(Q37247686)

English

The novel CXCR4 antagonist KRH-3955 is an orally bioavailable and extremely potent inhibitor of human immunodeficiency virus type 1 infection: comparative studies with AMD3100.

scientific article published on 18 May 2009

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

The novel CXCR4 antagonist KRH-3955 is an orally bioavailable and extremely potent inhibitor of human immunodeficiency virus type 1 infection: comparative studies with AMD3100. (English)

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

8

object named as

Jonathan Toma

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Europe PubMed Central

PMC publication ID

19 August 2017

12

object named as

Naoki Yamamoto

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Europe PubMed Central

PMC publication ID

19 August 2017

author name string

Tsutomu Murakami

1

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Europe PubMed Central

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19 August 2017

Sei Kumakura

2

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Europe PubMed Central

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19 August 2017

Toru Yamazaki

3

1 reference

Europe PubMed Central

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19 August 2017

Reiko Tanaka

4

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Makiko Hamatake

5

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Kazu Okuma

6

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Wei Huang

7

1 reference

Europe PubMed Central

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19 August 2017

Jun Komano

9

1 reference

Europe PubMed Central

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19 August 2017

Mikiro Yanaka

10

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19 August 2017

Yuetsu Tanaka

11

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19 August 2017

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publication date

18 May 2009

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Europe PubMed Central

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19 August 2017

Antimicrobial Agents and Chemotherapy

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Europe PubMed Central

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19 August 2017

53

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Europe PubMed Central

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19 August 2017

7

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

2940-2948

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Substitution of the myristoylation signal of human immunodeficiency virus type 1 Pr55Gag with the phospholipase C-delta1 pleckstrin homology domain results in infectious pseudovirion production

1 reference

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CXCR4 antagonism increases T cell trafficking in the central nervous system and improves survival from West Nile virus encephalitis

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Molecular mechanism of action of monocyclam versus bicyclam non-peptide antagonists in the CXCR4 chemokine receptor

1 reference

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Multiple-dose escalation study of the safety, pharmacokinetics, and biologic activity of oral AMD070, a selective CXCR4 receptor inhibitor, in human subjects

1 reference

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Development of low molecular weight CXCR4 antagonists by exploratory structural tuning of cyclic tetra- and pentapeptide-scaffolds towards the treatment of HIV infection, cancer metastasis and rheumatoid arthritis

1 reference

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Discovery and characterization of vicriviroc (SCH 417690), a CCR5 antagonist with potent activity against human immunodeficiency virus type 1

1 reference

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Maraviroc (UK-427,857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type 1 activity

1 reference

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TAK-652 inhibits CCR5-mediated human immunodeficiency virus type 1 infection in vitro and has favorable pharmacokinetics in humans

1 reference

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Potential clinical applications of the CXCR4 antagonist bicyclam AMD3100.

1 reference

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Highly potent inhibition of human immunodeficiency virus type 1 replication by TAK-220, an orally bioavailable small-molecule CCR5 antagonist

1 reference

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Assessing chemokine co-receptor usage in HIV

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Safety, pharmacokinetics, and antiviral activity of AMD3100, a selective CXCR4 receptor inhibitor, in HIV-1 infection.

1 reference

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Spirodiketopiperazine-based CCR5 inhibitor which preserves CC-chemokine/CCR5 interactions and exerts potent activity against R5 human immunodeficiency virus type 1 in vitro

1 reference

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A duodenally absorbable CXC chemokine receptor 4 antagonist, KRH-1636, exhibits a potent and selective anti-HIV-1 activity

1 reference

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Unique monoclonal antibody recognizing the third extracellular loop of CXCR4 induces lymphocyte agglutination and enhances human immunodeficiency virus type 1-mediated syncytium formation and productive infection

1 reference

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6 September 2017

SCH-C (SCH 351125), an orally bioavailable, small molecule antagonist of the chemokine receptor CCR5, is a potent inhibitor of HIV-1 infection in vitro and in vivo

1 reference

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6 September 2017

Molecular interactions of cyclam and bicyclam non-peptide antagonists with the CXCR4 chemokine receptor

1 reference

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6 September 2017

Pharmacokinetics and safety of AMD-3100, a novel antagonist of the CXCR-4 chemokine receptor, in human volunteers

1 reference

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6 September 2017

Inhibitory mechanism of the CXCR4 antagonist T22 against human immunodeficiency virus type 1 infection.

1 reference

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6 September 2017

A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity

1 reference

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6 September 2017

T134, a small-molecule CXCR4 inhibitor, has no cross-drug resistance with AMD3100, a CXCR4 antagonist with a different structure.

1 reference

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6 September 2017

Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development

1 reference

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The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract

1 reference

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A small molecule CXCR4 inhibitor that blocks T cell line-tropic HIV-1 infection

1 reference

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Inhibition of T-tropic HIV strains by selective antagonization of the chemokine receptor CXCR4

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HIV coreceptor downregulation as antiviral principle: SDF-1alpha-dependent internalization of the chemokine receptor CXCR4 contributes to inhibition of HIV replication

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Change in coreceptor use correlates with disease progression in HIV-1--infected individuals

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Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection

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3 September 2018

Identifiers

10.1128/AAC.01727-08

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

ResearchGate publication ID

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