(Q37210934)

English

The discovery of drugs for obesity, the metabolic effects of leptin and variable receptor pharmacology: perspectives from beta3-adrenoceptor agonists

scientific article published on 09 July 2008

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scholarly article

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Europe PubMed Central

PubMed publication ID

19 August 2017

1 reference

Europe PubMed Central

The discovery of drugs for obesity, the metabolic effects of leptin and variable receptor pharmacology: perspectives from beta3-adrenoceptor agonists (English)

1 reference

Europe PubMed Central

PubMed publication ID

19 August 2017

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1 reference

based on heuristic

inferred from title

author name string

Jonathan R S Arch

1

1 reference

Europe PubMed Central

PubMed publication ID

19 August 2017

publication date

9 July 2008

1 reference

Europe PubMed Central

PubMed publication ID

19 August 2017

Naunyn-Schmiedeberg's Archives of Pharmacology

1 reference

Europe PubMed Central

PubMed publication ID

19 August 2017

378

1 reference

Europe PubMed Central

PubMed publication ID

19 August 2017

2

1 reference

Europe PubMed Central

PubMed publication ID

19 August 2017

225-240

1 reference

Europe PubMed Central

PubMed publication ID

19 August 2017

https://scigraph.springernature.com/pub.10.1007/s00210-008-0271-1

0 references

In situ assessment of the role of the beta 1-, beta 2- and beta 3-adrenoceptors in the control of lipolysis and nutritive blood flow in human subcutaneous adipose tissue

1 reference

https://api.crossref.org/works/10.1007%2FS00210-008-0271-1

21 January 2018

Respective degree of expression of beta 1-, beta 2- and beta 3-adrenoceptors in human brown and white adipose tissues

1 reference

https://api.crossref.org/works/10.1007%2FS00210-008-0271-1

21 January 2018

Chemical sympathectomy alters regulation of body weight during prolonged ICV leptin infusion

1 reference

https://api.crossref.org/works/10.1007%2FS00210-008-0271-1

21 January 2018

The Effect of PPARalpha, PPARdelta, PPARgamma, and PPARpan Agonists on Body Weight, Body Mass, and Serum Lipid Profiles in Diet-Induced Obese AKR/J Mice

1 reference

https://api.crossref.org/works/10.1007%2FS00210-008-0271-1

21 January 2018

Effect of beta1- and beta2-adrenergic stimulation on energy expenditure, substrate oxidation, and UCP3 expression in humans

1 reference

https://api.crossref.org/works/10.1007%2FS00210-008-0271-1

21 January 2018

Reactivation of brown adipose tissue

1 reference

https://api.crossref.org/works/10.1007%2FS00210-008-0271-1

21 January 2018

Aspartate138 is required for the high-affinity ligand binding site but not for the low-affinity binding site of the beta1-adrenoceptor

1 reference

https://api.crossref.org/works/10.1007%2FS00210-008-0271-1

21 January 2018

Differences between the third cardiac beta-adrenoceptor and the colonic beta 3-adrenoceptor in the rat.

1 reference

https://api.crossref.org/works/10.1007%2FS00210-008-0271-1

21 January 2018

Meta-analysis: pharmacologic treatment of obesity

1 reference

https://api.crossref.org/works/10.1007%2FS00210-008-0271-1

21 January 2018

Central leptin increases insulin sensitivity in streptozotocin-induced diabetic rats

1 reference

https://api.crossref.org/works/10.1007%2FS00210-008-0271-1

21 January 2018

Mediation of the positive chronotropic effect of CGP 12177 and cyanopindolol in the pithed rat by atypical beta-adrenoceptors, different from beta 3-adrenoceptors

1 reference

https://api.crossref.org/works/10.1007%2FS00210-008-0271-1

21 January 2018

Fatty acid oxidation and triacylglycerol hydrolysis are enhanced after chronic leptin treatment in rats

1 reference

https://api.crossref.org/works/10.1007%2FS00210-008-0271-1

21 January 2018

Beta-adrenoceptor polymorphisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta(3)-Adrenoceptor agonists: potential, pitfalls and progress

