(Q37218738)

19 August 2017

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title

Cytochrome P450 and gene activation--from pharmacology to cholesterol elimination and regression of atherosclerosis (English)

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19 August 2017

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Pauli V Luoma

1

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19 August 2017

publication date

17 July 2008

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European Journal of Clinical Pharmacology

19 August 2017

published in

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19 August 2017

volume

64

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19 August 2017

issue

9

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19 August 2017

page(s)

841-850

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https://scigraph.springernature.com/pub.10.1007/s00228-008-0515-5

19 August 2017

exact match

0 references

cites work

Human cholesterol 7alpha-hydroxylase (CYP7A1) deficiency has a hypercholesterolemic phenotype

1 reference

https://api.crossref.org/works/10.1007%2FS00228-008-0515-5

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21 January 2018

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Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00228-008-0515-5

Bisphosphonates and atherosclerosis

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00228-008-0515-5

Alcohol consumption and atherosclerosis: what is the relation? Prospective results from the Bruneck Study.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00228-008-0515-5

Interferon-gamma induces downregulation of Tangier disease gene (ATP-binding-cassette transporter 1) in macrophage-derived foam cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00228-008-0515-5

ABCA1 mRNA and protein distribution patterns predict multiple different roles and levels of regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00228-008-0515-5

Plasma high-density lipoproteins and liver lipids and proteins in man. Relation to hepatic histology and microsomal enzyme induction

21 January 2018

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12 December 2020

Diet-dependent cardiovascular lipid metabolism controlled by hepatic LXRalpha

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12 December 2020

Effect of torcetrapib on the progression of coronary atherosclerosis

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12 December 2020

Effect of alcohol intake on high and low density lipoprotein metabolism in healthy volunteers

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12 December 2020

Oxysterols: friends, foes, or just fellow passengers?

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12 December 2020

Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers

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12 December 2020

Adenosine A2A receptor occupancy stimulates expression of proteins involved in reverse cholesterol transport and inhibits foam cell formation in macrophages.

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12 December 2020

Regulation of macrophage cholesterol efflux through hydroxymethylglutaryl-CoA reductase inhibition: a role for RhoA in ABCA1-mediated cholesterol efflux

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12 December 2020

Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters

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12 December 2020

PXR and the regulation of apoA1 and HDL-cholesterol in rodents

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12 December 2020

Molecular basis of cholesterol homeostasis: lessons from Tangier disease and ABCA1.

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12 December 2020

Evaluation of 170 xenobiotics as transactivators of human pregnane X receptor (hPXR) and correlation to known CYP3A4 drug interactions

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12 December 2020

Coronary atherosclerosis and alcohol consumption: angiographic and mortality data.

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12 December 2020

Cholesterol detoxification by the nuclear pregnane X receptor

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12 December 2020

ABCA1 and scavenger receptor class B, type I, are modulators of reverse sterol transport at an in vitro blood-brain barrier constituted of porcine brain capillary endothelial cells

1 reference

12 December 2020

Regulation of human liver cytochromes P-450 in family 3A in primary and continuous culture of human hepatocytes

1 reference

12 December 2020

Macrophage liver X receptor is required for antiatherogenic activity of LXR agonists

1 reference

12 December 2020

Effects of pravastatin on the expression of ATP-binding cassette transporter A1.

1 reference

12 December 2020

Meta-analysis of large randomized controlled trials to evaluate the impact of statins on cardiovascular outcomes

1 reference

12 December 2020

A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis

1 reference

12 December 2020

Pharmacologic augmentation of high-density lipoproteins: mechanisms of currently available and emerging therapies

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12 December 2020

Clofibrate, a peroxisome-proliferator, enhances reverse cholesterol transport through cytochrome P450 activation and oxysterol generation

1 reference

12 December 2020

Mutations in the bile acid biosynthetic enzyme sterol 27-hydroxylase underlie cerebrotendinous xanthomatosis

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12 December 2020

Pioglitazone decreases carotid intima-media thickness independently of glycemic control in patients with type 2 diabetes mellitus: results from a controlled randomized study

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12 December 2020

Effect of interferon on plasma lipoproteins and on the activity of postheparin plasma lipases

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12 December 2020

Statin-induced inhibition of the Rho-signaling pathway activates PPARalpha and induces HDL apoA-I

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12 December 2020

Effects of carbon monoxide exposure on the arterial walls

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12 December 2020

Expression and regulation of sterol 27-hydroxylase (CYP27A1) in human macrophages: a role for RXR and PPARgamma ligands

1 reference

12 December 2020

Telmisartan enhances cholesterol efflux from THP-1 macrophages by activating PPARgamma

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12 December 2020

Serum low-density lipoprotein and high-density lipoprotein cholesterol, and liver size in subjects on drugs inducing hepatic microsomal enzymes

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12 December 2020

Oxysterol 7 alpha-hydroxylase activity by cholesterol 7 alpha-hydroxylase (CYP7A).

