(Q37232834)

English

In vivo retargeting of adenovirus type 5 to alphavbeta6 integrin results in reduced hepatotoxicity and improved tumor uptake following systemic delivery.

scientific article published on 15 April 2009

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scholarly article

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26 January 2020

In vivo retargeting of adenovirus type 5 to alphavbeta6 integrin results in reduced hepatotoxicity and improved tumor uptake following systemic delivery (English)

1 reference

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26 January 2020

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based on heuristic

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1

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26 January 2020

Magdalena B Flak

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26 January 2020

5

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26 January 2020

Georges Vassaux

6

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26 January 2020

John F Marshall

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John F Marshall

7

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Sabari Vallath

2

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26 January 2020

Antonio Saha

3

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26 January 2020

Ian R Hart

8

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26 January 2020

Gareth J Thomas

9

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26 January 2020

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15 April 2009

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26 January 2020

Journal of Virology

1 reference

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26 January 2020

83

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26 January 2020

6416-6428

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26 January 2020

13

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26 January 2020

Loss of the coxsackie and adenovirus receptor contributes to gastric cancer progression

1 reference

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6 September 2017

Human erythrocytes bind and inactivate type 5 adenovirus by presenting Coxsackie virus-adenovirus receptor and complement receptor 1.

1 reference

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6 September 2017

Clearance of adenovirus by Kupffer cells is mediated by scavenger receptors, natural antibodies, and complement

1 reference

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6 September 2017

Adenovirus serotype 5 hexon is critical for virus infection of hepatocytes in vivo

1 reference

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6 September 2017

A peptide selected by biopanning identifies the integrin alphavbeta6 as a prognostic biomarker for nonsmall cell lung cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2698540

6 September 2017

Alphavbeta6 integrin in wound healing and cancer of the oral cavity

1 reference

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6 September 2017

Adenovirus Binding to Blood Factors Results in Liver Cell Infection and Hepatotoxicity

1 reference

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6 September 2017

Binding of TGF-beta1 latency-associated peptide (LAP) to alpha(v)beta6 integrin modulates behaviour of squamous carcinoma cells

1 reference

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6 September 2017

Modulation of adenovirus vector tropism via incorporation of polypeptide ligands into the fiber protein

1 reference

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6 September 2017

Expression of the coxsackie adenovirus receptor in normal prostate and in primary and metastatic prostate carcinoma: potential relevance to gene therapy.

1 reference

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6 September 2017

The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis

1 reference

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6 September 2017

An adenovirus vector with genetically modified fibers demonstrates expanded tropism via utilization of a coxsackievirus and adenovirus receptor-independent cell entry mechanism

1 reference

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6 September 2017

The murine CAR homolog is a receptor for coxsackie B viruses and adenoviruses.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2698540

6 September 2017

Generation of recombinant adenovirus vectors with modified fibers for altering viral tropism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2698540

6 September 2017

Integrins alpha v beta 3 and alpha v beta 5 promote adenovirus internalization but not virus attachment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2698540

6 September 2017

The epithelial integrin alphavbeta6 is a receptor for foot-and-mouth disease virus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2698540

14 September 2017

Identification of contact residues and definition of the CAR-binding site of adenovirus type 5 fiber protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2698540

14 September 2017

Macrophage depletion combined with anticoagulant therapy increases therapeutic window of systemic treatment with oncolytic adenovirus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2698540

14 September 2017

Polyinosinic acid enhances delivery of adenovirus vectors in vivo by preventing sequestration in liver macrophages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2698540

14 September 2017

Fiber-modified adenovirus vectors containing the TAT peptide derived from HIV-1 in the fiber knob have efficient gene transfer activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2698540

14 September 2017

Structure-function analysis of Arg-Gly-Asp helix motifs in alpha v beta 6 integrin ligands

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2698540

14 September 2017

Cyclooxygenase-2 inhibition suppresses alphavbeta6 integrin-dependent oral squamous carcinoma invasion.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2698540

