(Q37231486)

19 August 2017

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title

Homocysteine, MTHFR gene polymorphisms, and cardio-cerebrovascular risk (English)

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19 August 2017

Elisabetta Trabetti

1

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19 August 2017

publication date

1 January 2008

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Journal of Applied Genetics

19 August 2017

published in

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19 August 2017

volume

49

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19 August 2017

issue

3

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19 August 2017

page(s)

267-282

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Hyperhomocysteinemia as a risk factor for deep-vein thrombosis

19 August 2017

cites work

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12 December 2020

Thermolabile 5,10-methylenetetrahydrofolate reductase as a cause of mild hyperhomocysteinemia

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12 December 2020

Homocysteine as a risk factor for vascular disease. Enhanced collagen production and accumulation by smooth muscle cells

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12 December 2020

Additional genetic risk factors for venous thromboembolism in carriers of the factor V Leiden mutation.

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12 December 2020

Homocysteine and ischaemic heart disease in the Caerphilly cohort

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12 December 2020

Association between elevated plasma total homocysteine and increased common carotid artery wall thickness

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12 December 2020

The effect of folic acid fortification on plasma folate and total homocysteine concentrations

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12 December 2020

Hyperhomocysteinemia and thrombosis: an overview

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12 December 2020

Plasma homocysteine concentration, C677T MTHFR genotype, and 844ins68bp CBS genotype in young adults with spontaneous cervical artery dissection and atherothrombotic stroke.

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12 December 2020

A common mutation A1298C in human methylenetetrahydrofolate reductase gene: association with plasma total homocysteine and folate concentrations

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12 December 2020

The common 'thermolabile' variant of methylene tetrahydrofolate reductase is a major determinant of mild hyperhomocysteinaemia

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12 December 2020

Estimates of heritability of plasma homocyst(e)ine levels in aging adult male twins

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12 December 2020

Population variation and genetics of plasma homocyst(e)ine level

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12 December 2020

Effect of sulfinpyrazone on homocysteine-induced endothelial injury and arteriosclerosis in baboons

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12 December 2020

The controversy over homocysteine and cardiovascular risk

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12 December 2020

Medical hypothesis: hyperhomocysteinemia is a risk factor for estrogen-induced hormonal cancer.

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12 December 2020

MTHFR 677C-->T polymorphism and risk of coronary heart disease: a meta-analysis.

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12 December 2020

Carotid artery intimal-medial wall thickening and plasma homocyst(e)ine in asymptomatic adults. The Atherosclerosis Risk in Communities Study

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12 December 2020

Cumulative effect of predisposing genotypes and their interaction with modifiable factors on the risk of ischemic stroke in young adults

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12 December 2020

A Quantitative Assessment of Plasma Homocysteine as a Risk Factor for Vascular Disease

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12 December 2020

Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations.

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12 December 2020

Oxidative damage to cellular and isolated DNA by homocysteine: implications for carcinogenesis

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12 December 2020

Novel genomic loci influencing plasma homocysteine levels

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12 December 2020

Homocysteine and cognitive decline in healthy elderly

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12 December 2020

Homocysteine and stroke: evidence on a causal link from mendelian randomisation

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12 December 2020

Vascular dysfunction in monkeys with diet-induced hyperhomocyst(e)inemia

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12 December 2020

Polymorphisms of methylenetetrahydrofolate reductase and other enzymes: metabolic significance, risks and impact on folate requirement

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12 December 2020

Endothelium-Derived Relaxing Factor Modulates the Atherothrombogenic Effects of Homocysteine

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12 December 2020

Intermediate homocysteinemia: a thermolabile variant of methylenetetrahydrofolate reductase

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12 December 2020

Folate, homocysteine, endothelial function and cardiovascular disease

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12 December 2020

High prevalence of hyperchomocysteinemia in patients with inflammatory bowel disease: a pathogenic link with thromboembolic complications?

