(Q37156945)

18 August 2017

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title

Late sodium current inhibition as a new cardioprotective approach (English)

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18 August 2017

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Sharon L Hale

1

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18 August 2017

John C Shryock

2

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18 August 2017

Luiz Belardinelli

3

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18 August 2017

Michael Sweeney

4

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18 August 2017

Robert A Kloner

5

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18 August 2017

publication date

8 April 2008

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Journal of Molecular and Cellular Cardiology

18 August 2017

published in

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18 August 2017

volume

44

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18 August 2017

issue

6

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18 August 2017

page(s)

954-967

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Inhibition of sodium and calcium overload pathology in the myocardium: a new cytoprotective principle

18 August 2017

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Mechanisms of arrhythmogenic delayed and early afterdepolarizations in ferret ventricular muscle

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Cardiac-specific ablation of the Na+-Ca2+ exchanger confers protection against ischemia/reperfusion injury

7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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Vitamin C pretreatment attenuates hypoxia-induced disturbance of sodium currents in guinea pig ventricular myocytes

7 January 2021

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Palmitoyl carnitine modifies sodium currents and induces transient inward current in ventricular myocytes.

7 January 2021

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Inward sodium current at resting potentials in single cardiac myocytes induced by the ischemic metabolite lysophosphatidylcholine

7 January 2021

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Ionic mechanism of the effects of hydrogen peroxide in rat ventricular myocytes.

7 January 2021

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Blocking late sodium current reduces hydrogen peroxide-induced arrhythmogenic activity and contractile dysfunction.

7 January 2021

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Induction of persistent sodium current by exogenous and endogenous nitric oxide

7 January 2021

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Slow inactivation of a tetrodotoxin-sensitive current in canine cardiac Purkinje fibers

7 January 2021

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Mechanism of inactivation of single sodium channels after modification by chloramine-T, sea anemone toxin and scorpion toxin.

7 January 2021

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Late sodium current and its contribution to action potential configuration in guinea pig ventricular myocytes

7 January 2021

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On the molecular nature of the lidocaine receptor of cardiac Na+ channels. Modification of block by alterations in the alpha-subunit III-IV interdomain

7 January 2021

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Na channels that remain open throughout the cardiac action potential plateau.

7 January 2021

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Antagonism by ranolazine of the pro-arrhythmic effects of increasing late INa in guinea pig ventricular myocytes

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.019

Repolarization abnormalities in cardiomyocytes of dogs with chronic heart failure: role of sustained inward current.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.019

The role of sodium channel current in modulating transmural dispersion of repolarization and arrhythmogenesis.

7 January 2021

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Na(+) current in human ventricle: implications for sodium loading and homeostasis

7 January 2021

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Inactivation-resistant channels underlying the persistent sodium current in rat ventricular myocytes

7 January 2021

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Resurgent sodium current and action potential formation in dissociated cerebellar Purkinje neurons.

7 January 2021

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Tetrodotoxin differentially blocks peak and steady-state sodium channel currents in early embryonic chick ventricular myocytes

7 January 2021

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7 January 2021

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Late sodium current is a novel target for amiodarone: studies in failing human myocardium

7 January 2021

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A phosphorylation site in the Na+ channel required for modulation by protein kinase C

7 January 2021

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Modulation of Cardiac Sodium Channel Gating by Protein Kinase A Can Be Altered by Disease-linked Mutation

7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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The effects of the Anemonia sulcata toxin (ATX II) on membrane currents of isolated mammalian myocytes

7 January 2021

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Characterization of human cardiac Na+ channel mutations in the congenital long QT syndrome

7 January 2021

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Persistent sodium current in mammalian central neurons

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.019

Inhibition of oxidative metabolism increases persistent sodium current in rat CA1 hippocampal neurons

7 January 2021

1 reference

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Molecular basis of an inherited epilepsy

7 January 2021

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The roles of sodium channels in nociception: Implications for mechanisms of pain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.019

Larger late sodium conductance in M cells contributes to electrical heterogeneity in canine ventricle

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.019

A comparison between ranolazine and CVT-4325, a novel inhibitor of fatty acid oxidation, on cardiac metabolism and left ventricular function in rat isolated perfused heart during ischemia and reperfusion

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.019

Different pathways for sodium entry in cardiac cells during ischemia and early reperfusion.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.019

Blocking Na(+)-H+ exchange by cariporide reduces Na(+)-overload in ischemia and is cardioprotective

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.019

Molecular basis of ranolazine block of LQT-3 mutant sodium channels: evidence for site of action

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.019

Electrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic properties

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.019

Ranolazine improves abnormal repolarization and contraction in left ventricular myocytes of dogs with heart failure by inhibiting late sodium current

