and cancer stem cells: implications for the biology and treatment of breast cancer metastasis.

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12 December 2020

Differential expression of EphA7 receptor tyrosine kinase in gastric carcinoma

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12 December 2020

DNA methylation paradigm shift: 15-lipoxygenase-1 upregulation in prostatic intraepithelial neoplasia and prostate cancer by atypical promoter hypermethylation

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12 December 2020

Abnormal DNA methylation, epigenetics, and prostate cancer

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12 December 2020

Folate and DNA methylation: a mechanistic link between folate deficiency and colorectal cancer?

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12 December 2020

DNA methylation in breast and colorectal cancers

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12 December 2020

Cancer genetics of epigenetic genes

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12 December 2020

Phase II trial of DNA methyltransferase 1 inhibition with the antisense oligonucleotide MG98 in patients with metastatic renal carcinoma: a National Cancer Institute of Canada Clinical Trials Group investigational new drug study

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12 December 2020

Promoter hypermethylation and quantitative expression analysis of CDKN2A (p14ARF and p16INK4a) gene in esophageal squamous cell carcinoma.

1 reference

12 December 2020

Gene expression profiling in lymph node-positive and lymph node-negative colorectal cancer

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12 December 2020

Epigenetic inactivation of the metastasis suppressor RECK enhances invasion of human colon cancer cells

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12 December 2020

5-aza-2'-deoxycytidine restores the E-cadherin system in E-cadherin-silenced cancer cells and reduces cancer metastasis

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12 December 2020

The dynamic epigenome and its implications in toxicology

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12 December 2020

Genetic and epigenetic alterations in sentinel lymph nodes metastatic lesions compared to their corresponding primary breast tumors

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12 December 2020

Hypermethylation of the TPEF/HPP1 gene in primary and metastatic colorectal cancers

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12 December 2020

Demethylation of MAGE promoters during gastric cancer progression

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12 December 2020

Perceptions of epigenetics

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12 December 2020

Genome-wide H3K9 histone acetylation profiles are altered in benzopyrene-treated MCF7 breast cancer cells

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12 December 2020

Differential expression of MHC class II molecules in highly metastatic breast cancer cells is mediated by the regulation of the CIITA transcription Implication of CIITA in tumor and metastasis development

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12 December 2020

Hypomethylation-induced expression of S100A4 in endometrial carcinoma

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12 December 2020

Hypomethylation of the metastasis-associated S100A4 gene correlates with gene activation in human colon adenocarcinoma cell lines

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12 December 2020

The mammalian epigenome

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12 December 2020

Repression of IFN regulatory factor 8 by DNA methylation is a molecular determinant of apoptotic resistance and metastatic phenotype in metastatic tumor cells

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12 December 2020

Very high frequency of hypermethylated genes in breast cancer metastasis to the bone, brain, and lung

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12 December 2020

E-cadherin expression in early gastric carcinoma and correlation with lymph node metastasis

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12 December 2020

Models, mechanisms and clinical evidence for cancer dormancy

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12 December 2020

Epigenetic inactivation of the tissue inhibitor of metalloproteinase-2 (TIMP-2) gene in human prostate tumors

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12 December 2020

Hypomethylation of LINE-1 and Alu in well-differentiated neuroendocrine tumors (pancreatic endocrine tumors and carcinoid tumors).

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12 December 2020

Analyses of promoter hypermethylation for RUNX3 and other tumor suppressor genes in nasopharyngeal carcinoma.

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12 December 2020

Genes that mediate breast cancer metastasis to lung

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12 December 2020

KISS1 metastasis suppression and emergent pathways

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12 December 2020

Development and gene expression profiling of a metastatic variant of the human breast cancer MDA-MB-435 cells.

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12 December 2020

Suppression of human melanoma metastasis by the metastasis suppressor gene, BRMS1.

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12 December 2020

Hypermethylation of CpG islands in primary and metastatic human prostate cancer.

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12 December 2020

Silencing of the maspin gene by promoter hypermethylation in thyroid cancer

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12 December 2020

Differential expression of hypoxia and (lymph)angiogenesis-related genes at different metastatic sites in breast cancer

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12 December 2020

Epigenetics of prostate cancer

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12 December 2020

Tissue factor pathway inhibitor-2 was repressed by CpG hypermethylation through inhibition of KLF6 binding in highly invasive breast cancer cells

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12 December 2020

CLCA2 tumour suppressor gene in 1p31 is epigenetically regulated in breast cancer.

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12 December 2020

Promoter hypermethylation of the p16 gene and loss of its protein expression is correlated with tumor progression in extrahepatic bile duct carcinomas.

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12 December 2020

The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited

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12 December 2020

Loss of caspase-1 gene expression in human gastric carcinomas and cell lines.

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12 December 2020

Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals

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12 December 2020

Tumor suppressor gene hypermethylation as a predictor of gastric stromal tumor behavior.

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12 December 2020

Hypomethylation of the synuclein gamma gene CpG island promotes its aberrant expression in breast carcinoma and ovarian carcinoma

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12 December 2020

Promotor hypermethylation of p14ARF is a key alteration for progression of oral squamous cell carcinoma

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12 December 2020

Identification of molecular markers for metastasis-related genes in primary breast cancer cells.

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12 December 2020

Distinct hypermethylation profile of primary breast cancer is associated with sentinel lymph node metastasis

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12 December 2020

Homozygous deletions of the INK4a/ARF locus in renal cell cancer.

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12 December 2020

DNA hypermethylation of TIMP3 gene in invasive breast ductal carcinoma

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12 December 2020

Frequent death-associated protein-kinase promoter hypermethylation in brain metastases of solid tumors

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12 December 2020

Drastic down-regulation of Krüppel-like factor 4 expression is critical in human gastric cancer development and progression

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12 December 2020

DNA hypermethylation of PITX2 is a marker of poor prognosis in untreated lymph node-negative hormone receptor-positive breast cancer patients

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12 December 2020

Detection of lymph node micrometastases by gene promoter hypermethylation in samples obtained by endosonography- guided fine-needle aspiration biopsy

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12 December 2020

Differential gene and protein expression in primary breast malignancies and their lymph node metastases as revealed by combined cDNA microarray and tissue microarray analysis

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12 December 2020

The role of chromatin during transcription

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12 December 2020

Expression of family A melanoma antigen in human gastric carcinoma.

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12 December 2020

Methylation-dependent silencing of CST6 in primary human breast tumors and metastatic lesions

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12 December 2020

Wnt signaling promoter hypermethylation distinguishes lung primary adenocarcinomas from colorectal metastasis to the lung.

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12 December 2020

10.1007/S10585-008-9166-2

Identifiers

DOI

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18 August 2017

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