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12 December 2020

Mutation A1298C of methylenetetrahydrofolate reductase: risk for early coronary disease not associated with hyperhomocysteinemia

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12 December 2020

The pathogenesis of coronary artery disease. A possible role for methionine metabolism

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12 December 2020

Single and combined prothrombotic factors in patients with idiopathic venous thromboembolism: prevalence and risk assessment

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12 December 2020

Inhibition of thrombomodulin surface expression and protein C activation by the thrombogenic agent homocysteine

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12 December 2020

A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects?

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12 December 2020

Plasma homocysteine levels and mortality in patients with coronary artery disease

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12 December 2020

Hyperhomocysteinemia in end-stage renal disease: Prevalence, etiology, and potential relationship to arteriosclerotic outcomes

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12 December 2020

Plasma total homocysteine and cardiovascular and noncardiovascular mortality: the Hordaland Homocysteine Study

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12 December 2020

Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis

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12 December 2020

Endothelial dysfunction induced by hyperhomocyst(e)inemia: role of asymmetric dimethylarginine.

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12 December 2020

Role of oxidant stress in endothelial dysfunction produced by experimental hyperhomocyst(e)inemia in humans

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12 December 2020

Migraine as a risk factor for subclinical brain lesions

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12 December 2020

Homocysteine, traditional risk factors and impaired renal function in coronary artery disease

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12 December 2020

Mutations in methylenetetrahydrofolate reductase or cystathionine beta-synthase gene, or a high-methionine diet, increase homocysteine thiolactone levels in humans and mice

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12 December 2020

Plasma homocyst(e)ine as a risk factor for early familial coronary artery disease

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12 December 2020

[Hyperhomocysteinemia in pediatric age and nutritional aspects of folates: an early cardiovascular risk factor]

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12 December 2020

Adverse vascular effects of homocysteine are modulated by endothelium-derived relaxing factor and related oxides of nitrogen

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12 December 2020

Endothelial nitric oxide synthase gene polymorphism, homocysteine, cholesterol and vascular endothelial function

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12 December 2020

Lipoic acid and vitamin C potentiate nitric oxide synthesis in human aortic endothelial cells independently of cellular glutathione status.

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12 December 2020

Endothelial cell injury due to copper-catalyzed hydrogen peroxide generation from homocysteine

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12 December 2020

Homocysteine and hemostasis: pathogenic mechanisms predisposing to thrombosis

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12 December 2020

Homocysteine induces expression and secretion of monocyte chemoattractant protein-1 and interleukin-8 in human aortic endothelial cells: implications for vascular disease

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12 December 2020

[Interactions between the MTHFR C677T and MTHFR A1298C mutations in ischaemic stroke]

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12 December 2020

Hyperhomocysteinemia and prevalence of polymorphisms of homocysteine metabolism-related enzymes in patients with inflammatory bowel disease

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12 December 2020

[Risk factors for cardiovascular diseases: what is the role for homocysteine?]

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12 December 2020

Total serum homocysteine in senile dementia of Alzheimer type

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12 December 2020

Tissue plasminogen activator binding to the annexin II tail domain. Direct modulation by homocysteine

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12 December 2020

Coffee consumption and plasma total homocysteine: The Hordaland Homocysteine Study

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12 December 2020

Moderate homocysteinemia--a possible risk factor for arteriosclerotic cerebrovascular disease

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12 December 2020

Homocysteine stimulates the expression of monocyte chemoattractant protein-1 receptor (CCR2) in human monocytes: possible involvement of oxygen free radicals

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12 December 2020

Homocysteine at pathophysiologic concentrations activates human monocyte and induces cytokine expression and inhibits macrophage migration inhibitory factor expression.

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12 December 2020

Elevated fasting total plasma homocysteine levels and cardiovascular disease outcomes in maintenance dialysis patients. A prospective study

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12 December 2020

Acute stroke in relation to homocysteine and methylenetetrahydrofolate reductase gene polymorphisms

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12 December 2020

Prevalence of familial mild hyperhomocysteinemia.

