(Q24812406)

English

The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanases.

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Europe PubMed Central

PubMed publication ID

5 July 2017

The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanases. (English)

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Europe PubMed Central

PubMed publication ID

5 July 2017

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Johanne Martel-Pelletier

10

object named as

Johanne Martel-Pelletier

author given names

Johanne

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Martel-Pelletier

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5 July 2017

Jean-Pierre Pelletier

1

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Jean-Pierre Pelletier

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Jean-Pierre

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Pelletier

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Europe PubMed Central

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5 July 2017

Christelle Boileau

2

object named as

Christelle Boileau

author given names

Christelle

author last names

Boileau

1 reference

Europe PubMed Central

PubMed publication ID

5 July 2017

Daniel Lajeunesse

9

object named as

Daniel Lajeunesse

author given names

Daniel

author last names

Lajeunesse

1 reference

Europe PubMed Central

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5 July 2017

Douglas Martin Boyer

3

object named as

Martin Boily

author given names

Martin

author last names

Boily

1 reference

Europe PubMed Central

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5 July 2017

4

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Julie Brunet

author given names

Julie

author last names

Brunet

1 reference

Europe PubMed Central

PubMed publication ID

5 July 2017

François Mineau

5

object named as

François Mineau

author given names

François

author last names

Mineau

1 reference

Europe PubMed Central

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5 July 2017

7

object named as

Pascal Reboul

author given names

Pascal

author last names

Reboul

1 reference

Europe PubMed Central

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5 July 2017

author name string

Changshen Geng

6

author given names

Changshen

author last names

Geng

1 reference

Europe PubMed Central

PubMed publication ID

5 July 2017

Stefan Laufer

8

author given names

Stefan

author last names

Laufer

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Europe PubMed Central

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5 July 2017

language of work or name

0 references

publication date

19 July 2005

1 reference

Europe PubMed Central

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5 July 2017

Arthritis Research and Therapy

1 reference

Europe PubMed Central

PubMed publication ID

5 July 2017

7

1 reference

Europe PubMed Central

PubMed publication ID

5 July 2017

5

1 reference

Europe PubMed Central

PubMed publication ID

5 July 2017

R1091-102

1 reference

Europe PubMed Central

PubMed publication ID

5 July 2017

Aggrecanases and cartilage matrix degradation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1257437

7 April 2017

Metalloproteases and inhibitors in arthritic diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1257437

7 April 2017

ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1257437

28 September 2017

Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1257437

28 September 2017

Therapeutic role of dual inhibitors of 5-LOX and COX, selective and non-selective non-steroidal anti-inflammatory drugs.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1257437

28 September 2017

Inhibition of ADAM-TS4 and ADAM-TS5 prevents aggrecan degradation in osteoarthritic cartilage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1257437

28 September 2017

The modulation of matrix metalloproteinase and ADAM gene expression in human chondrocytes by interleukin-1 and oncostatin M: a time-course study using real-time quantitative reverse transcription-polymerase chain reaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1257437

28 September 2017

Expression and regulation of aggrecanase in arthritis: the role of TGF-beta

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1257437

28 September 2017

Osteoarthritis, an inflammatory disease: potential implication for the selection of new therapeutic targets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1257437

28 September 2017

Aggrecan degradation in human cartilage. Evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1257437

28 September 2017

Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. II. Correlation of morphology with biochemical and metabolic data

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1257437

28 September 2017

Oral treatment with PD-0200347, an alpha2delta ligand, reduces the development of experimental osteoarthritis by inhibiting metalloproteinases and inducible nitric oxide synthase gene expression and synthesis in cartilage chondrocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1257437

30 May 2018

Acidic cysteine endoproteinase cathepsin K in the degeneration of the superficial articular hyaline cartilage in osteoarthritis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1257437