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of sibutramine on weight maintenance after weight loss: a randomised trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Is visceral fat involved in the pathogenesis of the metabolic syndrome? Human model

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment of obesity with thermogenic beta-adrenoceptor agonists: studies on BRL 26830A in rodents

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Leptin increases energy expenditure and selectively promotes fat metabolism in ob/ob mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lower-body fat mass as an independent marker of insulin sensitivity--the role of adiponectin

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of cannabinoid receptors on skeletal muscle oxidative pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of food restriction on body composition of hereditary obese mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dobutamine as selective beta(1)-adrenoceptor agonist in in vivo studies on human thermogenesis and lipid utilization

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sibutramine and fat distribution: is there a role for pharmacotherapy in abdominal/visceral fat reduction?

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The link between abdominal obesity, metabolic syndrome and cardiovascular disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracerebroventricular administration of leptin markedly enhances insulin sensitivity and systemic glucose utilization in conscious rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracerebroventricular injection of leptin increases thermogenesis and mobilizes fat metabolism in ob/ob mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11 beta-hydroxysteroid dehydrogenase type 1-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peroxisome-Proliferator-Activated Receptor δ Activates Fat Metabolism to Prevent Obesity

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discovery of an orally bioavailable alkyl oxadiazole beta3 adrenergic receptor agonist

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stimulation of the beta3-Adrenoceptor as a novel treatment strategy for anxiety and depressive disorders.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Screening of drugs for thermogenic anti-obesity properties: antidepressants

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic antidiabetic and cardiovascular actions of leptin: role of CNS and increased adrenergic activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of moderate weight loss and orlistat on insulin resistance, regional adiposity, and fatty acids in type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Are pre-obese people energy thrifty?

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta1-adrenergic receptors mediate beta3-adrenergic-independent effects of CGP 12177 in brown adipose tissue

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Opposite effects of insulin-like molecules and leptin in coronary heart disease of type 2 diabetes Preliminary data

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 for the treatment of metabolic syndrome.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Weight reduction and the impaired plasma-derived free fatty acid oxidation in type 2 diabetic subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physiological response to long-term peripheral and central leptin infusion in lean and obese mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lower body subcutaneous fat accumulation and diabetes mellitus risk

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thermogenic drugs for the treatment of obesity: screening using obese rats and mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic central leptin infusion restores hyperglycemia independent of food intake and insulin level in streptozotocin-induced diabetic rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adiponectin and adiponectin receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thermogenic and anorectic effects of ephedrine and congeners in mice and rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ligand-directed signaling at the beta3-adrenoceptor produced by 3-(2-Ethylphenoxy)-1-[(1,S)-1,2,3,4-tetrahydronapth-1-ylamino]-2S-2-propanol oxalate (SR59230A) relative to receptor agonists.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular characterization of the human beta 3-adrenergic receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comment on: Schmidt MI, Duncan BB, Vigo A et al (2006) Leptin and incident type 2 diabetes: risk or protection? Diabetologia 49:2086-2096.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The direct effect of leptin on skeletal muscle thermogenesis is mediated by substrate cycling between de novo lipogenesis and lipid oxidation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intact sympathetic nervous system is required for leptin effects on resting metabolic rate in people with spinal cord injury.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

(-)-CGP 12177 causes cardiostimulation and binds to cardiac putative beta 4-adrenoceptors in both wild-type and beta 3-adrenoceptor knockout mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Atypical β-adrenoceptor on brown adipocytes as target for anti-obesity drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stereochemical aspects of β-adrenoceptor antagonist-receptor interaction in adipocytes. Differentiation of β-adrenoceptors in human and rat adipocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of agonist efficacy and receptor phosphorylation on antagonist affinity measurements: differences between second messenger and reporter gene responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of thermoregulatory thermogenesis in the development of obesity in genetically-obese (ob/ob) mice pair-fed with lean siblings

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired capacity to lose visceral adipose tissue during weight reduction in obese postmenopausal women with the Trp64Arg beta3-adrenoceptor gene variant

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of guanine, inosine, and xanthine nucleotides on beta(2)-adrenergic receptor/G(s) interactions: evidence for multiple receptor conformations

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A mutation of the b3-adrenergic receptor is associated with visceral obesity but decreased serum triglyceride

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of acyl-CoA:diacylglycerol acyltransferase (DGAT) in energy metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Efficacy and safety of the weight-loss drug rimonabant: a meta-analysis of randomised trials

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Is there a third heart beta-adrenoceptor?

