(Q37331541)

19 August 2017

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title

Progress in the discovery of compounds inhibiting orthopoxviruses in animal models (English)

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19 August 2017

1

Donald F Smee

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19 August 2017

publication date

1 January 2008

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Antiviral Chemistry & Chemotherapy

19 August 2017

published in

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19 August 2017

volume

19

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19 August 2017

issue

3

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19 August 2017

page(s)

115-124

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Countermeasures to the bioterrorist threat of smallpox

19 August 2017

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Smallpox as a bioterrorist weapon: myth or menace?

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Project BioShield: what it is, why it is needed, and its accomplishments so far

21 January 2018

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Potential antiviral therapeutics for smallpox, monkeypox and other orthopoxvirus infections

21 January 2018

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Cidofovir protects mice against lethal aerosol or intranasal cowpox virus challenge

21 January 2018

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The pathology of experimental aerosolized monkeypox virus infection in cynomolgus monkeys (Macaca fascicularis).

21 January 2018

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A review of compounds exhibiting anti-orthopoxvirus activity in animal models

21 January 2018

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A case of severe monkeypox virus disease in an American child: emerging infections and changing professional values

21 January 2018

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Smallpox antiviral drug development: satisfying the animal efficacy rule

21 January 2018

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https://api.crossref.org/works/10.1177%2F095632020801900302

Pharmacokinetics, safety and bioavailability of HPMPC (cidofovir) in human immunodeficiency virus-infected subjects

21 January 2018

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https://api.crossref.org/works/10.1177%2F095632020801900302

Esterification of cidofovir with alkoxyalkanols increases oral bioavailability and diminishes drug accumulation in kidney.

21 January 2018

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https://api.crossref.org/works/10.1177%2F095632020801900302

An orally bioavailable antipoxvirus compound (ST-246) inhibits extracellular virus formation and protects mice from lethal orthopoxvirus Challenge

21 January 2018

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https://api.crossref.org/works/10.1177%2F095632020801900302

Severe eczema vaccinatum in a household contact of a smallpox vaccinee

21 January 2018

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https://api.crossref.org/works/10.1177%2F095632020801900302

Single-dose safety and pharmacokinetics of ST-246, a novel orthopoxvirus egress inhibitor

21 January 2018

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https://api.crossref.org/works/10.1177%2F095632020801900302

Hepatic failure and lactic acidosis due to fialuridine (FIAU), an investigational nucleoside analogue for chronic hepatitis B.

21 January 2018

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https://api.crossref.org/works/10.1177%2F095632020801900302

Disabling poxvirus pathogenesis by inhibition of Abl-family tyrosine kinases

21 January 2018

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In vitro and in vivo evaluation of isatin-beta-thiosemicarbazone and marboran against vaccinia and cowpox virus infections

21 January 2018

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https://api.crossref.org/works/10.1177%2F095632020801900302

Cell line dependency for antiviral activity and in vivo efficacy of N-methanocarbathymidine against orthopoxvirus infections in mice

21 January 2018

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https://api.crossref.org/works/10.1177%2F095632020801900302

Antiviral chemotherapeutic activity of isatin beta-thiosemicarbazone in mice infected with rabbit-pox virus

21 January 2018

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https://api.crossref.org/works/10.1177%2F095632020801900302

Characterization of wild-type and cidofovir-resistant strains of camelpox, cowpox, monkeypox, and vaccinia viruses

21 January 2018

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https://api.crossref.org/works/10.1177%2F095632020801900302

Efficacy of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine for the treatment of lethal vaccinia virus infections in severe combined immune deficiency (SCID) mice

21 January 2018

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https://api.crossref.org/works/10.1177%2F095632020801900302

Efficacy of 2-amino-7-(1,3-dihydroxy-2-propoxymethyl)purine for treatment of vaccinia virus (orthopoxvirus) infections in mice

21 January 2018

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https://api.crossref.org/works/10.1177%2F095632020801900302

Treatment of Fatal Disseminated Vaccinia Virus Infection in Immunosuppressed Mice

21 January 2018

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https://api.crossref.org/works/10.1177%2F095632020801900302

Treatment of poxvirus infections in rabbits with 9-beta-D-arabinofuranosyladenine

21 January 2018

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https://api.crossref.org/works/10.1177%2F095632020801900302

Efficacy of oral active ether lipid analogs of cidofovir in a lethal mousepox model

21 January 2018

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https://api.crossref.org/works/10.1177%2F095632020801900302

Ectromelia virus: the causative agent of mousepox

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020801900302

The efficacy of cidofovir treatment of mice infected with ectromelia (mousepox) virus encoding interleukin-4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020801900302

Effects of cidofovir treatment on cytokine induction in murine models of cowpox and vaccinia virus infection

21 January 2018

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https://api.crossref.org/works/10.1177%2F095632020801900302

In vivo imaging of cidofovir treatment of cowpox virus infection.

