(Q37211125)

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IL-4 confers resistance to IL-27-mediated suppression on CD4+ T cells by impairing signal transducer and activator of transcription 1 signaling

scientific article published on 16 August 2013

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scholarly article

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Europe PubMed Central

PMC publication ID

19 August 2017

IL-4 confers resistance to IL-27-mediated suppression on CD4+ T cells by impairing signal transducer and activator of transcription 1 signaling (English)

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

author name string

Zhihong Chen

1

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Shanze Wang

2

1 reference

Europe PubMed Central

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19 August 2017

Nkiruka Erekosima

3

1 reference

Europe PubMed Central

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19 August 2017

Yapeng Li

4

1 reference

Europe PubMed Central

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19 August 2017

Jessie Hong

5

1 reference

Europe PubMed Central

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19 August 2017

Xiaopeng Qi

6

1 reference

Europe PubMed Central

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19 August 2017

Patricia Merkel

7

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Vijaya Nagabhushanam

8

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Eugene Choo

9

1 reference

Europe PubMed Central

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19 August 2017

Rohit Katial

10

1 reference

Europe PubMed Central

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19 August 2017

Rafeul Alam

11

1 reference

Europe PubMed Central

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19 August 2017

Anita Trikha

12

1 reference

Europe PubMed Central

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19 August 2017

Hong Wei Chu

13

1 reference

Europe PubMed Central

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19 August 2017

Yonghua Zhuang

14

1 reference

Europe PubMed Central

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19 August 2017

Meiling Jin

15

1 reference

Europe PubMed Central

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19 August 2017

Chunxue Bai

16

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Europe PubMed Central

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19 August 2017

Hua Huang

17

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19 August 2017

language of work or name

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publication date

16 August 2013

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Europe PubMed Central

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19 August 2017

The Journal of Allergy and Clinical Immunology

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Europe PubMed Central

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19 August 2017

132

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Europe PubMed Central

PMC publication ID

19 August 2017

4

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Europe PubMed Central

PMC publication ID

19 August 2017

912-21.e1-5

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

The transcription factor T-bet is induced by multiple pathways and prevents an endogenous Th2 cell program during Th1 cell responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3788709

6 September 2017

Cytokine signaling: birth of a pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3788709

6 September 2017

Human atopic dermatitis complicated by eczema herpeticum is associated with abnormalities in IFN-γ response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3788709

6 September 2017

CCAAT/enhancer-binding protein alpha (C/EBPalpha) is critical for interleukin-4 expression in response to FcepsilonRI receptor cross-linking

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3788709

6 September 2017

Viruses and asthma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3788709

6 September 2017

IL-2 and IL-4 Stimulate MEK1 Expression and Contribute to T Cell Resistance against Suppression by TGF-β and IL-10 in Asthma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3788709

6 September 2017

Cutting edge: Type I IFN reverses human Th2 commitment and stability by suppressing GATA3

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3788709

6 September 2017

Signaling pathways that lead to the silencing of the interleukin-4-producing potential in Th1 cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3788709

6 September 2017

Human basophils and eosinophils are the direct target leukocytes of the novel IL-1 family member IL-33.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3788709

6 September 2017

TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3788709

6 September 2017

Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3788709

6 September 2017

T-bet regulates Th1 responses through essential effects on GATA-3 function rather than on IFNG gene acetylation and transcription

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3788709

6 September 2017

T-bet polymorphisms are associated with asthma and airway hyperresponsiveness

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3788709

6 September 2017

New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3788709

6 September 2017

IL-27 regulates IL-12 responsiveness of naive CD4+ T cells through Stat1-dependent and -independent mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3788709

6 September 2017

Suppressors of cytokine signaling and immunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3788709

6 September 2017

SOCS3 negatively regulates IL-6 signaling in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3788709

6 September 2017

Impaired response to interferon-alpha/beta and lethal viral disease in human STAT1 deficiency

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3788709

6 September 2017

SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3788709

6 September 2017

A novel transcription factor, T-bet, directs Th1 lineage commitment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3788709

6 September 2017

Respiratory viruses and asthma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3788709

6 September 2017

SOCS-3 is tyrosine phosphorylated in response to interleukin-2 and suppresses STAT5 phosphorylation and lymphocyte proliferation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3788709

6 September 2017

Detection of Mycoplasma pneumoniae in the airways of adults with chronic asthma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3788709

6 September 2017

Regulation of the interleukin (IL)-12R beta 2 subunit expression in developing T helper 1 (Th1) and Th2 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3788709

6 September 2017

In differentiated CD4+ T cells, interleukin 4 production is cytokine-autonomous, whereas interferon gamma production is cytokine-dependent

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3788709

6 September 2017

Reversibility of T helper 1 and 2 populations is lost after long-term stimulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3788709

6 September 2017

Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3788709

6 September 2017

Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3788709

6 September 2017

Memory and flexibility of cytokine gene expression as separable properties of human T(H)1 and T(H)2 lymphocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3788709

14 September 2017

Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3788709

28 September 2017

Impairment of mycobacterial but not viral immunity by a germline human STAT1 mutation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3788709

28 September 2017

Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3788709

28 September 2017

The transcription factor STAT3 is required for T helper 2 cell development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3788709

26 June 2018

Genome-wide profiling of interleukin-4 and STAT6 transcription factor regulation of human Th2 cell programming.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3788709

3 September 2018

A continuous T-bet expression is required to silence the interleukin-4-producing potential in T helper type 1 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3788709

3 September 2018

Cutting edge: IL-4 induces suppressor of cytokine signaling-3 expression in B cells by a mechanism dependent on activation of p38 MAPK.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3788709

3 September 2018

IFN-gamma suppresses STAT6 phosphorylation by inhibiting its recruitment to the IL-4 receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3788709

3 September 2018

The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3788709

3 September 2018

SOCS-3 regulates onset and maintenance of T(H)2-mediated allergic responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3788709

3 September 2018

Negative control of basophil expansion by IRF-2 critical for the regulation of Th1/Th2 balance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3788709

4 December 2018

Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet

1 reference

https://pubmed.ncbi.nlm.nih.gov/23958647

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GATA-3 suppresses Th1 development by downregulation of Stat4 and not through effects on IL-12Rbeta2 chain or T-bet

1 reference

https://pubmed.ncbi.nlm.nih.gov/23958647

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The IL-27 receptor (WSX-1) is an inhibitor of innate and adaptive elements of type 2 immunity

1 reference

https://pubmed.ncbi.nlm.nih.gov/23958647

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Combination IL-2 and IL-4 reduces glucocorticoid receptor-binding affinity and T cell response to glucocorticoids

1 reference

https://pubmed.ncbi.nlm.nih.gov/23958647

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multistage regulation of Th1-type immune responses by the transcription factor IRF-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/23958647

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interferon regulatory factor-1 is required for a T helper 1 immune response in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/23958647

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mice lacking the IFN-gamma receptor or fyn develop severe experimental autoimmune uveoretinitis characterized by different immune responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/23958647

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-27 induces Th1 differentiation via p38 MAPK/T-bet- and intercellular adhesion molecule-1/LFA-1/ERK1/2-dependent pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/23958647

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-27 controls the development of inducible regulatory T cells and Th17 cells via differential effects on STAT1

1 reference

https://pubmed.ncbi.nlm.nih.gov/23958647

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-27 suppresses Th2 cell development and Th2 cytokines production from polarized Th2 cells: a novel therapeutic way for Th2-mediated allergic inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/23958647

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23958647

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppressing allergic immune responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/23958647

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.JACI.2013.06.035

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

ResearchGate publication ID

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