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Agonist potency at the cloned human beta-3 adrenoceptor depends on receptor expression level and nature of assay

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of leptin on energy metabolism in beta-less mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The contribution of classical (beta1/2-) and atypical beta-adrenoceptors to the stimulation of human white adipocyte lipolysis and right atrial appendage contraction by novel beta3-adrenoceptor agonists of differing selectivities

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of sibutramine on abdominal fat mass, insulin resistance and blood pressure in obese hypertensive patients.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Leptin rapidly lowers food intake and elevates metabolic rates in lean and ob/ob mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BVT.3531 reduces body weight and activates K(ATP) channels in isolated arcuate neurons in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Weight loss in obese subjects on a restricted diet given BRL 26830A, a new atypical beta adrenoceptor agonist

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of triglyceride synthesis as a treatment strategy for obesity: lessons from DGAT1-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long term pharmacotherapy for obesity and overweight: updated meta-analysis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta3-adrenoceptor agonist prevents alterations of muscle diacylglycerol and adipose tissue phospholipids induced by a cafeteria diet

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of (R)-2-(2-aminothiazol-4-yl)-4'-{2-[(2-hydroxy-2-phenylethyl)amino]ethyl} acetanilide (YM178), a novel selective beta3-adrenoceptor agonist, on bladder function

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of calorie restriction with or without exercise on body composition and fat distribution

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Is the beta3-adrenoceptor (ADRB3) a potential target for uterorelaxant drugs?

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 reduces food intake and weight gain but maintains energy expenditure in diet-induced obese mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Some mathematical and technical issues in the measurement and interpretation of open-circuit indirect calorimetry in small animals

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determinants of 24-hour energy expenditure in man. Methods and results using a respiratory chamber

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of an increased free fatty acid concentration on thermogenesis and substrate oxidation in obese and lean men

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ephedrine reduces weight of viable yellow obese mice (Avy/a).

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term weight loss maintenance

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional Selectivity and Classical Concepts of Quantitative Pharmacology

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epinephrine activates both Gs and Gi pathways, but norepinephrine activates only the Gs pathway through human beta2-adrenoceptors overexpressed in mouse heart

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thermogenic and metabolic antiobesity drugs: rationale and opportunities

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Agonist and inverse agonist actions of beta-blockers at the human beta 2-adrenoceptor provide evidence for agonist-directed signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Energy metabolism in weight-stable postobese individuals

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucose and fat metabolism in adipose tissue of acetyl-CoA carboxylase 2 knockout mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Site of action of beta-ligands at the human beta1-adrenoceptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipolytic effects of conventional beta 3-adrenoceptor agonists and of CGP 12,177 in rat and human fat cells: preliminary pharmacological evidence for a putative beta 4-adrenoceptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distinct signaling profiles of beta1 and beta2 adrenergic receptor ligands toward adenylyl cyclase and mitogen-activated protein kinase reveals the pluridimensionality of efficacy

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of Chronic β-Receptor Stimulation on Sympathetic Nervous System Activity, Energy Expenditure, and Thyroid Hormones*

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thermogenic drugs for the treatment of obesity: sympathetic stimulants in animal models

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective inhibition of 11 beta-hydroxysteroid dehydrogenase type 1 improves hepatic insulin sensitivity in hyperglycemic mice strains

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of BRL 35135, a beta-adrenoceptor agonist with novel selectivity, on glucose tolerance and insulin sensitivity in obese subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DGAT inhibitors for obesity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta3-adrenergic agonists: potential therapeutics for obesity

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

11beta-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Site-directed mutagenesis of the human beta3-adrenoceptor--transmembrane residues involved in ligand binding and signal transduction

