(Q37149236)

English

Applications of metabolomics and proteomics to the mdx mouse model of Duchenne muscular dystrophy: lessons from downstream of the transcriptome

scientific article published on 25 March 2009

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

1 reference

Europe PubMed Central

Applications of metabolomics and proteomics to the mdx mouse model of Duchenne muscular dystrophy: lessons from downstream of the transcriptome (English)

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

0 references

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based on heuristic

inferred from title

Duchenne muscular dystrophy

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based on heuristic

inferred from title

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based on heuristic

inferred from title

author name string

Julian L Griffin

1

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Christine Des Rosiers

2

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Europe PubMed Central

PMC publication ID

18 August 2017

language of work or name

1 reference

based on heuristic

inferred from title

publication date

25 March 2009

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Europe PubMed Central

PMC publication ID

18 August 2017

Genome Medicine

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Europe PubMed Central

PMC publication ID

18 August 2017

1

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

3

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

32

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Europe PubMed Central

PMC publication ID

18 August 2017

https://scigraph.springernature.com/pub.10.1186/gm32

0 references

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Metabolomic and mass isotopomer analysis of liver gluconeogenesis and citric acid cycle: II. Heterogeneity of metabolite labeling pattern

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Sildenafil and cardiomyocyte-specific cGMP signaling prevent cardiomyopathic changes associated with dystrophin deficiency

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Genetic networks of liver metabolism revealed by integration of metabolic and transcriptional profiling

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Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

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Shotgun metabolomics approach for the analysis of negatively charged water-soluble cellular metabolites from mouse heart tissue

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Inaccuracies in selected ion monitoring determination of isotope ratios obviated by profile acquisition: nucleotide 18O/16O measurements

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Metabolomic and genetic analysis of biomarkers for peroxisome proliferator-activated receptor alpha expression and activation.

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The failing heart--an engine out of fuel

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Proteome analysis of the dystrophin-deficient MDX diaphragm reveals a drastic increase in the heat shock protein cvHSP.

1 reference

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Application of stable isotopes and mass isotopomer distribution analysis to the study of intermediary metabolism of nutrients.

1 reference

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Reduced expression of regucalcin in young and aged mdx diaphragm indicates abnormal cytosolic calcium handling in dystrophin-deficient muscle.

1 reference

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Nutrient-gene interaction: tracer-based metabolomics

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Myocardial substrate metabolism in the normal and failing heart

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Metabolome analysis: the potential of in vivo labeling with stable isotopes for metabolite profiling

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Metabolic flux analysis based on 13C-labeling experiments and integration of the information with gene and protein expression patterns.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2664943

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Probing metabolic pathways with isotopic tracers: insights from mammalian metabolic physiology

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Metabolic biomarker and kinase drug target discovery in cancer using stable isotope-based dynamic metabolic profiling (SIDMAP).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2664943

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Proteomic analysis of mdx skeletal muscle: Great reduction of adenylate kinase 1 expression and enzymatic activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2664943

6 September 2017

Measuring in vivo metabolism using heavy water

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2664943

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In vivo measurement of fluxes through metabolic pathways: the missing link in functional genomics and pharmaceutical research

1 reference

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Initial sequencing and comparative analysis of the mouse genome

1 reference

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Metabonomics: a platform for studying drug toxicity and gene function

1 reference

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6 September 2017

Function and genetics of dystrophin and dystrophin-related proteins in muscle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2664943

6 September 2017

Muscular dystrophy--reason for optimism?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2664943

6 September 2017

Initial sequencing and analysis of the human genome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2664943

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A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations

1 reference

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Metabolite profiling for plant functional genomics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2664943

6 September 2017

The dystrophin complex forms a mechanically strong link between the sarcolemma and costameric actin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2664943

6 September 2017

Extensive but coordinated reorganization of the membrane skeleton in myofibers of dystrophic (mdx) mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2664943

6 September 2017

Enteroviral protease 2A cleaves dystrophin: evidence of cytoskeletal disruption in an acquired cardiomyopathy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2664943

6 September 2017

Expression of full-length utrophin prevents muscular dystrophy in mdx mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2664943

6 September 2017

Systematic functional analysis of the yeast genome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2664943

6 September 2017

Dystrophin protects the sarcolemma from stresses developed during muscle contraction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2664943

6 September 2017

Mechanical function of dystrophin in muscle cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2664943

6 September 2017

Nitric oxide synthase complexed with dystrophin and absent from skeletal muscle sarcolemma in Duchenne muscular dystrophy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2664943

6 September 2017

Isolation of candidate cDNAs for portions of the Duchenne muscular dystrophy gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2664943

6 September 2017

Dystrophin: the protein product of the Duchenne muscular dystrophy locus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2664943

6 September 2017

Clinical and molecular studies in Duchenne muscular dystrophy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2664943

6 September 2017

A 71-kilodalton protein is a major product of the Duchenne muscular dystrophy gene in brain and other nonmuscle tissues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2664943

6 September 2017

Isotopomer-based metabolomic analysis by NMR and mass spectrometry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2664943

14 September 2017

The structural and functional diversity of dystrophin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2664943

14 September 2017

Shotgun lipidomics identifies cardiolipin depletion in diabetic myocardium linking altered substrate utilization with mitochondrial dysfunction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2664943

27 June 2018

Regeneration and myogenic cell proliferation correlate with taurine levels in dystrophin- and MyoD-deficient muscles.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2664943

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Applications of mass isotopomer analysis to nutrition research

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2664943

27 June 2018

Components of energy expenditure in the mdx mouse model of Duchenne muscular dystrophy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2664943

