(Q37167019)

18 August 2017

Tolerance of Arc repressor to multiple-alanine substitutions (English)

1 reference

18 August 2017

B M Brown

1

1 reference

PMCID

26723

18 August 2017

R T Sauer

series ordinal

2

1 reference

PMCID

26723

18 August 2017

language of work or name

English

0 references

publication date

1 March 1999

1 reference

Proceedings of the National Academy of Sciences of the United States of America

18 August 2017

1 reference

18 August 2017

96

1 reference

18 August 2017

1983-1988

1 reference

18 August 2017

5

1 reference

De novo protein design: fully automated sequence selection

18 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26723

Sequence space, folding and protein design

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26723

Barriers to protein folding: formation of buried polar interactions is a slow step in acquisition of structure.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26723

De novo design of the hydrophobic cores of proteins

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26723

Structural basis of amino acid alpha helix propensity

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26723

Additivity of mutant effects assessed by binomial mutagenesis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26723

DNA recognition by beta-sheets in the Arc repressor-operator crystal structure

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26723

Nuclear magnetic resonance solution structure of the Arc repressor using relaxation matrix calculations

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26723

Probing the roles of residues at the e and g positions of the GCN4 leucine zipper by combinatorial mutagenesis.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26723

Design of a "minimAl" homeodomain: the N-terminal arm modulates DNA binding affinity and stabilizes homeodomain structure

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26723

Alanine scanning mutagenesis of the alpha-helix 115-123 of phage T4 lysozyme: effects on structure, stability and the binding of solvent

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26723

Crystal structure, folding, and operator binding of the hyperstable Arc repressor mutant PL8

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26723

Are buried salt bridges important for protein stability and conformational specificity?

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26723

Contribution of individual side-chains to the stability of BPTI examined by alanine-scanning mutagenesis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26723

Identifying determinants of folding and activity for a protein of unknown structure

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26723

Metal binding and folding properties of a minimalist Cys2His2 zinc finger peptide

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26723

Helix design, prediction and stability

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26723

P22 Arc repressor: enhanced expression of unstable mutants by addition of polar C-terminal sequences

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26723

Stabilization of myoglobin by multiple alanine substitutions in helical positions

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26723

Dissecting the energetics of an antibody-antigen interface by alanine shaving and molecular grafting

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26723

Isolation and analysis of arc repressor mutants: evidence for an unusual mechanism of DNA binding

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26723

Equilibrium dissociation and unfolding of the Arc repressor dimer

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26723

Identification of C-terminal extensions that protect proteins from intracellular proteolysis.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26723

Structure of Arc repressor in solution: evidence for a family of beta-sheet DNA-binding proteins.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26723

Arc repressor is tetrameric when bound to operator DNA.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26723

Systematic mutation of bacteriophage T4 lysozyme.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26723

Tolerance of a protein helix to multiple alanine and valine substitutions

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26723

Genetic studies of the lac repressor. XIV. Analysis of 4000 altered Escherichia coli lac repressors reveals essential and non-essential residues, as well as "spacers" which do not require a specific sequence.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26723

Critical side-chain interactions at a subunit interface in the Arc repressor dimer.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26723

Deciphering the message in protein sequences: tolerance to amino acid substitutions

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26723

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

3 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.96.5.1983

Dissection of protein structure and folding by directed mutagenesis

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.96.5.1983

Protein stabilization by removal of unsatisfied polar groups: computational approaches and experimental tests

21 January 2018

1 reference

12 December 2020

Building models of globular protein molecules from their amino acid sequences. I. Theory

1 reference

12 December 2020

P22 Arc repressor: folding kinetics of a single-domain, dimeric protein

1 reference

12 December 2020

Scanning mutagenesis of the Arc repressor as a functional probe of operator recognition

1 reference

12 December 2020

Protein stability effects of a complete set of alanine substitutions in Arc repressor

1 reference

12 December 2020

P22 Arc repressor: transition state properties inferred from mutational effects on the rates of protein unfolding and refolding

1 reference

12 December 2020

Nonlinear free energy relationships in Arc repressor unfolding imply the existence of unstable, native-like folding intermediates

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.96.5.1983

1 reference

18 August 2017

0 references

1 reference

18 August 2017

1 reference

PMCID

26723