(Q37327734)

19 August 2017

A novel Hsp90 inhibitor AT13387 induces senescence in EBV-positive nasopharyngeal carcinoma cells and suppresses tumor formation (English)

1 reference

19 August 2017

1 reference

ChEBI release 2020-05-28

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24156782%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Ricky N S Wong

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24156782%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Maria Li Lung

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24156782%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

author name string

King Chi Chan

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24156782%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Choi Man Ting

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24156782%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Pui Shan Chan

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24156782%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Ming Chu Lo

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24156782%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Kwok Wai Lo

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24156782%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Jayne E Curry

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24156782%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Tomoko Smyth

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24156782%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Anne Wing Mui Lee

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24156782%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

George Sai Wah Tsao

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24156782%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Nai Ki Mak

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24156782%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

publication date

24 October 2013

1 reference

19 August 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24156782%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

volume

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24156782%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

issue

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24156782%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

page(s)

128

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24156782%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1186/1476-4598-12-128

3 June 2020

exact match

0 references

cites work

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1 reference

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The HSP90 inhibitor, AT13387, is effective against imatinib-sensitive and -resistant gastrointestinal stromal tumor models

6 September 2017

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Complexity in the signaling network: insights from the use of targeted inhibitors in cancer therapy

6 September 2017

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Novel systemic therapeutic for nasopharyngeal carcinoma.

6 September 2017

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Senescence: a new weapon for cancer therapy

6 September 2017

1 reference

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Tumorspheres derived from prostate cancer cells possess chemoresistant and cancer stem cell properties

6 September 2017

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Novel roles of Skp2 E3 ligase in cellular senescence, cancer progression, and metastasis

6 September 2017

1 reference

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The heat shock protein 90 inhibitor, AT13387, displays a long duration of action in vitro and in vivo in non-small cell lung cancer

6 September 2017

1 reference

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Role of STAT3/5 and Bcl-2/xL in 2-methoxyestradiol-induced endoreduplication of nasopharyngeal carcinoma cells

6 September 2017

1 reference

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Isolation and characterization of spheroid cells from the HT29 colon cancer cell line

6 September 2017

1 reference

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CD44: can a cancer-initiating cell profit from an abundantly expressed molecule?

6 September 2017

1 reference

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Correlation of Skp2 overexpression to prognosis of patients with nasopharyngeal carcinoma from South China

6 September 2017

1 reference

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The role of HDAC6 in cancer

6 September 2017

1 reference

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Therapy-induced senescence in cancer

6 September 2017

1 reference

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Discovery of (2,4-dihydroxy-5-isopropylphenyl)-[5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl]methanone (AT13387), a novel inhibitor of the molecular chaperone Hsp90 by fragment based drug design

6 September 2017

1 reference

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Targeting the dynamic HSP90 complex in cancer

6 September 2017

1 reference

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Induction of premature senescence by hsp90 inhibition in small cell lung cancer

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3834878

A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3834878

Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3834878

Treatment approaches to nasopharyngeal carcinoma: a review.

6 September 2017

1 reference

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Senescence in tumours: evidence from mice and humans

6 September 2017

1 reference

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New developments in Hsp90 inhibitors as anti-cancer therapeutics: mechanisms, clinical perspective and more potential.

6 September 2017

1 reference

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Effect of S-phase kinase-associated protein 2 expression on distant metastasis and survival in nasopharyngeal carcinoma patients

6 September 2017

1 reference

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Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer

6 September 2017

1 reference

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HDAC6: a key regulator of cytoskeleton, cell migration and cell-cell interactions

6 September 2017

1 reference

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Involvement of CD44, a molecule with a thousand faces, in cancer dissemination.

6 September 2017

1 reference

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Nasopharyngeal carcinoma--review of the molecular mechanisms of tumorigenesis

6 September 2017

1 reference

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Development and application of Hsp90 inhibitors

6 September 2017

1 reference

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Cellular senescence: when bad things happen to good cells

6 September 2017

1 reference

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Tumor selectivity of Hsp90 inhibitors: the explanation remains elusive

6 September 2017

1 reference

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Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

6 September 2017

1 reference

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HSP90 and the chaperoning of cancer

6 September 2017

1 reference

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Focus on nasopharyngeal carcinoma

6 September 2017

1 reference

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The Hsp90 chaperone complex as a novel target for cancer therapy

6 September 2017

1 reference

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Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence

6 September 2017

1 reference

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CD44: from adhesion molecules to signalling regulators

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3834878

In vivo destabilization of dynamic microtubules by HDAC6-mediated deacetylation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3834878

Epstein-Barr virus in the pathogenesis of NPC.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3834878

HDAC6 is a microtubule-associated deacetylase

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3834878

Characterization of a new EBV-associated nasopharyngeal carcinoma cell line.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3834878

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3834878

Cancer stem cell traits in squamospheres derived from primary head and neck squamous cell carcinomas.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3834878

Preclinical activity of gefitinib in non-keratinizing nasopharyngeal carcinoma cell lines and biomarkers of response

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3834878

Role of p38 MAPKs in hypericin photodynamic therapy-induced apoptosis of nasopharyngeal carcinoma cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3834878

Antitumor effect and enhancement of cytotoxic drug activity by cetuximab in nasopharyngeal carcinoma cells.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3834878

A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3834878

Nasopharyngeal carcinoma signaling pathway: an update on molecular biomarkers.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3834878

Akt finds its new path to regulate cell cycle through modulating Skp2 activity and its destruction by APC/Cdh1.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3834878

Identification of aberrant cell cycle regulation in Epstein-Barr virus-associated nasopharyngeal carcinoma by cDNA microarray and gene set enrichment analysis

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3834878

2 September 2018

Skp2: caught in the Akt.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3834878

HDAC6 inhibition enhances 17-AAG--mediated abrogation of hsp90 chaperone function in human leukemia cells

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3834878

A phase II study of patients with metastatic or locoregionally recurrent nasopharyngeal carcinoma and evaluation of plasma Epstein-Barr virus DNA as a biomarker of efficacy.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3834878

Differential expression of Epstein-Barr virus-encoded RNA and several tumor-related genes in various types of nasopharyngeal epithelial lesions and nasopharyngeal carcinoma using tissue microarray analysis

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3834878

Prognostic significance of tumor angiogenesis, Ki 67, p53 oncoprotein, epidermal growth factor receptor and HER2 receptor protein expression in undifferentiated nasopharyngeal carcinoma--a prospective study.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3834878

2 September 2018

Nasopharyngeal carcinoma

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24156782

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1186/1476-4598-12-128

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24156782%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

3 June 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24156782%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

PubMed publication ID

24156782

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24156782%20AND%20SRC:MED&resulttype=core&format=json