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Clinical importance of the cytochromes P450
scientific article (publication date: 12 October 2002)
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scholarly article
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12387968
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12387968%20AND%20SRC:MED&resulttype=core&format=json
retrieved
14 December 2019
review article
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Europe PubMed Central
title
Clinical importance of the cytochromes P450
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12387968
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12387968%20AND%20SRC:MED&resulttype=core&format=json
retrieved
14 December 2019
author
David W. Russell
series ordinal
2
1 reference
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Europe PubMed Central
PubMed publication ID
12387968
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12387968%20AND%20SRC:MED&resulttype=core&format=json
retrieved
14 December 2019
author name string
Daniel W Nebert
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1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12387968
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12387968%20AND%20SRC:MED&resulttype=core&format=json
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14 December 2019
language of work or name
English
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publication date
1 October 2002
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12387968
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12387968%20AND%20SRC:MED&resulttype=core&format=json
retrieved
14 December 2019
published in
The Lancet
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Europe PubMed Central
PubMed publication ID
12387968
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12387968%20AND%20SRC:MED&resulttype=core&format=json
retrieved
14 December 2019
volume
360
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12387968
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12387968%20AND%20SRC:MED&resulttype=core&format=json
retrieved
14 December 2019
issue
9340
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12387968
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12387968%20AND%20SRC:MED&resulttype=core&format=json
retrieved
14 December 2019
page(s)
1155-1162
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12387968
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12387968%20AND%20SRC:MED&resulttype=core&format=json
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14 December 2019
cites work
Isolation and characterization of full-length mouse cDNA and genomic clones of 3-methylcholanthrene-inducible cytochrome P1-450 and P3-450.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0140-6736%2802%2911203-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
P450 genes: structure, evolution, and regulation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0140-6736%2802%2911203-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Evolution of the P450 gene superfamily: animal-plant 'warfare', molecular drive and human genetic differences in drug oxidation
1 reference
stated in
Crossref
reference URL
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retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The evolution of drug metabolism
1 reference
stated in
Crossref
reference URL
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retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Induction of cytochromes P450.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0140-6736%2802%2911203-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Heterotropic cooperativity of cytochrome P450 3A4 and potential drug-drug interactions
1 reference
stated in
Crossref
reference URL
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retrieved
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inferred from DOI database lookup
Pharmacogenetics and adverse drug reactions
1 reference
stated in
Crossref
reference URL
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1 reference
stated in
Crossref
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Pharmacogenetics and pharmacogenomics: why is this relevant to the clinical geneticist?
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Xenobiotic-metabolizing cytochromes P450 convert prostaglandin endoperoxide to hydroxyheptadecatrienoic acid and the mutagen, malondialdehyde.
1 reference
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Protection of the Cyp1a2(-/-) null mouse against uroporphyria and hepatic injury following exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin
1 reference
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Targeted knockout of Cyp1a1 gene does not alter hepatic constitutive expression of other genes in the mouse [Ah] battery
1 reference
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Crossref
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Cyp1a2(-/-) null mutant mice develop normally but show deficient drug metabolism
1 reference
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Crossref
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Understanding the role of xenobiotic-metabolism in chemical carcinogenesis using gene knockout mice
1 reference
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Identification of three different truncating mutations in cytochrome P4501B1 (CYP1B1) as the principal cause of primary congenital glaucoma (Buphthalmos) in families linked to the GLC3A locus on chromosome 2p21
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Cytochrome P450s: coupling development and environment
1 reference
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Crossref
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Molecular mechanisms of genetic polymorphisms of drug metabolism
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Cytochrome P450 2C is an EDHF synthase in coronary arteries
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Steroid hormone hydroxylase specificities of eleven cDNA-expressed human cytochrome P450s
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6alpha-hydroxylation of taurochenodeoxycholic acid and lithocholic acid by CYP3A4 in human liver microsomes
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1 reference
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1 reference
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7 January 2021
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inferred from DOI database lookup
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1 reference
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7 January 2021
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1 reference
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1 reference
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1 reference
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7 January 2021
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1 reference
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7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S0140-6736(02)11203-7
2 references
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2416645
stated in
Europe PubMed Central
PubMed publication ID
12387968
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12387968%20AND%20SRC:MED&resulttype=core&format=json
retrieved
14 December 2019
OpenCitations bibliographic resource ID
2416645
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2416645
PubMed publication ID
12387968
2 references
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2416645
stated in
Europe PubMed Central
PubMed publication ID
12387968
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12387968%20AND%20SRC:MED&resulttype=core&format=json
retrieved
14 December 2019
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