(Q35824079)

10 August 2017

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title

Hyaluronan: from extracellular glue to pericellular cue. (English)

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10 August 2017

Bryan P Toole

1

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10 August 2017

language of work or name

English

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publication date

1 July 2004

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10 August 2017

published in

Nature Reviews Cancer

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10 August 2017

volume

4

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10 August 2017

issue

7

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10 August 2017

page(s)

528-539

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10 August 2017

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Hyaluronan and homeostasis: a balancing act.

31 March 2020

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The six hyaluronidase-like genes in the human and mouse genomes

31 March 2020

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Hyaluronan in morphogenesis

31 March 2020

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ONCOGENESIS: Landscaping the Cancer Terrain

31 March 2020

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31 March 2020

The Hallmarks of Cancer

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Signaling properties of hyaluronan receptors

31 March 2020

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Putting tumours in context

31 March 2020

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Watch thy neighbor: cancer is a communal affair

31 March 2020

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Hyaluronate and invasiveness of the rabbit V2 carcinoma

31 March 2020

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Hyaluronan (hyaluronic acid) and hyaluronectin in the extracellular matrix of human breast carcinomas: comparison between invasive and non-invasive areas

31 March 2020

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Interactions between human tumor cells and fibroblasts stimulate hyaluronate synthesis

31 March 2020

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Characterization of hyaluronan synthase expression and hyaluronan synthesis in bone marrow mesenchymal progenitor cells: predominant expression of HAS1 mRNA and up-regulated hyaluronan synthesis in bone marrow cells derived from multiple myeloma pat

31 March 2020

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Hyaluronan-cell interactions in cancer and vascular disease

31 March 2020

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Hyaluronan in peritumoral stroma and malignant cells associates with breast cancer spreading and predicts survival

31 March 2020

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Prognostic value of hyaluronan expression in non-small-cell lung cancer: Increased stromal expression indicates unfavorable outcome in patients with adenocarcinoma

31 March 2020

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High stromal hyaluronan level is associated with poor differentiation and metastasis in prostate cancer

31 March 2020

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Stromal and epithelial expression of tumor markers hyaluronic acid and HYAL1 hyaluronidase in prostate cancer

31 March 2020

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Hyaluronan expression in gastric cancer cells is associated with local and nodal spread and reduced survival rate

31 March 2020

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Bladder tumor markers for monitoring recurrence and screening comparison of hyaluronic acid-hyaluronidase and BTA-Stat tests

31 March 2020

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Serum hyaluronan (hyaluronic acid) in breast cancer patients

31 March 2020

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Expression of tumor markers hyaluronic acid and hyaluronidase (HYAL1) in head and neck tumors

31 March 2020

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Reduced level of CD44 and hyaluronan associated with unfavorable prognosis in clinical stage I cutaneous melanoma

31 March 2020

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Hyaluronan, CD44 and versican in epidermal keratinocyte tumours

31 March 2020

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Expression of hyaluronan synthase 2 or hyaluronidase 1 differentially affect the growth rate of transplantable colon carcinoma cell tumors

31 March 2020

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Inhibition of prostate tumor cell hyaluronan synthesis impairs subcutaneous growth and vascularization in immunocompromised mice

31 March 2020

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Selective expression and functional characteristics of three mammalian hyaluronan synthases in oncogenic malignant transformation.

31 March 2020

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Hyaluronidase reduces human breast cancer xenografts in SCID mice

31 March 2020

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HYAL1LUCA-1, a candidate tumor suppressor gene on chromosome 3p21.3, is inactivated in head and neck squamous cell carcinomas by aberrant splicing of pre-mRNA

31 March 2020

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Hyaluronidase gene profiling and role of hyal-1 overexpression in an orthotopic model of prostate cancer.

31 March 2020

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ELEVATED TISSUE EXPRESSION OF HYALURONIC ACID AND HYALURONIDASE VALIDATES THE HA-HAase URINE TEST FOR BLADDER CANCER

31 March 2020

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Expression of hyaluronidase by tumor cells induces angiogenesis in vivo

31 March 2020

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Hyaluronan-binding proteins: tying up the giant

31 March 2020

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A lymphocyte molecule implicated in lymph node homing is a member of the cartilage link protein family

31 March 2020

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CD44 is the principal cell surface receptor for hyaluronate

31 March 2020

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CD44: from adhesion molecules to signalling regulators

31 March 2020

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CD44-mediated oncogenic signaling and cytoskeleton activation during mammary tumor progression

31 March 2020

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The role of the CD44 transmembrane and cytoplasmic domains in co-ordinating adhesive and signalling events.