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12 December 2020

Polymorphisms in the methylenetetrahydrofolate reductase gene and prostate cancer risk.

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12 December 2020

No association between the common MTHFR 677C->T polymorphism and venous thrombosis: results from the MEGA study

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12 December 2020

Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis

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12 December 2020

Activation of Hageman Factor by L-Homocystine

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12 December 2020

Worldwide distribution of a common methylenetetrahydrofolate reductase mutation

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12 December 2020

Prevalence and mechanisms of hyperhomocysteinemia in chronic alcoholics

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12 December 2020

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12 December 2020

A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase

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12 December 2020

Homocysteine, oxidative stress, and vascular disease

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12 December 2020

Methylenetetrahydrofolate reductase gene polymorphisms are associated with ischemic and hemorrhagic stroke: Dual effect of MTHFR polymorphisms C677T and A1298C.

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12 December 2020

Serum total homocysteine and coronary heart disease

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12 December 2020

Homocysteine concentrations in subclinical hypothyroidism

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12 December 2020

Cardiovascular risk factors and migraine: the GEM population-based study

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12 December 2020

Homocyst(e)ine decreases bioavailable nitric oxide by a mechanism involving glutathione peroxidase

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12 December 2020

Homozygous C677T mutation of the 5,10 methylenetetrahydrofolate reductase gene and hyperhomocysteinemia in Italian patients with a history of early-onset ischemic stroke

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12 December 2020

A1298C methylenetetrahydrofolate reductase mutation and coronary artery disease: relationships with C677T polymorphism and homocysteine/folate metabolism.

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12 December 2020

Hyperhomocysteinemia increases risk of death, especially in type 2 diabetes : 5-year follow-up of the Hoorn Study.

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12 December 2020

Prospective study of coronary heart disease incidence in relation to fasting total homocysteine, related genetic polymorphisms, and B vitamins: the Atherosclerosis Risk in Communities (ARIC) study.

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12 December 2020

Homocysteine and vascular disease

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12 December 2020

Nonfasting plasma total homocysteine levels and all-cause and cardiovascular disease mortality in elderly Framingham men and women.

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12 December 2020

The G20210A mutation of the prothrombin gene in patients with previous first episodes of deep-vein thrombosis: prevalence and association with factor V G1691A, methylenetetrahydrofolate reductase C677T and plasma prothrombin levels

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12 December 2020

Homocysteine and its effects on in-stent restenosis

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12 December 2020

Hyperhomocysteinemia and low pyridoxal phosphate. Common and independent reversible risk factors for coronary artery disease

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12 December 2020

Homocysteine, a risk factor for premature vascular disease and thrombosis, induces tissue factor activity in endothelial cells

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12 December 2020

Effect of plasma homocysteine concentration on early and late events in patients with acute coronary syndromes

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12 December 2020

Genetic modulation of homocysteinemia

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12 December 2020

Prospective study of serum total homocysteine concentration and risk of stroke in middle-aged British men.

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12 December 2020

Blood homocysteine levels in stroke patients undergoing rehabilitation

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12 December 2020

Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease

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12 December 2020

Severe and mild mutations in cis for the methylenetetrahydrofolate reductase (MTHFR) gene, and description of five novel mutations in MTHFR.

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12 December 2020

Migraine and MTHFR C677T genotype in a population-based sample

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12 December 2020

The Hordaland Homocysteine Studies

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12 December 2020

Synergistic effects of prothrombotic polymorphisms and atherogenic factors on the risk of myocardial infarction in young males

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12 December 2020

Mining literature for a comprehensive pathway analysis: a case study for retrieval of homocysteine related genes for genetic and epigenetic studies

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12 December 2020

Association of homocysteine (but not of MTHFR 677 C>T, MTR 2756 A>G, MTRR 66 A>G and TCN2 776 C>G) with ischaemic cerebrovascular disease in Sicily.

