(Q37147904)

18 August 2017

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title

Amphiregulin as a novel target for breast cancer therapy (English)

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18 August 2017

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Nicole E Willmarth

1

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18 August 2017

Stephen P Ethier

series ordinal

2

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18 August 2017

publication date

25 April 2008

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Journal of Mammary Gland Biology and Neoplasia

18 August 2017

published in

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18 August 2017

volume

13

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18 August 2017

issue

2

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18 August 2017

page(s)

171-179

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https://scigraph.springernature.com/pub.10.1007/s10911-008-9081-9

18 August 2017

exact match

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cites work

The amphiregulin gene encodes a novel epidermal growth factor-related protein with tumor-inhibitory activity

1 reference

https://api.crossref.org/works/10.1007%2FS10911-008-9081-9

The heparin-binding domain of amphiregulin necessitates the precursor pro-region for growth factor secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-008-9081-9

Amphiregulin overexpression results in rapidly growing keratinocytic tumors: an in vivo xenograft model of keratoacanthoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-008-9081-9

Expression of transforming growth factor alpha, amphiregulin and cripto-1 in human breast carcinomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-008-9081-9

Stimulation of amphiregulin expression in osteoblastic cells by parathyroid hormone requires the protein kinase A and cAMP response element-binding protein signaling pathway

21 January 2018

1 reference

12 December 2020

An essential role for ectodomain shedding in mammalian development

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12 December 2020

Increases of amphiregulin and transforming growth factor-alpha in serum as predictors of poor response to gefitinib among patients with advanced non-small cell lung cancers

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12 December 2020

Amphiregulin in lung branching morphogenesis: interaction with heparan sulfate proteoglycan modulates cell proliferation

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12 December 2020

Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: metalloproteinase inhibitors as a new therapy

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12 December 2020

Possible role of coexpression of CD9 with membrane-anchored heparin-binding EGF-like growth factor and amphiregulin in cultured human keratinocyte growth

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12 December 2020

Cell surface ectodomain cleavage of human amphiregulin precursor is sensitive to a metalloprotease inhibitor. Release of a predominant N-glycosylated 43-kDa soluble form

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12 December 2020

Expression of EGF-family receptors and amphiregulin in multiple myeloma. Amphiregulin is a growth factor for myeloma cells

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12 December 2020

Autocrine extracellular signal-regulated kinase (ERK) activation in normal human keratinocytes: metalloproteinase-mediated release of amphiregulin triggers signaling from ErbB1 to ERK.

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12 December 2020

Detection of amphiregulin and Cripto-1 in mammary tumors from transgenic mice

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12 December 2020

The proamphiregulin cytoplasmic domain is required for basolateral sorting, but is not essential for constitutive or stimulus-induced processing in polarized Madin-Darby canine kidney cells

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12 December 2020

Amphiregulin is an implantation-specific and progesterone-regulated gene in the mouse uterus

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12 December 2020

Metalloprotease-mediated ligand release regulates autocrine signaling through the epidermal growth factor receptor

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12 December 2020

Amphiregulin contributes to the transformed phenotype of human hepatocellular carcinoma cells.

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12 December 2020

Molecular portraits of human breast tumours

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12 December 2020

Ectodomain shedding of the EGF-receptor ligand epigen is mediated by ADAM17

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12 December 2020

Characterization of a novel amphiregulin-related molecule in 12-O-tetradecanoylphorbol-13-acetate-treated breast cancer cells

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12 December 2020

Tobacco smoke stimulates the transcription of amphiregulin in human oral epithelial cells: evidence of a cyclic AMP-responsive element binding protein-dependent mechanism

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12 December 2020

Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha

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12 December 2020

Amphiregulin causes functional downregulation of adherens junctions in psoriasis

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12 December 2020

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12 December 2020

Mammary ductal morphogenesis requires paracrine activation of stromal EGFR via ADAM17-dependent shedding of epithelial amphiregulin

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12 December 2020

Retinoid-induced epidermal hyperplasia is mediated by epidermal growth factor receptor activation via specific induction of its ligands heparin-binding EGF and amphiregulin in human skin in vivo

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12 December 2020

Autocrine and juxtacrine effects of amphiregulin on the proliferative, invasive, and migratory properties of normal and neoplastic human mammary epithelial cells

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12 December 2020

Metalloprotease-dependent amphiregulin release mediates tumor necrosis factor-alpha-induced IL-8 secretion in the human airway epithelial cell line NCI-H292.