31 March 2020

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Selective suppression of CD44 in keratinocytes of mice bearing an antisense CD44 transgene driven by a tissue-specific promoter disrupts hyaluronate metabolism in the skin and impairs keratinocyte proliferation

31 March 2020

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Resolution of lung inflammation by CD44

31 March 2020

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Identification of a common hyaluronan binding motif in the hyaluronan binding proteins RHAMM, CD44 and link protein.

31 March 2020

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The hyaluronan receptor RHAMM regulates extracellular-regulated kinase

31 March 2020

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31 March 2020

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Hyaluronan production increases the malignant properties of mesothelioma cells

31 March 2020

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Elevated hyaluronan production induces mesenchymal and transformed properties in epithelial cells

31 March 2020

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Perturbation of hyaluronan interactions by soluble CD44 inhibits growth of murine mammary carcinoma cells in ascites

31 March 2020

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Hyaluronan oligosaccharides inhibit anchorage-independent growth of tumor cells by suppressing the phosphoinositide 3-kinase/Akt cell survival pathway

31 March 2020

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Hyaluronan activates cell motility of v-Src-transformed cells via Ras-mitogen-activated protein kinase and phosphoinositide 3-kinase-Akt in a tumor-specific manner

31 March 2020

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Abnormal accumulation of hyaluronan matrix diminishes contact inhibition of cell growth and promotes cell migration

31 March 2020

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Regulation of Multidrug Resistance in Cancer Cells by Hyaluronan

31 March 2020

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Hyaluronan and the hyaluronan receptor RHAMM promote focal adhesion turnover and transient tyrosine kinase activity

31 March 2020

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CD44 signaling through focal adhesion kinase and its anti-apoptotic effect

31 March 2020

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31 March 2020

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Inhibition of phosphorylation of BAD and Raf-1 by Akt sensitizes human ovarian cancer cells to paclitaxel

31 March 2020

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Interaction between CD44 and hyaluronate is directly implicated in the regulation of tumor development.

31 March 2020

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Induction of apoptosis of metastatic mammary carcinoma cells in vivo by disruption of tumor cell surface CD44 function

31 March 2020

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Soluble CD44 inhibits melanoma tumor growth by blocking cell surface CD44 binding to hyaluronic acid

31 March 2020

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Soluble hyaluronan receptor RHAMM induces mitotic arrest by suppressing Cdc2 and cyclin B1 expression

31 March 2020

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Perturbation of hyaluronan interactions inhibits malignant properties of glioma cells

31 March 2020

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Hyaluronan-binding peptide can inhibit tumor growth by interacting with Bcl-2.

31 March 2020

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Intracellular localization of hyaluronan in proliferating cells

31 March 2020

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Rapid hyaluronan uptake is associated with enhanced motility: implications for an intracellular mode of action

31 March 2020

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RHAMM is a centrosomal protein that interacts with dynein and maintains spindle pole stability

31 March 2020

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A Novel Glycosaminoglycan-binding Protein Is the Vertebrate Homologue of the Cell Cycle Control Protein, Cdc37

31 March 2020

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A model for the cytoplasmic trafficking of signalling proteins involving the hsp90-binding immunophilins and p50cdc37.

31 March 2020

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Hsp-90-associated oncoproteins: multiple targets of geldanamycin and its analogs

31 March 2020

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Molecular characterization of a novel intracellular hyaluronan-binding protein

31 March 2020

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Constitutive expression of hyaluronan binding protein 1 (HABP1/p32/gC1qR) in normal fibroblast cells perturbs its growth characteristics and induces apoptosis

31 March 2020

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The deaf and the dumb: the biology of ErbB-2 and ErbB-3

31 March 2020

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HER (erbB) tyrosine kinase inhibitors in the treatment of breast cancer

31 March 2020

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Disruption of hyaluronan synthase-2 abrogates normal cardiac morphogenesis and hyaluronan-mediated transformation of epithelium to mesenchyme