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Monogenic human obesity syndromes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of leptin in fat regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Changes in fat-free mass during significant weight loss: a systematic review

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular characterization of the mouse beta 3-adrenergic receptor: relationship with the atypical receptor of adipocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exaggerated claim about adaptive thermogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of leptin on insulin sensitivity in normal rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

β3-Adrenergic Receptors on White and Brown Adipocytes Mediate β3-Selective Agonist-induced Effects on Energy Expenditure, Insulin Secretion, and Food Intake

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acetyl-CoA carboxylase 2 mutant mice are protected against obesity and diabetes induced by high-fat/high-carbohydrate diets

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of the obese gene product on body weight regulation in ob/ob mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isozyme-nonselective N-substituted bipiperidylcarboxamide acetyl-CoA carboxylase inhibitors reduce tissue malonyl-CoA concentrations, inhibit fatty acid synthesis, and increase fatty acid oxidation in cultured cells and in experimental animals

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stereoselective action of (R*,R*)-(+/-)-methyl-4-[2-[2-hydroxy-2-(3-chlorophenyl)ethylamino] propyl]-phenoxyacetic acid (BRL37344) on beta-adrenoceptors and metabolic chiral inversion

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolic effects of three weeks administration of the beta-adrenoceptor agonist BRL 26830A

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ephedrine, a thermogenic and potential slimming drug

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The promise of beta3-adrenoceptor agonists to treat the overactive bladder

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An adipose tissue-specific beta-adrenergic receptor. Molecular cloning and down-regulation in obesity

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetically obese C57BL/6 ob/ob mice respond normally to sympathomimetic compounds

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relative importance of sympathetic outflow and insulin in the reactivation of brown adipose tissue lipogenesis in rats adapted to a high-protein diet.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Agonist effects of zinterol at the mouse and human beta(3)-adrenoceptor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association of BMI with the beta3-adrenergic receptor gene polymorphism in Japanese: meta-analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preferential loss of visceral fat following aerobic exercise, measured by magnetic resonance imaging

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha1-, alpha2- and beta-adrenoceptors in the urinary bladder, urethra and prostate

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of resting energy expenditure from fat-free mass and fat mass

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta 3 and atypical beta-adrenoceptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stimulation of the extracellular signal-regulated kinase 1/2 pathway by human beta-3 adrenergic receptor: new pharmacological profile and mechanism of activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Validation of diacyl glycerolacyltransferase I as a novel target for the treatment of obesity and dyslipidemia using a potent and selective small molecule inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of a new, highly specific, beta 3-adrenergic receptor radioligand, [3H]SB 206606

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[D-LEU-4]-OB3, a synthetic leptin agonist, improves hyperglycemic control in C57BL/6J ob/ob mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased food intake does not completely account for adiposity reduction after ob protein infusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Improved glucose tolerance in acyl CoA:diacylglycerol acyltransferase 1-null mice is dependent on diet

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Unexpected evidence for active brown adipose tissue in adult humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Four beta-adrenoceptor subtypes in the mammalian heart

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and SAR of benzyl and phenoxymethylene oxadiazole benzenesulfonamides as selective beta3 adrenergic receptor agonist antiobesity agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Agonist actions of "beta-blockers" provide evidence for two agonist activation sites or conformations of the human beta1-adrenoceptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differentiation of β-adrenoceptors in right atrium, diaphragm and adipose tissue of the rat, using stereoisomers of propranolol, alprenolol, nifenalol and practolol

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Failure to increase lipid oxidation in response to increasing dietary fat content in formerly obese women.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Further evidence for differences between cardiac atypical beta-adrenoceptors and brown adipose tissue beta3-adrenoceptors in the pithed rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular cloning and expression of the rat beta 3-adrenergic receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple GPCR conformations and signalling pathways: implications for antagonist affinity estimates.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stimulation by leptin of 3H GDP binding to brown adipose tissue of fasted but not fed rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of lipolysis reduces beta1-adrenoceptor-mediated thermogenesis in man