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12 December 2020

Pharmacological activation of liver X receptors promotes reverse cholesterol transport in vivo

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12 December 2020

Early statin treatment in patients with acute coronary syndrome: demonstration of the beneficial effect on atherosclerotic lesions by serial volumetric intravascular ultrasound analysis during half a year after coronary event: the ESTABLISH Study

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12 December 2020

Plasma levels of 24S-hydroxycholesterol reflect the balance between cerebral production and hepatic metabolism and are inversely related to body surface

1 reference

12 December 2020

The bisphosphonate ibandronate stimulates reverse cholesterol transport out of monocytoid cells by enhanced ABCA1 transcription

1 reference

12 December 2020

Effect of HMGCoA reductase inhibitors on cytochrome P450 expression in endothelial cell line.

1 reference

12 December 2020

Statins, High-Density Lipoprotein Cholesterol, and Regression of Coronary Atherosclerosis

1 reference

12 December 2020

Function of cytochrome P-450 of microsomes

1 reference

12 December 2020

To drink (moderately) or not to drink?

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12 December 2020

Nuclear receptor signaling in the control of cholesterol homeostasis: have the orphans found a home?

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12 December 2020

Alcohol and mortality: a review

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12 December 2020

Liver X receptors (LXRs) regulate apolipoprotein AIV-implications of the antiatherosclerotic effect of LXR agonists

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12 December 2020

Regression of coronary atherosclerosis by simvastatin: a serial intravascular ultrasound study

1 reference

12 December 2020

Inhibition of early atherogenesis in transgenic mice by human apolipoprotein AI.

1 reference

12 December 2020

HDL as a target in the treatment of atherosclerotic cardiovascular disease

1 reference

12 December 2020

High density lipoprotein as a protective factor against coronary heart disease. The Framingham Study

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12 December 2020

Effects of fenofibrate on high and low density lipoprotein metabolism in heterozygous familial hypercholesterolemia

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12 December 2020

Mouse models for atherosclerosis and pharmaceutical modifiers.

1 reference

12 December 2020

Angiotensin receptor blockers versus angiotensin-converting enzyme inhibitors: where do we stand now?

1 reference

12 December 2020

Regulation of plasma high-density lipoprotein levels by the ABCA1 transporter and the emerging role of high-density lipoprotein in the treatment of cardiovascular disease

1 reference

12 December 2020

Liver X Receptor Signaling Pathways in Cardiovascular Disease

1 reference

12 December 2020

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

1 reference

12 December 2020

Coordinate transcriptional regulation of bile acid homeostasis and drug metabolism

1 reference

12 December 2020

The relationship between alcohol consumption, liver enzymes and high-density lipoprotein cholesterol

1 reference

12 December 2020

The effects of extended-release niacin on carotid intimal media thickness, endothelial function and inflammatory markers in patients with the metabolic syndrome

1 reference

12 December 2020

Retinoic Acid Receptor-Mediated Induction of ABCA1 in Macrophages

1 reference

12 December 2020

Inverse relationship of serum LDL cholesterol and the LDL/HDL cholesterol ratio to liver microsomal enzyme induction in man

1 reference

12 December 2020

Induction of drug-decomposing enzymes into the endoplasmic reticulum of liver cells by pharmacologic agents

1 reference

12 December 2020

High-density lipoproteins and hepatic microsomal enzyme induction in alcohol consumers

1 reference

12 December 2020

Plasma high-density lipoprotein cholesterol and hepatic cytochrome P-450 concentrations in epileptics undergoing anticonvulsant treatment

1 reference

12 December 2020

Pitavastatin, a potent hydroxymethylglutaryl coenzyme a reductase inhibitor, increases cholesterol 7 alpha-hydroxylase gene expression in HepG2 cells

1 reference

12 December 2020

Antiepileptic drugs increase plasma levels of 4beta-hydroxycholesterol in humans: evidence for involvement of cytochrome p450 3A4.

1 reference

12 December 2020

Gemfibrozil in the treatment of dyslipidemia: an 18-year mortality follow-up of the Helsinki Heart Study

1 reference

12 December 2020

Effects of gemfibrozil and ketoconazole on human apolipoprotein AI, B and E levels in two hepatoma cell lines, HepG2 and Hep3B

1 reference

12 December 2020

Effect of very high-intensity statin therapy on regression of coronary atherosclerosis: the ASTEROID trial

1 reference

12 December 2020

Cholestyramine promotes receptor-mediated low-density-lipoprotein catabolism

1 reference

12 December 2020

Heterogeneity of cardiovascular risk among smokers is related to degree of carbon monoxide exposure

1 reference

12 December 2020

Molecular cloning and expression of rabbit sterol 12alpha-hydroxylase

1 reference

12 December 2020

ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport

1 reference

12 December 2020

Gene activation, apolipoprotein A-I/high density lipoprotein, atherosclerosis prevention and longevity

1 reference

12 December 2020

Removal of cholesterol from extrahepatic sources by oxidative mechanisms

1 reference

12 December 2020

An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha

1 reference

12 December 2020

Effect of pitavastatin on apolipoprotein A-I production in HepG2 cell

1 reference

12 December 2020

Mortality from ischaemic heart disease among patients using anticonvulsive drugs: a case-control study.

