(Q37316694)

19 August 2017

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title

Challenges in elucidating structure and mechanism of proton pumping NADH:ubiquinone oxidoreductase (complex I). (English)

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19 August 2017

oxidoreductase complex

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Gene Ontology release 2020-05-02

Volker Zickermann

1

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19 August 2017

Stefan Dröse

2

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19 August 2017

Maja A Tocilescu

3

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19 August 2017

Klaus Zwicker

4

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19 August 2017

Stefan Kerscher

5

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19 August 2017

Ulrich Brandt

6

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19 August 2017

1 October 2008

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Journal of Bioenergetics and Biomembranes

19 August 2017

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19 August 2017

40

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19 August 2017

5

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19 August 2017

475-483

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https://scigraph.springernature.com/pub.10.1007/s10863-008-9171-9

19 August 2017

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cites work

Exploring the catalytic core of complex I by Yarrowia lipolytica yeast genetics

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12 December 2020

The proton pumping stoichiometry of purified mitochondrial complex I reconstituted into proteoliposomes

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12 December 2020

Complex I: a chimaera of a redox and conformation-driven proton pump?

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12 December 2020

Functional roles of four conserved charged residues in the membrane domain subunit NuoA of the proton-translocating NADH-quinone oxidoreductase from Escherichia coli

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12 December 2020

Functional significance of conserved histidines and arginines in the 49-kDa subunit of mitochondrial complex I.

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12 December 2020

Proton translocation in the respiratory chain involving ubiquinone--a hypothetical semiquinone switch mechanism for complex I.

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12 December 2020

Exploring the inhibitor binding pocket of respiratory complex I.

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12 December 2020

Modular evolution of the respiratory NADH:ubiquinone oxidoreductase and the origin of its modules

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12 December 2020

Presence of an acyl carrier protein in NADH:ubiquinone oxidoreductase from bovine heart mitochondria.

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12 December 2020

Studies on the electron transfer pathway, topography of iron-sulfur centers, and site of coupling in NADH-Q oxidoreductase.

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12 December 2020

Characterization of a subcomplex of mitochondrial NADH:ubiquinone oxidoreductase (complex I) lacking the flavoprotein part of the N-module.

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12 December 2020

Bovine complex I is a complex of 45 different subunits.

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12 December 2020

Superoxide Radical Formation by Pure Complex I (NADH:Ubiquinone Oxidoreductase) fromYarrowia lipolytica

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12 December 2020

Thermodynamic and EPR studies of slowly relaxing ubisemiquinone species in the isolated bovine heart complex I

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12 December 2020

A novel recurrent mitochondrial DNA mutation in ND3 gene is associated with isolated complex I deficiency causing Leigh syndrome and dystonia

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12 December 2020

Relaxation filtered hyperfine (REFINE) spectroscopy: a novel tool for studying overlapping biological electron paramagnetic resonance signals applied to mitochondrial complex I.

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12 December 2020

A reductant-induced oxidation mechanism for complex I

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12 December 2020

Structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus

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12 December 2020

A central functional role for the 49-kDa subunit within the catalytic core of mitochondrial complex I.

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12 December 2020

Inhibitors of NADH-ubiquinone reductase: an overview

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12 December 2020

Mutagenesis of three conserved Glu residues in a bacterial homologue of the ND1 subunit of complex I affects ubiquinone reduction kinetics but not inhibition by dicyclohexylcarbodiimide

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12 December 2020

Superoxide production by NADH:ubiquinone oxidoreductase (complex I) depends on the pH gradient across the mitochondrial inner membrane

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12 December 2020

Electron tunneling chains of mitochondria.

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12 December 2020

2D-REFINE spectroscopy: separation of overlapping hyperfine spectra

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12 December 2020

Evidence for a quinone binding site close to the interface between NUOD and NUOB subunits of Complex I.

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12 December 2020

Generation of reactive oxygen species by the mitochondrial electron transport chain

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12 December 2020

Consistent structure between bacterial and mitochondrial NADH:ubiquinone oxidoreductase (complex I).

