(Q37184070)

18 August 2017

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title

CD8+ T cell efficacy in vaccination and disease (English)

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18 August 2017

David A Price

3

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author name string

Victor Appay

series ordinal

1

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PubMed ID

18535580

18 August 2017

Daniel C Douek

series ordinal

2

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PubMed ID

18535580

18 August 2017

language of work or name

English

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publication date

1 June 2008

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18 August 2017

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18 August 2017

14

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18 August 2017

6

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18 August 2017

623-628

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https://scigraph.springernature.com/pub.10.1038/nm.f.1774

18 August 2017

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cites work

A shift in the phenotype of melan-A-specific CTL identifies melanoma patients with an active tumor-specific immune response

1 reference

Telomere length of transferred lymphocytes correlates with in vivo persistence and tumor regression in melanoma patients receiving cell transfer therapy.

21 January 2018

1 reference

High-avidity CTL exploit two complementary mechanisms to provide better protection against viral infection than low-avidity CTL.

21 January 2018

1 reference

Peptide requirement for CTL activation reflects the sensitivity to CD3 engagement: correlation with CD8alphabeta versus CD8alphaalpha expression

21 January 2018

1 reference

The functional profile of primary human antiviral CD8+ T cell effector activity is dictated by cognate peptide concentration.

21 January 2018

1 reference

Hierarchies in cytokine expression profiles for acute and resolving influenza virus-specific CD8+ T cell responses: correlation of cytokine profile and TCR avidity

21 January 2018

1 reference

Selection of T cell clones expressing high-affinity public TCRs within Human cytomegalovirus-specific CD8 T cell responses

21 January 2018

1 reference

Impact of HLA-B alleles, epitope binding affinity, functional avidity, and viral coinfection on the immunodominance of virus-specific CTL responses

21 January 2018

1 reference

A novel approach to characterize clonality and differentiation of human melanoma-specific T cell responses: spontaneous priming and efficient boosting by vaccination.

21 January 2018

1 reference

Clonal selection, clonal senescence, and clonal succession: the evolution of the T cell response to infection with a persistent virus

21 January 2018

1 reference

A novel approach to the analysis of specificity, clonality, and frequency of HIV-specific T cell responses reveals a potential mechanism for control of viral escape.

21 January 2018

1 reference

Gene transfer of tumor-reactive TCR confers both high avidity and tumor reactivity to nonreactive peripheral blood mononuclear cells and tumor-infiltrating lymphocytes

21 January 2018

1 reference

Cutting Edge: Predetermined Avidity of Human CD8 T Cells Expanded on Calibrated MHC/Anti-CD28-Coated Microspheres

21 January 2018

1 reference

Antigen density presented by dendritic cells in vivo differentially affects the number and avidity of primary, memory, and recall CD8+ T cells.

21 January 2018

1 reference

Selective induction of high avidity CTL by altering the balance of signals from APC.

21 January 2018

1 reference

Multiple costimulatory modalities enhance CTL avidity

21 January 2018

1 reference

Activation of resting human primary T cells with chimeric receptors: costimulation from CD28, inducible costimulator, CD134, and CD137 in series with signals from the TCR zeta chain

21 January 2018

1 reference

Rapid and strong human CD8+ T cell responses to vaccination with peptide, IFA, and CpG oligodeoxynucleotide 7909.

21 January 2018

1 reference

A novel functional CTL avidity/activity compartmentalization to the site of mucosal immunization contributes to protection of macaques against simian/human immunodeficiency viral depletion of mucosal CD4+ T cells

21 January 2018

1 reference

Mucosal HIV-1 pox virus prime-boost immunization induces high-avidity CD8+ T cells with regime-dependent cytokine/granzyme B profiles

21 January 2018

1 reference

Selective growth, in vitro and in vivo, of individual T cell clones from tumor-infiltrating lymphocytes obtained from patients with melanoma

21 January 2018

1 reference

Gag-specific CD8+ T lymphocytes recognize infected cells before AIDS-virus integration and viral protein expression

21 January 2018

1 reference

Vaccination preserves CD4 memory T cells during acute simian immunodeficiency virus challenge

