(Q37132712)

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Glioma Specific Extracellular Missense Mutations in the First Cysteine Rich Region of Epidermal Growth Factor Receptor (EGFR) Initiate Ligand Independent Activation

scientific article published on 18 April 2011

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Glioma Specific Extracellular Missense Mutations in the First Cysteine Rich Region of Epidermal Growth Factor Receptor (EGFR) Initiate Ligand Independent Activation (English)

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Sameer A Greenall

2

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24212795%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Anna N Cvrljevic

3

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24212795%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Jacqueline F Donoghue

5

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24212795%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

7

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24212795%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Timothy E Adams

8

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24212795%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Terrance G Johns

9

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24212795%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

author name string

Susie I Ymer

1

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6 June 2020

Diana X Cao

4

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24212795%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

V Chandana Epa

6

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24212795%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

publication date

18 April 2011

1 reference

Europe PubMed Central

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18 August 2017

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24212795%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

3

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24212795%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24212795%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

2032-2049

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24212795%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

copyright license

Creative Commons Attribution 4.0 International

18 April 2011

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April 2022 Public Data File from Crossref

copyright status

0 references

Phosphotyrosine signaling analysis of site-specific mutations on EGFRvIII identifies determinants governing glioblastoma cell growth

1 reference

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14 September 2017

Asymmetric tyrosine kinase arrangements in activation or autophosphorylation of receptor tyrosine kinases

1 reference

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Spatial control of EGF receptor activation by reversible dimerization on living cells

1 reference

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14 September 2017

Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4.

1 reference

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14 September 2017

The plasticity of oncogene addiction: implications for targeted therapies directed to receptor tyrosine kinases

1 reference

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14 September 2017

The EGFRvIII variant in glioblastoma multiforme

1 reference

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14 September 2017

Antibodies specifically targeting a locally misfolded region of tumor associated EGFR

1 reference

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14 September 2017

EGFR signals to mTOR through PKC and independently of Akt in glioma

1 reference

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14 September 2017

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

1 reference

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14 September 2017

Epidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3757403

14 September 2017

ErbB receptors: new insights on mechanisms and biology

1 reference

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14 September 2017

An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3757403

14 September 2017

Epidermal growth factor receptor: mechanisms of activation and signalling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3757403

14 September 2017

Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3757403

14 September 2017

Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3757403

14 September 2017

The type III epidermal growth factor receptor mutation. Biological significance and potential target for anti-cancer therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3757403

14 September 2017

Glycosylation-induced conformational modification positively regulates receptor-receptor association: a study with an aberrant epidermal growth factor receptor (EGFRvIII/DeltaEGFR) expressed in cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3757403

14 September 2017

Activating mutations in the extracellular domain of the fibroblast growth factor receptor 2 function by disruption of the disulfide bond in the third immunoglobulin-like domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3757403

14 September 2017

The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3757403

14 September 2017

Mutations affecting conserved cysteine residues within the extracellular domain of Neu promote receptor dimerization and activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3757403

14 September 2017

Activation of RET as a dominant transforming gene by germline mutations of MEN2A and MEN2B

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3757403

14 September 2017

Homodimerization and constitutive activation of the erythropoietin receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3757403

14 September 2017

The epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor AG1478 increases the formation of inactive untethered EGFR dimers. Implications for combination therapy with monoclonal antibody 806.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3757403

14 September 2017

The tumor-specific de2-7 epidermal growth factor receptor (EGFR) promotes cells survival and heterodimerizes with the wild-type EGFR.

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14 September 2017

Identification of the epitope for the epidermal growth factor receptor-specific monoclonal antibody 806 reveals that it preferentially recognizes an untethered form of the receptor

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14 September 2017

Receptor dimerization is not a factor in the signalling activity of a transforming variant epidermal growth factor receptor (EGFRvIII).

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27 June 2018

Mutation associated with Crouzon syndrome causes ligand-independent dimerization and activation of FGF receptor-2.

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1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.3390/CANCERS3022032

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24212795%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24212795%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24212795%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

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