(Q37194952)

English

A Toxoplasma dense granule protein, GRA24, modulates the early immune response to infection by promoting a direct and sustained host p38 MAPK activation.

scientific article published on 16 September 2013

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scholarly article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24043761%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

A Toxoplasma dense granule protein, GRA24, modulates the early immune response to infection by promoting a direct and sustained host p38 MAPK activation (English)

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22 February 2020

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22 February 2020

Isabelle Tardieux

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22 February 2020

Alexandre Bougdour

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22 February 2020

Mohamed-Ali Hakimi

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22 February 2020

Marie-Pierre Brenier-Pinchart

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Marie-Pierre Brenier-Pinchart

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22 February 2020

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Hervé Pelloux

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22 February 2020

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Laurence Braun

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22 February 2020

Manickam Yogavel

3

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22 February 2020

Aurélie Curt-Varesano

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22 February 2020

Rose-Laurence Curt-Bertini

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22 February 2020

Tahir Hussain

6

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22 February 2020

Sylvie Kieffer-Jaquinod

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22 February 2020

Amit Sharma

11

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22 February 2020

Hassan Belrhali

12

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22 February 2020

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16 September 2013

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22 February 2020

Journal of Experimental Medicine

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22 February 2020

210

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22 February 2020

10

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22 February 2020

2071-2086

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22 February 2020

Host cell subversion by Toxoplasma GRA16, an exported dense granule protein that targets the host cell nucleus and alters gene expression.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782045

6 September 2017

Modulation of innate immunity by Toxoplasma gondii virulence effectors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782045

6 September 2017

Specificity of linear motifs that bind to a common mitogen-activated protein kinase docking groove

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782045

6 September 2017

Admixture and recombination among Toxoplasma gondii lineages explain global genome diversity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782045

6 September 2017

NK cell-derived interferon-γ orchestrates cellular dynamics and the differentiation of monocytes into dendritic cells at the site of infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782045

6 September 2017

Generalized Lévy walks and the role of chemokines in migration of effector CD8+ T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782045

6 September 2017

Comparative genomics of the apicomplexan parasites Toxoplasma gondii and Neospora caninum: Coccidia differing in host range and transmission strategy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782045

6 September 2017

A distinct interaction mode revealed by the crystal structure of the kinase p38α with the MAPK binding domain of the phosphatase MKP5

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782045

6 September 2017

Immediate-early gene activation by the MAPK pathways: what do and don't we know?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782045

6 September 2017

Manipulation of kinase signaling by bacterial pathogens

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782045

6 September 2017

Structural basis of p38α regulation by hematopoietic tyrosine phosphatase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782045

6 September 2017

Toxoplasma gondii rhoptry kinase ROP16 activates STAT3 and STAT6 resulting in cytokine inhibition and arginase-1-dependent growth control

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782045

6 September 2017

Toxoplasma gondii effectors are master regulators of the inflammatory response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782045

6 September 2017

CD8α(+) dendritic cells are the critical source of interleukin-12 that controls acute infection by Toxoplasma gondii tachyzoites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782045

6 September 2017

The IRG protein-based resistance mechanism in mice and its relation to virulence in Toxoplasma gondii

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782045

6 September 2017

Toxoplasma polymorphic effectors determine macrophage polarization and intestinal inflammation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782045

6 September 2017

Type II Toxoplasma gondii KU80 knockout strains enable functional analysis of genes required for cyst development and latent infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782045

6 September 2017

Serum response factor regulates immediate early host gene expression in Toxoplasma gondii-infected host cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782045

6 September 2017

Strain-specific activation of the NF-kappaB pathway by GRA15, a novel Toxoplasma gondii dense granule protein.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782045

6 September 2017

Mechanisms and functions of p38 MAPK signalling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782045

6 September 2017

Features and development of Coot

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782045

6 September 2017

Whole genome analysis of p38 SAPK-mediated gene expression upon stress.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782045

