(Q37253985)

English

Aberrant splice variants of HAS1 (Hyaluronan Synthase 1) multimerize with and modulate normally spliced HAS1 protein: a potential mechanism promoting human cancer

scientific article published on 18 May 2009

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Aberrant splice variants of HAS1 (Hyaluronan Synthase 1) multimerize with and modulate normally spliced HAS1 protein: a potential mechanism promoting human cancer (English)

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

author name string

Anirban Ghosh

1

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Hemalatha Kuppusamy

2

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Linda M Pilarski

3

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

language of work or name

0 references

publication date

18 May 2009

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

284

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

28

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

18840-18850

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Genome-wide analysis of alternative pre-mRNA splicing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707203

6 September 2017

An enzyme capture assay for analysis of active hyaluronan synthases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707203

6 September 2017

Mutation analysis and characterization of ATR sequence variants in breast cancer cases from high-risk French Canadian breast/ovarian cancer families

1 reference

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6 September 2017

In silico and in vivo splicing analysis of MLH1 and MSH2 missense mutations shows exon- and tissue-specific effects.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707203

6 September 2017

The consensus coding sequences of human breast and colorectal cancers

1 reference

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6 September 2017

The cyclin D1b splice variant: an old oncogene learns new tricks

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707203

6 September 2017

Defective splicing, disease and therapy: searching for master checkpoints in exon definition.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707203

6 September 2017

Cyclin D1: polymorphism, aberrant splicing and cancer risk

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707203

6 September 2017

Unbalanced alternative splicing and its significance in cancer

1 reference

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6 September 2017

Cyclin D1b variant influences prostate cancer growth through aberrant androgen receptor regulation

1 reference

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6 September 2017

Plasma membrane residence of hyaluronan synthase is coupled to its enzymatic activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707203

6 September 2017

Involvement of nuclear export in human papillomavirus type 18 E6-mediated ubiquitination and degradation of p53.

1 reference

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6 September 2017

Role of hyaluronan and hyaluronan synthase in endometrial cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707203

6 September 2017

Intronic splicing of hyaluronan synthase 1 (HAS1): a biologically relevant indicator of poor outcome in multiple myeloma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707203

6 September 2017

Hyaluronan and hyaluronan synthases: potential therapeutic targets in cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707203

6 September 2017

Receptor for hyaluronan-mediated motility correlates with centrosome abnormalities in multiple myeloma and maintains mitotic integrity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707203

6 September 2017

Alterations of pre-mRNA splicing in cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707203

6 September 2017

A Novel IVS2-1G>A mutation causes aberrant splicing of the HRPT2 gene in a family with hyperparathyroidism-jaw tumor syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707203

6 September 2017

Aberrant and alternative splicing in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707203

6 September 2017

Regulation of human p53 activity and cell localization by alternative splicing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707203

6 September 2017

Hyaluronan: from extracellular glue to pericellular cue.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707203

6 September 2017

RHAMM expression and isoform balance predict aggressive disease and poor survival in multiple myeloma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707203

6 September 2017

Hyaluronan synthase-3 is upregulated in metastatic colon carcinoma cells and manipulation of expression alters matrix retention and cellular growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707203

6 September 2017

WWOX, the common chromosomal fragile site, FRA16D, cancer gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707203

6 September 2017

RHAMM is a centrosomal protein that interacts with dynein and maintains spindle pole stability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707203

6 September 2017

Abnormal expression of hyaluronan synthases in patients with Waldenstrom's macroglobulimenia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707203

6 September 2017

Inhibition of prostate tumor cell hyaluronan synthesis impairs subcutaneous growth and vascularization in immunocompromised mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707203

6 September 2017

Hyaluronan promotes the malignant phenotype

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707203

6 September 2017

Site-directed mutation of conserved cysteine residues does not inactivate the Streptococcus pyogenes hyaluronan synthase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707203

6 September 2017

Manipulation of hyaluronan synthase expression in prostate adenocarcinoma cells alters pericellular matrix retention and adhesion to bone marrow endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707203

6 September 2017

Hyaluronan and homeostasis: a balancing act.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707203

6 September 2017

Hyaluronan synthase 3 overexpression promotes the growth of TSU prostate cancer cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707203

6 September 2017

Somatic NF1 mutational spectrum in benign neurofibromas: mRNA splice defects are common among point mutations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707203

6 September 2017

Hyaluronan synthase elevation in metastatic prostate carcinoma cells correlates with hyaluronan surface retention, a prerequisite for rapid adhesion to bone marrow endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707203

6 September 2017

Hyaluronan in peritumoral stroma and malignant cells associates with breast cancer spreading and predicts survival

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707203

6 September 2017

Three isoforms of mammalian hyaluronan synthases have distinct enzymatic properties

