(Q37369629)

English

Aggrecan degradation in human cartilage. Evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints

scientific article published on July 1997

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scholarly article

1 reference

Europe PubMed Central

20 August 2017

Aggrecan degradation in human cartilage. Evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints (English)

1 reference

Europe PubMed Central

20 August 2017

0 references

1 reference

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inferred from title

Stefan Lohmander

12

object named as

Lohmander LS

1 reference

Europe PubMed Central

20 August 2017

author name string

Lark MW

1

1 reference

Europe PubMed Central

20 August 2017

Bayne EK

2

1 reference

Europe PubMed Central

20 August 2017

Flanagan J

3

1 reference

Europe PubMed Central

20 August 2017

Harper CF

4

1 reference

Europe PubMed Central

20 August 2017

Hoerrner LA

5

1 reference

Europe PubMed Central

20 August 2017

Hutchinson NI

6

1 reference

Europe PubMed Central

20 August 2017

Singer II

7

1 reference

Europe PubMed Central

20 August 2017

Donatelli SA

8

1 reference

Europe PubMed Central

20 August 2017

Weidner JR

9

1 reference

Europe PubMed Central

20 August 2017

Williams HR

10

1 reference

Europe PubMed Central

20 August 2017

Mumford RA

11

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20 August 2017

language of work or name

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publication date

1 July 1997

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Europe PubMed Central

20 August 2017

Journal of Clinical Investigation

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Europe PubMed Central

20 August 2017

100

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Europe PubMed Central

20 August 2017

93-106

1 reference

Europe PubMed Central

20 August 2017

1

1 reference

Europe PubMed Central

20 August 2017

Aggrecan is degraded by matrix metalloproteinases in human arthritis. Evidence that matrix metalloproteinase and aggrecanase activities can be independent

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508169

6 September 2017

Damage to type II collagen in aging and osteoarthritis starts at the articular surface, originates around chondrocytes, and extends into the cartilage with progressive degeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508169

6 September 2017

Fibroblast and neutrophil collagenases cleave at two sites in the cartilage aggrecan interglobular domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508169

6 September 2017

Neutrophil collagenase (MMP-8) cleaves at the aggrecanase site E373-A374 in the interglobular domain of cartilage aggrecan

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508169

6 September 2017

VDIPEN, a metalloproteinase-generated neoepitope, is induced and immunolocalized in articular cartilage during inflammatory arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508169

6 September 2017

Increased damage to type II collagen in osteoarthritic articular cartilage detected by a new immunoassay

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508169

6 September 2017

Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. II. Correlation of morphology with biochemical and metabolic data

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508169

6 September 2017

Evidence for metalloproteinase and metalloproteinase inhibitor imbalance in human osteoarthritic cartilage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508169

6 September 2017

Degradation of proteoglycan aggregate by a cartilage metalloproteinase. Evidence for the involvement of stromelysin in the generation of link protein heterogeneity in situ

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508169

6 September 2017

Complete coding sequence and deduced primary structure of the human cartilage large aggregating proteoglycan, aggrecan. Human-specific repeats, and additional alternatively spliced forms.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508169

6 September 2017

Cleavage of cartilage proteoglycan between G1 and G2 domains by stromelysins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508169

6 September 2017

The structure of aggrecan fragments in human synovial fluid. Evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the Glu 373-Ala 374 bond of the interglobular domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508169

6 September 2017

Preferential mRNA expression of prostromelysin relative to procollagenase and in situ localization in human articular cartilage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508169

28 September 2017

Cell-mediated catabolism of aggrecan. Evidence that cleavage at the "aggrecanase" site (Glu373-Ala374) is a primary event in proteolysis of the interglobular domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508169

28 September 2017

Correlated metabolism of proteoglycans and hyaluronic acid in bovine cartilage organ cultures.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508169

28 September 2017

A cartilage explant system for studies on aggrecan structure, biosynthesis and catabolism in discrete zones of the mammalian growth plate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508169

26 June 2018

Quantification of a matrix metalloproteinase-generated aggrecan G1 fragment using monospecific anti-peptide serum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508169

