(Q37152597)

English

Combined p21-activated kinase and farnesyltransferase inhibitor treatment exhibits enhanced anti-proliferative activity on melanoma, colon and lung cancer cell lines

scientific article published on 06 August 2013

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Combined p21-activated kinase and farnesyltransferase inhibitor treatment exhibits enhanced anti-proliferative activity on melanoma, colon and lung cancer cell lines (English)

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

author name string

Giampiero Porcu

1

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Ainslie B Parsons

2

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Daniele Di Giandomenico

3

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Giuseppe Lucisano

4

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Maria Giovanna Mosca

5

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Charles Boone

6

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Antonella Ragnini-Wilson

7

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

publication date

6 August 2013

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Molecular Cancer

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

12

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

1

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

88

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

https://scigraph.springernature.com/pub.10.1186/1476-4598-12-88

0 references

p-21-Activated kinase 1 mediates gastrin-stimulated proliferation in the colorectal mucosa via multiple signaling pathways

1 reference

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6 September 2017

Mapping the human phosphatome on growth pathways

1 reference

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6 September 2017

Targeting protein prenylation for cancer therapy

1 reference

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6 September 2017

The emergence of drug transporter-mediated multidrug resistance to cancer chemotherapy

1 reference

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6 September 2017

Novel and emerging drugs for acute myeloid leukemia: pharmacology and therapeutic activity.

1 reference

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6 September 2017

A yeast-based genomic strategy highlights the cell protein networks altered by FTase inhibitor peptidomimetics

1 reference

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6 September 2017

Tipifarnib in the treatment of newly diagnosed acute myelogenous leukemia

1 reference

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6 September 2017

PAK signaling in oncogenesis.

1 reference

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6 September 2017

ABC transporter Pdr10 regulates the membrane microenvironment of Pdr12 in Saccharomyces cerevisiae.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3765434

6 September 2017

PAK kinase regulates Rac GTPase and is a potential target in human schwannomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3765434

6 September 2017

Phase II trial of tipifarnib plus neoadjuvant doxorubicin-cyclophosphamide in patients with clinical stage IIB-IIIC breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3765434

6 September 2017

Pak protein kinases and their role in cancer

1 reference

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6 September 2017

An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3765434

6 September 2017

A tale of two Paks

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3765434

6 September 2017

The structure and regulation of vinculin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3765434

6 September 2017

ELM1 is required for multidrug resistance in Saccharomyces cerevisiae

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3765434

6 September 2017

Lipid posttranslational modifications. Farnesyl transferase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3765434

6 September 2017

The GIT-associated kinase PAK targets to the centrosome and regulates Aurora-A.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3765434

6 September 2017

Development of farnesyl transferase inhibitors: a review

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3765434

6 September 2017

Somatic mutation and gain of copy number of PIK3CA in human breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3765434

6 September 2017

The genetics of Pak.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3765434

6 September 2017

Microarray analysis reveals genetic pathways modulated by tipifarnib in acute myeloid leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3765434

6 September 2017

A tagging-via-substrate technology for detection and proteomics of farnesylated proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3765434

6 September 2017

Drs2p-related P-type ATPases Dnf1p and Dnf2p are required for phospholipid translocation across the yeast plasma membrane and serve a role in endocytosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3765434

6 September 2017

Dynamin participates in focal extracellular matrix degradation by invasive cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3765434

6 September 2017

Mlc1p promotes septum closure during cytokinesis via the IQ motifs of the vesicle motor Myo2p

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3765434

6 September 2017

p21-activated kinase 1 interacts with and phosphorylates histone H3 in breast cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3765434

6 September 2017

A protein interaction map for cell polarity development.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3765434

6 September 2017

Farnesyltransferase and geranylgeranyltransferase I inhibitors and cancer therapy: lessons from mechanism and bench-to-bedside translational studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3765434

6 September 2017

The pleitropic drug ABC transporters from Saccharomyces cerevisiae.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3765434

6 September 2017

Coupling of PAK-interacting exchange factor PIX to GIT1 promotes focal complex disassembly