21 January 2018

1 reference

7 January 2021

HLA B*5701 is highly associated with restriction of virus replication in a subgroup of HIV-infected long term nonprogressors

1 reference

7 January 2021

Analysis of total human immunodeficiency virus (HIV)-specific CD4(+) and CD8(+) T-cell responses: relationship to viral load in untreated HIV infection

1 reference

7 January 2021

Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients

1 reference

7 January 2021

HIV-specific CD8(+) T cells produce antiviral cytokines but are impaired in cytolytic function

1 reference

7 January 2021

Skewed maturation of memory HIV-specific CD8 T lymphocytes

1 reference

7 January 2021

In vivo activation of melanoma-specific CD8(+) T cells by endogenous tumor antigen and peptide vaccines. A comparison to virus-specific T cells

1 reference

7 January 2021

Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections

1 reference

7 January 2021

HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells

1 reference

7 January 2021

Lineage relationship and protective immunity of memory CD8 T cell subsets

1 reference

7 January 2021

Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells

1 reference

7 January 2021

Repertoire, diversity, and differentiation of specific CD8 T cells are associated with immune protection against human cytomegalovirus disease

1 reference

7 January 2021

Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primates

1 reference

7 January 2021

PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression

1 reference

7 January 2021

Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction

1 reference

7 January 2021

PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection

1 reference

7 January 2021

PD-1 expression on human CD8 T cells depends on both state of differentiation and activation status.

1 reference

7 January 2021

HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors

1 reference

7 January 2021

Skewed representation of functionally distinct populations of virus-specific CD4 T cells in HIV-1-infected subjects with progressive disease: changes after antiretroviral therapy

1 reference

7 January 2021

Superior control of HIV-1 replication by CD8+ T cells is reflected by their avidity, polyfunctionality, and clonal turnover

1 reference

7 January 2021

Immunisation with BCG and recombinant MVA85A induces long-lasting, polyfunctional Mycobacterium tuberculosis-specific CD4+ memory T lymphocyte populations

1 reference

7 January 2021

Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major

1 reference

7 January 2021

Immunization with vaccinia virus induces polyfunctional and phenotypically distinctive CD8(+) T cell responses

1 reference

7 January 2021

Epitope-dependent avidity thresholds for cytotoxic T-lymphocyte clearance of virus-infected cells

1 reference

7 January 2021

Selective expansion of high- or low-avidity cytotoxic T lymphocytes and efficacy for adoptive immunotherapy.

1 reference

7 January 2021

Direct link between mhc polymorphism, T cell avidity, and diversity in immune defense

1 reference

7 January 2021

Impact of vaccine-induced mucosal high-avidity CD8+ CTLs in delay of AIDS viral dissemination from mucosa

1 reference

7 January 2021

Acute phase cytotoxic T lymphocyte escape is a hallmark of simian immunodeficiency virus infection

1 reference

7 January 2021

HIV controllers exhibit potent CD8 T cell capacity to suppress HIV infection ex vivo and peculiar cytotoxic T lymphocyte activation phenotype

1 reference

7 January 2021

Coexistence of multivalent and monovalent TCRs explains high sensitivity and wide range of response

1 reference

7 January 2021

'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR.

1 reference

7 January 2021

T cell activation determined by T cell receptor number and tunable thresholds.

1 reference

7 January 2021

Different responses are elicited in cytotoxic T lymphocytes by different levels of T cell receptor occupancy.

1 reference

7 January 2021

Antigen-specific release of beta-chemokines by anti-HIV-1 cytotoxic T lymphocytes

1 reference

7 January 2021

T-cell quality in memory and protection: implications for vaccine design

1 reference

7 January 2021

Spatial and temporal dynamics of T cell receptor signaling with a photoactivatable agonist

1 reference

7 January 2021

Avidity of CD8 T cells sharpens immunodominance

1 reference

7 January 2021

Avidity for antigen shapes clonal dominance in CD8+ T cell populations specific for persistent DNA viruses

1 reference

7 January 2021

Replicative senescence of T cells: does the Hayflick Limit lead to immune exhaustion?