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12 December 2020

Homocysteine and cardiovascular disease

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12 December 2020

Hyperhomocyst(e)inemia as a risk factor for occlusive vascular disease

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12 December 2020

Determinants and vitamin responsiveness of intermediate hyperhomocysteinemia (> or = 40 micromol/liter). The Hordaland Homocysteine Study

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12 December 2020

On the role of vitamin C and other antioxidants in atherogenesis and vascular dysfunction

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12 December 2020

Inhibition of growth and p21ras methylation in vascular endothelial cells by homocysteine but not cysteine

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12 December 2020

Thermolabile methylenetetrahydrofolate reductase: an inherited risk factor for coronary artery disease.

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12 December 2020

Analysis of the 677 C-->T mutation of the methylenetetrahydrofolate reductase gene in different ethnic groups

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12 December 2020

Homocystine-induced arteriosclerosis. The role of endothelial cell injury and platelet response in its genesis

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12 December 2020

Effect of consumption of red wine, spirits, and beer on serum homocysteine

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12 December 2020

Pro-thrombotic effects of a folic acid deficient diet in rat platelets and macrophages related to elevated homocysteine and decreased n-3 polyunsaturated fatty acids

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12 December 2020

Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis.

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12 December 2020

Relation of serum homocysteine and lipoprotein(a) concentrations to atherosclerotic disease in a prospective Finnish population based study

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12 December 2020

Plasma homocysteine as a risk factor for dementia and Alzheimer's disease

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12 December 2020

Homocysteine and atheromatous renal artery stenosis

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12 December 2020

Atherosclerosis — An Inflammatory Disease

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12 December 2020

Emerging risk factors for ischemic stroke

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12 December 2020

Effects of homocysteine on l-arginine transport and nitric oxide formation in human platelets

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12 December 2020

Hyperhomocysteinemia in chronic alcoholism: correlation with folate, vitamin B-12, and vitamin B-6 status

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12 December 2020

Hyperhomocysteinaemia is not associated with increased levels of asymmetric dimethylarginine in patients with ischaemic heart disease

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12 December 2020

Association between Plasma Homocysteine Concentrations and Extracranial Carotid-Artery Stenosis

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12 December 2020

The structure and properties of methylenetetrahydrofolate reductase from Escherichia coli suggest how folate ameliorates human hyperhomocysteinemia

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12 December 2020

Methylenetetrahydrofolate reductase gene polymorphism and ischemic stroke in Japanese

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12 December 2020

Low Vitamin B6 but Not Homocyst(e)ine Is Associated With Increased Risk of Stroke and Transient Ischemic Attack in the Era of Folic Acid Grain Fortification

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12 December 2020

Platelet and monocyte variables in homocystinuria due to cystathionine-beta-synthase deficiency

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12 December 2020

Association of MTRRA66G polymorphism (but not of MTHFR C677T and A1298C, MTRA2756G, TCN C776G) with homocysteine and coronary artery disease in the French population.

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12 December 2020

Homocysteine and cerebral infarction in finnish male smokers

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12 December 2020

Risk factors for mild cognitive impairment in the Cardiovascular Health Study Cognition Study: part 2.

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12 December 2020

Plasma homocysteine as a risk factor for vascular disease. The European Concerted Action Project.

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12 December 2020

Major lifestyle determinants of plasma total homocysteine distribution: the Hordaland Homocysteine Study

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12 December 2020

MTHFR C677T gene mutation as a risk factor for arterial stroke: a hospital based study

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12 December 2020

Promotion of vascular smooth muscle cell growth by homocysteine: a link to atherosclerosis

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12 December 2020

Homocysteine theory of arteriosclerosis

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12 December 2020

Association of plasma homocysteine with restenosis after percutaneous coronary angioplasty

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12 December 2020

A prospective study of plasma homocyst(e)ine and risk of myocardial infarction in US physicians

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12 December 2020

Homocysteine, an atherogenic stimulus, reduces protein C activation by arterial and venous endothelial cells

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12 December 2020

Acute methionine load-induced hyperhomocysteinemia enhances platelet aggregation, thromboxane biosynthesis, and macrophage-derived tissue factor activity in rats

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12 December 2020

Effect of the MTHFRC677T variant on risk of venous thromboembolism: interaction with factor V Leiden and prothrombin (F2G20210A) mutations

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12 December 2020

Demonstration of rapid onset vascular endothelial dysfunction after hyperhomocysteinemia: an effect reversible with vitamin C therapy.