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.019

Antiarrhythmic effects of ranolazine in a guinea pig in vitro model of long-QT syndrome

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.019

An increase in late sodium current potentiates the proarrhythmic activities of low-risk QT-prolonging drugs in female rabbit hearts

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.019

Cardioprotective effects of ranolazine (RS-43285) in the isolated perfused rabbit heart.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.019

State- and use-dependent block of muscle Nav1.4 and neuronal Nav1.7 voltage-gated Na+ channel isoforms by ranolazine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.019

Atrium-selective sodium channel block as a strategy for suppression of atrial fibrillation: differences in sodium channel inactivation between atria and ventricles and the role of ranolazine

7 January 2021

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Ranolazine: ion-channel-blocking actions and in vivo electrophysiological effects

7 January 2021

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Evidence that ranolazine behaves as a weak beta1- and beta2-adrenoceptor antagonist in the rat [correction of cat] cardiovascular system

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.019

Protective effects of ranolazine in guinea-pig hearts during low-flow ischaemia and their association with increases in active pyruvate dehydrogenase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.019

Protective Effects of Ranolazine on Ventricular Fibrillation Induced by Activation of the ATP-Dependent Potassium Channel in the Rabbit Heart

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.019

Anti-ischemic effects and long-term survival during ranolazine monotherapy in patients with chronic severe angina

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.019

Effects of ranolazine with atenolol, amlodipine, or diltiazem on exercise tolerance and angina frequency in patients with severe chronic angina: a randomized controlled trial

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.019

Comparative efficacy of ranolazine versus atenolol for chronic angina pectoris

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.019

Ranolazine stimulates glucose oxidation in normoxic, ischemic, and reperfused ischemic rat hearts

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.019

Prevention of myocardial enzyme release by ranolazine in a primate model of ischaemia with reperfusion

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.019

Ranolazine, a partial fatty acid oxidation inhibitor, reduces myocardial infarct size and cardiac troponin T release in the rat.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.019

Improved left ventricular function and reduced necrosis after myocardial ischemia/reperfusion in rabbits treated with ranolazine, an inhibitor of the late sodium channel

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.019

Ranolazine, an inhibitor of the late sodium channel current, reduces postischemic myocardial dysfunction in the rabbit

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.019

Ranolazine, a partial fatty acid oxidation (pFOX) inhibitor, improves left ventricular function in dogs with chronic heart failure

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.019

Effects of ranolazine on the exercise capacity of rats with chronic heart failure induced by myocardial infarction.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.019

Short-term treatment with ranolazine improves mechanical efficiency in dogs with chronic heart failure

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.019

Comparison of coronary-artery bypass surgery and stenting for the treatment of multivessel disease

7 January 2021

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Optimal medical therapy with or without PCI for stable coronary disease

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.019

Ranolazine for the treatment of chronic angina and potential use in other cardiovascular conditions

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.019

Ranolazine (RS-43285): a preliminary study of a new anti-anginal agent with selective effect on ischaemic myocardium

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.019

A controlled trial with a novel anti-ischemic agent, ranolazine, in chronic stable angina pectoris that is responsive to conventional antianginal agents. Ranolazine Study Group

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.019

Long-term safety of a novel antianginal agent in patients with severe chronic stable angina: the Ranolazine Open Label Experience (ROLE).

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.019

Antianginal efficacy of ranolazine when added to treatment with amlodipine: the ERICA (Efficacy of Ranolazine in Chronic Angina) trial

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.019

Safety and efficacy of extended-release ranolazine in patients aged 70 years or older with chronic stable angina pectoris

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.019

Effects of ranolazine on recurrent cardiovascular events in patients with non-ST-elevation acute coronary syndromes: the MERLIN-TIMI 36 randomized trial

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.019

Effect of ranolazine, an antianginal agent with novel electrophysiological properties, on the incidence of arrhythmias in patients with non ST-segment elevation acute coronary syndrome: results from the Metabolic Efficiency With Ranolazine for Less

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.019

Effects of ranolazine on left ventricular regional diastolic function in patients with ischemic heart disease

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.019

Congestive heart failure in subjects with normal versus reduced left ventricular ejection fraction: prevalence and mortality in a population-based cohort.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.019

Prevalence, clinical features and prognosis of diastolic heart failure: an epidemiologic perspective

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.019

Effect of ranolazine on infarct size in a canine model of regional myocardial ischemia/reperfusion

7 January 2021

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7 January 2021

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DOI

10.1016/J.YJMCC.2008.03.019

1 reference

18 August 2017

1 reference