(Q37346228)

English

From delocalized lipophilic cations to hypoxia: blocking tumor cell mitochondrial function leads to therapeutic gain with glycolytic inhibitors

scientific article published on January 2009

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

1 reference

Europe PubMed Central

From delocalized lipophilic cations to hypoxia: blocking tumor cell mitochondrial function leads to therapeutic gain with glycolytic inhibitors (English)

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

0 references

1 reference

based on heuristic

inferred from title

author name string

Metin Kurtoglu

1

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Theodore J Lampidis

2

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

publication date

1 January 2009

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Molecular Nutrition and Food Research

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

53

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

1

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

68-75

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Mitochondrial alterations in human gastric carcinoma cell line.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928140

6 September 2017

A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928140

6 September 2017

Activation of the HIF pathway in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928140

6 September 2017

Delocalized lipophilic cations selectively target the mitochondria of carcinoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928140

6 September 2017

General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928140

6 September 2017

Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928140

6 September 2017

Localization of mitochondria in living cells with rhodamine 123

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928140

6 September 2017

Monitoring of relative mitochondrial membrane potential in living cells by fluorescence microscopy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928140

6 September 2017

Unusual retention of rhodamine 123 by mitochondria in muscle and carcinoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928140

6 September 2017

Cardiac toxicity of daunorubicin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928140

6 September 2017

Aromatic-aromatic interaction: a mechanism of protein structure stabilization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928140

6 September 2017

Multidrug resistance of DNA-mediated transformants is linked to transfer of the human mdr1 gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928140

6 September 2017

Mitochondrial Membrane Potential in Living Cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928140

6 September 2017

Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928140

6 September 2017

Essential features of the P-glycoprotein pharmacophore as defined by a series of reserpine analogs that modulate multidrug resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928140

6 September 2017

The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928140

6 September 2017

Expression of a multidrug-resistance gene in human tumors and tissues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928140

6 September 2017

Structural requirements of simple organic cations for recognition by multidrug-resistant cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928140

6 September 2017

Rational design and pre-clinical pharmacology of drugs for reversing multidrug resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928140

6 September 2017

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928140

6 September 2017

Adriamycin cardiotoxicity: early detection by systolic time interval and possible prevention by coenzyme Q10

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928140

6 September 2017

Weakly polar interactions in proteins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928140

14 September 2017

Hypoxia-inducible factor-1 confers resistance to the glycolytic inhibitor 2-deoxy-D-glucose

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928140

14 September 2017

Design and tumor targeting of anthracyclines able to overcome multidrug resistance: a double-advantage approach

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928140

14 September 2017

Regulation of hypoxia-inducible factor is preserved in the absence of a functioning mitochondrial respiratory chain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928140

28 September 2017

Circumvention of P-GP MDR as a function of anthracycline lipophilicity and charge

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928140

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928140

28 September 2017

Relationship of multidrug resistance to rhodamine-123 selectivity between carcinoma and normal epithelial cells: taxol and vinblastine modulate drug efflux

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928140

28 September 2017

A single membrane-embedded negative charge is critical for recognizing positively charged drugs by the Escherichia coli multidrug resistance protein MdfA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928140

26 June 2018

Oxidative phosphorylation enzymes in normal and neoplastic cell growth.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928140

26 June 2018

Mitochondrial biogenesis in the liver during development and oncogenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928140

26 June 2018

Resistance to lipophilic cationic compounds in multidrug resistant leukemia cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928140

26 June 2018

Removal of the basic center from doxorubicin partially overcomes multidrug resistance and decreases cardiotoxicity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928140

26 June 2018

Probing mitochondria in living cells with rhodamine 123.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928140

26 June 2018

Anticarcinoma activity in vivo of rhodamine 123, a mitochondrial-specific dye.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928140

26 June 2018

Decreased uptake and retention of rhodamine 123 by mitochondria in feline sarcoma virus-transformed mink cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928140

26 June 2018

Cellular resistance to daunomycin in Chinese hamster cells in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928140

26 June 2018

Mitochondrial and plasma membrane potentials cause unusual accumulation and retention of rhodamine 123 by human breast adenocarcinoma-derived MCF-7 cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928140