6 September 2017

A single polymorphic amino acid on Toxoplasma gondii kinase ROP16 determines the direct and strain-specific activation of Stat3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782045

6 September 2017

p38(MAPK): stress responses from molecular mechanisms to therapeutics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782045

6 September 2017

Drug inhibition of HDAC3 and epigenetic control of differentiation in Apicomplexa parasites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782045

6 September 2017

Tagging of endogenous genes in a Toxoplasma gondii strain lacking Ku80

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782045

6 September 2017

Hijacking of host cellular functions by the Apicomplexa.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782045

6 September 2017

Gr1(+) inflammatory monocytes are required for mucosal resistance to the pathogen Toxoplasma gondii

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782045

6 September 2017

The complexity of mitogen-activated protein kinases (MAPKs) made simple

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782045

6 September 2017

Modulation of the host cell proteome by the intracellular apicomplexan parasite Toxoplasma gondii

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782045

6 September 2017

The Toxoplasma gondii parasitophorous vacuole membrane: transactions across the border

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782045

6 September 2017

Toxoplasma co-opts host gene expression by injection of a polymorphic kinase homologue

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782045

6 September 2017

The many paths to p38 mitogen-activated protein kinase activation in the immune system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782045

6 September 2017

Genetic analysis of host resistance to intracellular pathogens: lessons from studies of Toxoplasma gondii infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782045

6 September 2017

TAB-1 modulates intracellular localization of p38 MAP kinase and downstream signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782045

6 September 2017

The role of docking interactions in mediating signaling input, output, and discrimination in the yeast MAPK network

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782045

6 September 2017

Recruitment of Gr-1+ monocytes is essential for control of acute toxoplasmosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782045

6 September 2017

Alternative p38 activation pathway mediated by T cell receptor-proximal tyrosine kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782045

6 September 2017

What turns CREB on?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782045

6 September 2017

Mechanism of p38 MAP kinase activation in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782045

6 September 2017

Induction and regulation of IL-12-dependent host resistance to Toxoplasma gondii

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782045

6 September 2017

Crystal structures of MAP kinase p38 complexed to the docking sites on its nuclear substrate MEF2A and activator MKK3b

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782045

6 September 2017

MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782045

6 September 2017

cAMP-response-element-binding-protein-binding protein (CBP) and p300 are transcriptional co-activators of early growth response factor-1 (Egr-1)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782045

6 September 2017

Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782045

6 September 2017

Factor binding and chromatin modification in the promoter of murine Egr1 gene upon induction

1 reference

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14 September 2017

Toxoplasma gondii rhoptry discharge correlates with activation of the early growth response 2 host cell transcription factor

1 reference

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14 September 2017

Acquisition of sensitivity of stress-activated protein kinases to the p38 inhibitor, SB 203580, by alteration of one or more amino acids within the ATP binding pocket

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782045

26 June 2018

Microarray analysis reveals previously unknown changes in Toxoplasma gondii-infected human cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782045

3 September 2018

Parasite-induced IL-12 stimulates early IFN-gamma synthesis and resistance during acute infection with Toxoplasma gondii.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782045

3 September 2018

In the absence of endogenous IFN-gamma, mice develop unimpaired IL-12 responses to Toxoplasma gondii while failing to control acute infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/24043761

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p38 MAPK autophosphorylation drives macrophage IL-12 production during intracellular infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/24043761

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Docking interactions induce exposure of activation loop in the MAP kinase ERK2

1 reference

https://pubmed.ncbi.nlm.nih.gov/24043761

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Host cell Ca2+ and protein kinase C regulate innate recognition of Toxoplasma gondii.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24043761

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structures of p38alpha active mutants reveal conformational changes in L16 loop that induce autophosphorylation and activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/24043761

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IP-10 is critical for effector T cell trafficking and host survival in Toxoplasma gondii infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/24043761

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1084/JEM.20130103

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24043761%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

PMC publication ID

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24043761%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24043761%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

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