(Q37274762)

English

Three-dimensional model of lanosterol 14 alpha-demethylase from Cryptococcus neoformans: active-site characterization and insights into azole binding

scientific article published on 26 May 2009

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Three-dimensional model of lanosterol 14 alpha-demethylase from Cryptococcus neoformans: active-site characterization and insights into azole binding (English)

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Cryptococcus neoformans

1 reference

based on heuristic

inferred from title

Haitao (mark) Ji

3

object named as

Haitao Ji

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

author name string

Chunquan Sheng

1

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Zhenyuan Miao

2

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Jianzhong Yao

4

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Wenya Wang

5

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Xiaoying Che

6

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Guoqiang Dong

7

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Jiaguo Lü

8

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Wei Guo

9

1 reference

Europe PubMed Central

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19 August 2017

Wannian Zhang

10

1 reference

Europe PubMed Central

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19 August 2017

language of work or name

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publication date

26 May 2009

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Antimicrobial Agents and Chemotherapy

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

53

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

8

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

3487-3495

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

X-ray Structure of 4,4'-Dihydroxybenzophenone Mimicking Sterol Substrate in the Active Site of Sterol 14 -Demethylase (CYP51)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715644

6 September 2017

Small-Molecule Scaffolds for CYP51 Inhibitors Identified by High-Throughput Screening and Defined by X-Ray Crystallography

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715644

6 September 2017

Ligand design by a combinatorial approach based on modeling and experiment: application to HLA-DR4.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715644

6 September 2017

The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715644

6 September 2017

Ravuconazole Eisai/Bristol-Myers Squibb

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715644

6 September 2017

Crystal structure of cytochrome P450 14 -sterol demethylase (CYP51) from Mycobacterium tuberculosis in complex with azole inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715644

6 September 2017

Prevalence of Cryptococcus neoformans var. neoformans (Serotype D) and Cryptococcus neoformans var. grubii (Serotype A) isolates in New York City

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715644

6 September 2017

Aspergillus fumigatus and aspergillosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715644

6 September 2017

Cryptococcus neoformans var. grubii: separate varietal status for Cryptococcus neoformans serotype A isolates.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715644

6 September 2017

Sterol 14-demethylase P450 (P45014DM*) is one of the most ancient and conserved P450 species

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715644

6 September 2017

Crystal structure of hemoprotein domain of P450BM-3, a prototype for microsomal P450's

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715644

6 September 2017

Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715644

6 September 2017

Epidemiologic differences between the two varieties of Cryptococcus neoformans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715644

6 September 2017

High-resolution crystal structure of cytochrome P450cam

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715644

6 September 2017

Assessment of protein models with three-dimensional profiles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715644

6 September 2017

Genetic basis for differential activities of fluconazole and voriconazole against Candida krusei

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715644

14 September 2017

Three-dimensional models of wild-type and mutated forms of cytochrome P450 14alpha-sterol demethylases from Aspergillus fumigatus and Candida albicans provide insights into posaconazole binding.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715644

14 September 2017

G484S amino acid substitution in lanosterol 14-alpha demethylase (ERG11) is related to fluconazole resistance in a recurrent Cryptococcus neoformans clinical isolate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715644

14 September 2017

Efficacy of albaconazole (UR-9825) in treatment of disseminated Scedosporium prolificans infection in rabbits

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715644

14 September 2017

Emergence of cryptococcal disease: epidemiologic perspectives 100 years after its discovery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715644

28 September 2017

Homology modeling of lanosterol 14alpha-demethylase of Candida albicans and Aspergillus fumigatus and insights into the enzyme-substrate Interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715644

26 June 2018

Deformylation of 32-oxo-24,25-dihydrolanosterol by the purified cytochrome P-45014DM (lanosterol 14 alpha-demethylase) from yeast evidence confirming the intermediate step of lanosterol 14 alpha-demethylation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715644

26 June 2018

Expression and homology modeling of sterol 14alpha-demethylase from Penicillium digitatum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715644

3 September 2018

Cloning and expression of the mutant 14alpha-demethylase containing the alteration of H310D in Candida albicans and the preliminary study on its functions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715644

3 September 2018

Estriol bound and ligand-free structures of sterol 14alpha-demethylase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715644

3 September 2018

Cloning and characterization of the lanosterol 14alpha-demethylase (ERG11) gene in Cryptococcus neoformans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715644

3 September 2018

Modeling and interactions of Aspergillus fumigatus lanosterol 14-alpha demethylase 'A' with azole antifungals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715644

3 September 2018

Structure-based de novo design, synthesis, and biological evaluation of non-azole inhibitors specific for lanosterol 14alpha-demethylase of fungi

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715644

3 September 2018

1,4-Benzothiazine and 1,4-benzoxazine imidazole derivatives with antifungal activity: a docking study.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715644

3 September 2018

A three-dimensional model of lanosterol 14alpha-demethylase of Candida albicans and its interaction with azole antifungals.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715644

3 September 2018

Generation of a complete, soluble, and catalytically active sterol 14 alpha-demethylase-reductase complex.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715644

3 September 2018

Modeling cytochrome P450 14 alpha demethylase (Candida albicans) from P450cam.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715644

3 September 2018

Taxonomic studies on Filobasidiella species and their anamorphs.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715644

3 September 2018

Functionality maps of binding sites: a multiple copy simultaneous search method

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715644

3 September 2018

Molecular modelling of the sterol C-14 demethylase of Saccharomyces cerevisiae

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715644

20 October 2018

Structural and evolutionary studies on sterol 14-demethylase P450 (CYP51), the most conserved P450 monooxygenase: II. Evolutionary analysis of protein and gene structures

1 reference

https://pubmed.ncbi.nlm.nih.gov/19470512

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure-based optimization of azole antifungal agents by CoMFA, CoMSIA, and molecular docking

1 reference

https://pubmed.ncbi.nlm.nih.gov/19470512

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antifungal and antimycobacterial activity of new imidazole and triazole derivatives. A combined experimental and computational approach

1 reference

https://pubmed.ncbi.nlm.nih.gov/19470512

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Yeast cytochrome P-450 catalyzing lanosterol 14 alpha-demethylation. II. Lanosterol metabolism by purified P-450(14)DM and by intact microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19470512

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural analysis of the interaction between the side-chain of substrates and the active site of lanosterol 14 alpha-demethylase (P-450(14)DM) of yeast

1 reference

https://pubmed.ncbi.nlm.nih.gov/19470512

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential inhibition of Candida albicans CYP51 with azole antifungal stereoisomers

1 reference

https://pubmed.ncbi.nlm.nih.gov/19470512

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular analysis of cyp51 from fluconazole-resistant Candida albicans strains

1 reference

https://pubmed.ncbi.nlm.nih.gov/19470512

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of the 8-double bond of lanosterol in the enzyme-substrate interaction of cytochrome P-450(14DM) (lanosterol 14 alpha-demethylase)

1 reference

https://pubmed.ncbi.nlm.nih.gov/19470512

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The 3-hydroxy group of lanosterol is essential for orienting the substrate site of cytochrome P-450(14DM) (lanosterol 14 alpha- demethylase)

1 reference

https://pubmed.ncbi.nlm.nih.gov/19470512

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of the side chain of lanosterol in substrate recognition and catalytic activity of lanosterol 14 alpha-demethylase (cytochrome P-450 (14DM)) of yeast

1 reference

https://pubmed.ncbi.nlm.nih.gov/19470512

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/AAC.01630-08

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

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