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707203

6 September 2017

Potential role for hyaluronan and the hyaluronan receptor RHAMM in mobilization and trafficking of hematopoietic progenitor cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707203

6 September 2017

Hyaluronan expression in gastric cancer cells is associated with local and nodal spread and reduced survival rate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707203

6 September 2017

Purification and lipid dependence of the recombinant hyaluronan synthases from Streptococcus pyogenes and Streptococcus equisimilis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707203

6 September 2017

Proinflammatory stimuli regulate endothelial hyaluronan expression and CD44/HA-dependent primary adhesion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707203

6 September 2017

Chromosomal localization of the human and mouse hyaluronan synthase genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707203

6 September 2017

Molecular identification of a putative human hyaluronan synthase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707203

6 September 2017

Analysis of cell-growth-phase-related variations in hyaluronate synthase activity of isolated plasma-membrane fractions of cultured human skin fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707203

6 September 2017

Identification of intronic point mutations as an alternative mechanism for p53 inactivation in lung cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707203

6 September 2017

Hyaluronan synthesis induces microvillus-like cell surface protrusions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707203

14 September 2017

Selective expression and functional characteristics of three mammalian hyaluronan synthases in oncogenic malignant transformation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707203

14 September 2017

An alternatively spliced cyclin D1 isoform, cyclin D1b, is a nuclear oncogene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707203

14 September 2017

Increased synthesis of hyaluronate enhances motility of human melanoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707203

28 September 2017

Relationship between hyaluronan production and metastatic potential of mouse mammary carcinoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707203

28 September 2017

Overproduction of hyaluronan by expression of the hyaluronan synthase Has2 enhances anchorage-independent growth and tumorigenicity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707203

26 June 2018

Characterization and molecular evolution of a vertebrate hyaluronan synthase gene family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707203

26 June 2018

Hyaluronan synthases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707203

26 June 2018

Evidence for rapid metabolic turnover of hyaluronate synthetase in Swarm rat chondrosarcoma chondrocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707203

26 June 2018

Synthesis of hyaluronate in cultured bovine articular cartilage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707203

26 June 2018

HAS1 expression in bladder cancer and its relation to urinary HA test.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707203

3 September 2018

Identification and characterization of a protein-tyrosine phosphatase in Leishmania: Involvement in virulence

1 reference

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3 September 2018

Systematic mRNA analysis for the effect of MLH1 and MSH2 missense and silent mutations on aberrant splicing.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707203

3 September 2018

Aberrant splicing in MLH1 and MSH2 due to exonic and intronic variants.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707203

3 September 2018

Sensitive multistep clinical molecular screening of 180 unrelated individuals with retinoblastoma detects 36 novel mutations in the RB1 gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707203

3 September 2018

Alternative splicing and mutation status of CHEK2 in stage III breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707203

3 September 2018

RNA analysis reveals splicing mutations and loss of expression defects in MLH1 and BRCA1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707203

3 September 2018

Elevated transcript level of hyaluronan synthase1 gene correlates with poor prognosis of human colon cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707203

3 September 2018

Characterization of the somatic mutational spectrum of the neurofibromatosis type 1 (NF1) gene in neurofibromatosis patients with benign and malignant tumors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707203

3 September 2018

Cyclin D1 splice variants. Differential effects on localization, RB phosphorylation, and cellular transformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707203

3 September 2018

Hyaluronan is not elevated in urine or serum in Hutchinson-Gilford Progeria Syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707203

3 September 2018

Different splicing defects lead to differential effects downstream of the lipid and protein phosphatase activities of PTEN

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.013813

21 January 2018

NF1mutation rather than individual genetic variability is the main determinant of theNF1-transcriptional profile of mutations affecting splicing

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.013813

21 January 2018

Inherited and acquired variations in the hyaluronan synthase 1 (HAS1) gene may contribute to disease progression in multiple myeloma and Waldenstrom macroglobulinemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/19451652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Catabolism of hyaluronan in rabbit skin takes place locally, in lymph nodes and liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/19451652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Different somatic and germline HPRT1 mutations promote use of a common, cryptic intron 1 splice site. Mutation in brief no. 259. Online

1 reference

https://pubmed.ncbi.nlm.nih.gov/19451652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Somatic ATM mutations indicate a pathogenic role of ATM in B-cell chronic lymphocytic leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/19451652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hyaluronan synthase expression in pleural malignant mesotheliomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/19451652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hyaluronan synthase expression in ovarian cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/19451652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of hyaluronan in benign and malignant breast lesions

1 reference

https://pubmed.ncbi.nlm.nih.gov/19451652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High levels of stromal hyaluronan predict poor disease outcome in epithelial ovarian cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/19451652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutational analysis of the CASP6 gene in colorectal and gastric carcinomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/19451652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M109.013813

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

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