(Q37361470)

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Aggrecan is degraded by matrix metalloproteinases in human arthritis. Evidence that matrix metalloproteinase and aggrecanase activities can be independent

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Aggrecan is degraded by matrix metalloproteinases in human arthritis. Evidence that matrix metalloproteinase and aggrecanase activities can be independent (English)

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

author name string

Fosang AJ

1

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Last K

2

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Maciewicz RA

3

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

language of work or name

0 references

publication date

1 November 1996

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Journal of Clinical Investigation

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

98

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

10

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

2292-2299

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Chondrocyte matrix metalloproteinase-8. Human articular chondrocytes express neutrophil collagenase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507679

6 September 2017

Age-related changes in the content of the C-terminal region of aggrecan in human articular cartilage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507679

6 September 2017

Fibroblast and neutrophil collagenases cleave at two sites in the cartilage aggrecan interglobular domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507679

6 September 2017

Neutrophil collagenase (MMP-8) cleaves at the aggrecanase site E373-A374 in the interglobular domain of cartilage aggrecan

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507679

6 September 2017

N- and O-Linked Keratan Sulfate on the Hyaluronan Binding Region of Aggrecan from Mature and Immature Bovine Cartilage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507679

6 September 2017

VDIPEN, a metalloproteinase-generated neoepitope, is induced and immunolocalized in articular cartilage during inflammatory arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507679

6 September 2017

Changes in cartilage metabolism in arthritis are reflected by altered serum and synovial fluid levels of the cartilage proteoglycan aggrecan. Implications for pathogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507679

6 September 2017

If nothing goes wrong, is everything all right? Interpreting zero numerators

1 reference

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6 September 2017

Electrophoretic analysis of the major polypeptides of the human erythrocyte membrane

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507679

6 September 2017

Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507679

6 September 2017

Therapeutic effects on cartilage metabolism in arthritis as measured by release of proteoglycan structures into the synovial fluid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507679

6 September 2017

The antigenic determinants recognized by three monoclonal antibodies to keratan sulphate involve sulphated hepta- or larger oligosaccharides of the poly(N-acetyllactosamine) series

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507679

6 September 2017

Complete coding sequence and deduced primary structure of the human cartilage large aggregating proteoglycan, aggrecan. Human-specific repeats, and additional alternatively spliced forms.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507679

6 September 2017

Cleavage of cartilage proteoglycan between G1 and G2 domains by stromelysins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507679

6 September 2017

The structure of aggrecan fragments in human synovial fluid. Evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the Glu 373-Ala 374 bond of the interglobular domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507679

6 September 2017

The interglobular domain of cartilage aggrecan is cleaved by PUMP, gelatinases, and cathepsin B

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507679

6 September 2017

Distribution of keratan sulfate in cartilage proteoglycans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507679

14 September 2017

Measurement of sulphated glycosaminoglycans and proteoglycan fragments in arthritic synovial fluid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507679

28 September 2017

Increased concentrations of proteoglycan components in the synovial fluids of patients with acute but not chronic joint disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507679

28 September 2017

Inhibition of interleukin 1 beta induced rat and human cartilage degradation in vitro by the metalloproteinase inhibitor U27391.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507679

28 September 2017

Blocking cartilage destruction with metalloproteinase inhibitors: a valid therapeutic target?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507679

28 September 2017

Cell-mediated catabolism of aggrecan. Evidence that cleavage at the "aggrecanase" site (Glu373-Ala374) is a primary event in proteolysis of the interglobular domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507679

28 September 2017

A cartilage explant system for studies on aggrecan structure, biosynthesis and catabolism in discrete zones of the mammalian growth plate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507679

26 June 2018

Proteoglycans isolated from dissociative extracts of differently aged human articular cartilage: characterization of naturally occurring hyaluronan-binding fragments of aggrecan

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507679

26 June 2018

Quantification of a matrix metalloproteinase-generated aggrecan G1 fragment using monospecific anti-peptide serum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507679

26 June 2018

Development of a cleavage-site-specific monoclonal antibody for detecting metalloproteinase-derived aggrecan fragments: detection of fragments in human synovial fluids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507679