21 January 2018

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https://api.crossref.org/works/10.1177%2F095632020801900302

Characterization and treatment of cidofovir-resistant vaccinia (WR strain) virus infections in cell culture and in mice

21 January 2018

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https://api.crossref.org/works/10.1177%2F095632020801900302

Cidofovir resistance in vaccinia virus is linked to diminished virulence in mice

21 January 2018

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https://api.crossref.org/works/10.1177%2F095632020801900302

Mutations in the E9L polymerase gene of cidofovir-resistant vaccinia virus strain WR are associated with the drug resistance phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020801900302

Effects of four antiviral substances on lethal vaccinia virus (IHD strain) respiratory infections in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020801900302

Differential pathogenesis of cowpox virus intranasal infections in mice induced by low and high inoculum volumes and effects of cidofovir treatment

21 January 2018

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https://api.crossref.org/works/10.1177%2F095632020801900302

Efficacy of cidofovir in a murine model of disseminated progressive vaccinia

21 January 2018

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https://api.crossref.org/works/10.1177%2F095632020801900302

Cutaneous infections of mice with vaccinia or cowpox viruses and efficacy of cidofovir

21 January 2018

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https://api.crossref.org/works/10.1177%2F095632020801900302

Topical cidofovir is more effective than is parenteral therapy for treatment of progressive vaccinia in immunocompromised mice

21 January 2018

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https://api.crossref.org/works/10.1177%2F095632020801900302

Rabbitpox virus and vaccinia virus infection of rabbits as a model for human smallpox

21 January 2018

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https://api.crossref.org/works/10.1177%2F095632020801900302

Antiviral treatment is more effective than smallpox vaccination upon lethal monkeypox virus infection

21 January 2018

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https://api.crossref.org/works/10.1177%2F095632020801900302

Smallpox DNA vaccine protects nonhuman primates against lethal monkeypox

21 January 2018

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https://api.crossref.org/works/10.1177%2F095632020801900302

Exploring the potential of variola virus infection of cynomolgus macaques as a model for human smallpox

21 January 2018

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https://api.crossref.org/works/10.1177%2F095632020801900302

Efficacy of therapeutic intervention with an oral ether-lipid analogue of cidofovir (CMX001) in a lethal mousepox model

21 January 2018

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https://api.crossref.org/works/10.1177%2F095632020801900302

Efficacy of Multiple- or Single-Dose Cidofovir against Vaccinia and Cowpox Virus Infections in Mice

21 January 2018

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https://api.crossref.org/works/10.1177%2F095632020801900302

Aerosolized cidofovir is retained in the respiratory tract and protects mice against intranasal cowpox virus challenge

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020801900302

Investigating the effects of stereochemistry on incorporation and removal of 5-fluorocytidine analogs by mitochondrial DNA polymerase gamma: comparison of D- and L-D4FC-TP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020801900302

Effect of oral treatment with hexadecyloxypropyl-[(S)-9-(3-hydroxy-2- phosphonylmethoxypropyl)adenine] [(S)-HPMPA] or octadecyloxyethyl-(S)-HPMPA on cowpox or vaccinia virus infections in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020801900302

Oral 1-O-octadecyl-2-O-benzyl-sn-glycero-3-cidofovir targets the lung and is effective against a lethal respiratory challenge with ectromelia virus in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020801900302

Oral treatment of cowpox and vaccinia virus infections in mice with ether lipid esters of cidofovir.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020801900302

Synergistic efficacy of the combination of ST-246 with CMX001 against orthopoxviruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020801900302

Efficacy of delayed treatment with ST-246 given orally against systemic orthopoxvirus infections in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020801900302

Evaluation of orally delivered ST-246 as postexposure prophylactic and antiviral therapeutic in an aerosolized rabbitpox rabbit model

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020801900302

Anti-cowpox virus activities of certain adenosine analogs, arabinofuranosyl nucleosides, and 2'-fluoro-arabinofuranosyl nucleosides

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020801900302

Antiviral potential of a new generation of acyclic nucleoside phosphonates, the 6-[2-(phosphonomethoxy)alkoxy]-2,4-diaminopyrimidines

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020801900302

Prevention of lethal respiratory vaccinia infections in mice with interferon-alpha and interferon-gamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020801900302

Murine interferon lambdas (type III interferons) exhibit potent antiviral activity in vivo in a poxvirus infection model

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020801900302

Activity and mechanism of action of N-methanocarbathymidine against herpesvirus and orthopoxvirus infections

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020801900302

Efficacy of N-methanocarbathymidine in treating mice infected intranasally with the IHD and WR strains of vaccinia virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020801900302

Comparative pathology of North American and central African strains of monkeypox virus in a ground squirrel model of the disease.

21 January 2018

1 reference

21 May 2022

https://opencitations.net/index/coci/api/v1/citations/10.4269/AJTMH.2007.76.155

Identifiers

DOI

10.1177/095632020801900302

1 reference

19 August 2017

1 reference