(Q37154867)

18 August 2017

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title

Licofelone: the answer to unmet needs in osteoarthritis therapy? (English)

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18 August 2017

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Shrinivas K Kulkarni

1

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18 August 2017

Vijay P Singh

series ordinal

2

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18 August 2017

publication date

1 January 2008

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Current Rheumatology Reports

18 August 2017

published in

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18 August 2017

volume

10

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18 August 2017

issue

1

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18 August 2017

page(s)

43-48

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Inhibition of gastric H,K-ATPase activity and gastric epithelial cell IL-8 secretion by the pyrrolizine derivative ML 3000

18 August 2017

cites work

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12 December 2020

Effect of licofelone against NSAIDs-induced gastrointestinal ulceration and inflammation.

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12 December 2020

The metabolic effects of inhibitors of 5-lipoxygenase and of cyclooxygenase 1 and 2 are an advancement in the efficacy and safety of anti-inflammatory therapy

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12 December 2020

Safety of anti-inflammatory treatment--new ways of thinking

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12 December 2020

Acetaminophen and the cyclooxygenase-3 puzzle: sorting out facts, fictions, and uncertainties

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12 December 2020

Efficacy of licofelone in dogs with clinical osteoarthritis

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12 December 2020

The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanases.

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12 December 2020

Cyclooxygenases 1 and 2

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12 December 2020

Prostaglandins and leukotrienes: advances in eicosanoid biology

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12 December 2020

Licofelone--clinical update on a novel LOX/COX inhibitor for the treatment of osteoarthritis

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12 December 2020

Relative contribution of acetylated cyclooxygenase (COX)‐2 and 5‐lipooxygenase (LOX) in regulating gastric mucosal integrity and adaptation to aspirin

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12 December 2020

Regulation of the expression of 5-lipoxygenase-activating protein/5-lipoxygenase and the synthesis of leukotriene B(4) in osteoarthritic chondrocytes: role of transforming growth factor beta and eicosanoids

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12 December 2020

[Cyclooxygenase and prostanoids--biological implications].

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12 December 2020

General pharmacology of [2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3- dihydro-1H-pyrrolizine-5-yl]-acetic acid in experimental animals

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12 December 2020

Collagenase-3 (matrix metalloprotease 13) is preferentially localized in the deep layer of human arthritic cartilage in situ: in vitro mimicking effect by transforming growth factor beta

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12 December 2020

Adverse effects of conventional non-steroidal anti-inflammatory drugs on the upper gastrointestinal tract

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12 December 2020

Effect of licofelone against mechanical hyperalgesia and cold allodynia in the rat model of incisional pain

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12 December 2020

Licofelone reduces progression of structural changes in a canine model of osteoarthritis under curative conditions: effect on protease expression and activity

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12 December 2020

Licofelone--a novel analgesic and anti-inflammatory agent

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12 December 2020

Treatment with licofelone prevents abnormal subchondral bone cell metabolism in experimental dog osteoarthritis

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12 December 2020

Prevention of thrombosis and vascular inflammation: benefits and limitations of selective or combined COX-1, COX-2 and 5-LOX inhibitors

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12 December 2020

Licofelone (Merckle).

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12 December 2020

Cyclooxygenases: new forms, new inhibitors, and lessons from the clinic

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12 December 2020

Prostaglandin endoperoxide H synthases (cyclooxygenases)-1 and -2

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12 December 2020

Eicosanoids, osteoarthritis, and crystal deposition diseases

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12 December 2020

Anti-inflammatory effect of licofelone against various inflammatory challenges

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12 December 2020

Osteoblast-like cells from human subchondral osteoarthritic bone demonstrate an altered phenotype in vitro: possible role in subchondral bone sclerosis

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12 December 2020

Activation of peroxisome proliferator-activated receptor gamma inhibits interleukin-1beta-induced membrane-associated prostaglandin E2 synthase-1 expression in human synovial fibroblasts by interfering with Egr-1.

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12 December 2020

Dual inhibition of 5-lipoxygenase and cyclooxygenases 1 and 2 by ML3000 reduces joint destruction in adjuvant arthritis.

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12 December 2020

Synthesis of interleukin 1beta, tumor necrosis factor-alpha, and interstitial collagenase (MMP-1) is eicosanoid dependent in human osteoarthritis synovial membrane explants: interactions with antiinflammatory cytokines

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12 December 2020

Therapeutic role of dual inhibitors of 5-LOX and COX, selective and non-selective non-steroidal anti-inflammatory drugs.

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12 December 2020

Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. VIGOR Study Group

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12 December 2020

10.1007/S11926-008-0008-7

Identifiers

DOI

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18 August 2017

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