(Q37129818)

18 August 2017

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title

Activated c-Abl tyrosine kinase in malignant solid tumors (English)

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18 August 2017

J Lin

1

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18 August 2017

R Arlinghaus

series ordinal

2

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18 August 2017

language of work or name

English

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publication date

7 April 2008

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18 August 2017

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18 August 2017

volume

27

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18 August 2017

issue

32

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18 August 2017

page(s)

4385-4391

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Epidermal growth factor receptor expression, signal pathway, and inhibitors in non-small cell lung cancer

18 August 2017

cites work

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c-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGF

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The tyrosine kinase Abl is required for Src-transforming activity in mouse fibroblasts and human breast cancer cells

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Activation of Abl tyrosine kinases promotes invasion of aggressive breast cancer cells

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Aggressive breast cancer cells are dependent on activated Abl kinases for proliferation, anchorage-independent growth and survival

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Abl tyrosine kinase regulates endocytosis of the epidermal growth factor receptor

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Myristoylation of the fus1 protein is required for tumor suppression in human lung cancer cells

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Treatment with Imatinib in NSCLC is associated with decrease of phosphorylated PDGFR-beta and VEGF expression, decrease in interstitial fluid pressure and improvement of oxygenation

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Regulation of cell death by the Abl tyrosine kinase

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The PAG gene product, a stress-induced protein with antioxidant properties, is an Abl SH3-binding protein and a physiological inhibitor of c-Abl tyrosine kinase activity

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Regulation of F-actin-dependent processes by the Abl family of tyrosine kinases

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Tumor suppressor genes on chromosome 3p involved in the pathogenesis of lung and other cancers

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Liposomal vector mediated delivery of the 3p FUS1 gene demonstrates potent antitumor activity against human lung cancer in vivo

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The HER-2/neu oncogene in breast cancer: prognostic factor, predictive factor, and target for therapy.

31 March 2020

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Potential involvement of the cyclooxygenase-2 pathway in the regulation of tumor-associated angiogenesis and growth in pancreatic cancer

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/ONC.2008.86

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18 August 2017

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