27 June 2018

Defective regulation of energy metabolism in mdx-mouse skeletal muscles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2664943

27 June 2018

Brain abnormalities in Duchenne muscular dystrophy: phosphorus-31 magnetic resonance spectroscopy and neuropsychological study.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2664943

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An explanation for the phenotypic differences between patients bearing partial deletions of the DMD locus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2664943

27 June 2018

Duchenne muscular dystrophy gene product is not identical in muscle and brain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2664943

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Increased activity of calcium leak channels in myotubes of Duchenne human and mdx mouse origin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2664943

27 June 2018

Identification of a chromosome 6-encoded dystrophin-related protein.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2664943

27 June 2018

Immunolocalization and developmental expression of dystrophin related protein in skeletal muscle.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2664943

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A combined metabolomic and proteomic investigation of the effects of a failure to express dystrophin in the mouse heart

1 reference

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Accurate assessment of amino acid mass isotopomer distributions for metabolic flux analysis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2664943

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2664943

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Determination of confidence intervals of metabolic fluxes estimated from stable isotope measurements.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2664943

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Dystrophin is a possible end-target of ischemic preconditioning against cardiomyocyte oncosis during the early phase of reperfusion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2664943

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Myocardial phenotyping using isotopomer analysis of metabolic fluxes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2664943

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Ischemia depletes dystrophin and inhibits protein synthesis in the canine heart: mechanisms of myocardial ischemic injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2664943

3 September 2018

Subproteomics analysis of Ca+-binding proteins demonstrates decreased calsequestrin expression in dystrophic mouse skeletal muscle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2664943

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2664943

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1 reference

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Defective RNA ribose synthesis in fibroblasts from patients with thiamine-responsive megaloblastic anemia (TRMA).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2664943

3 September 2018

Metabolic profiles of dystrophin and utrophin expression in mouse models of Duchenne muscular dystrophy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2664943

3 September 2018

Altered regional brain glucose metabolism in Duchenne muscular dystrophy: a pet study.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2664943

3 September 2018

Molecular remodelling of dystrophin in patients with end-stage cardiomyopathies and reversal in patients on assistance-device therapy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2664943

3 September 2018

A quantitative study of bioenergetics in skeletal muscle lacking utrophin and dystrophin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2664943

3 September 2018

Abnormal lipid profile of dystrophic cardiac tissue as demonstrated by one- and two-dimensional magic-angle spinning (1)H NMR spectroscopy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2664943

3 September 2018

Metabolic profiling of genetic disorders: a multitissue (1)H nuclear magnetic resonance spectroscopic and pattern recognition study into dystrophic tissue

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2664943

3 September 2018

Activation of calcineurin and stress activated protein kinase/p38-mitogen activated protein kinase in hearts of utrophin-dystrophin knockout mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2664943

3 September 2018

Brain biochemistry in Duchenne muscular dystrophy: a 1H magnetic resonance and neuropsychological study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2664943

3 September 2018

Skeletal muscle-specific expression of a utrophin transgene rescues utrophin-dystrophin deficient mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2664943

3 September 2018

Increased cerebral choline-compounds in Duchenne muscular dystrophy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2664943

3 September 2018

Dystrophin-deficient mdx muscle fibers are preferentially vulnerable to necrosis induced by experimental lengthening contractions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2664943

20 October 2018

A Functional Analysis of Mouse Models of Cardiac Disease through Metabolic Profiling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2664943

4 December 2018

Nuclear Magnetic Resonance Spectroscopic and Principal Components Analysis Investigations into Biochemical Effects of Three Model Hepatotoxins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2664943

4 December 2018

Alternative splicing of human dystrophin mRNA generates isoforms at the carboxy terminus

1 reference

https://pubmed.ncbi.nlm.nih.gov/19341503

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dystrophin-deficient myocardium is vulnerable to pressure overload in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/19341503

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cross-reactive protein in Duchenne muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/19341503

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain metabolism is abnormal in the mdx model of Duchenne muscular dystrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19341503

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dystrophin-deficient cardiomyocytes are abnormally vulnerable to mechanical stress-induced contractile failure and injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/19341503

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An optimized protocol for metabolome analysis in yeast using direct infusion electrospray mass spectrometry

1 reference

https://pubmed.ncbi.nlm.nih.gov/19341503

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular energetics of dystrophic muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/19341503

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of truncated utrophin leads to major functional improvements in dystrophin-deficient muscles of mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19341503

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Depressed myocardial fatty acid metabolism in patients with muscular dystrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19341503

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolic and signaling alterations in dystrophin-deficient hearts precede overt cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19341503

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amelioration of the dystrophic phenotype of mdx mice using a truncated utrophin transgene

1 reference

https://pubmed.ncbi.nlm.nih.gov/19341503

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An NMR-based metabonomic approach to investigate the biochemical consequences of genetic strain differences: application to the C57BL10J and Alpk:ApfCD mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/19341503

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dystrophin glycoprotein complex dysfunction: A regulatory link between muscular dystrophy and cancer cachexia

1 reference

https://pubmed.ncbi.nlm.nih.gov/19341503

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modeling of liver citric acid cycle and gluconeogenesis based on 13C mass isotopomer distribution analysis of intermediates

1 reference

https://pubmed.ncbi.nlm.nih.gov/19341503

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Magnetic resonance imaging of regenerating and dystrophic mouse muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/19341503

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correction of 13C mass isotopomer distributions for natural stable isotope abundance

1 reference

https://pubmed.ncbi.nlm.nih.gov/19341503

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The molecular basis of muscular dystrophy in the mdx mouse: a point mutation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19341503

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Dimensions Publication ID

0 references

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

ResearchGate publication ID

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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