(Q37218585)

English

Peripheral lipopolysaccharide (LPS) challenge promotes microglial hyperactivity in aged mice that is associated with exaggerated induction of both pro-inflammatory IL-1beta and anti-inflammatory IL-10 cytokines

scientific article published on 12 September 2008

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Peripheral lipopolysaccharide (LPS) challenge promotes microglial hyperactivity in aged mice that is associated with exaggerated induction of both pro-inflammatory IL-1beta and anti-inflammatory IL-10 cytokines (English)

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

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lipopolysaccharide

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author name string

Christopher J Henry

1

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Yan Huang

2

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Angela M Wynne

3

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Jonathan P Godbout

4

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

publication date

12 September 2008

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Brain, Behavior, and Immunity

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

23

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

3

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

309-317

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Minocycline attenuates lipopolysaccharide (LPS)-induced neuroinflammation, sickness behavior, and anhedonia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2692986

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Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice.

1 reference

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1 reference

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Microglia biology in health and disease.

1 reference

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Neuroinflammation and disruption in working memory in aged mice after acute stimulation of the peripheral innate immune system

1 reference

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Brain-immune communication pathways

1 reference

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Exaggerated sickness behavior and brain proinflammatory cytokine expression in aged mice in response to intracerebroventricular lipopolysaccharide

1 reference

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Isolation of murine microglial cells for RNA analysis or flow cytometry

1 reference

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6 September 2017

Minocycline down-regulates MHC II expression in microglia and macrophages through inhibition of IRF-1 and protein kinase C (PKC)alpha/betaII

1 reference

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6 September 2017

Aging sensitizes mice to behavioral deficits induced by central HIV-1 gp120

1 reference

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Age and neuroinflammation: a lifetime of psychoneuroimmune consequences

1 reference

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Understanding and exploiting the endogenous interleukin-10/STAT3-mediated anti-inflammatory response

1 reference

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Interleukin-1 and neuronal injury

1 reference

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6 September 2017

mRNA up-regulation of MHC II and pivotal pro-inflammatory genes in normal brain aging

1 reference

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Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo

1 reference

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1 reference

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6 September 2017

Expression of indoleamine 2,3-dioxygenase and production of quinolinic acid by human microglia, astrocytes, and neurons

1 reference

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6 September 2017

Cytokine-induced sickness behavior.

1 reference

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6 September 2017

The impact of systemic infection on the progression of neurodegenerative disease.

1 reference

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6 September 2017

Innate immunity: the missing link in neuroprotection and neurodegeneration?

1 reference

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6 September 2017

An age-related decline in interleukin-10 may contribute to the increased expression of interleukin-6 in brain of aged mice

1 reference

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6 September 2017

Interleukin (IL)-10 inhibits IL-6 production in microglia by preventing activation of NF-kappaB.

1 reference

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6 September 2017

Lipopolysaccharide-induced transcriptional activation of interleukin-10 is mediated by MAPK- and NF-kappaB-induced CCAAT/enhancer-binding protein delta in mouse macrophages

1 reference

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14 September 2017

Macrosialin increases during normal brain aging are attenuated by caloric restriction.

1 reference

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14 September 2017

NF-kappaB- and C/EBPbeta-driven interleukin-1beta gene expression and PAK1-mediated caspase-1 activation play essential roles in interleukin-1beta release from Helicobacter pylori lipopolysaccharide-stimulated macrophages

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A prominent role for Sp1 during lipopolysaccharide-mediated induction of the IL-10 promoter in macrophages

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Altered antigen expression of microglia in the aged rodent CNS.

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Microglia derived from aging mice exhibit an altered inflammatory profile.

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Microglial expression of MHC class II increases in normal aging of nonhuman primates.

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Effects of ageing on microglia in the normal rat brain: immunohistochemical observations.

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Aging exacerbates depressive-like behavior in mice in response to activation of the peripheral innate immune system.

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3 September 2018

Innate immune receptor expression in normal brain aging.

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3 September 2018

The age-related attenuation in long-term potentiation is associated with microglial activation.

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Inflammatory processes in the aging mouse brain: participation of dendritic cells and T-cells.

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Molecular basis of age-associated cytokine dysregulation in LPS-stimulated macrophages.

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Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system.

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Peripheral infection and aging interact to impair hippocampal memory consolidation.

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Alpha-tocopherol attenuates lipopolysaccharide-induced sickness behavior in mice.

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Gene-expression profile of the ageing brain in mice

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Normal adult ramified microglia separated from other central nervous system macrophages by flow cytometric sorting. Phenotypic differences defined and direct ex vivo antigen presentation to myelin basic protein-reactive CD4+ T cells compared

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814846

12 December 2020

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inferred from PubMed ID database lookup

The unresponsiveness of aged mice to polysaccharide antigens is a result of a defect in macrophage function

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814846

12 December 2020

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inferred from PubMed ID database lookup

Increased microglial activation and protein nitration in white matter of the aging monkey☆

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.BBI.2008.09.002

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

release_tspq4zkko5heboaq53qzx23asi

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https://api.fatcat.wiki/v0/release/tspq4zkko5heboaq53qzx23asi

24 November 2022

based on heuristic

mapped directly with Wikidata item

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

ResearchGate publication ID

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