(Q37132712)

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Glioma Specific Extracellular Missense Mutations in the First Cysteine Rich Region of Epidermal Growth Factor Receptor (EGFR) Initiate Ligand Independent Activation

scientific article published on 18 April 2011

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Europe PubMed Central

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18 August 2017

Glioma Specific Extracellular Missense Mutations in the First Cysteine Rich Region of Epidermal Growth Factor Receptor (EGFR) Initiate Ligand Independent Activation (English)

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Europe PubMed Central

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18 August 2017

Sameer A Greenall

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24212795%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Anna N Cvrljevic

3

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6 June 2020

Jacqueline F Donoghue

5

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6 June 2020

7

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6 June 2020

Timothy E Adams

8

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6 June 2020

Terrance G Johns

9

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6 June 2020

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Susie I Ymer

1

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6 June 2020

Diana X Cao

4

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6 June 2020

V Chandana Epa

6

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6 June 2020

publication date

18 April 2011

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Europe PubMed Central

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18 August 2017

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24212795%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24212795%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

2

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6 June 2020

2032-2049

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Europe PubMed Central

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6 June 2020

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Creative Commons Attribution 4.0 International

18 April 2011

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April 2022 Public Data File from Crossref

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Phosphotyrosine signaling analysis of site-specific mutations on EGFRvIII identifies determinants governing glioblastoma cell growth

1 reference

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Asymmetric tyrosine kinase arrangements in activation or autophosphorylation of receptor tyrosine kinases

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The plasticity of oncogene addiction: implications for targeted therapies directed to receptor tyrosine kinases

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The EGFRvIII variant in glioblastoma multiforme

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Antibodies specifically targeting a locally misfolded region of tumor associated EGFR

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EGFR signals to mTOR through PKC and independently of Akt in glioma

1 reference

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Comprehensive genomic characterization defines human glioblastoma genes and core pathways

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14 September 2017

Epidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domain

1 reference

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14 September 2017

ErbB receptors: new insights on mechanisms and biology

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An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor

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14 September 2017

Epidermal growth factor receptor: mechanisms of activation and signalling.

1 reference

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14 September 2017

Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains

1 reference

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14 September 2017

Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor alpha

1 reference

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14 September 2017

The type III epidermal growth factor receptor mutation. Biological significance and potential target for anti-cancer therapy

1 reference

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14 September 2017

Glycosylation-induced conformational modification positively regulates receptor-receptor association: a study with an aberrant epidermal growth factor receptor (EGFRvIII/DeltaEGFR) expressed in cancer cells

1 reference

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14 September 2017

Activating mutations in the extracellular domain of the fibroblast growth factor receptor 2 function by disruption of the disulfide bond in the third immunoglobulin-like domain

1 reference

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14 September 2017

The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling

1 reference

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14 September 2017

Mutations affecting conserved cysteine residues within the extracellular domain of Neu promote receptor dimerization and activation

1 reference

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14 September 2017

Activation of RET as a dominant transforming gene by germline mutations of MEN2A and MEN2B

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Homodimerization and constitutive activation of the erythropoietin receptor

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The epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor AG1478 increases the formation of inactive untethered EGFR dimers. Implications for combination therapy with monoclonal antibody 806.

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The tumor-specific de2-7 epidermal growth factor receptor (EGFR) promotes cells survival and heterodimerizes with the wild-type EGFR.

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12 December 2020

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10.3390/CANCERS3022032

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24212795%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24212795%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

PubMed publication ID

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24212795%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

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