31 March 2020

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Heart-valve mesenchyme formation is dependent on hyaluronan-augmented activation of ErbB2-ErbB3 receptors

31 March 2020

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Hyaluronan promotes CD44v3-Vav2 interaction with Grb2-p185(HER2) and induces Rac1 and Ras signaling during ovarian tumor cell migration and growth

31 March 2020

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EGF receptor modifies cellular responses to hyaluronan in glioblastoma cell lines

31 March 2020

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Hyaluronan promotes signaling interaction between CD44 and the transforming growth factor beta receptor I in metastatic breast tumor cells

31 March 2020

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CD44 is required for two consecutive steps in HGF/c-Met signaling.

31 March 2020

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Enhanced transformation by a plasma membrane-associated met oncoprotein: activation of a phosphoinositide 3'-kinase-dependent autocrine loop involving hyaluronic acid and CD44.

31 March 2020

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Multidrug resistance in cancer: role of ATP-dependent transporters

31 March 2020

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Molecular signals in anti-apoptotic survival pathways.

31 March 2020

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The impact of extracellular matrix on the chemoresistance of solid tumors--experimental and clinical results of hyaluronidase as additive to cytostatic chemotherapy.

31 March 2020

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Reversal by hyaluronidase of adhesion-dependent multicellular drug resistance in mammary carcinoma cells

31 March 2020

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Reversal of intrinsic and acquired forms of drug resistance by hyaluronidase treatment of solid tumors

31 March 2020

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Multicellular resistance: a paradigm for clinical resistance?

31 March 2020

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Hyaluronan, a major non‐protein glycosaminoglycan component of the extracellular matrix in human bone marrow, mediates dexamethasone resistance in multiple myeloma

31 March 2020

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Receptors for hyaluronate on the surface of parent and virus-transformed cell lines: binding and aggregation studies

31 March 2020

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Phosphoinositide 3-kinase lipid products regulate ATP-dependent transport by sister of P-glycoprotein and multidrug resistance associated protein 2 in bile canalicular membrane vesicles

31 March 2020

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Inhibition of hyaluronan export from human fibroblasts by inhibitors of multidrug resistance transporters

31 March 2020

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Emmprin promotes anchorage-independent growth in human mammary carcinoma cells by stimulating hyaluronan production

31 March 2020

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Emmprin (CD147), a cell surface regulator of matrix metalloproteinase production and function

31 March 2020

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Tumorigenic potential of extracellular matrix metalloproteinase inducer

31 March 2020

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Combined transcriptome and genome analysis of single micrometastatic cells

31 March 2020

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Introduction of antisense CD44S CDNA down-regulates expression of overall CD44 isoforms and inhibits tumor growth and metastasis in highly metastatic colon carcinoma cells

31 March 2020

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Dissemination and growth of cancer cells in metastatic sites

31 March 2020

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Manipulation of hyaluronan synthase expression in prostate adenocarcinoma cells alters pericellular matrix retention and adhesion to bone marrow endothelial cells

31 March 2020

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Differential involvement of the hyaluronan (HA) receptors CD44 and receptor for HA-mediated motility in endothelial cell function and angiogenesis

31 March 2020

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CD44v10 interaction with Rho-kinase (ROK) activates inositol 1,4,5-triphosphate (IP3) receptor-mediated Ca2+ signaling during hyaluronan (HA)-induced endothelial cell migration

31 March 2020

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Absence of lymphangiogenesis and intratumoural lymph vessels in human metastatic breast cancer

31 March 2020

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Formation of hyaluronan- and versican-rich pericellular matrix is required for proliferation and migration of vascular smooth muscle cells

31 March 2020

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Hyaluronic acid/CD44H interaction induces cell detachment and stimulates migration and invasion of human glioma cells in vitro.

31 March 2020

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Suppression of CD44 expression decreases migration and invasion of human glioma cells

31 March 2020

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Epidermal growth factor up-regulates CD44-dependent astrocytoma invasion in vitro

31 March 2020

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Hyaluronate receptors mediating glioma cell migration and proliferation

31 March 2020

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Changing views of the role of matrix metalloproteinases in metastasis

31 March 2020

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New functions for the matrix metalloproteinases in cancer progression

31 March 2020

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Localization of matrix metalloproteinase 9 to the cell surface provides a mechanism for CD44-mediated tumor invasion

31 March 2020

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CD44 directs membrane-type 1 matrix metalloproteinase to lamellipodia by associating with its hemopexin-like domain.

