(Q37214176)

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Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice.

scientific article published on 21 April 2009

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26 January 2020

Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice (English)

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26 January 2020

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26 January 2020

Melinda S. Yates

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Melinda S Yates

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26 January 2020

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Quynh T Tran

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26 January 2020

Patrick M Dolan

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26 January 2020

William O Osburn

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26 January 2020

Soona Shin

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26 January 2020

Colin C McCulloch

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26 January 2020

Jay B Silkworth

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26 January 2020

Keiko Taguchi

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26 January 2020

Masayuki Yamamoto

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26 January 2020

Charlotte R Williams

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26 January 2020

Michael B Sporn

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26 January 2020

Thomas R Sutter

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26 January 2020

Thomas W Kensler

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26 January 2020

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21 April 2009

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26 January 2020

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26 January 2020

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26 January 2020

6

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26 January 2020

1024-1031

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26 January 2020

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6 September 2017

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1 reference

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Prevention and treatment of experimental estrogen receptor-negative mammary carcinogenesis by the synthetic triterpenoid CDDO-methyl Ester and the rexinoid LG100268.

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Genetic or pharmacologic amplification of nrf2 signaling inhibits acute inflammatory liver injury in mice

1 reference

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6 September 2017

Triterpenoid CDDO-methyl ester inhibits the Janus-activated kinase-1 (JAK1)-->signal transducer and activator of transcription-3 (STAT3) pathway by direct inhibition of JAK1 and STAT3

1 reference

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6 September 2017

Preclinical evaluation of targeting the Nrf2 pathway by triterpenoids (CDDO-Im and CDDO-Me) for protection from LPS-induced inflammatory response and reactive oxygen species in human peripheral blood mononuclear cells and neutrophils

1 reference

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Energy balance and carcinogenesis: underlying pathways and targets for intervention

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6 September 2017

Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer.

1 reference

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6 September 2017

Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genes.

1 reference

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6 September 2017

Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer

1 reference

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6 September 2017

Identification of Nrf2-regulated genes induced by chemopreventive isothiocyanate PEITC by oligonucleotide microarray

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6 September 2017

Identification of novel transcriptional networks in response to treatment with the anticarcinogen 3H-1,2-dithiole-3-thione

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6 September 2017

Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress

1 reference

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6 September 2017

Nrf2-Keap1 defines a physiologically important stress response mechanism

1 reference

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6 September 2017

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1 reference

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6 September 2017

Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation

1 reference

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6 September 2017

Overweight, Obesity, and Mortality from Cancer in a Prospectively Studied Cohort of U.S. Adults

1 reference

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6 September 2017

Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival

1 reference

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6 September 2017

Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray

1 reference

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6 September 2017

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

1 reference

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6 September 2017

Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors

1 reference

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6 September 2017

Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice.

1 reference

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6 September 2017

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

1 reference

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6 September 2017

Role of transcription factor Nrf2 in the induction of hepatic phase 2 and antioxidative enzymes in vivo by the cancer chemoprotective agent, 3H-1, 2-dimethiole-3-thione

1 reference

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6 September 2017

Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

1 reference

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6 September 2017

High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes

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Cytoprotective role of Nrf2/Keap1 system in methylmercury toxicity

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1 reference

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12 December 2020

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10.1093/CARCIN/BGP100

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19386581%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

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26 January 2020

PubMed publication ID

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Europe PubMed Central

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26 January 2020

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