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3765434

6 September 2017

Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3765434

6 September 2017

A member of the Ste20/PAK family of protein kinases is involved in both arrest of Xenopus oocytes at G2/prophase of the first meiotic cell cycle and in prevention of apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3765434

6 September 2017

Protein prenyltransferases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3765434

6 September 2017

The protein kinase C-activated MAP kinase pathway of Saccharomyces cerevisiae mediates a novel aspect of the heat shock response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3765434

6 September 2017

Endocytosis and vacuolar degradation of the plasma membrane-localized Pdr5 ATP-binding cassette multidrug transporter in Saccharomyces cerevisiae.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3765434

6 September 2017

Effect of simvastatin on cetuximab resistance in human colorectal cancer with KRAS mutations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3765434

14 September 2017

The farnesyl transferase inhibitor lonafarnib inhibits mTOR signaling and enforces sorafenib-induced apoptosis in melanoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3765434

14 September 2017

KRAS mutant lung cancer cells are differentially responsive to MEK inhibitor due to AKT or STAT3 activation: implication for combinatorial approach

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3765434

14 September 2017

A 2-gene classifier for predicting response to the farnesyltransferase inhibitor tipifarnib in acute myeloid leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3765434

14 September 2017

Inhibition of the mitogen-activated protein kinase pathway results in the down-regulation of P-glycoprotein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3765434

14 September 2017

The farnesyl transferase inhibitor, tipifarnib, is a potent inhibitor of the MDR1 gene product, P-glycoprotein, and demonstrates significant cytotoxic synergism against human leukemia cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3765434

14 September 2017

The BRAF-MAPK signaling pathway is essential for cancer-immune evasion in human melanoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3765434

14 September 2017

Role of p53 mutations, protein function and DNA damage for the radiosensitivity of human tumour cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3765434

14 September 2017

Inactivation of Rho GTPases with Clostridium difficile toxin B impairs centrosomal activation of Aurora-A in G2/M transition of HeLa cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3765434

29 September 2017

The potential of farnesyltransferase inhibitors as cancer chemotherapeutics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3765434

29 September 2017

Do PAKs make good drug targets?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3765434

27 June 2018

Fibronectin expression increases during in vitro cellular senescence: correlation with increased cell area

1 reference

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27 June 2018

ABC transporters in cancer: more than just drug efflux pumps.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3765434

3 September 2018

Promyelocytic leukemia protein is required for gain of function by mutant p53.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3765434

3 September 2018

Additive effects of tamoxifen and the farnesyl transferase inhibitor FTI-277 on inhibition of MCF-7 breast cancer cell-cycle progression.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3765434

3 September 2018

Use of yeast for identification of farnesyltransferase inhibitors and for generation of mutant farnesyltransferases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3765434

3 September 2018

Exploring the Mode-of-Action of Bioactive Compounds by Chemical-Genetic Profiling in Yeast

1 reference

https://api.crossref.org/works/10.1186%2F1476-4598-12-88

21 January 2018

Increased p21-activated kinase-1 expression is associated with invasive potential in uveal melanoma

1 reference

https://api.crossref.org/works/10.1186%2F1476-4598-12-88

21 January 2018

Role of vinculin in regulating focal adhesion turnover

1 reference

https://pubmed.ncbi.nlm.nih.gov/23915247

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A peptidomimetic inhibitor of farnesyl:protein transferase blocks the anchorage-dependent and -independent growth of human tumor cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/23915247

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GGTI-298 induces G0-G1 block and apoptosis whereas FTI-277 causes G2-M enrichment in A549 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23915247

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ypt32p and Mlc1p bind within the vesicle binding region of the class V myosin Myo2p globular tail domain

1 reference

https://pubmed.ncbi.nlm.nih.gov/23915247

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A human melanoma line heterogeneous with respect to metastatic capacity in athymic nude mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23915247

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/1476-4598-12-88

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Dimensions Publication ID

0 references

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

ResearchGate publication ID

0 references

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