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12 December 2020

Estrogen regulation of mammary gland development and breast cancer: amphiregulin takes center stage

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12 December 2020

Autocrine action of amphiregulin in a colon carcinoma cell line and immunocytochemical localization of amphiregulin in human colon

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12 December 2020

EGF-like factor epiregulin and amphiregulin expression is regulated by gonadotropins/cAMP in human ovarian follicular cells

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12 December 2020

The Interaction of Amphiregulin with Nuclei and Putative Nuclear Localization Sequence Binding Proteins

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12 December 2020

Epidermal growth factor-related peptides in the pathogenesis of human breast cancer.

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12 December 2020

The Wilms tumor suppressor WT1 encodes a transcriptional activator of amphiregulin

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12 December 2020

Amphiregulin is a novel growth factor involved in normal bone development and in the cellular response to parathyroid hormone stimulation

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12 December 2020

Epidermal growth factor receptor activation induces nuclear targeting of cyclooxygenase-2, basolateral release of prostaglandins, and mitogenesis in polarizing colon cancer cells

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12 December 2020

Src family kinase inhibitors block amphiregulin-mediated autocrine ErbB signaling in normal human keratinocytes

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12 December 2020

Prostaglandin E2 stimulates the growth of colon cancer cells via induction of amphiregulin

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12 December 2020

Quantitation of the mRNA expression of the epidermal growth factor system: selective induction of heparin-binding epidermal growth factor-like growth factor and amphiregulin expression by growth factor stimulation of prostate stromal cells

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12 December 2020

Expression and function of amphiregulin during murine preimplantation development

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12 December 2020

Epidermal growth factor and amphiregulin up-regulate matrix metalloproteinase-9 (MMP-9) in human breast cancer cells

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12 December 2020

TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells

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12 December 2020

Amphiregulin acts as an autocrine survival factor for adult sensory neurons

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12 December 2020

Amphiregulin is coordinately expressed with heparin-binding epidermal growth factor-like growth factor in the interstitial smooth muscle of the human prostate

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12 December 2020

Control of ErbB signaling through metalloprotease mediated ectodomain shedding of EGF-like factors

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12 December 2020

Colorectum cell-derived growth factor (CRDGF) is homologous to amphiregulin, a member of the epidermal growth factor family

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12 December 2020

A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells

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12 December 2020

Amphiregulin antisense oligonucleotide inhibits the growth of T3M4 human pancreatic cancer cells and sensitizes the cells to EGF receptor-targeted therapy.

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12 December 2020

Epidermal growth factor receptor (EGFR) signaling in cancer

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12 December 2020

Characterization of high and low molecular weight forms of amphiregulin that differ in glycosylation and peptide core length. Evidence that the NH2-terminal region is not critical for bioactivity.

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12 December 2020

EGF and amphiregulin differentially regulate Cbl recruitment to endosomes and EGF receptor fate

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12 December 2020

Clinicopathologic analysis of amphiregulin and heregulin immunostaining in breast neoplasia

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12 December 2020

Topography of amphiregulin expression in cultured human keratinocytes: colocalization with the epidermal growth factor receptor and CD44.

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12 December 2020

Expression of messenger RNA for amphiregulin, heregulin, and cripto-1, three new members of the epidermal growth factor family, in human breast carcinomas

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12 December 2020

Untangling the ErbB signalling network

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12 December 2020

The complexity of targeting EGFR signalling in cancer: from expression to turnover

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12 December 2020

Platelet-activating factor receptor and ADAM10 mediate responses to Staphylococcus aureus in epithelial cells

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12 December 2020

Amphiregulin acts as an autocrine growth factor in two human polarizing colon cancer lines that exhibit domain selective EGF receptor mitogenesis.

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12 December 2020

Amphiregulin as a tumor promoter for oral squamous cell carcinoma: involvement of cyclooxygenase 2.