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12 December 2020

Methylenetetrahydrofolate reductase gene polymorphism in Indian stroke patients.

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12 December 2020

Common methylenetetrahydrofolate reductase gene mutation leads to hyperhomocysteinemia but not to vascular disease: the result of a meta-analysis

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12 December 2020

Genetic predisposition to hyperhomocysteinemia: deficiency of methylenetetrahydrofolate reductase (MTHFR)

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12 December 2020

Homocysteine induces monocyte chemoattractant protein-1 expression by activating NF-kappaB in THP-1 macrophages

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12 December 2020

Production of arteriosclerosis by homocysteinemia

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12 December 2020

Role of hyperhomocysteinemia in endothelial dysfunction and atherothrombotic disease.

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12 December 2020

The Interaction between MTHFR 677 C→T Genotype and Folate Status Is a Determinant of Coronary Atherosclerosis Risk

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12 December 2020

A second mutation in the methylenetetrahydrofolate reductase gene and the risk of venous thrombotic disease

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12 December 2020

Genetic analysis of the thermolabile variant of 5, 10-methylenetetrahydrofolate reductase as a risk factor for ischemic stroke

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12 December 2020

Mechanisms of homocysteine-induced atherothrombosis

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12 December 2020

Identification of cognitive impairment in the elderly: homocysteine is an early marker

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12 December 2020

Hyperhomocysteinemia is a risk factor for cancer and a new potential tumor marker

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12 December 2020

Vitamin Intervention For Stroke Prevention trial: an efficacy analysis

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12 December 2020

An association between the methylenetetrahydrofolate reductase (MTHFR) C677T mutation and inflammation markers related to cardiovascular disease

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12 December 2020

5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: a HuGE review

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12 December 2020

Plasma total homocysteine and hospitalizations for cardiovascular disease: the Hordaland Homocysteine Study

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12 December 2020

Homocysteine, EDRF, and endothelial function

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12 December 2020

Homocysteine, a thrombogenic agent, suppresses anticoagulant heparan sulfate expression in cultured porcine aortic endothelial cells

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12 December 2020

Prevalence of familial hyperhomocyst(e)inemia in men with premature coronary artery disease

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12 December 2020

Asymmetric dimethylarginine and total homocysteine in plasma after oral methionine loading

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12 December 2020

Impaired homocysteine metabolism and atherothrombotic disease

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12 December 2020

Methylenetetrahydrofolate reductase C677T mutation, plasma homocysteine, and folate in subjects from northern Italy with or without angiographically documented severe coronary atherosclerotic disease: evidence for an important genetic-environmental

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12 December 2020

Abnormally high thromboxane biosynthesis in homozygous homocystinuria. Evidence for platelet involvement and probucol-sensitive mechanism

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12 December 2020

Elevated plasma homocysteine was associated with hemorrhagic and ischemic stroke, but methylenetetrahydrofolate reductase gene C677T polymorphism was a risk factor for thrombotic stroke: a Multicenter Case-Control Study in China

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12 December 2020

No association between the MTHFR A1298C and transcobalamin C776G genetic polymorphisms and hyperhomocysteinemia in thrombotic disease

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12 December 2020

Relation between plasma homocysteine, gene polymorphisms of homocysteine metabolism-related enzymes, and angiographically proven coronary artery disease

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12 December 2020

Homocyst(e)ine and risk of cardiovascular disease in the Multiple Risk Factor Intervention Trial

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12 December 2020

Identifiers

DOI

10.1007/BF03195624

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19 August 2017

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