26 June 2018

Monoclonal antibodies that specifically recognize neoepitope sequences generated by 'aggrecanase' and matrix metalloproteinase cleavage of aggrecan: application to catabolism in situ and in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507679

26 June 2018

Quantification of keratan sulfate in blood as a marker of cartilage catabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507679

26 June 2018

Synovial fluids from infected joints contain active metalloproteinases and no inhibitory activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507679

26 June 2018

Synovial fluids from infected joints contain metalloproteinase--tissue inhibitor of metalloproteinase (TIMP) complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507679

26 June 2018

N-terminal sequence of proteoglycan fragments isolated from medium of interleukin-1-treated articular-cartilage cultures. Putative site(s) of enzymic cleavage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507679

26 June 2018

Mechanism of catabolism of aggrecan by articular cartilage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507679

26 June 2018

Monoclonal antibodies recognizing protease-generated neoepitopes from cartilage proteoglycan degradation. Application to studies of human link protein cleavage by stromelysin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507679

26 June 2018

Reiter's syndrome. Evaluation of preliminary criteria for definite disease.

1 reference

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2 September 2018

A direct spectrophotometric microassay for sulfated glycosaminoglycans in cartilage cultures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507679

2 September 2018

The immunologic detection and characterization of cartilage proteoglycan degradation products in synovial fluids of patients with arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507679

2 September 2018

Osteoarthritis in cynomolgus macaques II. Detection of modulated proteoglycan epitopes in cartilage and synovial fluid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507679

3 December 2018

DIAGNOSTIC criteria for rheumatoid arthritis: 1958 revision by a committee of the American Rheumatism Association

1 reference

https://pubmed.ncbi.nlm.nih.gov/8941646

12 December 2020

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Difference in cartilage proteoglycan level in synovial fluid in early rheumatoid arthritis and reactive arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/8941646

12 December 2020

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A method for the quantification of cartilage proteoglycan structures liberated to the synovial fluid during developing degenerative joint disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/8941646

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cartilage derived proteoglycans in body fluids of children. Inverse correlation with age

1 reference

https://pubmed.ncbi.nlm.nih.gov/8941646

12 December 2020

based on heuristic

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Catabolism of aggrecan in cartilage explants. Identification of a major cleavage site within the interglobular domain

1 reference

https://pubmed.ncbi.nlm.nih.gov/8941646

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cleavage of proteoglycan aggregate by leucocyte elastase

1 reference

https://pubmed.ncbi.nlm.nih.gov/8941646

12 December 2020

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inferred from PubMed ID database lookup

Synovial fluid analysis of two groups of proteoglycan epitopes distinguishes early and late cartilage lesions

1 reference

https://pubmed.ncbi.nlm.nih.gov/8941646

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The quantitation of a native chondroitin sulfate epitope in synovial fluid lavages and articular cartilage from canine experimental osteoarthritis and disuse atrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/8941646

12 December 2020

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Direct evidence for active metalloproteinases mediating matrix degradation in interleukin 1-stimulated human articular cartilage

1 reference

https://pubmed.ncbi.nlm.nih.gov/8941646

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The structure of aggrecan fragments in human synovial fluid. Evidence that aggrecanase mediates cartilage degradation in inflammatory joint disease, joint injury, and osteoarthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/8941646

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of cartilage proteoglycan release by a specific inactivator of cathepsin B and an inhibitor of matrix metalloproteinases. Evidence for two converging pathways of chondrocyte-mediated proteoglycan degradation

1 reference

https://pubmed.ncbi.nlm.nih.gov/8941646

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of animal age and chronicity of interleukin-1 exposure on cartilage proteoglycan depletion in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/8941646

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The effect of recombinant human interleukin 1 receptor antagonist on the induction phase of antigen induced arthritis in the rabbit

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MMP-8 (neutrophil collagenase) mRNA and aggrecanase cleavage products are present in normal and osteoarthritic human articular cartilage

1 reference

https://pubmed.ncbi.nlm.nih.gov/8941646

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Degradation of cartilage aggrecan by collagenase-3 (MMP-13)

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Identifiers

10.1172/JCI119040

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

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