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The contribution of increased thermogenesis to the effect of anorectic drugs on body composition in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acute effect of L-796568, a novel beta 3-adrenergic receptor agonist, on energy expenditure in obese men.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acute hyperleptinemia does not modify insulin sensitivity in vivo in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo beta3-adrenergic stimulation of human thermogenesis and lipid use

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tools to study beta3-adrenoceptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of leptin deficiency on metabolic rate in ob/ob mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic leptin administration increases insulin-stimulated skeletal muscle glucose uptake and transport

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for a secondary state of the human beta3-adrenoceptor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of CB1 antagonist on the control of metabolic functions in obese type 2 diabetic patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Body size and shape changes and the risk of diabetes in the diabetes prevention program

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increase in insulin action and fat oxidation after treatment with CL 316,243, a highly selective beta3-adrenoceptor agonist in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of diet and exercise for the maintenance of fat-free mass and resting metabolic rate during weight loss

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Leptin and incident type 2 diabetes: risk or protection?

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta(1)- and beta(2)-Adrenoceptor-mediated thermogenesis and lipid utilization in obese and lean men.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Substrate supply for thermogenesis induced by the beta-adrenoceptor agonist BRL 26830A

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The impact of fatty acid oxidation on energy utilization: targets and therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased 24-h energy expenditure in type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The rat lipolytic β-adrenoceptor: Studies using novel β-adrenoceptor agonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of a 28-d treatment with L-796568, a novel beta(3)-adrenergic receptor agonist, on energy expenditure and body composition in obese men.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thermogenic and antiobesity activity of a novel beta-adrenoceptor agonist (BRL 26830A) in mice and rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracerebroventricular leptin increases lumbar and renal sympathetic nerve activity and blood pressure in normal rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta3 receptors mediate relaxation in stomach fundus whereas a fourth beta receptor mediates tachycardia in atria from transgenic beta3 receptor knockout mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effects of drugs used to treat obesity on the autonomic nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of three radioligands for the labelling of human beta-adrenoceptor subtypes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Leptin effect in ob/ob mice under thermoneutral conditions depends not necessarily on central satiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abolition of (-)-CGP 12177-evoked cardiostimulation in double beta1/beta2-adrenoceptor knockout mice. Obligatory role of beta1-adrenoceptors for putative beta4-adrenoceptor pharmacology

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Do beta 3-adrenoceptors mediate metabolic responses to isoprenaline

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rimonabant for overweight or obesity

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Low ratio of fat to carbohydrate oxidation as predictor of weight gain: study of 24-h RQ.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-adrenoceptor studies. III. On the beta-adrenoceptors in rat adipose tissue.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic leptin administration promotes lipid utilization until fat mass is greatly reduced and preserves lean mass of normal female rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

β-adrenoceptor studies. 6. Further investigations on the hybrid nature of the rat adipocyte β-adrenoceptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lack of responses to a beta3-adrenergic agonist in lipoatrophic A-ZIP/F-1 mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effects of both noradrenaline and CGP12177, mediated through human beta1 -adrenoceptors, are reduced by PDE3 in human atrium but PDE4 in CHO cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Muscles of diabetic (db/db) mice: fibre size, fibre type and the effects of a thermogenic, beta-adrenoceptor agonist

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Leptin potentiates thermogenic sympathetic responses to hypothermia: a receptor-mediated effect.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Binding of (-)-[3H]-CGP12177 at two sites in recombinant human beta 1-adrenoceptors and interaction with beta-blockers

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta 3-adrenoceptors and intestinal motility

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of intravenously infused leptin on insulin sensitivity and on the expression of uncoupling proteins in brown adipose tissue

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Meta-analysis of the association of the Trp64Arg polymorphism in the beta3 adrenergic receptor with insulin resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for pleiotropic signaling at the mouse beta3-adrenoceptor revealed by SR59230A [3-(2-Ethylphenoxy)-1-[(1,S)-1,2,3,4-tetrahydronapth-1-ylamino]-2S-2-propanol oxalate].

1 reference

https://pubmed.ncbi.nlm.nih.gov/18612674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00210-008-0271-1

1 reference

Europe PubMed Central

PubMed publication ID

19 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

19 August 2017

Sitelinks

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