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12 December 2020

Structure, expression and function of a schwannoma-derived growth factor

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12 December 2020

Amphiregulin, epidermal growth factor receptor, and estrogen receptor expression in human primary breast cancer

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12 December 2020

Structure and function of human amphiregulin: a member of the epidermal growth factor family

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12 December 2020

Tobacco Smoke-induced Lung Cell Proliferation Mediated by Tumor Necrosis Factor α-converting Enzyme and Amphiregulin

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12 December 2020

Differential regulation of cell proliferation and protease secretion by epidermal growth factor and amphiregulin in tumoral versus normal breast epithelial cells

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12 December 2020

Human airway trypsin-like protease induces amphiregulin release through a mechanism involving protease-activated receptor-2-mediated ERK activation and TNF alpha-converting enzyme activity in airway epithelial cells

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12 December 2020

Transforming growth factor beta-1 and amphiregulin act in synergy to increase the production of urokinase-type plasminogen activator in transformed breast epithelial cells

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12 December 2020

The epidermal growth factor-like growth factor amphiregulin is strongly induced by the adenosine 3',5'-monophosphate pathway in various cell types

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12 December 2020

Heparan sulfate is essential to amphiregulin-induced mitogenic signaling by the epidermal growth factor receptor

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12 December 2020

Activation of a nuclear factor kappaB/interleukin-1 positive feedback loop by amphiregulin in human breast cancer cells

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12 December 2020

Distinct ADAM metalloproteinases regulate G protein-coupled receptor-induced cell proliferation and survival

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12 December 2020

Defective valvulogenesis in HB-EGF and TACE-null mice is associated with aberrant BMP signaling

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12 December 2020

Fine particulate matter induces amphiregulin secretion by bronchial epithelial cells

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12 December 2020

Amphiregulin as an autocrine growth factor for c-Ha-ras- and c-erbB-2-transformed human mammary epithelial cells

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12 December 2020

Direct interaction of Cbl with pTyr 1045 of the EGF receptor (EGFR) is required to sort the EGFR to lysosomes for degradation

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12 December 2020

Expression of amphiregulin and epidermal growth factor receptor in human breast cancer: analysis of autocriny and stromal-epithelial interactions

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12 December 2020

Differential effects of amphiregulin and TGF-alpha on the morphology of MDCK cells

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12 December 2020

Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development

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12 December 2020

Differential immunohistochemical detection of transforming growth factor alpha, amphiregulin and CRIPTO in human normal and malignant breast tissues

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12 December 2020

Expression of amphiregulin in human gastric cancer cell lines.

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12 December 2020

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12 December 2020

Amphiregulin: a bifunctional growth-modulating glycoprotein produced by the phorbol 12-myristate 13-acetate-treated human breast adenocarcinoma cell line MCF-7

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12 December 2020

A metalloprotease-disintegrin, MDC9/meltrin-gamma/ADAM9 and PKCdelta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor.

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12 December 2020

The role of the epidermal growth factor receptor in breast cancer

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12 December 2020

Autocrine growth loop of the epidermal growth factor receptor in normal and immortalized human bronchial epithelial cells.

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12 December 2020

Heparin-binding EGF-like growth factor is a promising target for ovarian cancer therapy.

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12 December 2020

Epidermal growth factor-related peptides and their receptors in human malignancies

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12 December 2020

Response to and expression of amphiregulin by ovarian carcinoma and normal ovarian surface epithelial cells: nuclear localization of endogenous amphiregulin

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12 December 2020

Antisense expression for amphiregulin suppresses tumorigenicity of a transformed human breast epithelial cell line

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12 December 2020

Differential effects of a heparin antagonist (hexadimethrine) or chlorate on amphiregulin, basic fibroblast growth factor, and heparin-binding EGF-like growth factor activity.

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12 December 2020

The many faces of epidermal growth factor repeats

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12 December 2020

Early changes in gene expression in the dorsal root ganglia after transection of the sciatic nerve; effects of amphiregulin and PAI-1 on regeneration

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12 December 2020

Ligand-dependent activation of the epidermal growth factor receptor by secondary bile acids in polarizing colon cancer cells

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12 December 2020

Transforming growth factor-alpha. A model for membrane-anchored growth factors.

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12 December 2020

Autocrine regulation of human urothelial cell proliferation and migration during regenerative responses in vitro

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12 December 2020

10.1007/S10911-008-9081-9

Identifiers

DOI

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18 August 2017

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