30 May 2018

Synthesis of interleukin 1beta, tumor necrosis factor-alpha, and interstitial collagenase (MMP-1) is eicosanoid dependent in human osteoarthritis synovial membrane explants: interactions with antiinflammatory cytokines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1257437

30 May 2018

Leukotriene and prostaglandin synthesis pathways in osteoarthritic synovial membranes: regulating factors for interleukin 1beta synthesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1257437

28 November 2018

Regulation of the expression of 5-lipoxygenase-activating protein/5-lipoxygenase and the synthesis of leukotriene B(4) in osteoarthritic chondrocytes: role of transforming growth factor beta and eicosanoids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1257437

28 November 2018

The regulation of human MMP-13 by licofelone, an inhibitor of cyclo-oxygenases and 5-lipoxygenase, in human osteoarthritic chondrocytes is mediated by the inhibition of the p38 MAP kinase signalling pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1257437

28 November 2018

Characterization of and osteoarthritis susceptibility in ADAMTS-4-knockout mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1257437

28 November 2018

The inhibition of subchondral bone resorption in the early phase of experimental dog osteoarthritis by licofelone is associated with a reduction in the synthesis of MMP-13 and cathepsin K.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1257437

28 November 2018

ADAMTS-1, a gene product of articular chondrocytes in vivo and in vitro, is downregulated by interleukin 1beta.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1257437

28 November 2018

Relative messenger RNA expression profiling of collagenases and aggrecanases in human articular chondrocytes in vivo and in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1257437

28 November 2018

Study of the role of leukotriene B()4 in abnormal function of human subchondral osteoarthritis osteoblasts: effects of cyclooxygenase and/or 5-lipoxygenase inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1257437

28 November 2018

In vivo dual inhibition of cyclooxygenase and lipoxygenase by ML-3000 reduces the progression of experimental osteoarthritis: suppression of collagenase 1 and interleukin-1beta synthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1257437

28 November 2018

Dual inhibition of 5-lipoxygenase and cyclooxygenases 1 and 2 by ML3000 reduces joint destruction in adjuvant arthritis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1257437

28 November 2018

Stimulation of the secretion of latent cysteine proteinase activity by tumor necrosis factor alpha and interleukin-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/16207326

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The structure of aggrecan fragments in human synovial fluid. Evidence that aggrecanase mediates cartilage degradation in inflammatory joint disease, joint injury, and osteoarthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16207326

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of antiinflammatory drugs on the progression of osteoarthritis of the knee. LINK Study Group. Longitudinal Investigation of Nonsteroidal Antiinflammatory Drugs in Knee Osteoarthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16207326

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of 5-lipoxygenase inhibitors on interleukin production by human synovial tissues in organ culture: comparison with interleukin-1-synthesis inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16207326

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of tenidap on the progression of osteoarthritic lesions in a canine experimental model. Suppression of metalloprotease and interleukin-1 activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/16207326

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Collagenase-3 (matrix metalloprotease 13) is preferentially localized in the deep layer of human arthritic cartilage in situ: in vitro mimicking effect by transforming growth factor beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/16207326

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The contribution of synovial fluid lipoproteins to the chronic synovitis of rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16207326

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of cathepsin K messenger RNA in giant cells and their precursors in human osteoarthritic synovial tissues

1 reference

https://pubmed.ncbi.nlm.nih.gov/16207326

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Matrix metalloproteinases and aggrecanases cleave aggrecan in different zones of normal cartilage but colocalize in the development of osteoarthritic lesions in STR/ort mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16207326

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) in a model of cartilage degradation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16207326

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synovitis reduced by inhibition of leukotriene B4: Carragheenan-induced gonarthritis studied in dogs

1 reference

https://pubmed.ncbi.nlm.nih.gov/16207326

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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Europe PubMed Central

PubMed publication ID

5 July 2017

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Europe PubMed Central

PubMed publication ID

5 July 2017

PubMed publication ID

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Europe PubMed Central

PubMed publication ID

5 July 2017

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