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PHD finger of autoimmune regulator: an epigenetic link between the histone modifications and tissue-specific antigen expression in thymus
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scholarly article
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Europe PubMed Central
PMCID
2635555
retrieved
19 August 2017
review article
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stated in
Europe PubMed Central
title
PHD finger of autoimmune regulator: an epigenetic link between the histone modifications and tissue-specific antigen expression in thymus
(English)
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stated in
Europe PubMed Central
PMCID
2635555
retrieved
19 August 2017
author
Giovanna Musco
object named as
Giovanna Musco
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1
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Pärt Peterson
object named as
Pärt Peterson
series ordinal
2
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publication date
14 November 2008
1 reference
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Europe PubMed Central
PMCID
2635555
retrieved
19 August 2017
published in
Epigenetics
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stated in
Europe PubMed Central
PMCID
2635555
retrieved
19 August 2017
volume
3
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stated in
Europe PubMed Central
PMCID
2635555
retrieved
19 August 2017
page(s)
310-314
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stated in
Europe PubMed Central
PMCID
2635555
retrieved
19 August 2017
issue
6
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stated in
Europe PubMed Central
PMCID
2635555
retrieved
19 August 2017
cites work
Aire employs a histone-binding module to mediate immunological tolerance, linking chromatin regulation with organ-specific autoimmunity.
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PHD fingers in human diseases: disorders arising from misinterpreting epigenetic marks
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The autoimmune regulator PHD finger binds to non-methylated histone H3K4 to activate gene expression
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PubMed Central
reference URL
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RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination
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Recognition of unmethylated histone H3 lysine 4 links BHC80 to LSD1-mediated gene repression
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DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA
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Chromatin modifications and their function
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PubMed Central
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It takes a PHD to read the histone code
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6 September 2017
Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF
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A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling
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Mutations in the gene encoding the PML nuclear body protein Sp110 are associated with immunodeficiency and hepatic veno-occlusive disease
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6 September 2017
A central role for central tolerance
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6 September 2017
Autoimmune polyendocrinopathy syndrome type 1 (APS1) and AIRE gene: new views on molecular basis of autoimmunity
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6 September 2017
Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels
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6 September 2017
Coordination of transcription factor phosphorylation and histone methylation by the P-TEFb kinase during human immunodeficiency virus type 1 transcription
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6 September 2017
AIRE functions as an E3 ubiquitin ligase
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PubMed Central
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6 September 2017
Projection of an immunological self shadow within the thymus by the aire protein
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6 September 2017
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6 September 2017
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6 September 2017
The autoimmune regulator protein has transcriptional transactivating properties and interacts with the common coactivator CREB-binding protein
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14 September 2017
AIRE recruits P-TEFb for transcriptional elongation of target genes in medullary thymic epithelial cells
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26 June 2018
Structural insight into the recognition of the H3K4me3 mark by the TFIID subunit TAF3.
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2 September 2018
NMR structure of the first PHD finger of autoimmune regulator protein (AIRE1). Insights into autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) disease
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2 September 2018
APECED-causing mutations in AIRE reveal the functional domains of the protein
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2 September 2018
Autoimmune regulator is expressed in the cells regulating immune tolerance in thymus medulla.
1 reference
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reference URL
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retrieved
2 September 2018
The autoimmune regulator PHD finger binds to non-methylated histone H3K4 to activate gene expression
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2635555
retrieved
3 December 2018
The autoimmune regulator directly controls the expression of genes critical for thymic epithelial function
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/19011376
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.4161/EPI.3.6.7182
1 reference
stated in
Europe PubMed Central
PMCID
2635555
retrieved
19 August 2017
PMCID
2635555
1 reference
stated in
Europe PubMed Central
PMCID
2635555
retrieved
19 August 2017
PubMed ID
19011376
1 reference
stated in
Europe PubMed Central
PMCID
2635555
retrieved
19 August 2017
ResearchGate publication ID
23475709
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