31 March 2020

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CD44 cleavage induced by a membrane-associated metalloprotease plays a critical role in tumor cell migration

31 March 2020

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Membrane-type 1 matrix metalloproteinase cleaves CD44 and promotes cell migration

31 March 2020

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CD44 interaction with Na+-H+ exchanger (NHE1) creates acidic microenvironments leading to hyaluronidase-2 and cathepsin B activation and breast tumor cell invasion

31 March 2020

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Interaction between CD44 and the repeat domain of ankyrin promotes hyaluronic acid-mediated ovarian tumor cell migration

31 March 2020

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A novel PKC-regulated mechanism controls CD44 ezrin association and directional cell motility

31 March 2020

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Epithelial-mesenchymal transitions in tumour progression

31 March 2020

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E-cadherin negatively regulates CD44-hyaluronan interaction and CD44-mediated tumor invasion and branching morphogenesis

31 March 2020

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Convergence of Wnt, beta-catenin, and cadherin pathways

31 March 2020

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Genetic deletion of receptor for hyaluronan-mediated motility (Rhamm) attenuates the formation of aggressive fibromatosis (desmoid tumor).

31 March 2020

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Hyaluronan digestion and synthesis in an experimental model of metastatic tumour

31 March 2020

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Free radical depolymerization of hyaluronan by Maillard reaction products: role in liquefaction of aging vitreous

31 March 2020

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Reactive oxygen species depolymerize hyaluronan: involvement of the hydroxyl radical

31 March 2020

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Angiogenesis induced by degradation products of hyaluronic acid.

31 March 2020

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The effect of hyaluronate and its oligosaccharides on endothelial cell proliferation and monolayer integrity

31 March 2020

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Application of Angiogenic Oligosaccharides of Hyaluronan Increases Blood Vessel Numbers in Rat Skin

31 March 2020

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Testicular hyaluronidase induces tubular structures of endothelial cells grown in three-dimensional collagen gel through a CD44-mediated mechanism

31 March 2020

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Angiogenic oligosaccharides of hyaluronan induce multiple signaling pathways affecting vascular endothelial cell mitogenic and wound healing responses

31 March 2020

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Evidence of involvement of CD44 in endothelial cell proliferation, migration and angiogenesis in vitro

31 March 2020

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Engagement of CD44 promotes Rac activation and CD44 cleavage during tumor cell migration.

31 March 2020

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Inhibition of tumor growth in vivo by hyaluronan oligomers

31 March 2020

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Cancer. Respect thy neighbor!

31 March 2020

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EGFR is a transducer of the urokinase receptor initiated signal that is required for in vivo growth of a human carcinoma

31 March 2020

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Mucins in cancer: protection and control of the cell surface

31 March 2020

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Hyaluronan is synthesized by primitive hemopoietic cells, participates in their lodgment at the endosteum following transplantation, and is involved in the regulation of their proliferation and differentiation in vitro.

31 March 2020

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Prospective identification of tumorigenic breast cancer cells

31 March 2020

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Hyaluronate production and removal during corneal development in the chick

31 March 2020

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Stimulation of matrix metalloproteinase production by recombinant extracellular matrix metalloproteinase inducer from transfected Chinese hamster ovary cells

31 March 2020

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EMMPRIN-mediated MMP regulation in tumor and endothelial cells

31 March 2020

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Assembly of pericellular matrices by COS-7 cells transfected with CD44 lymphocyte-homing receptor genes

31 March 2020

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The dynamic structure of the pericellular matrix on living cells

31 March 2020

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Synthesis and assembly of the hyaluronan-containing coats around normal human mesothelial cells.

31 March 2020

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Characterization and molecular evolution of a vertebrate hyaluronan synthase gene family

31 March 2020

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CD44 interaction with ankyrin and IP3 receptor in lipid rafts promotes hyaluronan-mediated Ca2+ signaling leading to nitric oxide production and endothelial cell adhesion and proliferation

31 March 2020

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Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN.

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRC1391

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10 August 2017

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