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12 December 2020

Characterization of the NuoM (ND4) subunit in Escherichia coli NDH-1: conserved charged residues essential for energy-coupled activities

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12 December 2020

Direct localization of the 51 and 24 kDa subunits of mitochondrial complex I by three-dimensional difference imaging

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12 December 2020

Conserved lysine residues of the membrane subunit NuoM are involved in energy conversion by the proton-pumping NADH:ubiquinone oxidoreductase (Complex I).

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12 December 2020

The location of NuoL and NuoM subunits in the membrane domain of the Escherichia coli complex I: implications for the mechanism of proton pumping

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12 December 2020

Generation of superoxide-radical by the NADH:ubiquinone oxidoreductase of heart mitochondria

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12 December 2020

S-nitrosation of mitochondrial complex I depends on its structural conformation

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12 December 2020

Higher plant-like subunit composition of mitochondrial complex I from Chlamydomonas reinhardtii: 31 conserved components among eukaryotes

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12 December 2020

Proton pumping by NADH:ubiquinone oxidoreductase. A redox driven conformational change mechanism?

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12 December 2020

Characterization of the membrane domain subunit NuoJ (ND6) of the NADH-quinone oxidoreductase from Escherichia coli by chromosomal DNA manipulation

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12 December 2020

Three classes of inhibitors share a common binding domain in mitochondrial complex I (NADH:ubiquinone oxidoreductase).

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12 December 2020

Reevaluating the relationship between EPR spectra and enzyme structure for the iron sulfur clusters in NADH:quinone oxidoreductase

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12 December 2020

NADH-quinone oxidoreductase: PSST subunit couples electron transfer from iron-sulfur cluster N2 to quinone

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12 December 2020

Exploring the Ubiquinone Binding Cavity of Respiratory Complex I

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12 December 2020

Production of reactive oxygen species by complex I (NADH:ubiquinone oxidoreductase) from Escherichia coli and comparison to the enzyme from mitochondria

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12 December 2020

Conformation-driven and semiquinone-gated proton-pump mechanism in the NADH-ubiquinone oxidoreductase (complex I).

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12 December 2020

A pair of membrane-embedded acidic residues in the NuoK subunit of Escherichia coli NDH-1, a counterpart of the ND4L subunit of the mitochondrial complex I, are required for high ubiquinone reductase activity

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12 December 2020

Inhibitors of the quinone-binding site allow rapid superoxide production from mitochondrial NADH:ubiquinone oxidoreductase (complex I).

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12 December 2020

Two protons are pumped from the mitochondrial matrix per electron transferred between NADH and ubiquinone

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12 December 2020

The Redox-Bohr Group Associated with Iron-Sulfur Cluster N2 of Complex I

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12 December 2020

Real-time electron transfer in respiratory complex I

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12 December 2020

Were there any "misassignments" among iron-sulfur clusters N4, N5 and N6b in NADH-quinone oxidoreductase (complex I)?

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12 December 2020

Keilin's Respiratory Chain Concept and Its Chemiosmotic Consequences

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12 December 2020

De novo mutations in the mitochondrial ND3 gene as a cause of infantile mitochondrial encephalopathy and complex I deficiency

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12 December 2020

Partial resolution of the enzymes catalyzing oxidative phosphorylation. XV. Reverse electron transfer in the flavin-cytochrome beta region of the respiratory chain of beef heart submitochondrial particles.

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12 December 2020

Transmembrane topology of the NuoL, M and N subunits of NADH:quinone oxidoreductase and their homologues among membrane-bound hydrogenases and bona fide antiporters

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12 December 2020

Catalytic sector of complex I (NADH:ubiquinone oxidoreductase): subunit stoichiometry and substrate-induced conformation changes

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12 December 2020

Complex I-mediated reactive oxygen species generation: modulation by cytochrome c and NAD(P)+ oxidation-reduction state.

