(Q37361140)

19 August 2017

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title

Decanalization and the origin of complex disease (English)

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19 August 2017

Greg Gibson

1

1 reference

19 August 2017

language of work or name

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2 January 2009

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19 August 2017

Nature Reviews Genetics

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19 August 2017

10

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19 August 2017

134-140

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19 August 2017

2

1 reference

https://scigraph.springernature.com/pub.10.1038/nrg2502

19 August 2017

0 references

cites work

The burden and costs of chronic diseases in low-income and middle-income countries

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The evolutionary genetics of canalization

31 March 2020

1 reference

The genetic basis of complex traits: rare variants or "common gene, common disease"?

31 March 2020

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Genome-wide association studies: potential next steps on a genetic journey

31 March 2020

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An evolutionary framework for common diseases: the ancestral-susceptibility model

31 March 2020

1 reference

What can genome-wide association studies tell us about the genetics of common disease?

31 March 2020

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Post genome-wide association studies of novel genes associated with type 2 diabetes show gene-gene interaction and high predictive value

31 March 2020

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Human genetics: the hidden text of genome-wide associations

31 March 2020

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The population genetic theory of hidden variation and genetic robustness.

31 March 2020

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Theoretical approaches to the evolution of development and genetic architecture

31 March 2020

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Population bottlenecks as a potential major shaping force of human genome architecture

31 March 2020

1 reference

THE ADDITIVE GENETIC VARIANCE AFTER BOTTLENECKS IS AFFECTED BY THE NUMBER OF LOCI INVOLVED IN EPISTATIC INTERACTIONS

31 March 2020

1 reference

The conversion of variance and the evolutionary potential of restricted recombination.

31 March 2020

1 reference

Will population bottlenecks and multilocus epistasis increase additive genetic variance?

31 March 2020

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Mechanisms linking obesity to insulin resistance and type 2 diabetes

31 March 2020

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The double puzzle of diabetes

31 March 2020

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Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution

31 March 2020

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New insights into the role of cytokines in asthma

31 March 2020

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The alliance of genes and environment in asthma and allergy

31 March 2020

1 reference

Balanced polymorphism selected by genetic versus infectious human disease

31 March 2020

1 reference

Natural selection on protein-coding genes in the human genome

31 March 2020

1 reference

Family size, infection and atopy: the first decade of the "hygiene hypothesis".

31 March 2020

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Crohn's disease: the cold chain hypothesis.

31 March 2020

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Variability and robustness in T cell activation from regulated heterogeneity in protein levels

31 March 2020

1 reference

Major depression as a disorder of serotonin resistance: inference from diabetes mellitus type II.

31 March 2020

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Estimates of global mortality attributable to smoking in 2000

31 March 2020

1 reference

Data and theory point to mainly additive genetic variance for complex traits

31 March 2020

1 reference

Large recurrent microdeletions associated with schizophrenia

31 March 2020

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Strong association of de novo copy number mutations with autism

31 March 2020

1 reference

Epistasis--the essential role of gene interactions in the structure and evolution of genetic systems

31 March 2020

1 reference

Flanking gene and genetic background problems in genetically manipulated mice

31 March 2020

1 reference

Developmental system drift and flexibility in evolutionary trajectories

31 March 2020

1 reference

Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk

31 March 2020

1 reference

Common variants of FUT2 are associated with plasma vitamin B12 levels

31 March 2020

1 reference

Genome-wide scan on total serum IgE levels identifies FCER1A as novel susceptibility locus

31 March 2020

1 reference

Novel association of ABO histo-blood group antigen with soluble ICAM-1: results of a genome-wide association study of 6,578 women

31 March 2020

1 reference

Association between nucleotide variation in Egfr and wing shape in Drosophila melanogaster

31 March 2020

1 reference

Metabolic changes in schizophrenia and human brain evolution

31 March 2020

1 reference

Uncovering cryptic genetic variation.

31 March 2020

1 reference

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

31 March 2020

1 reference

Identifying autism loci and genes by tracing recent shared ancestry

31 March 2020

1 reference

Analysis of the threshold liability model provides new understanding of causation in autoimmune diseases

31 March 2020

1 reference

Genome-wide association analysis identifies 20 loci that influence adult height

31 March 2020

1 reference

Prediction of individual genetic risk to disease from genome-wide association studies

31 March 2020

1 reference

A genome-wide gene expression signature of environmental geography in leukocytes of Moroccan Amazighs.

31 March 2020

1 reference

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

31 March 2020

1 reference

Canalization in evolutionary genetics: a stabilizing theory?

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19119265

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Evolutionary and Biomedical Insights from the Rhesus Macaque Genome

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19119265

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRG2502

1 reference

Dimensions Publication ID

19 August 2017

1005380080

0 references

Fatcat ID

release_lr53yudeivew5dxpbtabu5yse4

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/lr53yudeivew5dxpbtabu5yse4

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference