(Q3721138)

Peptidase S1, PA clan

1 reference

Serine proteases, trypsin domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Serine proteases, trypsin family, histidine active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Serine proteases, trypsin family, serine active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

transcription corepressor activity

2 references

26 September 2017

Contributions to neutropenia from PFAAP5 (N4BP2L2), a novel protein mediating transcriptional repressor cooperation between Gfi1 and neutrophil elastase

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08246&geneProductId=UniProtKB:P08246

8 April 2019

Contributions to neutropenia from PFAAP5 (N4BP2L2), a novel protein mediating transcriptional repressor cooperation between Gfi1 and neutrophil elastase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246

1 reference

8 April 2019

Killing activity of neutrophils is mediated through activation of proteases by K+ flux

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246

Proteolytic cleavage and inactivation of alpha 2-plasmin inhibitor and C1 inactivator by human polymorphonuclear leukocyte elastase

endopeptidase activity

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246

8 April 2019

Proteolysis of human thrombin generates novel host defense peptides

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246

8 April 2019

Killing activity of neutrophils is mediated through activation of proteases by K+ flux

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246

5 references

8 April 2019

Disruption of CD40/CD40 ligand interaction with cleavage of CD40 on human gingival fibroblasts by human leukocyte elastase resulting in down-regulation of chemokine production

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246

8 April 2019

Proteolytic regulation of the urokinase receptor/CD87 on monocytic cells by neutrophil elastase and cathepsin G

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246

8 April 2019

Contributions to neutropenia from PFAAP5 (N4BP2L2), a novel protein mediating transcriptional repressor cooperation between Gfi1 and neutrophil elastase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246

8 April 2019

Discriminating between the activities of human neutrophil elastase and proteinase 3 using serpin-derived fluorogenic substrates

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246

8 April 2019

Neutrophil elastase cleaves the murine hemidesmosomal protein BP180/type XVII collagen and generates degradation products that modulate experimental bullous pemphigoid

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246

serine-type peptidase activity

IPI

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246

1 reference

8 April 2019

Neutrophil elastase enzymatically antagonizes the in vitro action of G-CSF: implications for the regulation of granulopoiesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246

serine-type endopeptidase activity

IPI

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246

transcription repressor complex

IBA

cell component

1 reference

8 April 2019

Contributions to neutropenia from PFAAP5 (N4BP2L2), a novel protein mediating transcriptional repressor cooperation between Gfi1 and neutrophil elastase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246

1 reference

8 April 2019

Killing activity of neutrophils is mediated through activation of proteases by K+ flux

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246

1 reference

8 April 2019

Discriminating between the activities of human neutrophil elastase and proteinase 3 using serpin-derived fluorogenic substrates

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246

azurophil granule lumen

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246

TAS

specific granule lumen

1 reference

8 April 2019

3 references

8 April 2019

Proteolysis of human thrombin generates novel host defense peptides

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246

8 April 2019

Human neutrophils secrete bioactive paucimannosidic proteins from azurophilic granules into pathogen-infected sputum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246

positive regulation of MAP kinase activity

1 reference

8 April 2019

Neutrophil elastase induces IL-8 synthesis by lung epithelial cells via the mitogen-activated protein kinase pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246

negative regulation of chemotaxis

1 reference

8 April 2019

Human leukocyte elastase and cathepsin G are specific inhibitors of C5a-dependent neutrophil enzyme release and chemotaxis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246

cellular calcium ion homeostasis

1 reference

8 April 2019

Human leukocyte elastase and cathepsin G are specific inhibitors of C5a-dependent neutrophil enzyme release and chemotaxis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246

extracellular matrix disassembly

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246

negative regulation of transcription by RNA polymerase II

TAS

1 reference

8 April 2019

Contributions to neutropenia from PFAAP5 (N4BP2L2), a novel protein mediating transcriptional repressor cooperation between Gfi1 and neutrophil elastase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246

defense response to fungus

IMP

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246

4 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08246&geneProductId=UniProtKB:P08246

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08246&geneProductId=UniProtKB:P08246

26 September 2017

Proteolysis of human thrombin generates novel host defense peptides

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08246&geneProductId=UniProtKB:P08246

26 September 2017

Killing activity of neutrophils is mediated through activation of proteases by K+ flux

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08246&geneProductId=UniProtKB:P08246

response to lipopolysaccharide

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246

positive regulation of immune response

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246

protein catabolic process

1 reference

8 April 2019

Attenuated kinin release from human neutrophil elastase-pretreated kininogens by tissue and plasma kallikreins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246

defense response to bacterium

1 reference

8 April 2019

The periplasmic serine protease inhibitor ecotin protects bacteria against neutrophil elastase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246

neutrophil-mediated killing of fungus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246

negative regulation of inflammatory response

1 reference

8 April 2019

Human leukocyte elastase and cathepsin G are specific inhibitors of C5a-dependent neutrophil enzyme release and chemotaxis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246

1 reference

8 April 2019

UVA light stimulates the production of cathepsin G and elastase-like enzymes by dermal fibroblasts: a possible contribution to the remodeling of elastotic areas in sun-damaged skin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246

positive regulation of smooth muscle cell proliferation

1 reference

8 April 2019

Human neutrophil-derived elastase induces airway smooth muscle cell proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246

leukocyte migration involved in inflammatory response

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246

positive regulation of leukocyte tethering or rolling

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246

antimicrobial humoral response

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246

TAS

neutrophil degranulation

1 reference

8 April 2019

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246

8 April 2019

Proteolysis of human thrombin generates novel host defense peptides

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246

8 April 2019

Killing activity of neutrophils is mediated through activation of proteases by K+ flux

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246

physically interacts with

IBA

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

6441

17 August 2016

1 reference

Open Targets Platform

retrieved

14 August 2023

https://platform.opentargets.org/drug/CHEMBL3617964

Gene Atlas image

PBB GE ELA2 206871 at fs.png
732 × 530; 8 KB

0 references

has part(s)

serine proteases, trypsin family, histidine active site

1 reference

serine proteases, trypsin domain

1 reference

Serine proteases, trypsin family, serine active site

1 reference

D08.811.277.656.300.760.560.500

Identifiers

MeSH descriptor ID

D019272

subject named as

Leukocyte Elastase

0 references

MeSH tree code

0 references

D08.811.277.656.959.350.560.500

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

28 October 2013

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

inferred by common MeSH mappings on source and on Wikidata

1 reference