26 June 2018

Selective killing of carcinoma cells "in vitro" by lipophilic-cationic compounds: a cellular basis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928140

26 June 2018

Physical-chemical properties shared by compounds that modulate multidrug resistance in human leukemic cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928140

26 June 2018

Structure-activity relationships of antineoplastic agents in multidrug resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928140

26 June 2018

Expression of mitochondrial cytochrome c oxidase in human colonic cell differentiation, transformation, and risk for colonic cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928140

26 June 2018

Reduced ouabain-sensitive potassium entry as a possible mechanism of multidrug-resistance in P388 cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928140

26 June 2018

Comparison of the adenine nucleotide translocase in hepatomas and rat liver mitochondria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928140

26 June 2018

Targeting hypoxia, a novel treatment for advanced retinoblastoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928140

2 September 2018

Greater cell cycle inhibition and cytotoxicity induced by 2-deoxy-d-glucose in tumor cells treated under hypoxic vs aerobic conditions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928140

2 September 2018

Hypoxia increases tumor cell sensitivity to glycolytic inhibitors: a strategy for solid tumor therapy (Model C).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928140

2 September 2018

Hypersensitization of tumor cells to glycolytic inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928140

2 September 2018

Preclinical toxicity of liposome-incorporated annamycin: selective bone marrow toxicity with lack of cardiotoxicity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928140

2 September 2018

Improving cancer radiotherapy with 2-deoxy-D-glucose: phase I/II clinical trials on human cerebral gliomas.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928140

2 September 2018

Antitumor activity of free and liposome-entrapped annamycin, a lipophilic anthracycline antibiotic with non-cross-resistance properties.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928140

2 September 2018

Transmembrane aromatic amino acid distribution in P-glycoprotein. A functional role in broad substrate specificity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928140

2 September 2018

Cross resistance relevance of the chemical structure of different anthracyclines in multidrug resistant cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928140

2 September 2018

A phase I and pharmacokinetic study of the mitochondrial-specific rhodacyanine dye analog MKT 077

1 reference

https://pubmed.ncbi.nlm.nih.gov/19072739

12 December 2020

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Vascular endothelial growth factor, interleukin 8, platelet-derived endothelial cell growth factor, and basic fibroblast growth factor promote angiogenesis and metastasis in human melanoma xenografts

1 reference

https://pubmed.ncbi.nlm.nih.gov/19072739

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Active outward transport of daunomycin in resistant Ehrlich ascites tumor cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19072739

12 December 2020

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A study of some mitochondrial and peroxisomal enzymes in human colonic adenocarcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/19072739

12 December 2020

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Structural and functional effects of adriamycin on cardiac cells in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/19072739

12 December 2020

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Effects of Adriamycin on rat heart cells in culture: Increased accumulation and nucleoli fragmentation in cardiac muscle v. non-muscle cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19072739

12 December 2020

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Selective toxicity of rhodamine 123 in carcinoma cells in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/19072739

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rhodamine 123 inhibits bioenergetic function in isolated rat liver mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/19072739

12 December 2020

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Effects of the mitochondrial probe rhodamine 123 and related analogs on the function and viability of pulsating myocardial cells in culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/19072739

12 December 2020

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Interaction of rhodamine 123 with mitochondria isolated from drug-sensitive and -resistant Friend leukemia cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19072739

12 December 2020

based on heuristic

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Function of the anthracycline amino group in cellular transport and cytotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19072739

12 December 2020

based on heuristic

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Relationship between the structure of analogues of amsacrine and their degree of cross-resistance to adriamycin-resistant P388 leukaemia cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19072739

12 December 2020

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Increased steady-state levels of several mitochondrial and nuclear gene transcripts in rat hepatoma with a low content of mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/19072739

12 December 2020

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Ursodeoxycholate promotes protein phosphorylation in the cytosol of rat hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19072739

12 December 2020

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inferred from PubMed ID database lookup

Identifiers

10.1002/MNFR.200700457

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

ResearchGate publication ID

0 references

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