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12 December 2020

Mitochondrial formation of reactive oxygen species

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12 December 2020

Subunit proximity in the H+-translocating NADH-quinone oxidoreductase probed by zero-length cross-linking

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12 December 2020

The mechanism of superoxide production by NADH:ubiquinone oxidoreductase (complex I) from bovine heart mitochondria

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12 December 2020

Single particle analysis confirms distal location of subunits NuoL and NuoM in Escherichia coli complex I.

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12 December 2020

Catalytic properties of the mitochondrial NADH-ubiquinone oxidoreductase (complex I) and the pseudo-reversible active/inactive enzyme transition

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12 December 2020

Identification of the mitochondrial ND3 subunit as a structural component involved in the active/deactive enzyme transition of respiratory complex I.

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12 December 2020

Exploring the membrane domain of the reduced nicotinamide adenine dinucleotide-quinone oxidoreductase of Paracoccus denitrificans: characterization of the NQO7 subunit

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12 December 2020

The Biology of Oxygen Radicals

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12 December 2020

The 49-kDa subunit of NADH-ubiquinone oxidoreductase (Complex I) is involved in the binding of piericidin and rotenone, two quinone-related inhibitors.

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12 December 2020

Energy converting NADH:quinone oxidoreductase (complex I).

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12 December 2020

Analysis of the pathogenic human mitochondrial mutation ND1/3460, and mutations of strictly conserved residues in its vicinity, using the bacterium Paracoccus denitrificans

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12 December 2020

Histidine 129 in the 75-kDa subunit of mitochondrial complex I from Yarrowia lipolytica is not a ligand for [Fe4S4] cluster N5 but is required for catalytic activity

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12 December 2020

Energy-dependent Complex I-associated ubisemiquinones in submitochondrial particles.

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12 December 2020

Dissociation of superoxide production by mitochondrial complex I from NAD(P)H redox state

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12 December 2020

Iron-sulfur clusters/semiquinones in complex I.

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12 December 2020

Characterization of cluster N5 as a fast-relaxing [4Fe-4S] cluster in the Nqo3 subunit of the proton-translocating NADH-ubiquinone oxidoreductase from Paracoccus denitrificans

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12 December 2020

The site of production of superoxide radical in mitochondrial Complex I is not a bound ubisemiquinone but presumably iron-sulfur cluster N2.

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12 December 2020

Mitochondrial NADH-ubiquinone oxidoreductase (Complex I). Effect of substrates on the fragmentation of subunits by trypsin

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12 December 2020

Proton-translocation by membrane-bound NADH:ubiquinone-oxidoreductase (complex I) through redox-gated ligand conduction

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12 December 2020

Projection structure of the membrane domain of Escherichia coli respiratory complex I at 8 A resolution

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12 December 2020

The ND5 subunit was labeled by a photoaffinity analogue of fenpyroximate in bovine mitochondrial complex I.

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12 December 2020

DeltaPsi(m)-Dependent and -independent production of reactive oxygen species by rat brain mitochondria

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12 December 2020

Functional implications from an unexpected position of the 49-kDa subunit of NADH:ubiquinone oxidoreductase

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12 December 2020

Tight binding of NADPH to the 39-kDa subunit of complex I is not required for catalytic activity but stabilizes the multiprotein complex

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12 December 2020

Active/de-active transition of respiratory complex I in bacteria, fungi, and animals

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12 December 2020

Substrate-induced conformational change in bacterial complex I.

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12 December 2020

A reductase/isomerase subunit of mitochondrial NADH:ubiquinone oxidoreductase (complex I) carries an NADPH and is involved in the biogenesis of the complex.

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12 December 2020

Characterization of the membrane domain subunit NuoK (ND4L) of the NADH-quinone oxidoreductase from Escherichia coli

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12 December 2020

Active/de-active state transition of the mitochondrial complex I as revealed by specific sulfhydryl group labeling.

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12 December 2020

The three-dimensional structure of complex I from Yarrowia lipolytica: a highly dynamic enzyme

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12 December 2020

10.1007/S10863-008-9171-9

Identifiers

DOI

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19 August 2017

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