1 reference

7 January 2021

Selective depletion of high-avidity human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T cells after early HIV-1 infection

1 reference

7 January 2021

Continuous recruitment of naive T cells contributes to heterogeneity of antiviral CD8 T cells during persistent infection.

1 reference

7 January 2021

T Cell Receptor Recognition Motifs Govern Immune Escape Patterns in Acute SIV Infection

1 reference

7 January 2021

A viral CTL escape mutation leading to immunoglobulin-like transcript 4-mediated functional inhibition of myelomonocytic cells

1 reference

7 January 2021

The T cell repertoire in infection and vaccination: implications for control of persistent viruses

1 reference

7 January 2021

T cell dynamics in HIV-1 infection

1 reference

7 January 2021

Changes in thymic function with age and during the treatment of HIV infection

1 reference

7 January 2021

HIV infection rapidly induces and maintains a substantial suppression of thymocyte proliferation.

1 reference

7 January 2021

Insufficient production and tissue delivery of CD4+ memory T cells in rapidly progressive simian immunodeficiency virus infection.

1 reference

7 January 2021

Preserved CD4+ central memory T cells and survival in vaccinated SIV-challenged monkeys

1 reference

7 January 2021

Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes

1 reference

7 January 2021

Cancer regression in patients after transfer of genetically engineered lymphocytes

1 reference

7 January 2021

Cutting edge: CD8+ T cell clones possess the potential to differentiate into both high- and low-avidity effector cells

1 reference

7 January 2021

Quiescent phenotype of tumor-specific CD8+ T cells following immunization

1 reference

7 January 2021

Secondary immunisation with high-dose heterologous peptide leads to CD8 T cell populations with reduced functional avidity

1 reference

7 January 2021

Prime-boost immunization generates a high frequency, high-avidity CD8(+) cytotoxic T lymphocyte population

1 reference

7 January 2021

Human T-lymphocyte cytotoxicity and proliferation directed by a single chimeric TCRζ /CD28 receptor

1 reference

7 January 2021

In vivo induction of a high-avidity, high-frequency cytotoxic T-lymphocyte response is associated with antiviral protective immunity

1 reference

7 January 2021

Cooperation between CD4+ and CD8+ T cells: when, where, and how.

1 reference

7 January 2021

HIV preferentially infects HIV-specific CD4+ T cells

1 reference

7 January 2021

Amplification of tumor-specific regulatory T cells following therapeutic cancer vaccines

1 reference

7 January 2021

Effector and memory CTL differentiation

1 reference

7 January 2021

Toll-like receptor agonists influence the magnitude and quality of memory T cell responses after prime-boost immunization in nonhuman primates

1 reference

7 January 2021

The microbial mimic poly IC induces durable and protective CD4+ T cell immunity together with a dendritic cell targeted vaccine

1 reference

7 January 2021

Multifunctional human immunodeficiency virus (HIV) gag-specific CD8+ T-cell responses in rectal mucosa and peripheral blood mononuclear cells during chronic HIV type 1 infection.

1 reference

7 January 2021

New generation vaccine induces effective melanoma-specific CD8+ T cells in the circulation but not in the tumor site

1 reference

7 January 2021

CD8+ T-cell responses to different HIV proteins have discordant associations with viral load

1 reference

7 January 2021

Subdominant CD8+ T-cell responses are involved in durable control of AIDS virus replication

1 reference

7 January 2021

Decreased specific CD8+ T cell cross-reactivity of antigen recognition following vaccination with Melan-A peptide

1 reference

7 January 2021

Diversity and recognition efficiency of T cell responses to cancer

1 reference

7 January 2021

Unmodified self antigen triggers human CD8 T cells with stronger tumor reactivity than altered antigen

1 reference

7 January 2021

Characterization of functional and phenotypic changes in anti-Gag vaccine-induced T cell responses and their role in protection after HIV-1 infection

1 reference

7 January 2021

An HIV-1 clade C DNA prime, NYVAC boost vaccine regimen induces reliable, polyfunctional, and long-lasting T cell responses

1 reference

7 January 2021

Identifiers

DOI

10.1038/NM.F.1774

1 reference

18 August 2017

1 reference

PubMed ID

18535580