26 June 2018

Monoclonal antibodies that specifically recognize neoepitope sequences generated by 'aggrecanase' and matrix metalloproteinase cleavage of aggrecan: application to catabolism in situ and in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508169

26 June 2018

Identification of a hyaluronic acid-binding protein that interferes with the preparation of high-buoyant-density proteoglycan aggregates from adult human articular cartilage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508169

26 June 2018

The glucose oxidase-DAB-nickel method in peroxidase histochemistry of the nervous system.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508169

26 June 2018

Production and purification of prostromelysin and procollagenase from IL-1 beta-stimulated human gingival fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508169

26 June 2018

Sites of stromelysin cleavage in collagen types II, IX, X, and XI of cartilage.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508169

26 June 2018

Gene expression (collagenase, tissue inhibitor of metalloproteinases, complement, and HLA-DR) in rheumatoid arthritis and osteoarthritis synovium. Quantitative analysis and effect of intraarticular corticosteroids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508169

26 June 2018

Expression of metalloproteinases and metalloproteinase inhibitor in human arthritic synovium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508169

26 June 2018

N-terminal sequence of proteoglycan fragments isolated from medium of interleukin-1-treated articular-cartilage cultures. Putative site(s) of enzymic cleavage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508169

26 June 2018

Mechanism of catabolism of aggrecan by articular cartilage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508169

26 June 2018

Link protein shows species variation in its susceptibility to proteolysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508169

26 June 2018

Turnover of proteoglycans in guinea pig costal cartilage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508169

26 June 2018

Use of an antibody against the matrix metalloproteinase-generated aggrecan neoepitope FVDIPEN-COOH to assess the effects of stromelysin in a rabbit model of cartilage degradation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508169

2 September 2018

Aggrecan synthesized by mature bovine chondrocytes suspended in alginate. Identification of two distinct metabolic matrix pools

1 reference

https://pubmed.ncbi.nlm.nih.gov/9202061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathways of aggrecan processing in joint tissues. Implications for disease mechanism and monitoring

1 reference

https://pubmed.ncbi.nlm.nih.gov/9202061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/9202061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detection of stromelysin and collagenase in synovial fluid from patients with rheumatoid arthritis and posttraumatic knee injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/9202061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synovial fluid analysis of two groups of proteoglycan epitopes distinguishes early and late cartilage lesions

1 reference

https://pubmed.ncbi.nlm.nih.gov/9202061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metalloproteinases, tissue inhibitor, and proteoglycan fragments in knee synovial fluid in human osteoarthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9202061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteoglycans: isolation and characterization

1 reference

https://pubmed.ncbi.nlm.nih.gov/9202061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of interleukin-1 and lipopolysaccharides on protein and carbohydrate metabolism in bovine articular cartilage organ cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/9202061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Substrate specificity of human fibroblast stromelysin. Hydrolysis of substance P and its analogues

1 reference

https://pubmed.ncbi.nlm.nih.gov/9202061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Catabolism of aggrecan in cartilage explants. Identification of a major cleavage site within the interglobular domain

1 reference

https://pubmed.ncbi.nlm.nih.gov/9202061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In situ hybridization studies of stromelysin and collagenase messenger RNA expression in rheumatoid synovium

1 reference

https://pubmed.ncbi.nlm.nih.gov/9202061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a stromelysin cleavage site within the interglobular domain of human aggrecan. Evidence for proteolysis at this site in vivo in human articular cartilage

1 reference

https://pubmed.ncbi.nlm.nih.gov/9202061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The structure of aggrecan fragments in human synovial fluid. Evidence that aggrecanase mediates cartilage degradation in inflammatory joint disease, joint injury, and osteoarthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9202061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential in vivo expression of collagenase messenger RNA in synovium and cartilage. Quantitative comparison with stromelysin messenger RNA levels in human rheumatoid arthritis and osteoarthritis patients and in two animal models of acute inflamm

1 reference

https://pubmed.ncbi.nlm.nih.gov/9202061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1172/JCI119526

1 reference

Europe PubMed Central

20 August 2017

1 reference

Europe PubMed Central

20 August 2017

1 reference

Europe PubMed Central

20 August 2017

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