14 September 2017

Analysis of the interaction between RGD-expressing adenovirus type 5 fiber knob domains and alphavbeta3 integrin reveals distinct binding profiles and intracellular trafficking.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2698540

14 September 2017

Multiple vitamin K-dependent coagulation zymogens promote adenovirus-mediated gene delivery to hepatocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2698540

14 September 2017

Increased in vitro and in vivo gene transfer by adenovirus vectors containing chimeric fiber proteins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2698540

14 September 2017

Structure of the receptor binding domain of adenovirus type 5 fiber protein.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2698540

14 September 2017

Gene delivery from the E3 region of replicating human adenovirus: evaluation of the 6.7 K/gp19 K region

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2698540

28 September 2017

A photosensitising adenovirus for photodynamic therapy

1 reference

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28 September 2017

Copy number-dependent expression of a YAC-cloned human CFTR gene in a human epithelial cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2698540

28 September 2017

Foot-and-mouth disease virus forms a highly stable, EDTA-resistant complex with its principal receptor, integrin alphavbeta6: implications for infectiousness

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2698540

26 June 2018

The role of surface charge in the activation of the classical and alternative pathways of complement by liposomes.

1 reference

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26 June 2018

Integrin expression in human melanoma cell lines: heterogeneity of vitronectin receptor composition and function

1 reference

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26 June 2018

Coagulation factors determine tumor transduction in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2698540

3 September 2018

Adenovirus serotype 5 hexon mediates liver gene transfer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2698540

3 September 2018

SPECT/CT imaging of oncolytic adenovirus propagation in tumours in vivo using the Na/I symporter as a reporter gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2698540

3 September 2018

Fiber-modified adenovirus vectors decrease liver toxicity through reduced IL-6 production

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2698540

3 September 2018

Rapid Kupffer cell death after intravenous injection of adenovirus vectors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2698540

3 September 2018

Colorectal cancer progression: integrin alphavbeta6 and the epithelial-mesenchymal transition (EMT).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2698540

3 September 2018

Loss of coxsackie and adenovirus receptor expression is associated with features of aggressive bladder cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2698540

3 September 2018

Hepatic uptake of negatively charged particles in rats: possible involvement of serum proteins in recognition by scavenger receptor

1 reference

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3 September 2018

The alphavbeta5 integrin of hematopoietic and nonhematopoietic cells is a transduction receptor of RGD-4C fiber-modified adenoviruses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2698540

3 September 2018

Reduced expression of coxsackievirus and adenovirus receptor (CAR) in tumor tissue compared to normal epithelium in head and neck squamous cell carcinoma patients.

1 reference

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3 September 2018

KAI1, CAR, and Smad4 expression in the progression of colorectal tumor.

1 reference

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3 September 2018

Expression of the alphavbeta6 integrin promotes migration and invasion in squamous carcinoma cells.

1 reference

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3 September 2018

Acute cytokine response to systemic adenoviral vectors in mice is mediated by dendritic cells and macrophages

1 reference

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3 September 2018

Blood clearance rates of adenovirus type 5 in mice

1 reference

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3 September 2018

Modifications of the fiber in adenovirus vectors increase tropism for malignant glioma models

1 reference

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1 reference

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3 September 2018

Insertion of an RGD motif into the HI loop of adenovirus fiber protein alters the distribution of transgene expression of the systemically administered vector

1 reference

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3 September 2018

Expression of the beta 6 integrin subunit in development, neoplasia and tissue repair suggests a role in epithelial remodeling.

1 reference

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3 September 2018

Antibody-mediated blockade of integrin alpha v beta 6 inhibits tumor progression in vivo by a transforming growth factor-beta-regulated mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/19369326

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha(v)beta(6) integrin-A marker for the malignant potential of epithelial ovarian cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/19369326

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/JVI.00445-09

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19369326%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19369326%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19369326%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

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