1 reference

12 December 2020

Pregnane X receptor prevents hepatorenal toxicity from cholesterol metabolites

1 reference

12 December 2020

Decrease in carotid intima-media thickness after 1-year therapy with etidronate for osteopenia associated with type 2 diabetes

1 reference

12 December 2020

The effects of cholestyramine on high density lipoprotein metabolism

1 reference

12 December 2020

PPAR-alpha and PPAR-gamma activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway

1 reference

12 December 2020

27-hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells

1 reference

12 December 2020

Effects of high-dose itraconazole treatment on lipoproteins in men.

1 reference

12 December 2020

Clinical importance of the cytochromes P450

1 reference

12 December 2020

Niacin in cardiovascular prevention: mechanisms, efficacy, and safety.

1 reference

12 December 2020

Phenobarbital induces rat liver apolipoprotein A-I mRNA

1 reference

12 December 2020

Pharmacological implications of microsomal enzyme induction.

1 reference

12 December 2020

Serum LDL cholesterol, the LDL/HDL cholesterol ratio and liver microsomal enzyme induction evaluated by antipyrine kinetics

1 reference

12 December 2020

The role of cytochrome P450 in the regulation of cholesterol biosynthesis

1 reference

12 December 2020

Simultaneous low-density lipoprotein-C lowering and high-density lipoprotein-C elevation for optimum cardiovascular disease prevention with various drug classes, and their combinations: a meta-analysis of 23 randomized lipid trials

1 reference

12 December 2020

Verapamil increases the apolipoprotein-mediated release of cellular cholesterol by induction of ABCA1 expression via Liver X receptor-independent mechanism

1 reference

12 December 2020

Transcriptional regulation of human CYP27 integrates retinoid, peroxisome proliferator-activated receptor, and liver X receptor signaling in macrophages

1 reference

12 December 2020

Multiplicity of mammalian microsomal cytochromes P-45

1 reference

12 December 2020

An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma)

1 reference

12 December 2020

Effect of atorvastatin on high density lipoprotein cholesterol and its relationship with coronary events: a subgroup analysis of the GREek Atorvastatin and Coronary-heart-disease Evaluation (GREACE) Study

1 reference

12 December 2020

PXR induces CYP27A1 and regulates cholesterol metabolism in the intestine

1 reference

12 December 2020

Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins

1 reference

12 December 2020

Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial

1 reference

12 December 2020

Effect of Rosiglitazone on the Risk of Myocardial Infarction and Death from Cardiovascular Causes

1 reference

12 December 2020

Effects of ketoconazole on cholesterol precursors and low density lipoprotein kinetics in hypercholesterolemia

1 reference

12 December 2020

Interferon-gamma impedes reverse cholesterol transport and promotes foam cell transformation in THP-1 human monocytes/macrophages.

1 reference

12 December 2020

Regulation of CYP2B6 and CYP3A expression by hydroxymethylglutaryl coenzyme A inhibitors in primary cultured human hepatocytes

1 reference

12 December 2020

Crossing the barrier: oxysterols as cholesterol transporters and metabolic modulators in the brain.

1 reference

12 December 2020

Oxysterol regulators of 3-hydroxy-3-methylglutaryl-CoA reductase in liver. Effect of dietary cholesterol

1 reference

12 December 2020

Moderate alcohol consumption increases cholesterol efflux mediated by ABCA1.

1 reference

12 December 2020

Comparative effects of fibrates on drug metabolizing enzymes in human hepatocytes

1 reference

12 December 2020

P450 CYP2C epoxygenase and CYP4A omega-hydroxylase mediate ciprofibrate-induced PPARalpha-dependent peroxisomal proliferation

1 reference

12 December 2020

Use of a reporter gene assay to predict and rank the potency and efficacy of CYP3A4 inducers

1 reference

12 December 2020

Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway

1 reference

12 December 2020

Intestinal ABCA1 directly contributes to HDL biogenesis in vivo

1 reference

12 December 2020

World Heart Day 2002: the international burden of cardiovascular disease: responding to the emerging global epidemic

1 reference

12 December 2020

Angiographic assessment of effects of bezafibrate on progression of coronary artery disease in young male postinfarction patients

1 reference

12 December 2020

10.1007/S00228-008-0515-5

Identifiers

DOI

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19 August 2017

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